URMC / Labs / Dewhurst Lab / Publications

Recent Publications from the Dewhurst Lab

1. Evans AL
2. Sogn AK
3. Mora AC
4. Arthur MN
5. Leach JR
6. Bosch SI
7. Araselvan S
8. Beard JW
9. Dewhurst S
10. Mace CR
11. Miller BL
QuickDraw: detecting HIV in whole blood using an integrated paper-based consumable that enables direct amplification of purified RNA from paper.; Lab on a chip. 2026 Jan 05.
1. Abdelmageed AA
2. Smerczynski JF
3. Kandwal M
4. Douglas LJ
5. Russell TL
6. Morris MC
7. Dewhurst S
8. Ferran MC
Constitutive NF-kB Activation Is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells That Resist Viral Oncolysis.; Viruses; Vol 18(1). 2026 Jan 01.
1. Leach JR
2. Oo A
3. Nogales A
4. Bosch SI
5. Martínez-Sobrido L
6. Feng C
7. Kim B
8. Dewhurst S
LAIV Mutations Selectively Alter Influenza Viral RNA Polymerase Function, Favoring Transcription over Genome Synthesis.; Viruses; Vol 17(11). 2025 Oct 23.
1. Abdelmageed AA
2. Smerczynski J
3. Douglas L
4. Russell T
5. Morris M
6. Dewhurst S
7. Ferran MC
Constitutive NF-κB Activation is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells that Resist Viral Oncolysis.; bioRxiv : the preprint server for biology. 2025 Sep 25.
1. Alcantara Sanchez L
2. Alvarez Guerra E
3. Li D
4. King SM
5. Hilchey SP
6. Zhou Q
7. Dewhurst S
8. Fiscella K
9. Zand MS
Antibody Responses to SARS-CoV-2 and Common HCoVs in Hemodialysis Patients and Transplant Recipients: Data from the Dominican Republic.; Vaccines; Vol 13(9). 2025 Sep 11.
1. Hinkle JJ
2. Trychta KA
3. Wires ES
4. Osborn RM
5. Leach JR
6. Faraz ZF
7. Svarcbahs R
8. Richie CT
9. Dewhurst S
10. Harvey BK
Subcellular localization of SARS-CoV-2 E and 3a proteins along the secretory pathway.; Journal of molecular histology; Vol 56(2), pp. 98. 2025 Mar 01.
1. Osborn RM
2. Anderson CS
3. Leach JR
4. Chu CY
5. Dewhurst S
6. Mariani TJ
7. Thakar J
Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells.; Clinical and experimental immunology. 2025 Jan 09.
1. Abdelmageed AA
2. Dewhurst S
3. Ferran MC
Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations.; Viruses; Vol 17(1). 2024 Dec 25.
1. Alcantara Sanchez L
2. Alvarez Guerra E
3. Li D
4. King SM
5. Hilchey SP
6. Zhou Q
7. Dewhurst S
8. Fiscella K
9. Zand MS
Antibody Response to SARS-CoV-2 Vaccines in Transplant Recipients and Hemodialysis Patients: Data from the Dominican Republic.; Vaccines; Vol 12(12). 2024 Nov 23.
1. Rahman SM
2. Buchholz DW
3. Imbiakha B
4. Jager MC
5. Leach J
6. Osborn RM
7. Birmingham AO
8. Dewhurst S
9. Aguilar HC
10. Luebke AE
Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs.; Journal of virology. 2024 May 30.
1. Zand MS
2. Spallina S
3. Ross A
4. Zandi K
5. Pawlowski A
6. Seplaki CL
7. Herington J
8. Corbett AM
9. Kaukeinen K
10. Holden-Wiltse J
11. Freedman EG
12. Alcantara L
13. Li D
14. Cameron A
15. Beaumont N
16. Dozier A
17. Dewhurst S
18. Foxe JJ
Ventilation during COVID-19 in a school for students with intellectual and developmental disabilities (IDD).; PloS one; Vol 19(4), pp. e0291840. 2024 Apr 03.
