URMC / Labs / Dewhurst Lab / Publications Publications Nogales ASteel JLiu WCLowen ACRodriguez LChiem KCox AGarcía-Sastre AAlbrecht RADewhurst SMartínez-Sobrido L Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine.; Microbiology spectrum. 2022 May 18. Raymonda MHCiesla JHMonaghan MLeach JAsantewaa GSmorodintsev-Schiller LALutz MMSchafer XLTakimoto TDewhurst SMunger JHarris IS Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27. Sherby MRKalb LGColler RJDeMuri GPButteris SFoxe JJZand MSFreedman EGDewhurst SNewland JGGurnett CA Supporting COVID-19 School Safety for Children With Disabilities and Medical Complexity.; Pediatrics. 2021 Nov 04. Chojnacki MDobrotka COsborn RJohnson WYoung MMeyer BLaskey EWozniak RAFDewhurst SDunman PM Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.; mSphere; Vol 6(2). 2021 Mar 03. Cox ASchmierer JD'Angelo JSmith ALevenson DTreanor JKim BDewhurst S A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity.; Viruses; Vol 12(11). 2020 Oct 31. Simpson SRSingh MVDewhurst SSchifitto GMaggirwar SB Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation.; Blood advances; Vol 4(18). 2020 Sep 22. Piekna-Przybylska DBambara RAMaggirwar SBDewhurst S G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells.; Cell cycle (Georgetown, Tex.). 2020 Aug 17. Ma QSchifitto GVenuto COcque ADewhurst SMorse GDAalinkeel RSchwartz SAMahajan SD Effect of Dolutegravir and Sertraline on the Blood Brain Barrier (BBB).; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 15(1). 2020 Mar. Smith ARodriguez LGhouayel MENogales AChamberlain JMSortino KReilly EFeng CTopham DJMartínez-Sobrido LDewhurst S A live-attenuated influenza vaccine (LAIV) elicits enhanced heterologous protection when the internal genes of the vaccine are matched to the challenge virus.; Journal of virology. 2019 Nov 20. Rodriguez LBlanco-Lobo PReilly ECMaehigashi TNogales ASmith ATopham DJDewhurst SKim BMartínez-Sobrido L Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza Vaccines.; Viruses; Vol 11(10). 2019 Oct 10. Chamberlain JMSortino KSethna PBae ALanier RBambara RADewhurst S Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.; Antimicrobial agents and chemotherapy; Vol 63(1). 2019 Jan. Mathew EZhu HConnelly SMSullivan MABrewer MGPiepenbrink MSKobie JJDewhurst SDumont ME Display of the HIV envelope protein at the yeast cell surface for immunogen development.; PloS one; Vol 13(10). 2018. Sheik DADewhurst SYang J Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission.; Accounts of chemical research; Vol 50(9). 2017 Sep 19. Hilimire TAChamberlain JMAnokhina VBennett RPSwart OMyers JRAshton JMStewart RAFeatherston ALGates KHelms EDSmith HCDewhurst SMiller BL HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.; ACS chemical biology. 2017 May 05. Sheik DAChamberlain JMBrooks LClark MKim YHLeriche GKubiak CPDewhurst SYang J Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity.; Langmuir : the ACS journal of surfaces and colloids; Vol 33(10). 2017 Mar 14. Brewer MGDiPiazza AAcklin JFeng CSant AJDewhurst S Nanoparticles decorated with viral antigens are more immunogenic at low surface density.; Vaccine; Vol 35(5). 2017 Feb 01. Buckley GSmith SDeCaro JBarnett SDewhurst S Building community for deaf scientists.; Science (New York, N.Y.); Vol 355(6322). 2017 Jan 20. Mattiacio JLBrewer MDewhurst S Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.; Methods in molecular biology (Clifton, N.J.); Vol 1581. 2017. Blanchard CBrooks LEbsworth-Mojica KDidione LWucher BDewhurst SKrysan DDunman PMWozniak RA Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.; mSphere; Vol 1(5). 2016 Sep. Blanchard CBrooks LBeckley AColquhoun JDewhurst SDunman PM Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.; Antimicrobial agents and chemotherapy; Vol 60(2). 2016 Feb. Nishimura CPolesskaya ODewhurst SSilva JN Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation.; Journal of visualized experiments : JoVE. 2016. Puccini JMMarker DFFitzgerald TBarbieri JKim CSMiller-Rhodes PLu SMDewhurst SGelbard HA Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(13). 2015 Apr 1. Cox ABaker SFNogales AMartínez-Sobrido LDewhurst S Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.; Journal of virology; Vol 89(6). 2015 Mar. Sheik DABrooks LFrantzen KDewhurst SYang J Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.; ACS nano; Vol 9(2). 2015 Feb 24. Cox ADewhurst S A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy.; Journal of virology; Vol 90(5). 