URMC / Labs / Dewhurst Lab / Publications Publications Blanchard CBrooks LBeckley AColquhoun JDewhurst SDunman PM (2016 Feb). Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments. Antimicrobial agents and chemotherapy. Nishimura CPolesskaya ODewhurst SSilva JN (2016). Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation. Journal of visualized experiments : JoVE. Puccini JMMarker DFFitzgerald TBarbieri JKim CSMiller-Rhodes PLu SMDewhurst SGelbard HA (2015 Apr 1). Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. Cox ABaker SFNogales AMartínez-Sobrido LDewhurst S (2015 Mar). Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine. Journal of virology. Cox ADewhurst S (2015). A Single Mutation at PB1 Residue 319 Dramatically Increases the Safety of PR8 Live Attenuated Influenza Vaccine in a Murine Model without Compromising Vaccine Efficacy. Journal of virology. Ying BTollefson AESpencer JFBalakrishnan LDewhurst SCapella CBuller RMToth KWold WS (2014 Dec). Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters. Antimicrobial agents and chemotherapy. Silva JNPolesskaya OWei HSRasheed IYChamberlain JMNishimura CFeng CDewhurst S (2014 Oct). Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation (New York, N.Y. : 1994). Nogales ABaker SFOrtiz-Riaño EDewhurst STopham DJMartínez-Sobrido L (2014 Sep). Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development. Journal of virology. Polesskaya OWong CLebron LChamberlain JMGelbard HAGoodfellow VKim MDaiss JLDewhurst S (2014 Apr). MLK3 regulates fMLP-stimulated neutrophil motility. Molecular immunology. Domm WBrewer MBaker SFFeng CMartínez-Sobrido LTreanor JDewhurst S (2014 Mar). Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies. Journal of virological methods. Lewis CADewhurst SMcMahon JMBunce CAKeefer MCAlio AP (2014). Theoretical model of critical issues in informed consent in HIV vaccine trials. AIDS care. Rhoo KHGranger MSur JFeng CGelbard HADewhurst SPolesskaya O (2014). Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model. PloS one. Easterhoff DDiMaio JTLiyanage WLo CWBae WDoran TMSmrcka ANilsson BLDewhurst S (2013 Sep 15). Fluorescence detection of cationic amyloid fibrils in human semen. Bioorganic & medicinal chemistry letters. Lu NSilva JGu YGerber SWu HGelbard HDewhurst SMiao H (2013 Jul 01). Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images. Pattern recognition. Marker DFTremblay MÈPuccini JMBarbieri JGantz Marker MALoweth CJMuly ECLu SMGoodfellow VSDewhurst SGelbard HA (2013 Jun 12). The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. Arany SBenoit DSDewhurst SOvitt CE (2013 Jun). Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. Ma QGelbard HAMaggirwar SBDewhurst SGendelman HEPeterson DRDiFrancesco RHochreiter JSMorse GDSchifitto G (2013 Jun). Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients. Journal of neurovirology. Easterhoff DOntiveros FBrooks LRKim YRoss BSilva JNOlsen JSFeng CHardy DJDunman PMDewhurst S (2013 Jun). Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen. Antimicrobial agents and chemotherapy. Sullivan MABrooks LRWeidenborner PDomm WMattiacio JXu QTiberio MWentworth TKobie JBryk PZheng BMurphy MSanz IDewhurst S (2013 Mar 12). Anti-idiotypic monobodies derived from a fibronectin scaffold. Biochemistry. Mapstone MHilton TNYang HGuido JJLuque AEHall WJDewhurst SShah K (2013). Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging and disease. Alcéna DCKobie JJKaminski DARosenberg AFMattiacio JLBrewer MDewhurst SDykes CJin XKeefer MCSanz I (2013). 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles. PloS one. Capella CBeltejar MJBrown CFong VDaddacha WKim BDewhurst S (2012 Oct). Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase. Journal of virology. Arany SXu QHernady EBenoit DSDewhurst SOvitt CE (2012 Jun). Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures. Journal of cellular biochemistry. Olsen JSDiMaio JTDoran TMBrown CNilsson BLDewhurst S (2012 Apr 6). Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide. The Journal of biological chemistry. Polesskaya OSun ASalahura GSilva JNDewhurst SKasischke K (2012). Detection of microregional hypoxia in mouse cerebral cortex by two-photon imaging of endogenous NADH fluorescence. Journal of visualized experiments : JoVE. Kobie JJAlcena DCZheng BBryk PMattiacio JLBrewer MLabranche CYoung FMDewhurst SMontefiori DCRosenberg AFFeng CJin XKeefer MCSanz I (2012). 