Dr. Gugger is Assistant Professor of Neurology at the University of Rochester. He specializes in the treatment of epilepsy in adults with expertise in antiseizure medication management as well as surgical management of drug-resistant epilepsy.

Prior to medical training, Dr. Gugger earned a Doctor of Pharmacy degree and went on to a clinical faculty position at St. John’s University College of Pharmacy. He attended medical school at SUNY Downstate, completed his Neurology training at Johns Hopkins and Epilepsy training at the University of Pennsylvania. Prior to his appointment at the University of Rochester he was Assistant Professor of Neurology at the University of Pennsylvania Perelman School of Medicine.

Faculty Appointments

Assistant Professor - Department of Neurology, Epilepsy (SMD)

Assistant Professor - Department of Neuroscience (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Epilepsy, Hospital of the University of Pennsylvania. 2019 - 2020

Residency, Neurology, Johns Hopkins University School of Medicine. 2016 - 2019

Internship, Internal Medicine, Johns Hopkins University School of Medicine. 2015 - 2016

Education

MD | SUNY Downstate Health Sciences University - College of Medicine. 2015

Awards

The Frank L. Coulson Jr. Award for Clinical Excellence. 2019

AAN Medical Student Prize for Excellence in Neurology. 2015

Alpha Omega Alpha. 2014

Merck & Co. Award. 2006

Rho Chi Pharmaceutical Honor Society. 2004

Research

Dr. Gugger is an Assistant Professor of Neurology at the University of Rochester with clinical expertise in both epilepsy and traumatic brain injury. His lab is focused on the use quantitative brain imaging to improve our understanding of neurological disorders, including epilepsy and traumatic brai...

Research Lab

Epilepsy Imaging Phenotypes Lab

Visit Research Lab Website

Publications

Journal Articles

Clinical characteristics and surgical outcomes of epilepsy associated with temporal encephalocele: A systematic review.

Zhou DJ, Woodson-Smith S, Emmert BE, Kornspun A, Larocque J, Kulick-Soper CV, Qiu MK, Ellis CA, Gugger JJ, Conrad EC, Waldman G, Ganguly T, Sinha SR, Davis KA, Stein JM, Liu GT, Gelfand M, Raghupathi R

Epilepsy & behavior : E&B.. 2024 September 158 :109928. Epub 07/02/2024.

Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury.

Vaz A, Wathen C, Miranda S, Thomas R, Darlington T, Jabarkheel R, Tomlinson S, Arena J, Bond K, Salwi S, Ajmera S, Bachschmid-Romano L, Gugger J, Sandsmark D, Diaz-Arrastia R, Schuster J, Ramayya AG, Cajigas I, Pesaran B, Chen HI, Petrov D

bioRxiv : the preprint server for biology.. 2024 July 23 Epub 07/23/2024.

Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.

Lucas A, Jaskir M, Sinha N, Pattnaik A, Mouchtaris S, Josyula M, Petillo N, Roth RW, Dikecligil GN, Bonilha L, Gottfried J, Gleichgerrcht E, Das S, Stein JM, Gugger JJ, Davis KA

medRxiv : the preprint server for health sciences.. 2024 July 22 Epub 07/22/2024.

Enhancing the Diagnostic Utility of ASL Imaging in Temporal Lobe Epilepsy through FlowGAN: An ASL to PET Image Translation Framework.

Lucas A, Vadali C, Mouchtaris S, Arnold TC, Gugger JJ, Kulick-Soper C, Josyula M, Petillo N, Das S, Dubroff J, Detre JA, Stein JM, Davis KA

medRxiv : the preprint server for health sciences.. 2024 May 30 Epub 05/30/2024.

Posttraumatic Epilepsy and Dementia Risk.

Schneider ALC, Law CA, Gottesman RF, Krauss G, Huang J, Kucharska-Newton A, Jensen FE, Gugger JJ, Diaz-Arrastia R, Johnson EL

JAMA neurology.. 2024 February 2681 (4):346-53. Epub 02/26/2024.

