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New Patent Issued for Ultrasound Technology

Monday, August 28, 2017

The patent titled “Ultrasound Technology to Control the Spatial Organization of Cells and Proteins in Engineered Tissues” (US 9,688,962) has recently been assigned to the University of Rochester with inventors Diane Dalecki, Ph.D., Denise C. Hocking, Ph.D., and Kelley Garvin, Ph.D. The patent describes novel technology that uses acoustic forces within ultrasound standing wave fields to pattern cells volumetrically and engineer three-dimensional blood vessel networks within hydrogels. Primary applications of this technology include engineering vascularized tissue models for drug testing, tissue engineering, and regenerative medicine. The technology is a result of a multidisciplinary collaboration between faculty members of the Rochester Center for Biomedical Ultrasound, Diane Dalecki (BME) and Denise Hocking (Pharmacology and Physiology) and their former doctoral student Kelley Garvin.

Hocking and Roy Receive Patent

Wednesday, February 22, 2017

The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (U.S. Patent No. 9,572,869; awarded February 21, 2017) has recently been assigned to the UR with inventors Denise Hocking, Ph.D. and Daniel Roy, Ph.D. (BME B.S.‘06, Ph.D.‘12). The patent relates to the use of recombinant fibronectin-based peptides for wound healing and tissue regeneration applications. The technology falls under a new and exciting class of therapies known as wound biologics. The primary commercial application for this technology is to promote healing of hard-to-heal or chronic wounds, including diabetic, venous, and pressure ulcers, which impose a significant health care burden worldwide. Topical application of fibronectin matrix mimetic peptides to full-thickness excisional wounds in diabetic mice accelerates wound closure and promotes granulation tissue deposition, remodeling, and re-vascularization.

Denise Hocking is a Professor of Pharmacology and Physiology and of Biomedical Engineering. Daniel Roy is a Scientist at KeraNetics, LLC, a biotechnology company located in Winston-Salem, North Carolina that develops keratin-based biomaterials for wound healing applications.