Welcome to the Epilepsy Imaging Phenotypes (Gugger) Lab
We are interested in quantitative brain imaging and its clinical applications in neuroscience, particularly in epilepsy and traumatic brain injury. Much of this work utilizes structural and diffusion MRI as well as functional imaging modalities such as arterial spin labeling, functional MRI, and FDG-PET. The overarching goal of our research is to develop neuroimaging-based biomarkers that can be rapidly translated to the clinic to better characterize neurological disorders, predict outcomes, and ultimately lead to more effective therapies.
James J. Gugger, M.D., Pharm.D..
Principal Investigator
Current Projects
The two major focus areas of the lab are:
- Identification of individuals at high risk for epilepsy after traumatic brain injury
- Characterization of epilepsy phenotypes.
Both areas utilize multimodal neuroimaging including structural and diffusion MRI as well as functional imaging.
Publications
View All Publications- Contusions bias cortical thickness estimates after traumatic brain injury: A TRACK-TBI study.; NeuroImage. Clinical; Vol 50, pp. 104003. 2026 May 06.
- Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival.; Annals of clinical and translational neurology. 2026 May 05.
- Advancing Dry Electroencephalography With Scalable, Soft, and Transcranial Magnetic Stimulation-Compatible Ti3C2Tx MXene Electrodes for Research and Clinical-Grade Applications.; Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2026 Feb 15.
- Improving Standardization and Access to Care via Seizure Pathways in the Emergency Department.; The western journal of emergency medicine; Vol 27(1), pp. 61-66. 2026 Jan 03.
Contact Us
Gugger Lab
University of Rochester Center for Advanced Brain Imaging and Neurophysiology
430 Elmwood Ave
Room 2.B210
Rochester, NY 14642