URMC / Labs / Dunman Lab / Publications

Recent Publications from the Dunman Lab

1. Piraino LR
2. Chen CY
3. Mereness JA
4. Dunman PM
5. Ovitt CE
6. Benoit DSW
7. DeLouise LA
Salivary gland tissue chip screening identifies candidate radioprotective drugs.; Communications medicine; Vol 5(1), pp. 420. 2025 Oct 09.
1. Lin B
2. Woo S
3. Philbrick A
4. Bacsa J
5. Laskey E
6. Mehra N
7. Gondil VS
8. Mei JA
9. Jones G
10. Pavelka MS
11. Dziejman M
12. Shutter DA
13. Melander C
14. Perritt AM
15. Jakober R
16. Shen Y
17. Chang W-C
18. Quave CL
19. Dunman PM
20. Luedemann G
Testing the Luedemann hypothesis: the discovery of novel antimicrobials from slow-growing microbes from nutrient-limited environments.; mSphere. 2025 Sep 23.
1. Butman HS
2. Stefaniak MA
3. Walsh DJ
4. Gondil VS
5. Young M
6. Crow AH
7. Nemeth AM
8. Melander RJ
9. Dunman PM
10. Melander C
Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus.; Bioorganic & medicinal chemistry letters. 2025 Mar 03.
1. Gondil VS
2. Butman HS
3. Young M
4. Walsh DJ
5. Narkhede Y
6. Zeiler MJ
7. Crow AH
8. Carpenter ME
9. Mardikar A
10. Melander RJ
11. Wiest O
12. Dunman PM
13. Melander C
Development of phenyl-urea-based small molecules that target penicillin-binding protein 4.; Chemical biology & drug design; Vol 103(6), pp. e14569. 2024 Jun.
1. Gowtham L
2. Wozniak RAF
3. Dunman PM
4. Sheba E
5. Garg P
6. Joseph J
Efficacy of a Novel Antibiotic Drug Combination Toward Multidrug-Resistant Ocular Pathogens.; Cornea. 2024 Mar 26.
1. Piraino L
2. Chen CY
3. Mereness J
4. Dunman PM
5. Ovitt C
6. Benoit D
7. DeLouise L
Identifying novel radioprotective drugs via salivary gland tissue chip screening.; bioRxiv : the preprint server for biology. 2023 Jul 13.
1. Young M
2. Chojnacki M
3. Blanchard C
4. Cao X
5. Johnson WL
6. Flaherty D
7. Dunman PM
Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance.; Antibiotics (Basel, Switzerland); Vol 12(7). 2023 Jul 11.
1. King KA
2. Benton AH
3. Caudill MT
4. Stoyanof ST
5. Kang L
6. Michalak P
7. Lahmers KK
8. Dunman PM
9. DeHart TG
10. Ahmad SS
11. Jutras BL
12. Poncin K
13. De Bolle X
14. Caswell CC
Post-transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus.; Molecular microbiology. 2023 Jan 11.
1. Mei JA
2. Johnson W
3. Kinn B
4. Laskey E
5. Nolin L
6. Bhamare P
7. Stalker C
8. Dunman PM
9. Wozniak RAF
Antimicrobial Activity of a Triple Antibiotic Combination Toward Ocular Pseudomonas aeruginosa Clinical Isolates.; Translational vision science & technology; Vol 11(5). 2022 May 02.
1. Young M
2. Walsh DJ
3. Masters E
4. Gondil VS
5. Laskey E
6. Klaczko M
7. Awad H
8. McGrath J
9. Schwarz EM
10. Melander C
11. Dunman PM
Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors.; Antibiotics (Basel, Switzerland); Vol 11(10). 2022 Jan 04.
1. Yang H
2. Kundra S
3. Chojnacki M
4. Liu K
5. Fuse MA
6. Abouelhassan Y
7. Kallifidas D
8. Zhang P
9. Huang G
10. Jin S
11. Ding Y
12. Luesch H
13. Rohde KH
14. Dunman PM
15. Lemos JA
16. Huigens RW
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.; Journal of medicinal chemistry. 2021 Apr 21.
1. Suigo L
2. Chojnacki M
3. Zanotto C
4. Sebastián-Pérez V
5. Morghen CG
6. Casiraghi A
7. Dunman PM
8. Valoti E
9. Straniero V
Staphylococcus aureus RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation.; Antibiotics (Basel, Switzerland); Vol 10(4). 2021 Apr 14.
1. Chojnacki M
2. Cao X
3. Flaherty DP
4. Dunman PM
Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA.; Antibiotics (Basel, Switzerland); Vol 10(4). 2021 Mar 31.
1. Chojnacki M
2. Dobrotka C
3. Osborn R
4. Johnson W
5. Young M
6. Meyer B
7. Laskey E
8. Wozniak RAF
9. Dewhurst S
10. Dunman PM
Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.; mSphere; Vol 6(2). 2021 Mar 03.