1. Imbiakha B
2. Sahler JM
3. Buchholz DW
4. Ezzatpour S
5. Jager M
6. Choi A
7. Monreal IA
8. Byun H
9. Adeleke RA
10. Leach J
11. Whittaker G
12. Dewhurst S
13. Rudd BD
14. Aguilar HC
15. August A
Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.; Science advances; Vol 10(1), pp. eadg5461. 2024 Jan 03.
1. Zand MS
2. Spallina S
3. Ross A
4. Zandi K
5. Pawlowski A
6. Seplaki CL
7. Herington J
8. Corbett AM
9. Kaukeinen K
10. Holden-Wiltse J
11. Freedman EG
12. Alcantara L
13. Li D
14. Cameron A
15. Beaumont N
16. Dozier A
17. Dewhurst S
18. Foxe JJ
Ventilation during COVID-19 in a school for students with intellectual and developmental disabilities (IDD).; medRxiv : the preprint server for health sciences. 2023 Sep 10.
1. Schuster JE
2. Erickson TR
3. Goldman JL
4. Benjamin DK
5. Brookhart MA
6. Dewhurst S
7. Fist A
8. Foxe J
9. Godambe M
10. Gwynn L
11. Kiene SM
12. Keener Mast D
13. McDaniels-Davidson C
14. Newland JG
15. Oren E
16. Selvarangan R
17. Shinde N
18. Walsh T
19. Watterson T
20. Zand M
21. Zimmerman KO
22. Kalu IC
Utilization and Impact of Symptomatic and Exposure SARS-CoV-2 Testing in K-12 Schools.; Pediatrics; Vol 152(Suppl 1). 2023 Jul 01.
1. Goldman JL
2. Kalu IC
3. Schuster JE
4. Erickson T
5. Mast DK
6. Zimmerman K
7. Benjamin DK
8. Kalb LG
9. Gurnett C
10. Newland JG
11. Sherby M
12. Godambe M
13. Shinde N
14. Watterson T
15. Walsh T
16. Foxe J
17. Zand M
18. Dewhurst S
19. Coller R
20. DeMuri GP
21. Archuleta S
22. Ko LK
23. Inkelas M
24. Manuel V
25. Lee R
26. Oh H
27. Murugan V
28. Kramer J
29. Okihiro M
30. Gwynn L
31. Pulgaron E
32. McCulloh R
33. Broadhurst J
34. McDaniels-Davidson C
35. Kiene S
36. Oren E
37. Wu Y
38. Wetter DW
39. Stump T
40. Brookhart MA
41. Fist A
42. Haroz E
Building School-Academic Partnerships to Implement COVID-19 Testing in Underserved Populations.; Pediatrics; Vol 152(Suppl 1). 2023 Jul 01.
1. Zhou T
2. Gilliam NJ
3. Li S
4. Spandau S
5. Osborn RM
6. Connor S
7. Anderson CS
8. Mariani TJ
9. Thakar J
10. Dewhurst S
11. Mathews DH
12. Huang L
13. Sun Y
Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection.; mBio. 2023 Apr 19.
1. Osborn RM
2. Leach J
3. Zanche M
4. Ashton JM
5. Chu C
6. Thakar J
7. Dewhurst S
8. Rosenberger S
9. Pavelka M
10. Pryhuber GS
11. Mariani TJ
12. Anderson CS
Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells.; PloS one; Vol 18(2), pp. e0281898. 2023 Feb 24.
1. Molina Vargas AM
2. Sinha S
3. Osborn R
4. Arantes PR
5. Patel A
6. Dewhurst S
7. Hardy DJ
8. Cameron A
9. Palermo G
10. O'Connell MR
New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity.; Nucleic acids research. 2023 Jan 30.
1. Zhou T
2. Gilliam NJ
3. Li S
4. Spaudau S
5. Osborn RM
6. Anderson CS
7. Mariani TJ
8. Thakar J
9. Dewhurst S
10. Mathews DH
11. Huang L
12. Sun Y
Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection.; bioRxiv : the preprint server for biology. 2022 Sep 23.