Association between structural brain MRI abnormalities and epilepsy in older adults.

Gugger JJ, Walter AE, Diaz-Arrastia R, Huang J, Jack CR, Reid R, Kucharska-Newton AM, Gottesman RF, Schneider ALC, Johnson EL

Annals of clinical and translational neurology.. 2024 February 11 (2):342-354. Epub 12/28/2023.

Alcohol for seizure induction in the epilepsy monitoring unit.

Emmert BE, Xie K, Conrad EC, Ghosn NJ, Bauman K, Korzun J, Kulick-Soper CV, Naveed O, Hartmann N, LaRocque JJ, Mindy Ganguly T, Gugger JJ, Raghupathi R, Gelfand MA, Davis KA, Sinha SR, Litt B, Shinohara RT, Ellis CA

Epilepsy & behavior : E&B.. 2024 January 150 :109572. Epub 12/08/2023.

Spatiotemporal profile of atrophy in the first year following moderate-severe traumatic brain injury.

Brennan DJ, Duda J, Ware JB, Whyte J, Choi JY, Gugger J, Focht K, Walter AE, Bushnik T, Gee JC, Diaz-Arrastia R, Kim JJ

Human brain mapping.. 2023 September 44 (13):4692-4709. Epub 07/03/2023.

Veteran perspectives of epilepsy care: Impact of Veteran satisfaction, knowledge, and proactivity.

Panahi S, Kennedy E, Roghani A, VegaYon G, VanCott A, Gugger JJ, Raquel Lopez M, Jo Pugh M

Epilepsy & behavior : E&B.. 2023 July 144 :109218. Epub 05/30/2023.

Toward a Patient-Specific Readout of Neurodegeneration: The Case for Spatial Normative Modeling in Alzheimer Disease.

Sinha N, Gugger JJ

Neurology.. 2023 June 13100 (24):1125-1126. Epub 05/01/2023.

A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit.

Ghosn NJ, Xie K, Pattnaik AR, Gugger JJ, Ellis CA, Sweeney E, Fox E, Bernabei JM, Johnson J, Boccanfuso J, Litt B, Conrad EC

Epilepsia.. 2023 May 64 (5):1236-1247. Epub 03/17/2023.

Longitudinal Abnormalities in White Matter Extracellular Free Water Volume Fraction and Neuropsychological Functioning in Patients with Traumatic Brain Injury.

Gugger JJ, Walter AE, Parker D, Sinha N, Morrison J, Ware J, Schneider ALC, Petrov D, Sandsmark DK, Verma R, Diaz-Arrastia R

Journal of neurotrauma.. 2023 April 40 (7-8):683-692. Epub 01/19/2023.

Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy.

Conrad EC, Revell AY, Greenblatt AS, Gallagher RS, Pattnaik AR, Hartmann N, Gugger JJ, Shinohara RT, Litt B, Marsh ED, Davis KA

Epilepsia.. 2023 March 64 (3):754-768. Epub 01/14/2023.

Subcortical Functional Connectivity Gradients in Temporal Lobe Epilepsy.

Lucas A, Mouchtaris S, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Gugger JJ, Das S, Stein JM, Davis KA

medRxiv : the preprint server for health sciences.. 2023 January 9 Epub 01/09/2023.

A team science approach for the preclinical and clinical characterization and biomarker development for post?traumatic epilepsy

Iyengar SS; Lubbers LS; Harte?Hargrove L; CURE Epilepsy Post?Traumatic Initiative Advisors, and Investigators.

Epilepsia Open. 2023; 8(3): 820-33.

Structural brain network deviations predict recovery after traumatic brain injury.

Gugger JJ, Sinha N, Huang Y, Walter AE, Lynch C, Kalyani P, Smyk N, Sandsmark D, Diaz-Arrastia R, Davis KA

NeuroImage. Clinical.. 2023 38 :103392. Epub 03/30/2023.

Subcortical functional connectivity gradients in temporal lobe epilepsy.

