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Publications, Patents, and Publicity


Polesskaya O; Wong C; Lebron L; Chamberlain JM; Gelbard HA; Goodfellow V; Kim M; Daiss JL; Dewhurst S. "MLK3 regulates fMLP-stimulated neutrophil motility." Molecular immunology.. 2014; 58(2):214-22. Epub 2014 Jan 03.

Kapetanovic S; Griner R; Zeldow B; Nichols S; Leister E; Gelbard HA; Miller TL; Hazra R; Mendez AJ; Malee K; Kammerer B; Williams PL; . "Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis." AIDS.. 2014; 28(3):355-64.

Tremblay MÈ; Marker DF; Puccini JM; Muly EC; Lu SM; Gelbard HA. "Ultrastructure of microglia-synapse interactions in the HIV-1 Tat-injected murine central nervous system." Communicative & integrative biology. 2013; 6(6):e27670. Epub 2013 Dec 31.

Goodfellow VS; Loweth CJ; Ravula SB; Wiemann T; Nguyen TX; Xu Y; Todd DE; Sheppard DW; Pollack S; Polesskaya O; Marker DF; Dewhurst S; Gelbard HA. "Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3." Journal of medicinal chemistry.. 2013; 56(20):8032-48. Epub 2013 Oct 03.

Gelbard HA; Gendelman HE. "Lipids and cognition make good bedfellows for neuroAIDS." Neurology.. 2013; 81(17):1480-1. Epub 2013 Sep 11.

Marker DF; Tremblay ME; Puccini JM; Barbieri J; Gantz Marker MA; Loweth CJ; Muly EC; Lu SM; Goodfellow VS; Dewhurst S; Gelbard HA. "The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013; 33(24):9998-10010.

Ma Q; Gelbard HA; Maggirwar SB; Dewhurst S; Gendelman HE; Peterson DR; Difrancesco R; Hochreiter JS; Morse GD; Schifitto G. "Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients." Journal of neurovirology.. 2013; 19(3):254-60. Epub 2013 Jun 05.

Dash PK; Gendelman HE; Roy U; Balkundi S; Alnouti Y; Mosley RL; Gelbard HA; McMillan J; Gorantla S; Poluektova LY. "Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice." AIDS.. 2012; 26(17):2135-44.

Lapin ZJ; Höppener C; Gelbard HA; Novotny L. "Near-field quantification of complement receptor 1 (CR1/CD35) protein clustering in human erythrocytes." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012; 7(3):539-43. Epub 2012 Feb 29.

Liu W; Ren Y; Bossert A; Wang X; Dayawansa S; Tong J; He X; Smith DH; Gelbard HA; Huang JH. "Allotransplanted neurons used to repair peripheral nerve injury do not elicit overt immunogenicity." PloS one. 2012; 7(2):e31675. Epub 2012 Feb 09.

Marker DF; Puccini JM; Mockus TE; Barbieri J; Lu SM; Gelbard HA. "LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein." Journal of neuroinflammation. 2012; 9():261. Epub 2012 Nov 29.

Dash PK; Gorantla S; Gendelman HE; Knibbe J; Casale GP; Makarov E; Epstein AA; Gelbard HA; Boska MD; Poluektova LY. "Loss of neuronal integrity during progressive HIV-1 infection of humanized mice." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011; 31(9):3148-57.

Perry SW; Norman JP; Barbieri J; Brown EB; Gelbard HA. "Mitochondrial membrane potential probes and the proton gradient: a practical usage guide." BioTechniques.. 2011; 50(2):98-115.

Kasischke KA; Lambert EM; Panepento B; Sun A; Gelbard HA; Burgess RW; Foster TH; Nedergaard M. "Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2011; 31(1):68-81. Epub 2010 Sep 22.

Lu SM; Tremblay MÈ; King IL; Qi J; Reynolds HM; Marker DF; Varrone JJ; Majewska AK; Dewhurst S; Gelbard HA. "HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells." PloS one. 2011; 6(9):e23915. Epub 2011 Sep 02.

Perry SW; Barbieri J; Tong N; Polesskaya O; Pudasaini S; Stout A; Lu R; Kiebala M; Maggirwar SB; Gelbard HA. "Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010; 30(42):14153-64.