1. Simpson S
2. McMinn C
3. Van Mondfrans SM
4. Hendry J
5. Ronayne S
6. Dewhurst S
7. Feng C
8. Bal BS
9. Bock RM
10. McEntire BJ
A Novel Antipathogenic Agent for Nonwoven Fabric.; Biomedical materials & devices (New York, N.Y.). 2022 Jul 20.
1. Nogales A
2. Steel J
3. Liu WC
4. Lowen AC
5. Rodriguez L
6. Chiem K
7. Cox A
8. García-Sastre A
9. Albrecht RA
10. Dewhurst S
11. Martínez-Sobrido L
Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine.; Microbiology spectrum. 2022 May 18.
1. Raymonda MH
2. Ciesla JH
3. Monaghan M
4. Leach J
5. Asantewaa G
6. Smorodintsev-Schiller LA
7. Lutz MM
8. Schafer XL
9. Takimoto T
10. Dewhurst S
11. Munger J
12. Harris IS
Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27.
1. Sherby MR
2. Kalb LG
3. Coller RJ
4. DeMuri GP
5. Butteris S
6. Foxe JJ
7. Zand MS
8. Freedman EG
9. Dewhurst S
10. Newland JG
11. Gurnett CA
Supporting COVID-19 School Safety for Children With Disabilities and Medical Complexity.; Pediatrics. 2021 Nov 04.
1. Chojnacki M
2. Dobrotka C
3. Osborn R
4. Johnson W
5. Young M
6. Meyer B
7. Laskey E
8. Wozniak RAF
9. Dewhurst S
10. Dunman PM
Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.; mSphere; Vol 6(2). 2021 Mar 03.
1. Cox A
2. Schmierer J
3. D'Angelo J
4. Smith A
5. Levenson D
6. Treanor J
7. Kim B
8. Dewhurst S
A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.; Viruses; Vol 12(11). 2020 Oct 31.
1. Simpson SR
2. Singh MV
3. Dewhurst S
4. Schifitto G
5. Maggirwar SB
Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation.; Blood advances; Vol 4(18). 2020 Sep 22.
1. Piekna-Przybylska D
2. Bambara RA
3. Maggirwar SB
4. Dewhurst S
G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells.; Cell cycle (Georgetown, Tex.). 2020 Aug 17.
1. Ma Q
2. Schifitto G
3. Venuto C
4. Ocque A
5. Dewhurst S
6. Morse GD
7. Aalinkeel R
8. Schwartz SA
9. Mahajan SD
Effect of Dolutegravir and Sertraline on the Blood Brain Barrier (BBB).; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 15(1). 2020 Mar.
1. Smith A
2. Rodriguez L
3. Ghouayel ME
4. Nogales A
5. Chamberlain JM
6. Sortino K
7. Reilly E
8. Feng C
9. Topham DJ
10. Martínez-Sobrido L
11. Dewhurst S
A live-attenuated influenza vaccine (LAIV) elicits enhanced heterologous protection when the internal genes of the vaccine are matched to the challenge virus.; Journal of virology. 2019 Nov 20.
1. Rodriguez L
2. Blanco-Lobo P
3. Reilly EC
4. Maehigashi T
5. Nogales A
6. Smith A
7. Topham DJ
8. Dewhurst S
9. Kim B
10. Martínez-Sobrido L
Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.; Viruses; Vol 11(10). 2019 Oct 10.
1. Chamberlain JM
2. Sortino K
3. Sethna P
4. Bae A
5. Lanier R
6. Bambara RA
7. Dewhurst S
Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.; Antimicrobial agents and chemotherapy; Vol 63(1). 2019 Jan.
1. Mathew E
2. Zhu H
3. Connelly SM
4. Sullivan MA
5. Brewer MG
6. Piepenbrink MS
7. Kobie JJ
8. Dewhurst S
9. Dumont ME
Display of the HIV envelope protein at the yeast cell surface for immunogen development.; PloS one; Vol 13(10). 2018.
1. Sheik DA
2. Dewhurst S
3. Yang J
Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission.; Accounts of chemical research; Vol 50(9). 2017 Sep 19.
