URochester Medicine / Labs / Dean Lab / Publications

Recent Publications

1. Porter JJ
2. Ko W
3. Sorensen EG
4. Cheung Z
5. Thrasher K
6. Couch T
7. Gabell JT
8. Shwe V
9. Hyatt J
10. Licata JB
11. Peterson LK
12. Dean DA
13. Lueck JD
Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors.; Nucleic acids research; Vol 54(4). 2026 Feb 05.
1. Gu N
2. Baliga UK
3. Porter JJ
4. Lueck JD
5. Dean DA
Subnuclear organization and mislocalization of plasmids reduce transgene expression.; Molecular therapy. Nucleic acids; Vol 36(4), pp. 102730. 2025 Oct 09.
1. Porter JJ
2. Ko W
3. Sorensen EG
4. Cheung Z
5. Couch T
6. Gabell JT
7. Shwe V
8. Hyatt J
9. Licata JB
10. Peterson LK
11. Dean DA
12. Lueck JD
Anticodon Edited Transfer RNAs (ACE-tRNAs) Encoded as Therapeutic Nonviral Minimal DNA Vectors.; bioRxiv : the preprint server for biology. 2025 Sep 06.
1. Baliga UK
2. Gurunian A
3. Nogales A
4. Martinez-Sobrido L
5. Dean DA
Electroporation- and Liposome-Mediated Co-Transfection of Single and Multiple Plasmids.; Pharmaceutics; Vol 17(7). 2025 Jul 12.
1. Yee M
2. Misra R
3. Vesecky S
4. Barravecchia M
5. Najar RA
6. Rahman A
7. Pryhuber GS
8. Dean DA
9. Lawrence BP
10. Fisher D
11. O'Reilly MA
Ki-67 promotes inflammatory signaling governing neutrophil recruitment during respiratory infections.; EMBO molecular medicine. 2025 Jun 10.
1. Millar MW
2. Najar RA
3. Slavin SA
4. Shadab M
5. Tahir I
6. Mahamed Z
7. Lin X
8. Abe JI
9. Wright TW
10. Dean DA
11. Fazal F
12. Rahman A
MTOR maintains endothelial cell integrity to limit lung vascular injury.; The Journal of biological chemistry. 2024 Nov 05.
1. Lin X
2. Bai H
3. Barravecchia M
4. Norman R
5. Schiralli Lester GM
6. Kottmann RM
7. Leonard A
8. Rahman A
9. Young JL
10. Dean DA
Occludin Is Essential to Maintain Normal Alveolar Barrier Integrity and Its Protective Role During ARDS Progression.; International journal of molecular sciences; Vol 25(21). 2024 Oct 29.
1. Shadab M
2. Slavin SA
3. Mahamed Z
4. Millar MW
5. Najar RA
6. Leonard A
7. Pietropaoli A
8. Dean DA
9. Fazal F
10. Rahman A
Spleen Tyrosine Kinase phosphorylates VE-cadherin to cause endothelial barrier disruption in acute lung injury.; The Journal of biological chemistry; Vol 299(12), pp. 105408. 2023 Oct 28.
1. Liu J
2. Schiralli-Lester GM
3. Norman R
4. Dean DA
Upregulation of alveolar fluid clearance is not sufficient for Na+,K+-ATPase β subunit-mediated gene therapy of LPS-induced acute lung injury in mice.; Scientific reports; Vol 13(1), pp. 6792. 2023 Apr 26.
1. Gurunian A
2. Dean DA
Multiple conductance states of lipid pores during Voltage-Clamp electroporation.; Bioelectrochemistry (Amsterdam, Netherlands); Vol 151, pp. 108396. 2023 Feb 11.
1. Jagrosse ML
2. Baliga UK
3. Jones CW
4. Russell JJ
5. García CI
6. Najar RA
7. Rahman A
8. Dean DA
9. Nilsson BL
Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.; Molecular pharmaceutics. 2023 Jan 14.
1. Gurunian A
2. Dean DA
Modeling and simulation of current-clamp electroporation.; Bioelectrochemistry (Amsterdam, Netherlands); Vol 147. 2022 May 19.
1. Liu J
2. Dean DA
Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function.; Scientific reports; Vol 11(1). 2021 Oct 21.
1. Bai H
2. Zhou R
3. Barravecchia M
4. Norman R
5. Friedman AE
6. Yu D
7. Lin X
8. Young JL
9. Dean DA
MRCKα interacts with and mediates Na+, K+-ATPase-induced tight junction assembly in the lung epithelium.; JCI insight. 2021 Jan 28.