Gelbard HA; Dewhurst S; Maggirwar SB; Kiebala M; Polesskaya O; Gendelman HE. "Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2010; 7(4):392-8.

Kapetanovic S; Leister E; Nichols S; Miller T; Tassiopoulos K; Hazra R; Gelbard HA; Malee KM; Kammerer B; Mendez AJ; Williams PL; . "Relationships between markers of vascular dysfunction and neurodevelopmental outcomes in perinatally HIV-infected youth." AIDS.. 2010; 24(10):1481-91.

Eggert D; Dash PK; Gorantla S; Dou H; Schifitto G; Maggirwar SB; Dewhurst S; Poluektova L; Gelbard HA; Gendelman HE. "Neuroprotective activities of CEP-1347 in models of neuroAIDS." The Journal of immunology : official journal of the American Association of Immunologists.. 2010; 184(2):746-56. Epub 2009 Dec 04.

Polesskaya O; Cunningham LL; Francis SP; Luebke AE; Zhu X; Collins D; Vasilyeva ON; Sahler J; Desmet EA; Gelbard HA; Maggirwar SB; Walton JP; Frisina RD; Dewhurst S. "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." Hearing research.. 2010; 270(1-2):21-7. Epub 2010 Oct 27.

Marker DF; Tremblay ME; Lu SM; Majewska AK; Gelbard HA. "A thin-skull window technique for chronic two-photon in vivo imaging of murine microglia in models of neuroinflammation." Journal of visualized experiments : JoVE.. 2010; Epub 2010 Sep 19.

Joseph J; Clifford D; Douglas SD; Fox H; Gendelman HE; Gonzalez-Scarano F; Grant I; Major E; McArthur J; . "Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2009; 4(3):283-97. Epub 2009 May 20.

Eggert D; Dash PK; Serradji N; Dong CZ; Clayette P; Heymans F; Dou H; Gorantla S; Gelbard HA; Poluektova L; Gendelman HE. "Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders." Journal of neuroimmunology.. 2009; 213(1-2):47-59. Epub 2009 Jun 21.

Schifitto G; Zhong J; Gill D; Peterson DR; Gaugh MD; Zhu T; Tivarus M; Cruttenden K; Maggirwar SB; Gendelman HE; Dewhurst S; Gelbard HA. "Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment." Journal of neurovirology.. 2009; 15(2):176-86.

DiCenzo R; Peterson DR; Cruttenden K; Mariuz P; Rezk NL; Hochreiter J; Gelbard H; Schifitto G. "Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir." Antimicrobial agents and chemotherapy.. 2008; 52(9):3035-9. Epub 2008 Jun 23.

Norman JP; Perry SW; Reynolds HM; Kiebala M; De Mesy Bentley KL; Trejo M; Volsky DJ; Maggirwar SB; Dewhurst S; Masliah E; Gelbard HA. "HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization." PloS one. 2008; 3(11):e3731. Epub 2008 Nov 14.

Lu SM; Tong N; Gelbard HA. "The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2007; 2(2):194-201. Epub 2007 Feb 27.

Sui Z; Sniderhan LF; Schifitto G; Phipps RP; Gelbard HA; Dewhurst S; Maggirwar SB. "Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia." The Journal of immunology : official journal of the American Association of Immunologists.. 2007; 178(5):3226-36.

Dewhurst S; Maggirwar SB; Schifitto G; Gendelman HE; Gelbard HA. "Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2007; 2(1):93-6. Epub 2006 Dec 16.

Norman JP; Perry SW; Kasischke KA; Volsky DJ; Gelbard HA. "HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons." The Journal of immunology : official journal of the American Association of Immunologists.. 2007; 178(2):869-76.

Sui Z; Fan S; Sniderhan L; Reisinger E; Litzburg A; Schifitto G; Gelbard HA; Dewhurst S; Maggirwar SB. "Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation." The Journal of immunology : official journal of the American Association of Immunologists.. 2006; 177(1):702-11.

Sui Z; Sniderhan LF; Fan S; Kazmierczak K; Reisinger E; Kovács AD; Potash MJ; Dewhurst S; Gelbard HA; Maggirwar SB. "Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons." The European journal of neuroscience.. 2006; 23(10):2623-34.

