Publications

• 1. Sheik DA
  2. Dewhurst S
  3. Yang J
  Natural Seminal Amyloids as Targets for Development of Synthetic Inhibitors of HIV Transmission.; Accounts of chemical research; Vol 50(9). 2017 Sep 19.
• 1. Hilimire TA
  2. Chamberlain JM
  3. Anokhina V
  4. Bennett RP
  5. Swart O
  6. Myers JR
  7. Ashton JM
  8. Stewart RA
  9. Featherston AL
  10. Gates K
  11. Helms ED
  12. Smith HC
  13. Dewhurst S
  14. Miller BL
  HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells.; ACS chemical biology. 2017 May 05.
• 1. Sheik DA
  2. Chamberlain JM
  3. Brooks L
  4. Clark M
  5. Kim YH
  6. Leriche G
  7. Kubiak CP
  8. Dewhurst S
  9. Yang J
  Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity.; Langmuir : the ACS journal of surfaces and colloids; Vol 33(10). 2017 Mar 14.
• 1. Brewer MG
  2. DiPiazza A
  3. Acklin J
  4. Feng C
  5. Sant AJ
  6. Dewhurst S
  Nanoparticles decorated with viral antigens are more immunogenic at low surface density.; Vaccine; Vol 35(5). 2017 Feb 01.
• 1. Buckley G
  2. Smith S
  3. DeCaro J
  4. Barnett S
  5. Dewhurst S
  Building community for deaf scientists.; Science (New York, N.Y.); Vol 355(6322). 2017 Jan 20.
• 1. Mattiacio JL
  2. Brewer M
  3. Dewhurst S
  Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.; Methods in molecular biology (Clifton, N.J.); Vol 1581. 2017.
• 1. Blanchard C
  2. Brooks L
  3. Ebsworth-Mojica K
  4. Didione L
  5. Wucher B
  6. Dewhurst S
  7. Krysan D
  8. Dunman PM
  9. Wozniak RA
  Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.; mSphere; Vol 1(5). 2016 Sep.
• 1. Blanchard C
  2. Brooks L
  3. Beckley A
  4. Colquhoun J
  5. Dewhurst S
  6. Dunman PM
  Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.; Antimicrobial agents and chemotherapy; Vol 60(2). 2016 Feb.
• 1. Nishimura C
  2. Polesskaya O
  3. Dewhurst S
  4. Silva JN
  Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation.; Journal of visualized experiments : JoVE. 2016.
• 1. Puccini JM
  2. Marker DF
  3. Fitzgerald T
  4. Barbieri J
  5. Kim CS
  6. Miller-Rhodes P
  7. Lu SM
  8. Dewhurst S
  9. Gelbard HA
  Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(13). 2015 Apr 1.
• 1. Cox A
  2. Baker SF
  3. Nogales A
  4. Martínez-Sobrido L
  5. Dewhurst S
  Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.; Journal of virology; Vol 89(6). 2015 Mar.
• 1. Sheik DA
  2. Brooks L
  3. Frantzen K
  4. Dewhurst S
  5. Yang J
  Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.; ACS nano; Vol 9(2). 2015 Feb 24.
• 1. Cox A
  2. Dewhurst S
  A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy.; Journal of virology; Vol 90(5). 2015.
• 1. Ying B
  2. Tollefson AE
  3. Spencer JF
  4. Balakrishnan L
  5. Dewhurst S
  6. Capella C
  7. Buller RM
  8. Toth K
  9. Wold WS
  Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.; Antimicrobial agents and chemotherapy; Vol 58(12). 2014 Dec.
• 1. Silva JN
  2. Polesskaya O
  3. Wei HS
  4. Rasheed IY
  5. Chamberlain JM
  6. Nishimura C
  7. Feng C
  8. Dewhurst S
  Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity.; Microcirculation (New York, N.Y. : 1994); Vol 21(7). 2014 Oct.
• 1. Nogales A
  2. Baker SF
  3. Ortiz-Riaño E
  4. Dewhurst S
  5. Topham DJ
  6. Martínez-Sobrido L
  Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.; Journal of virology; Vol 88(18). 2014 Sep.
• 1. Polesskaya O
  2. Wong C
  3. Lebron L
  4. Chamberlain JM
  5. Gelbard HA
  6. Goodfellow V
  7. Kim M
  8. Daiss JL
  9. Dewhurst S
  MLK3 regulates fMLP-stimulated neutrophil motility.; Molecular immunology; Vol 58(2). 2014 Apr.
• 1. Domm W
  2. Brewer M
  3. Baker SF
  4. Feng C
  5. Martínez-Sobrido L
  6. Treanor J
  7. Dewhurst S
  Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.; Journal of virological methods; Vol 197. 2014 Mar.