1. Eliseeva SI
2. Knowlden ZA
3. Lester GM
4. Dean DA
5. Georas SN
6. Chapman TJ
Changes in lung immune cell infiltrates after electric field treatment in mice.; Scientific reports; Vol 11(1). 2021 Jan 14.
1. Welch JJ
2. Dean DA
3. Nilsson BL
Synthesis and Application of Peptide-siRNA Nanoparticles from Disulfide-Constrained Cyclic Amphipathic Peptides for the Functional Delivery of Therapeutic Oligonucleotides to the Lung.; Methods in molecular biology (Clifton, N.J.); Vol 2208. 2021.
1. Liu J
2. Dean DA
Gene Therapy for Acute Respiratory Distress Syndrome.; Frontiers in physiology; Vol 12. 2021.
1. Baliga UK
2. Dean DA
Pulmonary gene delivery-Realities and possibilities.; Experimental biology and medicine (Maywood, N.J.). 2020 Nov 12.
1. Ávila-Pérez G
2. Nogales A
3. Park JG
4. Vasquez DM
5. Dean DA
6. Barravecchia M
7. Perez DR
8. Almazán F
9. Martínez-Sobrido L
In vivo rescue of recombinant Zika virus from an infectious cDNA clone and its implications in vaccine development.; Scientific reports; Vol 10(1). 2020 Jan 16.
1. Steiner LA
2. Getman M
3. Schiralli Lester GM
4. Iqbal MA
5. Katzman P
6. Szafranski P
7. Stankiewicz P
8. Bhattacharya S
9. Mariani T
10. Pryhuber G
11. Lin X
12. Young JL
13. Dean DA
14. Scheible K
Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.; Journal of medical genetics. 2019 Oct 29.
1. Jagrosse ML
2. Dean DA
3. Rahman A
4. Nilsson BL
RNAi therapeutic strategies for acute respiratory distress syndrome.; Translational research : the journal of laboratory and clinical medicine. 2019 Jul 27.
1. Leonard A
2. Millar MW
3. Slavin SA
4. Bijli KM
5. Dionisio Santos DA
6. Dean DA
7. Fazal F
8. Rahman A
Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.; Cellular signalling. 2019 May 01.
1. Bai H
2. Schiralli Lester GM
3. Petishnok LC
4. Dean DA
Cytoplasmic transport and nuclear import of plasmid DNA.; Bioscience reports. 2017 Oct 20.
1. Barnett RC
2. Lin X
3. Barravecchia M
4. Norman RA
5. de Mesy Bentley KL
6. Fazal F
7. Young JL
8. Dean DA
Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency.; Experimental biology and medicine (Maywood, N.J.); Vol 242(13). 2017 Jul.
1. Rahmani K
2. Dean DA
Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).; Biochemical and biophysical research communications; Vol 488(2). 2017 Jun 24.
1. Parikh P
2. Bai H
3. Swartz MF
4. Alfieris GM
5. Dean DA
Identification of differentially regulated genes in human patent ductus arteriosus.; Experimental biology and medicine (Maywood, N.J.). 2016 Jul 27.
1. Gottfried L
2. Lin X
3. Barravecchia M
4. Dean DA
Identification of an alveolar type I epithelial cell-specific DNA nuclear import sequence for gene delivery.; Gene therapy. 2016 Jul 1.
1. Welch JJ
2. Swanekamp RJ
3. King C
4. Dean DA
5. Nilsson BL
Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.; ACS medicinal chemistry letters; Vol 7(6). 2016 Jun 09.
1. Lin X
2. Barravecchia M
3. Kothari P
4. Young JL
5. Dean DA
β1-Na(+),K(+)-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury.; Gene therapy; Vol 23(6). 2016 Jun.
1. Emr BM
2. Roy S
3. Kollisch-Singule M
4. Gatto LA
5. Barravecchia M
6. Lin X
7. Young JL
8. Wang G
9. Liu J
10. Satalin J
11. Snyder K
12. Nieman GF
13. Dean DA
Electroporation-mediated gene delivery of Na+,K+ -ATPase, and ENaC subunits to the lung attenuates acute respiratory distress syndrome in a two-hit porcine model.; Shock (Augusta, Ga.); Vol 43(1). 2015 Jan.
1. Young JL
2. Dean DA
Electroporation-mediated gene delivery.; Advances in genetics; Vol 89. 2015.
1. Huber AR
2. Tan D
3. Sun J
4. Dean D
5. Wu T
6. Zhou Z
High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7.; BMC gastroenterology; Vol 15. 2015.