Schifitto G; Peterson DR; Zhong J; Ni H; Cruttenden K; Gaugh M; Gendelman HE; Boska M; Gelbard H. "Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report." Neurology.. 2006; 66(6):919-21. Epub 2006 Mar 01.

Bellizzi MJ; Lu SM; Gelbard HA. "Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2006; 1(1):20-31.

Bellizzi MJ; Lu SM; Masliah E; Gelbard HA. "Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor." The Journal of clinical investigation.. 2005; 115(11):3185-92.

Perry SW; Norman JP; Gelbard HA. "Adjunctive therapies for HIV-1 associated neurologic disease." Neurotoxicity research.. 2005; 8(1-2):161-6.

Dou H; Ellison B; Bradley J; Kasiyanov A; Poluektova LY; Xiong H; Maggirwar S; Dewhurst S; Gelbard HA; Gendelman HE. "Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2005; 25(37):8375-85.

Nelson JA; Dou H; Ellison B; Uberti M; Xiong H; Anderson E; Mellon M; Gelbard HA; Boska M; Gendelman HE. "Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis." Journal of neuroscience research.. 2005; 80(4):562-75.

Perry SW; Norman JP; Litzburg A; Zhang D; Dewhurst S; Gelbard HA. "HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis." The Journal of immunology : official journal of the American Association of Immunologists.. 2005; 174(7):4333-44.

Perry SW; Norman JP; Litzburg A; Gelbard HA. "Antioxidants are required during the early critical period, but not later, for neuronal survival." Journal of neuroscience research.. 2004; 78(4):485-92.

DiCenzo R; Peterson D; Cruttenden K; Morse G; Riggs G; Gelbard H; Schifitto G. "Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults." Antimicrobial agents and chemotherapy.. 2004; 48(11):4328-31.

Ramirez SH; Fan S; Maguire CA; Perry S; Hardiek K; Ramkumar V; Gelbard HA; Dewhurst S; Maggirwar SB. "Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal." Journal of neuroscience research.. 2004; 77(2):258-69.

Latchney LR; Fallon MA; Culp DJ; Gelbard HA; Dewhurst S. "Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2004; 52(5):671-81.

Guo H; Liu D; Gelbard H; Cheng T; Insalaco R; Fernández JA; Griffin JH; Zlokovic BV. "Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3." Neuron.. 2004; 41(4):563-72.

Gelbard HA. "Synapses and Sisyphus: life without paraplegin." The Journal of clinical investigation.. 2004; 113(2):185-7.

Wang Z; Trillo-Pazos G; Kim SY; Canki M; Morgello S; Sharer LR; Gelbard HA; Su ZZ; Kang DC; Brooks AI; Fisher PB; Volsky DJ. "Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis." Journal of neurovirology.. 2004; 10 Suppl 1():25-32.

Dou H; Kingsley JD; Mosley RL; Gelbard HA; Gendelman HE. "Neuroprotective strategies for HIV-1 associated dementia." Neurotoxicity research.. 2004; 6(7-8):503-21.

Nitkiewicz J; Chao W; Bentsman G; Li J; Kim SY; Choi SY; Grunig G; Gelbard H; Potash MJ; Volsky DJ. "Productive infection of primary murine astrocytes, lymphocytes, and macrophages by human immunodeficiency virus type 1 in culture." Journal of neurovirology.. 2004; 10(6):400-8.

Dou H; Birusingh K; Faraci J; Gorantla S; Poluektova LY; Maggirwar SB; Dewhurst S; Gelbard HA; Gendelman HE. "Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003; 23(27):9162-70.

Wang Z; Pekarskaya O; Bencheikh M; Chao W; Gelbard HA; Ghorpade A; Rothstein JD; Volsky DJ. "Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120." Virology.. 2003; 312(1):60-73.

Diesing TS; Swindells S; Gelbard H; Gendelman HE. "HIV-1-associated dementia: a basic science and clinical perspective." The AIDS reader. 2002; 12(8):358-68.

Perry SW; Dewhurst S; Bellizzi MJ; Gelbard HA. "Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?" Journal of neurovirology.. 2002; 8(6):611-24.

