URMC / Labs / Hinkle Lab / Publications Recent Publications Gehret AUHinkle PM siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor.; ACS chemical biology; Vol 83. 2013 Mar 15. Thal DMHoman KTChen JWu EKHinkle PMHuang ZMChuprun JKSong JGao ECheung JYSklar LAKoch WJTesmer JJ Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.; ACS chemical biology; Vol 711. 2012 Nov 16. Christian WVLi NHinkle PMBallatori N β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.; The Journal of biological chemistry; Vol 28725. 2012 Jun 15. Hinkle PMGehret AUJones BW Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor.; Frontiers in neuroscience; Vol 6. 2012. Liang LSebag JAEagelston LSerasinghe MNVeo KReinick CAngleson JHinkle PMDores RM Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.; General and comparative endocrinology; Vol 1741. 2011 Oct 1. Gehret AUHinkle PM Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.; The Biochemical journal; Vol 4282. 2010 Jun 1. Gehret AUJones BWTran PNCook LBGreuber EKHinkle PM Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.; Molecular pharmacology; Vol 772. 2010 Feb. Sebag JAHinkle PM Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.; Science signaling; Vol 3116. 2010. Jones BWHinkle PM Subcellular trafficking of the TRH receptor: effect of phosphorylation.; Molecular endocrinology (Baltimore, Md.); Vol 239. 2009 Sep. Sebag JAHinkle PM Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.; The Journal of biological chemistry; Vol 28434. 2009 Aug 21. Hinkle PMSebag JA Structure and function of the melanocortin2 receptor accessory protein (MRAP).; Molecular and cellular endocrinology; Vol 3001-2. 2009 Mar 5. Sebag JAHinkle PM Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.; The Journal of biological chemistry; Vol 2841. 2009 Jan 2. Jones BWHinkle PM Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.; Molecular pharmacology; Vol 741. 2008 Jul. Hogan NO'Boyle KMHinkle PMKelly JA A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2.; Neuroscience letters; Vol 4311. 2008 Jan 24. Sebag JAHinkle PM Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers.; Proceedings of the National Academy of Sciences of the United States of America; Vol 10451. 2007 Dec 18. Song GJJones BWHinkle PM Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 10446. 2007 Nov 13. Scalabrino GAHogan NO'Boyle KMSlator GRGregg DJFitchett CMDraper SMBennett GWHinkle PMBauer KWilliams CHTipton KFKelly JA Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone.; Neuropharmacology; Vol 527. 2007 Jun. Jones BWSong GJGreuber EKHinkle PM Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies.; The Journal of biological chemistry; Vol 28217. 2007 Apr 27. Sebag JAHinkle PM Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids.; Endocrinology; Vol 14712. 2006 Dec. Jones BWHinkle PM Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor.; The Journal of biological chemistry; Vol 28046. 2005 Nov 18. Song GJHinkle PM Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.; Molecular endocrinology (Baltimore, Md.); Vol 1911. 2005 Nov. Cook LBHinkle PM Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.; Endocrinology; Vol 1457. 2004 Jul. Cook LBHinkle PM Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.; The Biochemical journal; Vol 380Pt 3. 2004 Jun 15. Hinkle PMPuskas JA Detection of G protein-coupled receptors by immunofluorescence microscopy.; Methods in molecular biology (Clifton, N.J.); Vol 237. 2004. Sattin APekary AELloyd RLPaulson MMeyerhoff JAHinkle PMFaull K TRH and related peptides: homeostatic regulators of glutamate transmission?; Annals of the New York Academy of Sciences; Vol 1003. 2003 Nov. Cook LBZhu CCHinkle PM Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.; Molecular endocrinology (Baltimore, Md.); Vol 179. 2003 Sep. Graves TKHinkle PM Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.; Endocrinology; Vol 1448. 2003 Aug. Goubaeva FGhosh MMalik SYang JHinkle PMGriendling KKNeubig RRSmrcka AV Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.; The Journal of biological chemistry; Vol 27822. 2003 May 30. Graves TKHinkle PM Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone.; Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; Vol 131. 2003 Feb. Zhu CCCook LBHinkle PM Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.; The Journal of biological chemistry; Vol 27731. 2002 Aug 2. Hinkle PMPekary AESenanayaki SSattin A Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.; Brain research; Vol 9351-2. 2002 May 10. Graves TKPatel SDannies PSHinkle PM Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic.; Journal of cell science; Vol 114Pt 20. 2001 Oct. Smith JYu RHinkle PM Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis.; Molecular endocrinology (Baltimore, Md.); Vol 159. 2001 Sep. Rapoport APSimons-Evelyn MChen TSidell RLuhowskyj SRosell KObrig THicks DHinkle PMNahm MInsel RAAbboud CN Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.; Blood cells, molecules & diseases; Vol 273. 2001 May. Romoser VAGraves TKWu DJiang HHinkle PM Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice.; Molecular endocrinology (Baltimore, Md.); Vol 151. 2001 Jan. Yu RHinkle PM Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators.; The Journal of biological chemistry; Vol 27531. 2000 Aug 4. Xie WSamoriski GMMcLaughlin JPRomoser VASmrcka AHinkle PMBidlack JMGross RAJiang HWu D Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids.; Proceedings of the National Academy of Sciences of the United States of America; Vol 9618. 1999 Aug 31. Yu RHinkle PM Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11.; The Journal of biological chemistry; Vol 27422. 1999 May 28. Fliss MSHinkle PMBancroft C Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity.; Molecular endocrinology (Baltimore, Md.); Vol 134. 1999 Apr. Yu RAshworth RHinkle PM Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes.; Thyroid : official journal of the American Thyroid Association; Vol 810. 1998 Oct. Yu RHinkle PM Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization.; Molecular endocrinology (Baltimore, Md.); Vol 125. 1998 May. Nelson EJZinkin NTHinkle PM Fluorescence methods to assess multidrug resistance in individual cells.; Cancer chemotherapy and pharmacology; Vol 424. 1998. Yu RHinkle PM Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps.; The Journal of biological chemistry; Vol 27245. 1997 Nov 7. Kerper LEHinkle PM Lead uptake in brain capillary endothelial cells: activation by calcium store depletion.; Toxicology and applied pharmacology; Vol 1461. 1997 Sep. Romoser VAHinkle PMPersechini A Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators.; The Journal of biological chemistry; Vol 27220. 1997 May 16. Yu RHinkle PM Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor.; Molecular pharmacology; Vol 515. 1997 May. Kerper LEHinkle PM Cellular uptake of lead is activated by depletion of intracellular calcium stores.; The Journal of biological chemistry; Vol 27213. 1997 Mar 28. Ashworth RHinkle PM Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs.; Endocrinology; Vol 13712. 1996 Dec. Shupnik MAWeck JHinkle PM Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.; Molecular endocrinology (Baltimore, Md.); Vol 101. 1996 Jan. Ashworth RYu RNelson EJDermer SGershengorn MCHinkle PM Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 922. 1995 Jan 17.