1. Vernon MM
2. Dean DA
3. Dobson J
DNA Targeting Sequence Improves Magnetic Nanoparticle-Based Plasmid DNA Transfection Efficiency in Model Neurons.; International journal of molecular sciences; Vol 16(8). 2015.
1. Young JL
2. Barravecchia MS
3. Dean DA
Electroporation-mediated gene delivery to the lungs.; Methods in molecular biology (Clifton, N.J.); Vol 1121. 2014.
1. Emr B
2. Gatto LA
3. Roy S
4. Satalin J
5. Ghosh A
6. Snyder K
7. Andrews P
8. Habashi N
9. Marx W
10. Ge L
11. Wang G
12. Dean DA
13. Vodovotz Y
14. Nieman G
Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs.; JAMA surgery; Vol 148(11). 2013 Nov.
1. Dean DA
Cell-specific targeting strategies for electroporation-mediated gene delivery in cells and animals.; The Journal of membrane biology; Vol 246(10). 2013 Oct.
1. Roy SK
2. Emr B
3. Sadowitz B
4. Gatto LA
5. Ghosh A
6. Satalin JM
7. Snyder KP
8. Ge L
9. Wang G
10. Marx W
11. Dean D
12. Andrews P
13. Singh A
14. Scalea T
15. Habashi N
16. Nieman GF
Preemptive application of airway pressure release ventilation prevents development of acute respiratory distress syndrome in a rat traumatic hemorrhagic shock model.; Shock (Augusta, Ga.); Vol 40(3). 2013 Sep.
1. Badding MA
2. Dean DA
Highly acetylated tubulin permits enhanced interactions with and trafficking of plasmids along microtubules.; Gene therapy; Vol 20(6). 2013 Jun.
1. Badding MA
2. Lapek JD
3. Friedman AE
4. Dean DA
Proteomic and functional analyses of protein-DNA complexes during gene transfer.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 21(4). 2013 Apr.
1. Roy S
2. Habashi N
3. Sadowitz B
4. Andrews P
5. Ge L
6. Wang G
7. Roy P
8. Ghosh A
9. Kuhn M
10. Satalin J
11. Gatto LA
12. Lin X
13. Dean DA
14. Vodovotz Y
15. Nieman G
Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury.; Shock (Augusta, Ga.); Vol 39(1). 2013 Jan.
1. Cramer F
2. Christensen CL
3. Poulsen TT
4. Badding MA
5. Dean DA
6. Poulsen HS
Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines.; Cancer gene therapy; Vol 19(10). 2012 Oct.
1. O'Reilly MA
2. Yee M
3. Buczynski BW
4. Vitiello PF
5. Keng PC
6. Welle SL
7. Finkelstein JN
8. Dean DA
9. Lawrence BP
Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.; The American journal of pathology; Vol 181(2). 2012 Aug.
1. Roy S
2. Sadowitz B
3. Andrews P
4. Gatto LA
5. Marx W
6. Ge L
7. Wang G
8. Lin X
9. Dean DA
10. Kuhn M
11. Ghosh A
12. Satalin J
13. Snyder K
14. Vodovotz Y
15. Nieman G
16. Habashi N
Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury.; The journal of trauma and acute care surgery; Vol 73(2). 2012 Aug.
1. Yao H
2. Chung S
3. Hwang JW
4. Rajendrasozhan S
5. Sundar IK
6. Dean DA
7. McBurney MW
8. Guarente L
9. Gu W
10. Rönty M
11. Kinnula VL
12. Rahman I
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.; The Journal of clinical investigation; Vol 122(6). 2012 Jun.
1. Badding MA
2. Vaughan EE
3. Dean DA
Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer.; Gene therapy; Vol 19(3). 2012 Mar.
1. Lin X
2. Dean DA
Gene therapy for ALI/ARDS.; Critical care clinics; Vol 27(3). 2011 Jul.
1. Eldib M
2. Dean DA
Cyclic stretch of alveolar epithelial cells alters cytoskeletal micromechanics.; Biotechnology and bioengineering; Vol 108(2). 2011 Feb.
1. Dean DA
2. Barravecchia BD
Use of Electroporation for Efficacious Gene Delivery to the Lungs; ECS Trans; Vol 35, pp. 167-177. 2011 Jan 01.
1. Kaufman CD
2. Geiger RC
3. Dean DA
Electroporation- and mechanical ventilation-mediated gene transfer to the lung.; Gene therapy; Vol 17(9). 2010 Sep.
1. Staversky RJ
2. Vitiello PF
3. Yee M
4. Callahan LM
5. Dean DA
6. O'Reilly MA
Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development.; American journal of respiratory cell and molecular biology; Vol 43(3). 2010 Sep.