Ramirez SH; Sanchez JF; Dimitri CA; Gelbard HA; Dewhurst S; Maggirwar SB. "Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism." Journal of neurochemistry.. 2001; 78(4):874-89.

Tong N; Sanchez JF; Maggirwar SB; Ramirez SH; Guo H; Dewhurst S; Gelbard HA. "Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons." The European journal of neuroscience.. 2001; 13(10):1913-22.

Zhu Y; Gelbard HA; Roshal M; Pursell S; Jamieson BD; Planelles V. "Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes." Journal of virology.. 2001; 75(8):3791-801.

Guo H; Tong N; Turner T; Epstein LG; McDermott MP; Kilgannon P; Gelbard HA. "Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury." Annals of neurology.. 2000; 48(4):590-602.

Tong N; Perry SW; Zhang Q; James HJ; Guo H; Brooks A; Bal H; Kinnear SA; Fine S; Epstein LG; Dairaghi D; Schall TJ; Gendelman HE; Dewhurst S; Sharer LR; Gelbard HA. "Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system." The Journal of immunology : official journal of the American Association of Immunologists.. 2000; 164(3):1333-9.

Maggirwar SB; Ramirez S; Tong N; Gelbard HA; Dewhurst S. "Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells." Journal of neurochemistry.. 2000; 74(2):527-39.

James HJ; Sharer LR; Zhang Q; Wang HG; Epstein LG; Reed JC; Gelbard HA. "Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis." Neuropathology and applied neurobiology. 1999; 25(5):380-6.

Zheng J; Thylin MR; Ghorpade A; Xiong H; Persidsky Y; Cotter R; Niemann D; Che M; Zeng YC; Gelbard HA; Shepard RB; Swartz JM; Gendelman HE. "Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia." Journal of neuroimmunology.. 1999; 98(2):185-200.

Maggirwar SB; Tong N; Ramirez S; Gelbard HA; Dewhurst S. "HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity." Journal of neurochemistry.. 1999; 73(2):578-86.

Schifitto G; Sacktor N; Marder K; McDermott MP; McArthur JC; Kieburtz K; Small S; Epstein LG. "Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium." Neurology.. 1999; 53(2):391-6.

Epstein LG; Gelbard HA. "HIV-1-induced neuronal injury in the developing brain." Journal of leukocyte biology.. 1999; 65(4):453-7.

Brooks AI; Chadwick CA; Gelbard HA; Cory-Slechta DA; Federoff HJ. "Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss." Brain research.. 1999; 823(1-2):1-10.

Fine SM; Maggirwar SB; Elliott PR; Epstein LG; Gelbard HA; Dewhurst S. "Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia." Journal of neuroimmunology.. 1999; 95(1-2):55-64.

Deng SX; Panahian N; James H; Gelbard HA; Federoff HJ; Dewhurst S; Epstein LG. "Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption." Journal of neuroscience methods.. 1998; 83(2):159-64.

Perry SW; Hamilton JA; Tjoelker LW; Dbaibo G; Dzenko KA; Epstein LG; Hannun Y; Whittaker JS; Dewhurst S; Gelbard HA. "Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis." The Journal of biological chemistry.. 1998; 273(28):17660-4.

New DR; Maggirwar SB; Epstein LG; Dewhurst S; Gelbard HA. "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism." The Journal of biological chemistry.. 1998; 273(28):17852-8.

Teicher MH; Andersen SL; Campbell A; Gelbard HA; Baldessarini RJ. "Progressive accumbens degeneration after neonatal striatal 6-hydroxydopamine in rats." Neuroscience letters.. 1998; 247(2-3):99-102.

. "A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders." Neurology.. 1998; 50(3):645-51.

. "Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders." Neurology.. 1997; 49(1):142-6.

Perry SW; Epstein LG; Gelbard HA. "In situ trypan blue staining of monolayer cell cultures for permanent fixation and mounting." BioTechniques.. 1997; 22(6):1020-1, 1024.

Perry SW; Epstein LG; Gelbard HA. "Simultaneous in situ detection of apoptosis and necrosis in monolayer cultures by TUNEL and trypan blue staining." BioTechniques.. 1997; 22(6):1102-6.

