URochester Medicine / Labs / Hinkle Lab / Publications

Recent Publications

1. Gehret AU
2. Hinkle PM
siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor.; ACS chemical biology; Vol 8(3). 2013 Mar 15.
1. Thal DM
2. Homan KT
3. Chen J
4. Wu EK
5. Hinkle PM
6. Huang ZM
7. Chuprun JK
8. Song J
9. Gao E
10. Cheung JY
11. Sklar LA
12. Koch WJ
13. Tesmer JJ
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.; ACS chemical biology; Vol 7(11). 2012 Nov 16.
1. Christian WV
2. Li N
3. Hinkle PM
4. Ballatori N
β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.; The Journal of biological chemistry; Vol 287(25). 2012 Jun 15.
1. Hinkle PM
2. Gehret AU
3. Jones BW
Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor.; Frontiers in neuroscience; Vol 6. 2012.
1. Liang L
2. Sebag JA
3. Eagelston L
4. Serasinghe MN
5. Veo K
6. Reinick C
7. Angleson J
8. Hinkle PM
9. Dores RM
Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.; General and comparative endocrinology; Vol 174(1). 2011 Oct 1.
1. Gehret AU
2. Hinkle PM
Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.; The Biochemical journal; Vol 428(2). 2010 Jun 1.
1. Gehret AU
2. Jones BW
3. Tran PN
4. Cook LB
5. Greuber EK
6. Hinkle PM
Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.; Molecular pharmacology; Vol 77(2). 2010 Feb.
1. Sebag JA
2. Hinkle PM
Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.; Science signaling; Vol 3(116). 2010.
1. Jones BW
2. Hinkle PM
Subcellular trafficking of the TRH receptor: effect of phosphorylation.; Molecular endocrinology (Baltimore, Md.); Vol 23(9). 2009 Sep.
1. Sebag JA
2. Hinkle PM
Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.; The Journal of biological chemistry; Vol 284(34). 2009 Aug 21.
1. Hinkle PM
2. Sebag JA
Structure and function of the melanocortin2 receptor accessory protein (MRAP).; Molecular and cellular endocrinology; Vol 300(1-2). 2009 Mar 5.
1. Sebag JA
2. Hinkle PM
Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.; The Journal of biological chemistry; Vol 284(1). 2009 Jan 2.
1. Jones BW
2. Hinkle PM
Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.; Molecular pharmacology; Vol 74(1). 2008 Jul.
1. Hogan N
2. O'Boyle KM
3. Hinkle PM
4. Kelly JA
A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2.; Neuroscience letters; Vol 431(1). 2008 Jan 24.
1. Sebag JA
2. Hinkle PM
Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(51). 2007 Dec 18.
1. Song GJ
2. Jones BW
3. Hinkle PM
Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(46). 2007 Nov 13.
1. Scalabrino GA
2. Hogan N
3. O'Boyle KM
4. Slator GR
5. Gregg DJ
6. Fitchett CM
7. Draper SM
8. Bennett GW
9. Hinkle PM
10. Bauer K
11. Williams CH
12. Tipton KF
13. Kelly JA
Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone.; Neuropharmacology; Vol 52(7). 2007 Jun.
1. Jones BW
2. Song GJ
3. Greuber EK
4. Hinkle PM
Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies.; The Journal of biological chemistry; Vol 282(17). 2007 Apr 27.
1. Sebag JA
2. Hinkle PM
Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids.; Endocrinology; Vol 147(12). 2006 Dec.
1. Jones BW
2. Hinkle PM
Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor.; The Journal of biological chemistry; Vol 280(46). 2005 Nov 18.
1. Song GJ
2. Hinkle PM
Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.; Molecular endocrinology (Baltimore, Md.); Vol 19(11). 2005 Nov.
1. Cook LB
2. Hinkle PM
Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.; Endocrinology; Vol 145(7). 2004 Jul.
1. Cook LB
2. Hinkle PM
Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.; The Biochemical journal; Vol 380(Pt 3). 2004 Jun 15.
1. Hinkle PM
2. Puskas JA
Detection of G protein-coupled receptors by immunofluorescence microscopy.; Methods in molecular biology (Clifton, N.J.); Vol 237. 2004.
1. Sattin A
2. Pekary AE
3. Lloyd RL
4. Paulson M
5. Meyerhoff JA
6. Hinkle PM
7. Faull K
TRH and related peptides: homeostatic regulators of glutamate transmission?; Annals of the New York Academy of Sciences; Vol 1003. 2003 Nov.
