URMC / Labs / Georas Lab / Publications Recent Publications Knowlden SAHillman SEChapman TJPatil RMiller DDTigyi GGeoras SN (2016 Mar). Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation. American journal of respiratory cell and molecular biology. Levy BDNoel PJFreemer MMCloutier MMGeoras SNJarjour NNOber CWoodruff PGBarnes KCBender BGCamargo CAChupp GLDenlinger LCFahy JVFitzpatrick AMFuhlbrigge AGaston BMHartert TVKolls JKLynch SVMoore WCMorgan WJNadeau KCOwnby DRSolway JSzefler SJWenzel SEWright RJSmith RAErzurum SC (2015 Dec 1). Future Research Directions in Asthma. An NHLBI Working Group Report. American journal of respiratory and critical care medicine. Long XChen QZhao JRafaels NMathias PLiang HPotee JCampbell MZhang BGao LGeoras SNVercelli DBeaty THRuczinski IMathias RBarnes KCChen X (2015). An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum. PloS one. Chapman TJGeoras SN (2014 Nov). Regulatory tone and mucosal immunity in asthma. International immunopharmacology. Georas SNRezaee F (2014 Sep). Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation. The Journal of allergy and clinical immunology. Rezaee FGeoras SN (2014 May). Breaking barriers. New insights into airway epithelial barrier function in health and disease. American journal of respiratory cell and molecular biology. Carlsten CGeoras SN (2014 May 1). Update in environmental and occupational lung diseases 2013. American journal of respiratory and critical care medicine. Abdolahi AGeoras SNBrenna JTCai XThevenet-Morrison KPhipps RPLawrence PMousa SABlock RC (2014 Feb). The effects of aspirin and fish oil consumption on lysophosphatidylcholines and lysophosphatidic acids and their correlates with platelet aggregation in adults with diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. Knowlden SGeoras SN (2014 Feb 1). The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation. Journal of immunology (Baltimore, Md. : 1950). Georas SNUpham J (2014 Jan). Environmental exposures and innate immunity in the lung. Journal of environmental immunology and toxicology. Knowlden SACapece TPopovic MChapman TJRezaee FKim MGeoras SN (2014). Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PloS one. Chapman TJGeoras SN (2013 Dec 31). Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains. Journal of immunological methods. Chapman TJEmo JAKnowlden SARezaee FGeoras SN (2013 Oct 15). Pre-existing tolerance shapes the outcome of mucosal allergen sensitization in a murine model of asthma. Journal of immunology (Baltimore, Md. : 1950). Georas SN (2013 Oct 15). Allergic to autotaxin. A new role for lysophospholipase d and lysophosphatidic Acid in asthma? American journal of respiratory and critical care medicine. Rezaee FDeSando SAIvanov AIChapman TJKnowlden SABeck LAGeoras SN (2013 Oct). Sustained protein kinase D activation mediates respiratory syncytial virus-induced airway barrier disruption. Journal of virology. Kuo IHCarpenter-Mendini AYoshida TMcGirt LYIvanov AIBarnes KCGallo RLBorkowski AWYamasaki KLeung DYGeoras SNDe Benedetto ABeck LA (2013 Apr). Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair. The Journal of investigative dermatology. Saatian BRezaee FDesando SEmo JChapman TKnowlden SGeoras SN (2013 Apr 1). Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells. Tissue barriers. Bauer SMRoy AEmo JChapman TJGeoras SNLawrence BP (2012 Nov). The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood. Toxicological sciences : an official journal of the Society of Toxicology. Emo JMeednu NChapman TJRezaee FBalys MRandall TRangasamy TGeoras SN (2012 Apr 15). Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation. Journal of immunology (Baltimore, Md. : 1950). Qi YOperario DJGeoras SNMosmann TR (2012). The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PloS one. Rezaee FMeednu NEmo JASaatian BChapman TJNaydenov NGDe Benedetto ABeck LAIvanov AIGeoras SN (2011 Dec). Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells. The Journal of allergy and clinical immunology. De Benedetto ASlifka MKRafaels NMKuo IHGeoras SNBoguniewicz MHata TSchneider LCHanifin JMGallo RLJohnson DCBarnes KCLeung DYBeck LA (2011 Jul). Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. The Journal of allergy and clinical immunology. Rangasamy TSemenza GLGeoras SN (2011 Jul). What is hypoxia-inducible factor-1 doing in the allergic lung? Allergy. Lin XSime PJXu HWilliams MALaRussa LGeoras SNGuo J (2011 Jun 15). Yin yang 1 is a novel regulator of pulmonary fibrosis. American journal of respiratory and critical care medicine. De Benedetto ARafaels NMMcGirt LYIvanov AIGeoras SNCheadle CBerger AEZhang KVidyasagar SYoshida TBoguniewicz MHata TSchneider LCHanifin JMGallo RLNovak NWeidinger SBeaty THLeung DYBarnes KCBeck LA (2011 Mar). Tight junction defects in patients with atopic dermatitis. The Journal of allergy and clinical immunology. Bezemer GFBauer SMOberdörster GBreysse PNPieters RHGeoras SNWilliams MA (2011). Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo. Journal of innate immunity. Qi YOperario DJOberholzer CMKobie JJLooney RJGeoras SNMosmann TR (2010 Dec). Human basophils express amphiregulin in response to T cell-derived IL-3. The Journal of allergy and clinical immunology. Lee FEGeoras SNBeck LA (2010 Nov). IL-17: important for host defense, autoimmunity, and allergy? The Journal of investigative dermatology. Rangasamy TWilliams MABauer STrush MAEmo JGeoras SNBiswal S (2010 Sep). Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract. American journal of respiratory cell and molecular biology. Georas SNRezaee FLerner LBeck L (2010 Mar). Dangerous allergens: why some allergens are bad actors. Current allergy and asthma reports. Roman JRangasamy TGuo JSugunan SMeednu NPackirisamy GShimoda LAGolding ASemenza GGeoras SN (2010 Jan). T-cell activation under hypoxic conditions enhances IFN-gamma secretion. American journal of respiratory cell and molecular biology. Williams MABauer SLu WGuo JWalter SBushnell TPLillehoj EPGeoras SN (2010). Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands. Journal of innate immunity. Georas SN (2009 Dec). Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity. Immunologic research. Pietropaoli AGeoras SN (2009 Oct). Resolving lung injury: a new role for Tregs in controlling the innate immune response. The Journal of clinical investigation. Guo JLu WShimoda LASemenza GLGeoras SN (2009). Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. International archives of allergy and immunology. Georas SNBeck L (2008 Nov). Dangerous allergens: innate immunity, dendritic cells and allergic asthma. Expert review of clinical immunology. Guo JWilliams MAGeoras SN (2008 Oct 15). Epigenetic studies should focus on specific cell types. American journal of respiratory and critical care medicine. Williams MARangasamy TBauer SMKilledar SKarp MKensler TWYamamoto MBreysse PBiswal SGeoras SN (2008 Oct 1). Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. Journal of immunology (Baltimore, Md. : 1950). Guo JLin XWilliams MAHamid QGeoras SN (2008 Jul). Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses. The Journal of allergy and clinical immunology. Hansel NNCheadle CDiette GBWright JThompson KMBarnes KCGeoras SN (2008 Mar). Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms. Allergy. Porter MKarp MKilledar SBauer SMGuo JWilliams DBreysse PGeoras SNWilliams MA (2007 Dec). Diesel-enriched particulate matter functionally activates human dendritic cells. American journal of respiratory cell and molecular biology. Zhao YHe DZhao JWang LLeff ARSpannhake EWGeoras SNatarajan V (2007 Apr 6). Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. The Journal of biological chemistry. Georas SNBerdyshev EHubbard WGorshkova IAUsatyuk PVSaatian BMyers ACWilliams MAXiao HQLiu MNatarajan V (2007 Mar). Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. Williams MAPorter MHorton MGuo JRoman JWilliams DBreysse PGeoras SN (2007 Feb). Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells. The Journal of allergy and clinical immunology. Williams MACheadle CWatkins TTailor AKilledar SBreysse PBarnes KCGeoras SN (2007). TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells. Biomarker insights. Chen RRoman JGuo JWest EMcDyer JWilliams MAGeoras SN (2006 Dec). Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells. Stem cells and development. Barekzi ERoman JHise KGeoras SSteinke JW (2006 Jun). Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells. Prostaglandins, leukotrienes, and essential fatty acids. Saatian BZhao YHe DGeoras SNWatkins TSpannhake EWNatarajan V (2006 Feb 1). Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. The Biochemical journal. Rubenfeld JGuo JSookrung NChen RChaicumpa WCasolaro VZhao YNatarajan VGeoras S (2006 Jan). Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells. American journal of physiology. Lung cellular and molecular physiology. Keen JCCianferoni AFlorio GGuo JChen RRoman JWills-Karp MCasolaro VGeoras SN (2006 Jan). Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells. Immunology.