• 1. Lewis CA
  2. Dewhurst S
  3. McMahon JM
  4. Bunce CA
  5. Keefer MC
  6. Alio AP
  Theoretical model of critical issues in informed consent in HIV vaccine trials.; AIDS care; Vol 26(11). 2014.
• 1. Rhoo KH
  2. Granger M
  3. Sur J
  4. Feng C
  5. Gelbard HA
  6. Dewhurst S
  7. Polesskaya O
  Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model.; PloS one; Vol 9(9). 2014.
• 1. Easterhoff D
  2. DiMaio JT
  3. Liyanage W
  4. Lo CW
  5. Bae W
  6. Doran TM
  7. Smrcka A
  8. Nilsson BL
  9. Dewhurst S
  Fluorescence detection of cationic amyloid fibrils in human semen.; Bioorganic & medicinal chemistry letters; Vol 23(18). 2013 Sep 15.
• 1. Lu N
  2. Silva J
  3. Gu Y
  4. Gerber S
  5. Wu H
  6. Gelbard H
  7. Dewhurst S
  8. Miao H
  Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images.; Pattern recognition; Vol 46(7). 2013 Jul 01.
• 1. Marker DF
  2. Tremblay MÈ
  3. Puccini JM
  4. Barbieri J
  5. Gantz Marker MA
  6. Loweth CJ
  7. Muly EC
  8. Lu SM
  9. Goodfellow VS
  10. Dewhurst S
  11. Gelbard HA
  The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(24). 2013 Jun 12.
• 1. Arany S
  2. Benoit DS
  3. Dewhurst S
  4. Ovitt CE
  Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 21(6). 2013 Jun.
• 1. Ma Q
  2. Gelbard HA
  3. Maggirwar SB
  4. Dewhurst S
  5. Gendelman HE
  6. Peterson DR
  7. DiFrancesco R
  8. Hochreiter JS
  9. Morse GD
  10. Schifitto G
  Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.; Journal of neurovirology; Vol 19(3). 2013 Jun.
• 1. Easterhoff D
  2. Ontiveros F
  3. Brooks LR
  4. Kim Y
  5. Ross B
  6. Silva JN
  7. Olsen JS
  8. Feng C
  9. Hardy DJ
  10. Dunman PM
  11. Dewhurst S
  Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.; Antimicrobial agents and chemotherapy; Vol 57(6). 2013 Jun.
• 1. Sullivan MA
  2. Brooks LR
  3. Weidenborner P
  4. Domm W
  5. Mattiacio J
  6. Xu Q
  7. Tiberio M
  8. Wentworth T
  9. Kobie J
  10. Bryk P
  11. Zheng B
  12. Murphy M
  13. Sanz I
  14. Dewhurst S
  Anti-idiotypic monobodies derived from a fibronectin scaffold.; Biochemistry; Vol 52(10). 2013 Mar 12.
• 1. Mapstone M
  2. Hilton TN
  3. Yang H
  4. Guido JJ
  5. Luque AE
  6. Hall WJ
  7. Dewhurst S
  8. Shah K
  Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults.; Aging and disease; Vol 4(6). 2013.
• 1. Alcéna DC
  2. Kobie JJ
  3. Kaminski DA
  4. Rosenberg AF
  5. Mattiacio JL
  6. Brewer M
  7. Dewhurst S
  8. Dykes C
  9. Jin X
  10. Keefer MC
  11. Sanz I
  9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles.; PloS one; Vol 8(12). 2013.
• 1. Capella C
  2. Beltejar MJ
  3. Brown C
  4. Fong V
  5. Daddacha W
  6. Kim B
  7. Dewhurst S
  Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.; Journal of virology; Vol 86(19). 2012 Oct.
• 1. Arany S
  2. Xu Q
  3. Hernady E
  4. Benoit DS
  5. Dewhurst S
  6. Ovitt CE
  Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures.; Journal of cellular biochemistry; Vol 113(6). 2012 Jun.
• 1. Olsen JS
  2. DiMaio JT
  3. Doran TM
  4. Brown C
  5. Nilsson BL
  6. Dewhurst S
  Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.; The Journal of biological chemistry; Vol 287(15). 2012 Apr 6.
• 1. Polesskaya O
  2. Sun A
  3. Salahura G
  4. Silva JN
  5. Dewhurst S
  6. Kasischke K
  Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence.; Journal of visualized experiments : JoVE. 2012.
• 1. Kobie JJ
  2. Alcena DC
  3. Zheng B
  4. Bryk P
  5. Mattiacio JL
  6. Brewer M
  7. Labranche C
  8. Young FM
  9. Dewhurst S
  10. Montefiori DC
  11. Rosenberg AF
  12. Feng C
  13. Jin X
  14. Keefer MC
  15. Sanz I
  9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.; PloS one; Vol 7(4). 2012.