Krajewski S; James HJ; Ross J; Blumberg BM; Epstein LG; Gendelman HE; Gummuluru S; Dewhurst S; Sharer LR; Reed JC; Gelbard HA. "Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis." Neuropathology and applied neurobiology. 1997; 23(3):242-53.

New DR; Ma M; Epstein LG; Nath A; Gelbard HA. "Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures." Journal of neurovirology.. 1997; 3(2):168-73.

Gelbard HA; Boustany RM; Schor NF. "Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease." Pediatric neurology.. 1997; 16(2):93-7.

Canki M; Potash MJ; Bentsman G; Chao W; Flynn T; Heinemann M; Gelbard H; Volsky DJ. "Isolation and long-term culture of primary ocular human immunodeficiency virus type 1 isolates in primary astrocytes." Journal of neurovirology.. 1997; 3(1):10-5.

Gummuluru S; Novembre FJ; Lewis M; Gelbard HA; Dewhurst S. "Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14." Virology.. 1996; 225(1):21-32.

. "Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders." Neurology.. 1996; 47(5):1247-53.

Persidsky Y; Limoges J; McComb R; Bock P; Baldwin T; Tyor W; Patil A; Nottet HS; Epstein L; Gelbard H; Flanagan E; Reinhard J; Pirruccello SJ; Gendelman HE. "Human immunodeficiency virus encephalitis in SCID mice." The American journal of pathology.. 1996; 149(3):1027-53.

Fine SM; Angel RA; Perry SW; Epstein LG; Rothstein JD; Dewhurst S; Gelbard HA. "Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia." The Journal of biological chemistry.. 1996; 271(26):15303-6.

Sharer LR; Saito Y; Da Cunha A; Ung PC; Gelbard HA; Epstein LG; Blumberg BM. "In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue." Human pathology.. 1996; 27(6):614-7.

Nottet HS; Flanagan EM; Flanagan CR; Gelbard HA; Gendelman HE; Reinhard JF. "The regulation of quinolinic acid in human immunodeficiency virus-infected monocytes." Journal of neurovirology.. 1996; 2(2):111-7.

Dewhurst S; Gelbard HA; Fine SM. "Neuropathogenesis of AIDS." Molecular medicine today. 1996; 2(1):16-23.

Gelbard HA; James HJ; Sharer LR; Perry SW; Saito Y; Kazee AM; Blumberg BM; Epstein LG. "Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy." Neuropathology and applied neurobiology. 1995; 21(3):208-17.

Talley AK; Dewhurst S; Perry SW; Dollard SC; Gummuluru S; Fine SM; New D; Epstein LG; Gendelman HE; Gelbard HA. "Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA." Molecular and cellular biology.. 1995; 15(5):2359-66.

Dollard SC; James HJ; Sharer LR; Epstein LG; Gelbard HA; Dewhurst S. "Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis." Neuropathology and applied neurobiology. 1995; 21(6):518-28.

Gelbard HA; Epstein LG. "HIV-1 encephalopathy in children." Current opinion in pediatrics.. 1995; 7(6):655-62.

Gelbard HA; Nottet HS; Swindells S; Jett M; Dzenko KA; Genis P; White R; Wang L; Choi YB; Zhang D. "Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin." Journal of virology.. 1994; 68(7):4628-35.

Blumberg BM; Gelbard HA; Epstein LG. "HIV-1 infection of the developing nervous system: central role of astrocytes in pathogenesis." Virus research.. 1994; 32(2):253-67.

Gelbard HA; Applegate CD. "Persistent increases in dopamine D2 receptor mRNA expression in basal ganglia following kindling." Epilepsy research.. 1994; 17(1):23-9.

Teicher MH; Barber NI; Gelbard HA; Gallitano AL; Campbell A; Marsh E; Baldessarini RJ. "Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 1993; 9(2):147-56.

Faedda GL; Tondo L; Teicher MH; Baldessarini RJ; Gelbard HA; Floris GF. "Seasonal mood disorders. Patterns of seasonal recurrence in mania and depression." Archives of general psychiatry.. 1993; 50(1):17-23.

Gelbard HA; Dzenko KA; DiLoreto D; del Cerro C; del Cerro M; Epstein LG. "Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis." Developmental neuroscience.. 1993; 15(6):417-22.

