URMC / Labs / Hinkle Lab / Publications Recent Publications Gehret AUHinkle PM (2013 Mar 15). siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor. ACS chemical biology. Thal DMHoman KTChen JWu EKHinkle PMHuang ZMChuprun JKSong JGao ECheung JYSklar LAKoch WJTesmer JJ (2012 Nov 16). Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS chemical biology. Christian WVLi NHinkle PMBallatori N (2012 Jun 15). β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. The Journal of biological chemistry. Hinkle PMGehret AUJones BW (2012). Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor. Frontiers in neuroscience. Liang LSebag JAEagelston LSerasinghe MNVeo KReinick CAngleson JHinkle PMDores RM (2011 Oct 1). Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s. General and comparative endocrinology. Gehret AUHinkle PM (2010 Jun 1). Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation. The Biochemical journal. Gehret AUJones BWTran PNCook LBGreuber EKHinkle PM (2010 Feb). Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase. Molecular pharmacology. Sebag JAHinkle PM (2010). Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Science signaling. Jones BWHinkle PM (2009 Sep). Subcellular trafficking of the TRH receptor: effect of phosphorylation. Molecular endocrinology (Baltimore, Md.). Sebag JAHinkle PM (2009 Aug 21). Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. The Journal of biological chemistry. Hinkle PMSebag JA (2009 Mar 5). Structure and function of the melanocortin2 receptor accessory protein (MRAP). Molecular and cellular endocrinology. Sebag JAHinkle PM (2009 Jan 2). Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling. The Journal of biological chemistry. Jones BWHinkle PM (2008 Jul). Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences. Molecular pharmacology. Hogan NO'Boyle KMHinkle PMKelly JA (2008 Jan 24). A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2. Neuroscience letters. Sebag JAHinkle PM (2007 Dec 18). Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proceedings of the National Academy of Sciences of the United States of America. Song GJJones BWHinkle PM (2007 Nov 13). Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. Scalabrino GAHogan NO'Boyle KMSlator GRGregg DJFitchett CMDraper SMBennett GWHinkle PMBauer KWilliams CHTipton KFKelly JA (2007 Jun). Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone. Neuropharmacology. Jones BWSong GJGreuber EKHinkle PM (2007 Apr 27). Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies. The Journal of biological chemistry. Sebag JAHinkle PM (2006 Dec). Regulation of endogenous melanocortin-4 receptor expression and signaling by glucocorticoids. Endocrinology. Jones BWHinkle PM (2005 Nov 18). Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. The Journal of biological chemistry. Song GJHinkle PM (2005 Nov). Regulated dimerization of the thyrotropin-releasing hormone receptor affects receptor trafficking but not signaling. Molecular endocrinology (Baltimore, Md.). Cook LBHinkle PM (2004 Jul). Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein. Endocrinology. Cook LBHinkle PM (2004 Jun 15). Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein. The Biochemical journal. Hinkle PMPuskas JA (2004). Detection of G protein-coupled receptors by immunofluorescence microscopy. Methods in molecular biology (Clifton, N.J.). Sattin APekary AELloyd RLPaulson MMeyerhoff JAHinkle PMFaull K (2003 Nov). TRH and related peptides: homeostatic regulators of glutamate transmission? Annals of the New York Academy of Sciences. Cook LBZhu CCHinkle PM (2003 Sep). Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation. Molecular endocrinology (Baltimore, Md.). Graves TKHinkle PM (2003 Aug). Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release. Endocrinology. Goubaeva FGhosh MMalik SYang JHinkle PMGriendling KKNeubig RRSmrcka AV (2003 May 30). Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. The Journal of biological chemistry. Graves TKHinkle PM (2003 Feb). Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. Zhu CCCook LBHinkle PM (2002 Aug 2). Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. The Journal of biological chemistry. Hinkle PMPekary AESenanayaki SSattin A (2002 May 10). Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides. Brain research. Graves TKPatel SDannies PSHinkle PM (2001 Oct). Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic. Journal of cell science. Smith JYu RHinkle PM (2001 Sep). Activation of MAPK by TRH requires clathrin-dependent endocytosis and PKC but not receptor interaction with beta-arrestin or receptor endocytosis. Molecular endocrinology (Baltimore, Md.). Rapoport APSimons-Evelyn MChen TSidell RLuhowskyj SRosell KObrig THicks DHinkle PMNahm MInsel RAAbboud CN (2001 May). Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes. Blood cells, molecules & diseases. Romoser VAGraves TKWu DJiang HHinkle PM (2001 Jan). Calcium responses to thyrotropin-releasing hormone, gonadotropin-releasing hormone and somatostatin in phospholipase css3 knockout mice. Molecular endocrinology (Baltimore, Md.). Yu RHinkle PM (2000 Aug 4). Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicators. The Journal of biological chemistry. Xie WSamoriski GMMcLaughlin JPRomoser VASmrcka AHinkle PMBidlack JMGross RAJiang HWu D (1999 Aug 31). Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proceedings of the National Academy of Sciences of the United States of America. Yu RHinkle PM (1999 May 28). Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11. The Journal of biological chemistry. Fliss MSHinkle PMBancroft C (1999 Apr). Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. Molecular endocrinology (Baltimore, Md.). Yu RAshworth RHinkle PM (1998 Oct). Receptors for thyrotropin-releasing hormone on rat lactotropes and thyrotropes. Thyroid : official journal of the American Thyroid Association. Yu RHinkle PM (1998 May). Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization. Molecular endocrinology (Baltimore, Md.). Nelson EJZinkin NTHinkle PM (1998). Fluorescence methods to assess multidrug resistance in individual cells. Cancer chemotherapy and pharmacology. Yu RHinkle PM (1997 Nov 7). Desensitization of thyrotropin-releasing hormone receptor-mediated responses involves multiple steps. The Journal of biological chemistry. Kerper LEHinkle PM (1997 Sep). Lead uptake in brain capillary endothelial cells: activation by calcium store depletion. Toxicology and applied pharmacology. Romoser VAHinkle PMPersechini A (1997 May 16). Detection in living cells of Ca2+-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. A new class of fluorescent indicators. The Journal of biological chemistry. Yu RHinkle PM (1997 May). Effect of cell type on the subcellular localization of the thyrotropin-releasing hormone receptor. Molecular pharmacology. Kerper LEHinkle PM (1997 Mar 28). Cellular uptake of lead is activated by depletion of intracellular calcium stores. The Journal of biological chemistry. Ashworth RHinkle PM (1996 Dec). Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs. Endocrinology. Shupnik MAWeck JHinkle PM (1996 Jan). Thyrotropin (TSH)-releasing hormone stimulates TSH beta promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C. Molecular endocrinology (Baltimore, Md.). Ashworth RYu RNelson EJDermer SGershengorn MCHinkle PM (1995 Jan 17). Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling. Proceedings of the National Academy of Sciences of the United States of America.