• 1. Silva J
  2. Polesskaya O
  3. Knight W
  4. Zheng JT
  5. Granger M
  6. Lopez T
  7. Ontiveros F
  8. Feng C
  9. Yan C
  10. Kasischke KA
  11. Dewhurst S
  Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.; Journal of neuroinflammation; Vol 9. 2012.
• 1. Olsen JS
  2. Easterhoff D
  3. Dewhurst S
  Advances in HIV microbicide development.; Future medicinal chemistry; Vol 3(16). 2011 Dec.
• 1. Aggarwal S
  2. Dewhurst S
  3. Takimoto T
  4. Kim B
  Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.; The Journal of biological chemistry; Vol 286(40). 2011 Oct 7.
• 1. Hazard M
  2. Steele S
  3. Wang D
  4. Pearson T
  5. Scheideler M
  6. Dewhurst S
  CTSA-IP: a solution to identifying and aggregating intellectual property across the NIH Clinical Translational Science Award (CTSA) consortium of biomedical research institutes.; Clinical and translational science; Vol 4(5). 2011 Oct.
• 1. Domm W
  2. Brooks L
  3. Chung HL
  4. Feng C
  5. Bowers WJ
  6. Watson G
  7. McGrath JL
  8. Dewhurst S
  Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.; Vaccine; Vol 29(40). 2011 Sep 16.
• 1. Bussey KA
  2. Desmet EA
  3. Mattiacio JL
  4. Hamilton A
  5. Bradel-Tretheway B
  6. Bussey HE
  7. Kim B
  8. Dewhurst S
  9. Takimoto T
  PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.; Journal of virology; Vol 85(14). 2011 Jul.
• 1. Caserta MT
  2. Dewhurst S
  Dazed and confused by HHV-6.; Blood; Vol 117(19). 2011 May 12.
• 1. Mattiacio J
  2. Walter S
  3. Brewer M
  4. Domm W
  5. Friedman AE
  6. Dewhurst S
  Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env.; Vaccine; Vol 29(14). 2011 Mar 21.
• 1. Easterhoff D
  2. DiMaio JT
  3. Doran TM
  4. Dewhurst S
  5. Nilsson BL
  Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides.; Biophysical journal; Vol 100(5). 2011 Mar 2.
• 1. Polesskaya O
  2. Silva J
  3. Sanfilippo C
  4. Desrosiers T
  5. Sun A
  6. Shen J
  7. Feng C
  8. Polesskiy A
  9. Deane R
  10. Zlokovic B
  11. Kasischke K
  12. Dewhurst S
  Methamphetamine causes sustained depression in cerebral blood flow.; Brain research; Vol 1373. 2011 Feb 10.
• 1. Lu SM
  2. Tremblay MÈ
  3. King IL
  4. Qi J
  5. Reynolds HM
  6. Marker DF
  7. Varrone JJ
  8. Majewska AK
  9. Dewhurst S
  10. Gelbard HA
  HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.; PloS one; Vol 6(9). 2011.
• 1. Fong V
  2. Osterbur M
  3. Capella C
  4. Kim YE
  5. Hine C
  6. Gorbunova V
  7. Seluanov A
  8. Dewhurst S
  Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.; PloS one; Vol 6(12). 2011.
• 1. Polesskaya O
  2. Cunningham LL
  3. Francis SP
  4. Luebke AE
  5. Zhu X
  6. Collins D
  7. Vasilyeva ON
  8. Sahler J
  9. Desmet EA
  10. Gelbard HA
  11. Maggirwar SB
  12. Walton JP
  13. Frisina RD
  14. Dewhurst S
  Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.; Hearing research; Vol 270(1-2). 2010 Dec 1.
• 1. Olsen JS
  2. Brown C
  3. Capule CC
  4. Rubinshtein M
  5. Doran TM
  6. Srivastava RK
  7. Feng C
  8. Nilsson BL
  9. Yang J
  10. Dewhurst S
  Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection.; The Journal of biological chemistry; Vol 285(46). 2010 Nov 12.
• 1. Gelbard HA
  2. Dewhurst S
  3. Maggirwar SB
  4. Kiebala M
  5. Polesskaya O
  6. Gendelman HE
  Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.; Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics; Vol 7(4). 2010 Oct.
• 1. Gorantla S
  2. Makarov E
  3. Finke-Dwyer J
  4. Gebhart CL
  5. Domm W
  6. Dewhurst S
  7. Gendelman HE
  8. Poluektova LY
  CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.; Journal of immunology (Baltimore, Md. : 1950); Vol 184(12). 2010 Jun 15.