1. Cook LB
2. Zhu CC
3. Hinkle PM
Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.; Molecular endocrinology (Baltimore, Md.); Vol 17(9). 2003 Sep.
1. Graves TK
2. Hinkle PM
Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.; Endocrinology; Vol 144(8). 2003 Aug.
1. Goubaeva F
2. Ghosh M
3. Malik S
4. Yang J
5. Hinkle PM
6. Griendling KK
7. Neubig RR
8. Smrcka AV
Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.; The Journal of biological chemistry; Vol 278(22). 2003 May 30.
1. Graves TK
2. Hinkle PM
Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone.; Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; Vol 13(1). 2003 Feb.
1. Zhu CC
2. Cook LB
3. Hinkle PM
Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.; The Journal of biological chemistry; Vol 277(31). 2002 Aug 2.
1. Hinkle PM
2. Pekary AE
3. Senanayaki S
4. Sattin A
Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.; Brain research; Vol 935(1-2). 2002 May 10.
1. Graves TK
2. Patel S
3. Dannies PS
4. Hinkle PM
Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic.; Journal of cell science; Vol 114(Pt 20). 2001 Oct.
1. Smith J
2. Yu R
3. Hinkle PM
Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis.; Molecular endocrinology (Baltimore, Md.); Vol 15(9). 2001 Sep.
1. Rapoport AP
2. Simons-Evelyn M
3. Chen T
4. Sidell R
5. Luhowskyj S
6. Rosell K
7. Obrig T
8. Hicks D
9. Hinkle PM
10. Nahm M
11. Insel RA
12. Abboud CN
Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.; Blood cells, molecules & diseases; Vol 27(3). 2001 May.
1. Romoser VA
2. Graves TK
3. Wu D
4. Jiang H
5. Hinkle PM
Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice.; Molecular endocrinology (Baltimore, Md.); Vol 15(1). 2001 Jan.
1. Yu R
2. Hinkle PM
Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators.; The Journal of biological chemistry; Vol 275(31). 2000 Aug 4.
1. Xie W
2. Samoriski GM
3. McLaughlin JP
4. Romoser VA
5. Smrcka A
6. Hinkle PM
7. Bidlack JM
8. Gross RA
9. Jiang H
10. Wu D
Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids.; Proceedings of the National Academy of Sciences of the United States of America; Vol 96(18). 1999 Aug 31.
1. Yu R
2. Hinkle PM
Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11.; The Journal of biological chemistry; Vol 274(22). 1999 May 28.
1. Fliss MS
2. Hinkle PM
3. Bancroft C
Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity.; Molecular endocrinology (Baltimore, Md.); Vol 13(4). 1999 Apr.
1. Yu R
2. Ashworth R
3. Hinkle PM
Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes.; Thyroid : official journal of the American Thyroid Association; Vol 8(10). 1998 Oct.
1. Yu R
2. Hinkle PM
Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization.; Molecular endocrinology (Baltimore, Md.); Vol 12(5). 1998 May.
1. Nelson EJ
2. Zinkin NT
3. Hinkle PM
Fluorescence methods to assess multidrug resistance in individual cells.; Cancer chemotherapy and pharmacology; Vol 42(4). 1998.
1. Yu R
2. Hinkle PM
Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps.; The Journal of biological chemistry; Vol 272(45). 1997 Nov 7.
1. Kerper LE
2. Hinkle PM
Lead uptake in brain capillary endothelial cells: activation by calcium store depletion.; Toxicology and applied pharmacology; Vol 146(1). 1997 Sep.
1. Romoser VA
2. Hinkle PM
3. Persechini A
Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators.; The Journal of biological chemistry; Vol 272(20). 1997 May 16.
1. Yu R
2. Hinkle PM
Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor.; Molecular pharmacology; Vol 51(5). 1997 May.
1. Kerper LE
2. Hinkle PM
Cellular uptake of lead is activated by depletion of intracellular calcium stores.; The Journal of biological chemistry; Vol 272(13). 1997 Mar 28.
1. Ashworth R
2. Hinkle PM
Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs.; Endocrinology; Vol 137(12). 1996 Dec.
1. Shupnik MA
2. Weck J
3. Hinkle PM
Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.; Molecular endocrinology (Baltimore, Md.); Vol 10(1). 1996 Jan.
1. Ashworth R
2. Yu R
3. Nelson EJ
4. Dermer S
5. Gershengorn MC
6. Hinkle PM
Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 92(2). 1995 Jan 17.