1. Scherzi T
2. D'Ambrosio EA
3. Daher SS
4. Grimes CL
5. Dunman PM
6. Andrade RB
Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools.; Bioorganic & medicinal chemistry; Vol 32. 2021 Jan 07.
1. Johnson WL
2. Sohn MB
3. Taffner S
4. Chatterjee P
5. Dunman PM
6. Pecora N
7. Wozniak RAF
Genomics of Staphylococcus aureus ocular isolates.; PloS one; Vol 16(5). 2021.
1. Daher SS
2. Franklin KP
3. Scherzi T
4. Dunman PM
5. Andrade RB
Synthesis and biological evaluation of semi-synthetic albocycline analogs.; Bioorganic & medicinal chemistry letters; Vol 30(21). 2020 Nov 01.
1. Chojnacki M
2. Cao X
3. Young M
4. Fritz RN
5. Dunman PM
6. Flaherty DP
Optimization of 4-Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance.; ChemMedChem; Vol 15(18). 2020 Sep 16.
1. Morrison JM
2. Chojnacki M
3. Fadrowski JJ
4. Bauza C
5. Dunman PM
6. Dudas RA
7. Goldenberg NA
8. Berman DM
Serum-Associated Antibiotic Tolerance in Pediatric Clinical Isolates of Pseudomonas aeruginosa.; Journal of the Pediatric Infectious Diseases Society. 2019 Dec 30.
1. Chojnacki M
2. Philbrick A
3. Scherzi T
4. Pecora N
5. Dunman PM
6. Wozniak RAF
A novel, broad-spectrum antimicrobial combination for the treatment of Pseudomonas aeruginosa corneal infections.; Antimicrobial agents and chemotherapy. 2019 Jul 22.
1. Colquhoun JM
2. Ha L
3. Beckley A
4. Meyers B
5. Flaherty DP
6. Dunman PM
Identification of Small Molecule Inhibitors of Staphylococcus aureus RnpA.; Antibiotics (Basel, Switzerland); Vol 8(2). 2019 Apr 28.
1. Trombetta RP
2. Ninomiya MJ
3. El-Atawneh IM
4. Knapp EK
5. de Mesy Bentley KL
6. Dunman PM
7. Schwarz EM
8. Kates SL
9. Awad HA
Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.; Pharmaceutics; Vol 11(2). 2019 Feb 22.
1. Shehatou C
2. Logunov SL
3. Dunman PM
4. Haidaris CG
5. Klubben WS
Characterizing the Antimicrobial Properties of 405 nm Light and the Corning® Light-Diffusing Fiber Delivery System.; Lasers in surgery and medicine; Vol 51(10). 2019 Jan.
1. Chojnacki M
2. Philbrick A
3. Wucher B
4. Reed JN
5. Tomaras A
6. Dunman PM
7. Wozniak RAF
Development of a broad-spectrum antimicrobial combination for the treatment of Staphylococcus aureus and Pseudomonas aeruginosa corneal infections.; Antimicrobial agents and chemotherapy. 2018 Nov 12.
1. Trombetta RP
2. Dunman PM
3. Schwarz EM
4. Kates SL
5. Awad HA
A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants.; mSphere; Vol 3(5). 2018 Oct 31.
1. Ha L
2. Colquhoun J
3. Noinaj N
4. Das C
5. Dunman PM
6. Flaherty DP
Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.; Acta crystallographica. Section F, Structural biology communications; Vol 74(Pt 10). 2018 Oct 01.
1. Liang H
2. Zhou G
3. Ge Y
4. D'Ambrosio EA
5. Eidem TM
6. Blanchard C
7. Shehatou C
8. Chatare VK
9. Dunman PM
10. Valentine AM
11. Voelz VA
12. Grimes CL
13. Andrade RB
Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus.; Bioorganic & medicinal chemistry; Vol 26(12). 2018 Jul 23.
1. Budnick JA
2. Sheehan LM
3. Colquhoun JM
4. Dunman PM
5. Walker GC
6. Roop RM
7. Caswell CC
The endoribonuclease YbeY is linked to proper cellular morphology and virulence in Brucella abortus.; Journal of bacteriology. 2018 Apr 09.
1. Lounsbury N
2. Eidem T
3. Colquhoun J
4. Mateo G
5. Abou-Gharbia M
6. Dunman PM
7. Childers WE
Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.; Bioorganic & medicinal chemistry letters; Vol 28(6). 2018 Apr 01.
1. Schwan WR
2. Polanowski R
3. Dunman PM
4. Medina-Bielski S
5. Lane M
6. Rott M
7. Lipker L
8. Wescott A
9. Monte A
10. Cook JM
11. Baumann DD
12. Tiruveedhula VVNPB
13. Witzigmann CM
14. Mikel C
15. Rahman MT
Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray.; Antibiotics (Basel, Switzerland); Vol 6(3). 2017 Sep 11.
1. Choby JE
2. Mike LA
3. Mashruwala AA
4. Dutter BF
5. Dunman PM
6. Sulikowski GA
7. Boyd JM
8. Skaar EP
A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus.; Cell chemical biology; Vol 23(11). 2016 Nov 17.
