Recent Publications

• 1. Gehret AU
  2. Hinkle PM
  siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor.; ACS chemical biology; Vol 8(3). 2013 Mar 15.
• 1. Thal DM
  2. Homan KT
  3. Chen J
  4. Wu EK
  5. Hinkle PM
  6. Huang ZM
  7. Chuprun JK
  8. Song J
  9. Gao E
  10. Cheung JY
  11. Sklar LA
  12. Koch WJ
  13. Tesmer JJ
  Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.; ACS chemical biology; Vol 7(11). 2012 Nov 16.
• 1. Christian WV
  2. Li N
  3. Hinkle PM
  4. Ballatori N
  β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.; The Journal of biological chemistry; Vol 287(25). 2012 Jun 15.
• 1. Hinkle PM
  2. Gehret AU
  3. Jones BW
  Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor.; Frontiers in neuroscience; Vol 6. 2012.
• 1. Liang L
  2. Sebag JA
  3. Eagelston L
  4. Serasinghe MN
  5. Veo K
  6. Reinick C
  7. Angleson J
  8. Hinkle PM
  9. Dores RM
  Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.; General and comparative endocrinology; Vol 174(1). 2011 Oct 1.
• 1. Gehret AU
  2. Hinkle PM
  Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.; The Biochemical journal; Vol 428(2). 2010 Jun 1.
• 1. Gehret AU
  2. Jones BW
  3. Tran PN
  4. Cook LB
  5. Greuber EK
  6. Hinkle PM
  Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase.; Molecular pharmacology; Vol 77(2). 2010 Feb.
• 1. Sebag JA
  2. Hinkle PM
  Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.; Science signaling; Vol 3(116). 2010.
• 1. Jones BW
  2. Hinkle PM
  Subcellular trafficking of the TRH receptor: effect of phosphorylation.; Molecular endocrinology (Baltimore, Md.); Vol 23(9). 2009 Sep.
• 1. Sebag JA
  2. Hinkle PM
  Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.; The Journal of biological chemistry; Vol 284(34). 2009 Aug 21.
• 1. Hinkle PM
  2. Sebag JA
  Structure and function of the melanocortin2 receptor accessory protein (MRAP).; Molecular and cellular endocrinology; Vol 300(1-2). 2009 Mar 5.
• 1. Sebag JA
  2. Hinkle PM
  Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.; The Journal of biological chemistry; Vol 284(1). 2009 Jan 2.
• 1. Jones BW
  2. Hinkle PM
  Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.; Molecular pharmacology; Vol 74(1). 2008 Jul.
• 1. Hogan N
  2. O'Boyle KM
  3. Hinkle PM
  4. Kelly JA
  A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2.; Neuroscience letters; Vol 431(1). 2008 Jan 24.
• 1. Sebag JA
  2. Hinkle PM
  Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(51). 2007 Dec 18.
• 1. Song GJ
  2. Jones BW
  3. Hinkle PM
  Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(46). 2007 Nov 13.
• 1. Scalabrino GA
  2. Hogan N
  3. O'Boyle KM
  4. Slator GR
  5. Gregg DJ
  6. Fitchett CM
  7. Draper SM
  8. Bennett GW
  9. Hinkle PM
  10. Bauer K
  11. Williams CH
  12. Tipton KF
  13. Kelly JA
  Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone.; Neuropharmacology; Vol 52(7). 2007 Jun.
• 1. Jones BW
  2. Song GJ
  3. Greuber EK
  4. Hinkle PM
  Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies.; The Journal of biological chemistry; Vol 282(17). 2007 Apr 27.
• 1. Sebag JA
  2. Hinkle PM
  Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids.; Endocrinology; Vol 147(12). 2006 Dec.
• 1. Jones BW
  2. Hinkle PM
  Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor.; The Journal of biological chemistry; Vol 280(46). 2005 Nov 18.
• 1. Song GJ
  2. Hinkle PM
  Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling.; Molecular endocrinology (Baltimore, Md.); Vol 19(11). 2005 Nov.
• 1. Cook LB
  2. Hinkle PM
  Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.; Endocrinology; Vol 145(7). 2004 Jul.
• 1. Cook LB
  2. Hinkle PM
  Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein.; The Biochemical journal; Vol 380(Pt 3). 2004 Jun 15.
• 1. Hinkle PM
  2. Puskas JA
  Detection of G protein-coupled receptors by immunofluorescence microscopy.; Methods in molecular biology (Clifton, N.J.); Vol 237. 2004.
• 1. Sattin A
  2. Pekary AE
  3. Lloyd RL
  4. Paulson M
  5. Meyerhoff JA
  6. Hinkle PM
  7. Faull K
  TRH and related peptides: homeostatic regulators of glutamate transmission?; Annals of the New York Academy of Sciences; Vol 1003. 2003 Nov.
