URMC / Labs / Dean Lab / Publications Recent Publications Bai HSchiralli Lester GMPetishnok LCDean DA (2017 Oct 20). Cytoplasmic transport and nuclear import of plasmid DNA. Bioscience reports. Barnett RCLin XBarravecchia MNorman RAde Mesy Bentley KLFazal FYoung JLDean DA (2017 Jul). Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency. Experimental biology and medicine (Maywood, N.J.). Rahmani KDean DA (2017 Jun 24). Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1). Biochemical and biophysical research communications. Parikh PBai HSwartz MFAlfieris GMDean DA (2016 Jul 27). Identification of differentially regulated genes in human patent ductus arteriosus. Experimental biology and medicine (Maywood, N.J.). Gottfried LLin XBarravecchia MDean DA (2016 Jul 1). Identification of an alveolar type I epithelial cell-specific DNA nuclear import sequence for gene delivery. Gene therapy. Welch JJSwanekamp RJKing CDean DANilsson BL (2016 Jun 09). Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides. ACS medicinal chemistry letters. Lin XBarravecchia MKothari PYoung JLDean DA (2016 Jun). β1-Na(+),K(+)-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury. Gene therapy. Emr BMRoy SKollisch-Singule MGatto LABarravecchia MLin XYoung JLWang GLiu JSatalin JSnyder KNieman GFDean DA (2015 Jan). Electroporation-mediated gene delivery of Na+,K+ -ATPase, and ENaC subunits to the lung attenuates acute respiratory distress syndrome in a two-hit porcine model. Shock (Augusta, Ga.). Young JLDean DA (2015). Electroporation-mediated gene delivery. Advances in genetics. Huber ARTan DSun JDean DWu TZhou Z (2015). High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7. BMC gastroenterology. Vernon MMDean DADobson J (2015). DNA Targeting Sequence Improves Magnetic Nanoparticle-Based Plasmid DNA Transfection Efficiency in Model Neurons. International journal of molecular sciences. Young JLBarravecchia MSDean DA (2014). Electroporation-mediated gene delivery to the lungs. Methods in molecular biology (Clifton, N.J.). Emr BGatto LARoy SSatalin JGhosh ASnyder KAndrews PHabashi NMarx WGe LWang GDean DAVodovotz YNieman G (2013 Nov). Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs. JAMA surgery. Dean DA (2013 Oct). Cell-specific targeting strategies for electroporation-mediated gene delivery in cells and animals. The Journal of membrane biology. Roy SKEmr BSadowitz BGatto LAGhosh ASatalin JMSnyder KPGe LWang GMarx WDean DAndrews PSingh AScalea THabashi NNieman GF (2013 Sep). Preemptive application of airway pressure release ventilation prevents development of acute respiratory distress syndrome in a rat traumatic hemorrhagic shock model. Shock (Augusta, Ga.). Badding MADean DA (2013 Jun). Highly acetylated tubulin permits enhanced interactions with and trafficking of plasmids along microtubules. Gene therapy. Badding MALapek JDFriedman AEDean DA (2013 Apr). Proteomic and functional analyses of protein-DNA complexes during gene transfer. Molecular therapy : the journal of the American Society of Gene Therapy. Roy SHabashi NSadowitz BAndrews PGe LWang GRoy PGhosh AKuhn MSatalin JGatto LALin XDean DAVodovotz YNieman G (2013 Jan). Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock (Augusta, Ga.). Cramer FChristensen CLPoulsen TTBadding MADean DAPoulsen HS (2012 Oct). Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines. Cancer gene therapy. O'Reilly MAYee MBuczynski BWVitiello PFKeng PCWelle SLFinkelstein JNDean DALawrence BP (2012 Aug). Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1. The American journal of pathology. Roy SSadowitz BAndrews PGatto LAMarx WGe LWang GLin XDean DAKuhn MGhosh ASatalin JSnyder KVodovotz YNieman GHabashi N (2012 Aug). Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. The journal of trauma and acute care surgery. Yao HChung SHwang JWRajendrasozhan SSundar IKDean DAMcBurney MWGuarente LGu WRönty MKinnula VLRahman I (2012 Jun). SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. The Journal of clinical investigation. Badding MAVaughan EEDean DA (2012 Mar). Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer. Gene therapy. Lin XDean DA (2011 Jul). Gene therapy for ALI/ARDS. Critical care clinics. Eldib MDean DA (2011 Feb). Cyclic stretch of alveolar epithelial cells alters cytoskeletal micromechanics. Biotechnology and bioengineering. Dean DABarravecchia BD (2011 Jan 01). Use of Electroporation for Efficacious Gene Delivery to the Lungs ECS Trans. Staversky RJVitiello PFYee MCallahan LMDean DAO'Reilly MA (2010 Sep). Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development. American journal of respiratory cell and molecular biology. Kaufman CDGeiger RCDean DA (2010 Sep). Electroporation- and mechanical ventilation-mediated gene transfer to the lung. Gene therapy. Degiulio JVKaufman CDDean DA (2010 Apr). The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression. Gene therapy. Lam APDean DA (2010 Apr). Progress and prospects: nuclear import of nonviral vectors. Gene therapy. Wang YHeilig KOMinto AWChen SXiang MDean DAGeiger RCChang APravtcheva DDSchlimme MDeb DKWang YHeilig CW (2010 Jan). Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF. Laboratory investigation; a journal of technical methods and pathology. Miller AMMunkonge FMAlton EWDean DA (2009 Nov). Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import. Molecular therapy : the journal of the American Society of Gene Therapy. Yee MChess PRMcGrath-Morrow SAWang ZGelein RZhou RDean DANotter RHO'Reilly MA (2009 Oct). Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity. American journal of physiology. Lung cellular and molecular physiology. Munkonge FMAmin VHyde SCGreen AMPringle IAGill DRSmith JWHooley RPXenariou SWard MALeeds NLeung KYChan MHillery EGeddes DMGriesenbach UPostel EHDean DADunn MJAlton EW (2009 Sep 25). Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import. The Journal of biological chemistry. Aistrup GLVilluendas RNg JGilchrist ALynch TWGordon DCokic IMottl SZhou RDean DAWasserstrom JAGoldberger JJKadish AHArora R (2009 Aug 1). Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation. Cardiovascular research. Miller AMDean DA (2009 Jul 2). Tissue-specific and transcription factor-mediated nuclear entry of DNA. Advanced drug delivery reviews. Xavier JSingh SDean DARao NMGopal V (2009 Jan 19). Designed multi-domain protein as a carrier of nucleic acids into cells. Journal of controlled release : official journal of the Controlled Release Society. Geiger RCKaufman CDLam APBudinger GRDean DA (2009 Jan). Tubulin acetylation and histone deacetylase 6 activity in the lung under cyclic load. American journal of respiratory cell and molecular biology. Vaughan EEGeiger RCMiller AMLoh-Marley PLSuzuki TMiyata NDean DA (2008 Nov). Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency. Molecular therapy : the journal of the American Society of Gene Therapy. Miller AMDean DA (2008 Aug). Cell-specific nuclear import of plasmid DNA in smooth muscle requires tissue-specific transcription factors and DNA sequences. Gene therapy. Young JLZimmer WEDean DA (2008 Jul). Smooth muscle-specific gene delivery in the vasculature based on restriction of DNA nuclear import. Experimental biology and medicine (Maywood, N.J.). Lam APDean DA (2008 Jun). Cyclic stretch-induced nuclear localization of transcription factors results in increased nuclear targeting of plasmids in alveolar epithelial cells. The journal of gene medicine. Dean DARamanathan TMachado DSundararajan R (2008 Mar). Electrical Impedance Spectroscopy Study of Biological Tissues. Journal of electrostatics. Zhou RNorton JEDean DA (2008). Electroporation-mediated gene delivery to the lungs. Methods in molecular biology (Clifton, N.J.). Dean DA (2008 Jan 01). Quantifying Induced Electric Field Strengths During Gene Transfer to the Intact Rat Vasculature. J Electrostatics. Gasiorowski JZDean DA (2007 Dec). Intranuclear trafficking of episomal DNA is transcription-dependent. Molecular therapy : the journal of the American Society of Gene Therapy. Mutlu GMGreen DBellmeyer ABaker CMBurgess ZRajamannan NChristman JWFoiles NKamp DWGhio AJChandel NSDean DASznajder JIBudinger GR (2007 Oct). Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. The Journal of clinical investigation. Mutlu GMMachado-Aranda DNorton JEBellmeyer AUrich DZhou RDean DA (2007 Sep 15). Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury. American journal of respiratory and critical care medicine. Zhou RNorton JEZhang NDean DA (2007 May). Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and inflammation. Gene therapy. Bellmeyer AMartino JMChandel NSScott Budinger GRDean DAMutlu GM (2007 Mar 15). Leptin resistance protects mice from hyperoxia-induced acute lung injury. American journal of respiratory and critical care medicine.