1. Blanchard C
2. Brooks L
3. Ebsworth-Mojica K
4. Didione L
5. Wucher B
6. Dewhurst S
7. Krysan D
8. Dunman PM
9. Wozniak RA
Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.; mSphere; Vol 1(5). 2016 Sep.
1. Blanchard C
2. Brooks L
3. Beckley A
4. Colquhoun J
5. Dewhurst S
6. Dunman PM
Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.; Antimicrobial agents and chemotherapy; Vol 60(2). 2016 Feb.
1. Wilde AD
2. Snyder DJ
3. Putnam NE
4. Valentino MD
5. Hammer ND
6. Lonergan ZR
7. Hinger SA
8. Aysanoa EE
9. Blanchard C
10. Dunman PM
11. Wasserman GA
12. Chen J
13. Shopsin B
14. Gilmore MS
15. Skaar EP
16. Cassat JE
Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.; PLoS pathogens; Vol 11(12). 2015 Dec.
1. Sheehan LM
2. Budnick JA
3. Blanchard C
4. Dunman PM
5. Caswell CC
A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the α-proteobacteria.; Molecular microbiology; Vol 98(2). 2015 Oct.
1. Tomaras AP
2. Dunman PM
In the midst of the antimicrobial discovery conundrum: an overview.; Current opinion in microbiology; Vol 27. 2015 Oct.
1. Dunman PM
2. Tomaras AP
Translational deficiencies in antibacterial discovery and new screening paradigms.; Current opinion in microbiology; Vol 27. 2015 Oct.
1. Dunman PM
2. Tomaras AP
Editorial overview: Antimicrobials.; Current opinion in microbiology; Vol 27. 2015 Oct.
1. Eidem TM
2. Lounsbury N
3. Emery JF
4. Bulger J
5. Smith A
6. Abou-Gharbia M
7. Childers W
8. Dunman PM
Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing.; Antimicrobial agents and chemotherapy; Vol 59(4). 2015 Apr.
1. Mootz JM
2. Benson MA
3. Heim CE
4. Crosby HA
5. Kavanaugh JS
6. Dunman PM
7. Kielian T
8. Torres VJ
9. Horswill AR
Rot is a key regulator of Staphylococcus aureus biofilm formation.; Molecular microbiology; Vol 96(2). 2015 Apr.
1. Forbes L
2. Ebsworth-Mojica K
3. DiDone L
4. Li SG
5. Freundlich JS
6. Connell N
7. Dunman PM
8. Krysan DJ
A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.; PloS one; Vol 10(6). 2015.
1. Colquhoun JM
2. Wozniak RA
3. Dunman PM
Clinically Relevant Growth Conditions Alter Acinetobacter baumannii Antibiotic Susceptibility and Promote Identification of Novel Antibacterial Agents.; PloS one; Vol 10(11). 2015.
1. Blanchard C
2. Barnett P
3. Perlmutter J
4. Dunman PM
Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors.; Antimicrobial agents and chemotherapy; Vol 58(11). 2014 Nov.
1. Perlmutter JI
2. Forbes LT
3. Krysan DJ
4. Ebsworth-Mojica K
5. Colquhoun JM
6. Wang JL
7. Dunman PM
8. Flaherty DP
Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.; Journal of medicinal chemistry; Vol 57(20). 2014 Oct 23.
1. Olson ME
2. Todd DA
3. Schaeffer CR
4. Paharik AE
5. Van Dyke MJ
6. Büttner H
7. Dunman PM
8. Rohde H
9. Cech NB
10. Fey PD
11. Horswill AR
Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization.; Journal of bacteriology; Vol 196(19). 2014 Oct.
1. Lindgren JK
2. Thomas VC
3. Olson ME
4. Chaudhari SS
5. Nuxoll AS
6. Schaeffer CR
7. Lindgren KE
8. Jones J
9. Zimmerman MC
10. Dunman PM
11. Bayles KW
12. Fey PD
Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis.; Journal of bacteriology; Vol 196(12). 2014 Jun.
1. Eidem TM
2. Coughlan A
3. Towler MR
4. Dunman PM
5. Wren AW
Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus.; Journal of biomaterials applications; Vol 28(8). 2014 Apr.
1. Jacobs AC
2. Blanchard CE
3. Catherman SC
4. Dunman PM
5. Murata Y
An ribonuclease T2 family protein modulates Acinetobacter baumannii abiotic surface colonization.; PloS one; Vol 9(1). 2014.
1. Hanses F
2. Roux C
3. Dunman PM
4. Salzberger B
5. Lee JC
Staphylococcus aureus gene expression in a rat model of infective endocarditis.; Genome medicine; Vol 6(10). 2014.
1. Scherr TD
2. Roux CM
3. Hanke ML
4. Angle A
5. Dunman PM
6. Kielian T
Global transcriptome analysis of Staphylococcus aureus biofilms in response to innate immune cells.; Infection and immunity; Vol 81(12). 2013 Dec.