Lucas A, Mouchtaris S, Cornblath EJ, Sinha N, Caciagli L, Hadar P, Gugger JJ, Das S, Stein JM, Davis KA

NeuroImage. Clinical.. 2023 38 :103418. Epub 05/05/2023.

Using Generalized Polyspike Train to Predict Drug-Resistant Idiopathic Generalized Epilepsy.

Conrad EC, Chugh N, Ganguly TM, Gugger JJ, Tizazu EF, Shinohara RT, Raghupathi R, Becker DA, Gelfand MA, Omole AT, Decker BM, Pathmanathan JS, Davis KA, Ellis CA

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.. 2022 September 139 (6):459-465. Epub 12/08/2020.

Connectomic assessment of injury burden and longitudinal structural network alterations in moderate-to-severe traumatic brain injury.

Osmanl?o?lu Y, Parker D, Alappatt JA, Gugger JJ, Diaz-Arrastia RR, Whyte J, Kim JJ, Verma R

Human brain mapping.. 2022 September 43 (13):3944-3957. Epub 04/29/2022.

Implanting intracranial electrodes does not affect spikes or network connectivity in nearby or connected brain regions.

Conrad EC, Shinohara RT, Gugger JJ, Revell AY, Das S, Stein JM, Marsh ED, Davis KA, Litt B

Network neuroscience.. 2022 July 6 (3):834-849. Epub 07/01/2022.

The Frontier of Electrophysiologic Monitoring in Acute Brain Injury.

Gugger JJ, Diaz-Arrastia R

Neurocritical care.. 2022 June 37 (Suppl 1):3-4. Epub 04/29/2022.

Multimodal Quality of Life Assessment in Post-9/11 Veterans With Epilepsy: Impact of Drug Resistance, Traumatic Brain Injury, and Comorbidity.

Gugger JJ, Kennedy E, Panahi S, Tate DF, Roghani A, Van Cott AC, Lopez MR, Altalib H, Diaz-Arrastia R, Pugh MJ

Neurology.. 2022 April 2698 (17):e1761-e1770. Epub 04/06/2022.

Early Posttraumatic Seizures-Putting Things in Perspective.

Gugger JJ, Diaz-Arrastia R

JAMA neurology.. 2022 April 179 (4):325-326. Epub 1900 01 01.

Association of Head Injury With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Cohort.

Schneider ALC, Gottesman RF, Krauss GL, Gugger J, Diaz-Arrastia R, Kucharska-Newton A, Huang J, Johnson EL

Neurology.. 2022 February 2298 (8):e808-e817. Epub 12/17/2021.

Dynamic contrast enhanced MRI for characterization of blood-brain-barrier dysfunction after traumatic brain injury.

Ware JB, Sinha S, Morrison J, Walter AE, Gugger JJ, Schneider ALC, Dabrowski C, Zamore H, Wesley L, Magdamo B, Petrov D, Kim JJ, Diaz-Arrastia R, Sandsmark DK

NeuroImage. Clinical.. 2022 36 :103236. Epub 10/17/2022.

Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury.

Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, , Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R

JAMA network open.. 2021 December 14 (12):e2140191. Epub 12/01/2021.

The Military Injuries: Understanding Post-Traumatic Epilepsy Study: Understanding Relationships among Lifetime Traumatic Brain Injury History, Epilepsy, and Quality of Life.

Pugh MJ, Kennedy E, Gugger JJ, Mayo J, Tate D, Swan A, Kean J, Altalib H, Gowda S, Towne A, Hinds S, Van Cott A, Lopez MR, Jaramillo CA, Eapen BC, McCafferty RR, Salinsky M, Cramer J, McMillan KK, Kalvesmaki A, Diaz-Arrastia R,

Journal of neurotrauma.. 2021 October 1538 (20):2841-2850. Epub 1900 01 01.

Residency Training: A practical guide for medical students who are planning a future in neurology.

Gugger JJ, Reoma LB, Soni M, Olson V, Tiryaki E, Noble JM,

Neurology.. 2020 April 1494 (15):673-677. Epub 03/12/2020.

New-onset refractory status epilepticus: A retrospective cohort study.