• 1. Cook LB
  2. Zhu CC
  3. Hinkle PM
  Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.; Molecular endocrinology (Baltimore, Md.); Vol 17(9). 2003 Sep.
• 1. Graves TK
  2. Hinkle PM
  Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.; Endocrinology; Vol 144(8). 2003 Aug.
• 1. Goubaeva F
  2. Ghosh M
  3. Malik S
  4. Yang J
  5. Hinkle PM
  6. Griendling KK
  7. Neubig RR
  8. Smrcka AV
  Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.; The Journal of biological chemistry; Vol 278(22). 2003 May 30.
• 1. Graves TK
  2. Hinkle PM
  Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone.; Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; Vol 13(1). 2003 Feb.
• 1. Zhu CC
  2. Cook LB
  3. Hinkle PM
  Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.; The Journal of biological chemistry; Vol 277(31). 2002 Aug 2.
• 1. Hinkle PM
  2. Pekary AE
  3. Senanayaki S
  4. Sattin A
  Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.; Brain research; Vol 935(1-2). 2002 May 10.
• 1. Graves TK
  2. Patel S
  3. Dannies PS
  4. Hinkle PM
  Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic.; Journal of cell science; Vol 114(Pt 20). 2001 Oct.
• 1. Smith J
  2. Yu R
  3. Hinkle PM
  Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis.; Molecular endocrinology (Baltimore, Md.); Vol 15(9). 2001 Sep.
• 1. Rapoport AP
  2. Simons-Evelyn M
  3. Chen T
  4. Sidell R
  5. Luhowskyj S
  6. Rosell K
  7. Obrig T
  8. Hicks D
  9. Hinkle PM
  10. Nahm M
  11. Insel RA
  12. Abboud CN
  Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.; Blood cells, molecules & diseases; Vol 27(3). 2001 May.
• 1. Romoser VA
  2. Graves TK
  3. Wu D
  4. Jiang H
  5. Hinkle PM
  Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice.; Molecular endocrinology (Baltimore, Md.); Vol 15(1). 2001 Jan.
• 1. Yu R
  2. Hinkle PM
  Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators.; The Journal of biological chemistry; Vol 275(31). 2000 Aug 4.
• 1. Xie W
  2. Samoriski GM
  3. McLaughlin JP
  4. Romoser VA
  5. Smrcka A
  6. Hinkle PM
  7. Bidlack JM
  8. Gross RA
  9. Jiang H
  10. Wu D
  Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids.; Proceedings of the National Academy of Sciences of the United States of America; Vol 96(18). 1999 Aug 31.
• 1. Yu R
  2. Hinkle PM
  Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11.; The Journal of biological chemistry; Vol 274(22). 1999 May 28.
• 1. Fliss MS
  2. Hinkle PM
  3. Bancroft C
  Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity.; Molecular endocrinology (Baltimore, Md.); Vol 13(4). 1999 Apr.
• 1. Yu R
  2. Ashworth R
  3. Hinkle PM
  Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes.; Thyroid : official journal of the American Thyroid Association; Vol 8(10). 1998 Oct.
• 1. Yu R
  2. Hinkle PM
  Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization.; Molecular endocrinology (Baltimore, Md.); Vol 12(5). 1998 May.
• 1. Nelson EJ
  2. Zinkin NT
  3. Hinkle PM
  Fluorescence methods to assess multidrug resistance in individual cells.; Cancer chemotherapy and pharmacology; Vol 42(4). 1998.
• 1. Yu R
  2. Hinkle PM
  Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps.; The Journal of biological chemistry; Vol 272(45). 1997 Nov 7.
• 1. Kerper LE
  2. Hinkle PM
  Lead uptake in brain capillary endothelial cells: activation by calcium store depletion.; Toxicology and applied pharmacology; Vol 146(1). 1997 Sep.
• 1. Romoser VA
  2. Hinkle PM
  3. Persechini A
  Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators.; The Journal of biological chemistry; Vol 272(20). 1997 May 16.
• 1. Yu R
  2. Hinkle PM
  Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor.; Molecular pharmacology; Vol 51(5). 1997 May.
• 1. Kerper LE
  2. Hinkle PM
  Cellular uptake of lead is activated by depletion of intracellular calcium stores.; The Journal of biological chemistry; Vol 272(13). 1997 Mar 28.
• 1. Ashworth R
  2. Hinkle PM
  Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs.; Endocrinology; Vol 137(12). 1996 Dec.
• 1. Shupnik MA
  2. Weck J
  3. Hinkle PM
  Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.; Molecular endocrinology (Baltimore, Md.); Vol 10(1). 1996 Jan.
• 1. Ashworth R
  2. Yu R
  3. Nelson EJ
  4. Dermer S
  5. Gershengorn MC
  6. Hinkle PM
  Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 92(2). 1995 Jan 17.