Ito Y; Teicher MH; Glod CA; Harper D; Magnus E; Gelbard HA. "Increased prevalence of electrophysiological abnormalities in children with psychological, physical, and sexual abuse." The Journal of neuropsychiatry and clinical neurosciences.. 1993; 5(4):401-8.

Mizrachi Y; Genis P; Volsky DJ; Jett M; Bernton EW; Boyle T; Gelbard HA; Dzenko K; Keane RW; Resnick L; Mizrachi Y; Volsky DJ. "Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease." The Journal of experimental medicine.. 1992; 176(6):1703-18.

Teicher MH; Gallitano AL; Gelbard HA; Evans HK; Marsh ER; Booth RG; Baldessarini RJ. "Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum." Brain research. Developmental brain research.. 1991; 63(1-2):229-35.

Gelbard, H.A.; Teicher, M.H.; Beers, N.B.; Gallitano, A. and R.J. Baldessarini. "Neonatal depletion of dopamine decreases D1 and forskolin binding sites in rat striatum". Posters in Neuroscience. 1991; 1: 9-11.

Kieburtz KD; Epstein LG; Gelbard HA; Greenamyre JT. "Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syndrome dementia complex. Therapeutic implications." Archives of neurology.. 1991; 48(12):1281-4.

Gelbard HA; Teicher MH; Baldessarini RJ; Gallitano A; Marsh ER; Zorc J; Faedda G. "Dopamine D1 receptor development depends on endogenous dopamine." Brain research. Developmental brain research.. 1990; 56(1):137-40.

Gelbard HA; Teicher MH; Faedda G; Baldessarini RJ. "Postnatal development of dopamine D1 and D2 receptor sites in rat striatum." Brain research. Developmental brain research.. 1989; 49(1):123-30.

Gelbard HA; Stern PH; U'Prichard DC. "Characteristics of [3H]1 alpha, 25-(OH)2D3 binding to nuclear fractions from rat pituitary adenoma GH3 cells." Life sciences.. 1981; 29(10):1051-6.

Gelbard HA; Stern PH; U'Prichard DC. "1 alpha, 25-Dihydroxyvitamin D3 nuclear receptors in pituitary." Science.. 1980; 209(4462):1247-9.


  1. Chemical preconditioning as a preventative or treatment for excitotoxic synaptic damage. US Provisional Patent Application No. 60/731,742. International Patent Application No. PCT/US2006/042213.  Inventors: M.J. Bellizzi, S.-M. Lu, H.A. Gelbard.
  2. Treatment of NeuroAIDS using inhibitors of glycogen synthase kinase (GSK)-3. US Provisional Patent Application No. 60/753,614. International Patent Application No. PCT/US2006/009390.  Inventors: H.A. Gelbard, S.B. Maggirwar, S. Dewhurst.
  3. MLK inhibitors and methods of use. Composition of matter, attorney docket: URMC0001-101-US. International Patent Application No. PCT/065878 Inventors: H.A. Gelbard, S. Dewhurst, VS Goodfellow, T. Wiemann.


Jamie Talan. Thinking could be harmful to people with brain diseases. Newsday, February 3, 2006

Jamie Talan. Stopping HIV dementia. Scientific American Mind, August 2006.

Scott P. Edwards. The other side of cytokines. The Dana Foundation News and Periodicals, September 1, 2006

Lauran Neergard. Surviving AIDS can wreak havoc on the brain – Associated Press, October 2, 2006

Chael Needle Brain Matter: Researchers look to adjunctive therapies to treat NeuroAIDS. A&U, November 2006, pp. 34-35

Laura Whitehorn and Rebecca Minnich. Dazed and Confused. POZ, April 2007, pp. 33-34.

Jamie Talan. Valproic acid is neuroprotective in a mouse model of Alzheimer’s disease. Neurology Today 18 December 2008 - Volume 8 - Issue 24 - p 17-18doi: 10.1097/01.NT.0000343222.76902.59

Elizabeth Norton Lasley. Researchers find new point of entry for HIV in brain cells. The Dana Foundation News and Periodicals January 5, 2009

Tom Rickey. Researchers target HIV-related brain difficulties.  URMC Newsroom: October 7, 2010