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. PloS one. Silva JPolesskaya OKnight WZheng JTGranger MLopez TOntiveros FFeng CYan CKasischke KADewhurst S (2012). Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5. Journal of neuroinflammation. Olsen JSEasterhoff DDewhurst S (2011 Dec). Advances in HIV microbicide development. Future medicinal chemistry. Aggarwal SDewhurst STakimoto TKim B (2011 Oct 7). Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex. The Journal of biological chemistry. Hazard MSteele SWang DPearson TScheideler MDewhurst S (2011 Oct). CTSA-IP: a solution to identifying and aggregating intellectual property across the NIH Clinical Translational Science Award (CTSA) consortium of biomedical research institutes. Clinical and translational science. Domm WBrooks LChung HLFeng CBowers WJWatson GMcGrath JLDewhurst S (2011 Sep 16). Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier. Vaccine. Bussey KADesmet EAMattiacio JLHamilton ABradel-Tretheway BBussey HEKim BDewhurst STakimoto T (2011 Jul). PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. Journal of virology. Caserta MTDewhurst S (2011 May 12). Dazed and confused by HHV-6. Blood. Mattiacio JWalter SBrewer MDomm WFriedman AEDewhurst S (2011 Mar 21). Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env. Vaccine. Easterhoff DDiMaio JTDoran TMDewhurst SNilsson BL (2011 Mar 2). Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides. Biophysical journal. Polesskaya OSilva JSanfilippo CDesrosiers TSun AShen JFeng CPolesskiy ADeane RZlokovic BKasischke KDewhurst S (2011 Feb 10). Methamphetamine causes sustained depression in cerebral blood flow. Brain research. Lu SMTremblay MÈKing ILQi JReynolds HMMarker DFVarrone JJMajewska AKDewhurst SGelbard HA (2011). HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PloS one. Fong VOsterbur MCapella CKim YEHine CGorbunova VSeluanov ADewhurst S (2011). Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. PloS one. Polesskaya OCunningham LLFrancis SPLuebke AEZhu XCollins DVasilyeva ONSahler JDesmet EAGelbard HAMaggirwar SBWalton JPFrisina RDDewhurst S (2010 Dec 1). Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing research. Olsen JSBrown CCapule CCRubinshtein MDoran TMSrivastava RKFeng CNilsson BLYang JDewhurst S (2010 Nov 12). Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection. The Journal of biological chemistry. Gelbard HADewhurst SMaggirwar SBKiebala MPolesskaya OGendelman HE (2010 Oct). Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. Gorantla SMakarov EFinke-Dwyer JGebhart CLDomm WDewhurst SGendelman HEPoluektova LY (2010 Jun 15). CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. Journal of immunology (Baltimore, Md. : 1950). Love TMThurston SWKeefer MCDewhurst SLee HY (2010 Jun). Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences. Journal of virology. Desmet EAHollenbaugh JASime PJWright TWTopham DJSant AJTakimoto TDewhurst SMaggirwar SB (2010 May 10). Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. Eggert DDash PKGorantla SDou HSchifitto GMaggirwar SBDewhurst SPoluektova LGelbard HAGendelman HE (2010 Jan 15). Neuroprotective activities of CEP-1347 in models of neuroAIDS. Journal of immunology (Baltimore, Md. : 1950). Aggarwal SBradel-Tretheway BTakimoto TDewhurst SKim B (2010). Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. PloS one. Kennedy EMHergott CDewhurst SKim B (2009 Dec 1). The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate. Biochemistry. Schifitto GZhong JGill DPeterson DRGaugh MDZhu TTivarus MCruttenden KMaggirwar SBGendelman HEDewhurst SGelbard HA (2009 Apr). Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment. Journal of neurovirology. Volcy KDewhurst S (2009 Feb 5). Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells. Virology. Bimber BNChugh PGiorgi EEKim BAlmudevar ALDewhurst SO'Connor DHLee HY (2009). Nef gene evolution from a single transmitted strain in acute SIV infection. Retrovirology.