1. Hilimire TA
2. Chamberlain JM
3. Anokhina V
4. Bennett RP
5. Swart O
6. Myers JR
7. Ashton JM
8. Stewart RA
9. Featherston AL
10. Gates K
11. Helms ED
12. Smith HC
13. Dewhurst S
14. Miller BL
HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.; ACS chemical biology. 2017 May 05.
1. Sheik DA
2. Chamberlain JM
3. Brooks L
4. Clark M
5. Kim YH
6. Leriche G
7. Kubiak CP
8. Dewhurst S
9. Yang J
Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity.; Langmuir : the ACS journal of surfaces and colloids; Vol 33(10). 2017 Mar 14.
1. Brewer MG
2. DiPiazza A
3. Acklin J
4. Feng C
5. Sant AJ
6. Dewhurst S
Nanoparticles decorated with viral antigens are more immunogenic at low surface density.; Vaccine; Vol 35(5). 2017 Feb 01.
1. Buckley G
2. Smith S
3. DeCaro J
4. Barnett S
5. Dewhurst S
Building community for deaf scientists.; Science (New York, N.Y.); Vol 355(6322). 2017 Jan 20.
1. Mattiacio JL
2. Brewer M
3. Dewhurst S
Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.; Methods in molecular biology (Clifton, N.J.); Vol 1581. 2017.
1. Blanchard C
2. Brooks L
3. Ebsworth-Mojica K
4. Didione L
5. Wucher B
6. Dewhurst S
7. Krysan D
8. Dunman PM
9. Wozniak RA
Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.; mSphere; Vol 1(5). 2016 Sep.
1. Blanchard C
2. Brooks L
3. Beckley A
4. Colquhoun J
5. Dewhurst S
6. Dunman PM
Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.; Antimicrobial agents and chemotherapy; Vol 60(2). 2016 Feb.
1. Nishimura C
2. Polesskaya O
3. Dewhurst S
4. Silva JN
Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation.; Journal of visualized experiments : JoVE. 2016.
1. Puccini JM
2. Marker DF
3. Fitzgerald T
4. Barbieri J
5. Kim CS
6. Miller-Rhodes P
7. Lu SM
8. Dewhurst S
9. Gelbard HA
Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(13). 2015 Apr 1.
1. Cox A
2. Baker SF
3. Nogales A
4. Martínez-Sobrido L
5. Dewhurst S
Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.; Journal of virology; Vol 89(6). 2015 Mar.
1. Sheik DA
2. Brooks L
3. Frantzen K
4. Dewhurst S
5. Yang J
Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.; ACS nano; Vol 9(2). 2015 Feb 24.
1. Cox A
2. Dewhurst S
A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy.; Journal of virology; Vol 90(5). 2015.
1. Ying B
2. Tollefson AE
3. Spencer JF
4. Balakrishnan L
5. Dewhurst S
6. Capella C
7. Buller RM
8. Toth K
9. Wold WS
Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.; Antimicrobial agents and chemotherapy; Vol 58(12). 2014 Dec.
1. Silva JN
2. Polesskaya O
3. Wei HS
4. Rasheed IY
5. Chamberlain JM
6. Nishimura C
7. Feng C
8. Dewhurst S
Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity.; Microcirculation (New York, N.Y. : 1994); Vol 21(7). 2014 Oct.
1. Nogales A
2. Baker SF
3. Ortiz-Riaño E
4. Dewhurst S
5. Topham DJ
6. Martínez-Sobrido L
Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.; Journal of virology; Vol 88(18). 2014 Sep.
1. Polesskaya O
2. Wong C
3. Lebron L
4. Chamberlain JM
5. Gelbard HA
6. Goodfellow V
7. Kim M
8. Daiss JL
9. Dewhurst S
MLK3 regulates fMLP-stimulated neutrophil motility.; Molecular immunology; Vol 58(2). 2014 Apr.
1. Domm W
2. Brewer M
3. Baker SF
4. Feng C
5. Martínez-Sobrido L
6. Treanor J
7. Dewhurst S
Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.; Journal of virological methods; Vol 197. 2014 Mar.