Gugger JJ, Husari K, Probasco JC, Cervenka MC

Seizure.. 2020 January 74 :41-48. Epub 12/03/2019.

The role of CT perfusion in the evaluation of seizures, the post-ictal state, and status epilepticus.

Gugger JJ, Llinas RH, Kaplan PW

Epilepsy research.. 2020 January 159 :106256. Epub 12/12/2019.

Subarachnoid Hemorrhage in the Setting of Electroconvulsive Therapy in a Patient With an Unsecured Cerebral Aneurysm: A Case Report and Review of the Literature.

Gugger JJ, Dunn LE

The journal of ECT.. 2019 September 35 (3):212-214. Epub 1900 01 01.

Does the Magnitude of the Electrocardiogram QT Interval Dispersion Predict Stroke Outcome?

Lederman YS, Balucani C, Steinberg LR, Philip C, Lazar JM, Weedon J, Mirchandani G, Weingast SZ, Viticchi G, Falsetti L, Silvestrini M, Gugger JJ, Aharonoff D, Piran P, Adler Z, Levine SR

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2019 January 28 (1):44-48. Epub 10/02/2018.

A multimodal approach using somatosensory evoked potentials for prognostication in hypoglycemic encephalopathy.

Gugger JJ, Geocadin RG, Kaplan PW

Clinical neurophysiology practice.. 2019 4 :194-197. Epub 10/17/2019.

Clinical and Electrographic Correlates of Bilateral Independent Periodic Discharges.

Freund B, Gugger JJ, Reynolds A, Tatum WO, Claassen J, Kaplan PW

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.. 2018 May 35 (3):234-241. Epub 1900 01 01.

Relationship between QT interval dispersion in acute stroke and stroke prognosis: a systematic review.

Lederman YS, Balucani C, Lazar J, Steinberg L, Gugger J, Levine SR

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2014 23 (10):2467-2478. Epub 10/03/2014.

Tardive dyskinesia from atypical antipsychotic agents in patients with mood disorders in a clinical setting.

Coplan J, Gugger JJ, Tasleem H

Journal of affective disorders.. 2013 September 25150 (3):868-71. Epub 05/30/2013.

Neuroleptic-induced catatonia in two hospitalized patients.

Gugger JJ, Saad M, Smith C

Journal of pharmacy practice.. 2012 April 25 (2):250-4. Epub 11/02/2011.

Antipsychotic pharmacotherapy and orthostatic hypotension: identification and management.

Gugger JJ

CNS drugs.. 2011 August 25 (8):659-71. Epub 1900 01 01.

Is there a link between aripiprazole and treatment-emergent psychosis?

Gugger JJ; Tam CL; Ashby CR Jr.

Current Psychiatry. 2011; 10(10): 53-9.

Delirium in a patient with toxic flecainide plasma concentrations: the role of a pharmacokinetic drug interaction with paroxetine.

Tsao YY, Gugger JJ

The Annals of pharmacotherapy.. 2009 July 43 (7):1366-9. Epub 06/16/2009.

Low-dose quetiapine is not a benign sedative-hypnotic agent.

Gugger JJ, Cassagnol M

The American journal on addictions. 2008 17 (5):454-5. Epub 1900 01 01.

Rapid eye movement sleep behavior disorder.

Gugger JJ, Wagner ML

The Annals of pharmacotherapy.. 2007 November 41 (11):1833-41. Epub 10/09/2007.

Clozapine treatment in a patient with a persistently low neutrophil count.

Gugger JJ, Caley CF.

Clinical schizophrenia & related psychoses. 2007; 1: 270-2.

Percutaneous coronary intervention-related bleeding risk factors in current practice.

Mathis AS, Gugger JJ

The Annals of pharmacotherapy.. 2005 October 39 (10):1627-33. Epub 09/06/2005.

Books

Life-threatening Effects of Antipsychotic Drugs (2016)

Chapter: Orthostatic Hypertension

Authors: Gugger JJ, Ehret MJ

Publisher: Elsevier 2016

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