2015. Ying BTollefson AESpencer JFBalakrishnan LDewhurst SCapella CBuller RMToth KWold WS Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.; Antimicrobial agents and chemotherapy; Vol 58(12). 2014 Dec. Silva JNPolesskaya OWei HSRasheed IYChamberlain JMNishimura CFeng CDewhurst S Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity.; Microcirculation (New York, N.Y. : 1994); Vol 21(7). 2014 Oct. Nogales ABaker SFOrtiz-Riaño EDewhurst STopham DJMartínez-Sobrido L Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.; Journal of virology; Vol 88(18). 2014 Sep. Polesskaya OWong CLebron LChamberlain JMGelbard HAGoodfellow VKim MDaiss JLDewhurst S MLK3 regulates fMLP-stimulated neutrophil motility.; Molecular immunology; Vol 58(2). 2014 Apr. Domm WBrewer MBaker SFFeng CMartínez-Sobrido LTreanor JDewhurst S Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.; Journal of virological methods; Vol 197. 2014 Mar. Lewis CADewhurst SMcMahon JMBunce CAKeefer MCAlio AP Theoretical model of critical issues in informed consent in HIV vaccine trials.; AIDS care; Vol 26(11). 2014. Rhoo KHGranger MSur JFeng CGelbard HADewhurst SPolesskaya O Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model.; PloS one; Vol 9(9). 2014. Easterhoff DDiMaio JTLiyanage WLo CWBae WDoran TMSmrcka ANilsson BLDewhurst S Fluorescence detection of cationic amyloid fibrils in human semen.; Bioorganic & medicinal chemistry letters; Vol 23(18). 2013 Sep 15. Lu NSilva JGu YGerber SWu HGelbard HDewhurst SMiao H Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images.; Pattern recognition; Vol 46(7). 2013 Jul 01. Marker DFTremblay MÈPuccini JMBarbieri JGantz Marker MALoweth CJMuly ECLu SMGoodfellow VSDewhurst SGelbard HA The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(24). 2013 Jun 12. Ma QGelbard HAMaggirwar SBDewhurst SGendelman HEPeterson DRDiFrancesco RHochreiter JSMorse GDSchifitto G Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.; Journal of neurovirology; Vol 19(3). 2013 Jun. Arany SBenoit DSDewhurst SOvitt CE Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 21(6). 2013 Jun. Easterhoff DOntiveros FBrooks LRKim YRoss BSilva JNOlsen JSFeng CHardy DJDunman PMDewhurst S Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.; Antimicrobial agents and chemotherapy; Vol 57(6). 2013 Jun. Sullivan MABrooks LRWeidenborner PDomm WMattiacio JXu QTiberio MWentworth TKobie JBryk PZheng BMurphy MSanz IDewhurst S Anti-idiotypic monobodies derived from a fibronectin scaffold.; Biochemistry; Vol 52(10). 2013 Mar 12. Alcéna DCKobie JJKaminski DARosenberg AFMattiacio JLBrewer MDewhurst SDykes CJin XKeefer MCSanz I 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles.; PloS one; Vol 8(12). 2013. Mapstone MHilton TNYang HGuido JJLuque AEHall WJDewhurst SShah K Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults.; Aging and disease; Vol 4(6). 2013. Capella CBeltejar MJBrown CFong VDaddacha WKim BDewhurst S Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.; Journal of virology; Vol 86(19). 2012 Oct. Arany SXu QHernady EBenoit DSDewhurst SOvitt CE Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures.; Journal of cellular biochemistry; Vol 113(6). 2012 Jun. Olsen JSDiMaio JTDoran TMBrown CNilsson BLDewhurst S Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.; The Journal of biological chemistry; Vol 287(15). 2012 Apr 06. Polesskaya OSun ASalahura GSilva JNDewhurst SKasischke K Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence.; Journal of visualized experiments : JoVE. 2012 Feb 21. Kobie JJAlcena DCZheng BBryk PMattiacio JLBrewer MLabranche CYoung FMDewhurst SMontefiori DCRosenberg AFFeng CJin XKeefer MCSanz I 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.; PloS one; Vol 7(4). 2012. Silva JPolesskaya OKnight WZheng JTGranger MLopez TOntiveros FFeng CYan CKasischke KADewhurst S Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.; Journal of neuroinflammation; Vol 9. 2012. Olsen JSEasterhoff DDewhurst S Advances in HIV microbicide development.; Future medicinal chemistry; Vol 3(16). 2011 Dec. Aggarwal SDewhurst STakimoto TKim B Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.; The Journal of biological chemistry; Vol 286(40). 2011 Oct 7. Hazard MSteele SWang DPearson TScheideler MDewhurst S CTSA-IP: a solution to identifying and aggregating intellectual property across the NIH Clinical Translational Science Award (CTSA) consortium of biomedical research institutes.; Clinical and translational science; Vol 4(5). 2011 Oct.