URochester Medicine / Labs / Lueck Lab / Publications

Recent Publications

1. Lueck JD
Editing tRNA Genes to Broaden Nonsense Therapeutics.; The New England journal of medicine; Vol 394(16), pp. 1651-1654. 2026 Apr 23.
1. Kelly-Aubert M
2. Thrasher K
3. Korostelev AA
4. Lueck JD
5. Sermet-Gaudelus I
Therapeutic approaches for nonsense mutations in CFTR.; Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2026 Mar 03.
1. Porter JJ
2. Ko W
3. Sorensen EG
4. Cheung Z
5. Thrasher K
6. Couch T
7. Gabell JT
8. Shwe V
9. Hyatt J
10. Licata JB
11. Peterson LK
12. Dean DA
13. Lueck JD
Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors.; Nucleic acids research; Vol 54(4). 2026 Feb 05.
1. Omachi K
2. Porter JJ
3. Lueck JD
4. Miner JH
Anticodon-edited tRNA enables translational readthrough of COL4A5 premature termination codons.; PloS one; Vol 20(12), pp. e0330804. 2025 Dec 19.
1. Gu N
2. Baliga UK
3. Porter JJ
4. Lueck JD
5. Dean DA
Subnuclear organization and mislocalization of plasmids reduce transgene expression.; Molecular therapy. Nucleic acids; Vol 36(4), pp. 102730. 2025 Oct 09.
1. Sipple MT
2. Hamazaki S
3. Todorow V
4. Cisco LA
5. Lupia KM
6. Heil CS
7. Meinke P
8. Thornton CA
9. Lueck JD
Elimination of myotonia improves myopathy in a muscleblind knockout model of myotonic dystrophy.; bioRxiv : the preprint server for biology. 2025 Sep 21.
1. Porter JJ
2. Ko W
3. Sorensen EG
4. Cheung Z
5. Couch T
6. Gabell JT
7. Shwe V
8. Hyatt J
9. Licata JB
10. Peterson LK
11. Dean DA
12. Lueck JD
Anticodon Edited Transfer RNAs (ACE-tRNAs) Encoded as Therapeutic Nonviral Minimal DNA Vectors.; bioRxiv : the preprint server for biology. 2025 Sep 06.
1. Ko W
2. Porter JJ
3. Spelier S
4. Sorensen EG
5. Bhatt P
6. Gabell JT
7. van der Windt I
8. Couch T
9. Coote K
10. Mense M
11. Beekman JM
12. Lueck JD
ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis.; Nucleic acids research; Vol 53(13). 2025 Jul 08.
1. Franchini L
2. Porter JJ
3. Lueck JD
4. Orlandi C
GzESTY as an optimized cell-based assay for initial steps in GPCR deorphanization.; Nature communications; Vol 16(1), pp. 4521. 2025 May 15.
1. Bhat SY
2. Bhattacharya A
3. Li H
4. Cui X
5. Lueck JD
6. Goldman YE
7. Cooperman BS
Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases.; Nucleic acids research; Vol 53(6). 2025 Mar 20.
1. Pezzini S
2. Mustaccia A
3. Aboa P
4. Faustini G
5. Branchini A
6. Pinotti M
7. Frasca A
8. Porter JJ
9. Lueck JD
10. Landsberger N
Engineered tRNAs efficiently suppress CDKL5 premature termination codons.; Scientific reports; Vol 14(1), pp. 31791. 2024 Dec 30.
1. Porter JJ
2. Ko W
3. Sorensen EG
4. Lueck JD
Optimization of ACE-tRNAs function in translation for suppression of nonsense mutations.; Nucleic acids research. 2024 Nov 30.
1. Bhat S
2. Bhattacharya A
3. Li H
4. Lueck JD
5. Goldman YE
6. Cooperman BS
Mechanism-based approach in designing patient-specific combination therapies for nonsense mutation diseases.; bioRxiv : the preprint server for biology. 2024 Nov 14.
1. Franchini L
2. Porter JJ
3. Lueck JD
4. Orlandi C
Gz Enhanced Signal Transduction assaY (G Z ESTY) for GPCR deorphanization.; bioRxiv : the preprint server for biology. 2024 Jul 26.
1. Porter JJ
2. Lueck JD
A cystic fibrosis gene editing approach that is on target.; Molecular therapy. Nucleic acids; Vol 35(2), pp. 102197. 2024 May 08.
1. Cisco LA
2. Sipple MT
3. Edwards KM
4. Thornton CA
5. Lueck JD
Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model.; The Journal of clinical investigation; Vol 134(1). 2024 Jan 02.
1. Cisco LA
2. Sipple MT
3. Edwards KM
4. Thornton CA
5. Lueck JD
Combinatorial chloride and calcium channelopathy in myotonic dystrophy.; bioRxiv : the preprint server for biology. 2023 Jun 01.
1. Allaire NE
2. Griesenbach U
3. Kerem B
4. Lueck JD
5. Stanleigh N
6. Oren YS
Gene, RNA, and ASO-based therapeutic approaches in Cystic Fibrosis.; Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2023 Jan 17.
1. Rook ML
2. McCullock TW
3. Couch T
4. Lueck JD
5. MacLean DM
Photomodulation of the ASIC1a acidic pocket destabilizes the open state.; Protein science : a publication of the Protein Society. 2023 Jan 08.
1. Ko W
2. Porter JJ
3. Sipple MT
4. Edwards KM
5. Lueck JD
Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs.; Molecular therapy. Nucleic acids; Vol 28. 2022 Jun 14.
1. Porter JJ
2. Heil CS
3. Lueck JD
Therapeutic promise of engineered nonsense suppressor tRNAs.; Wiley interdisciplinary reviews. RNA. 2021 Feb 10.
1. Rook ML
2. Williamson A
3. Lueck JD
4. Musgaard M
5. Maclean DM
β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.; eLife; Vol 9. 2020 Feb 07.
1. Lueck JD
2. Yoon JS
3. Perales-Puchalt A
4. Mackey AL
5. Infield DT
6. Behlke MA
7. Pope MR
8. Weiner DB
9. Skach WR
10. McCray PB
11. Ahern CA
Engineered transfer RNAs for suppression of premature termination codons.; Nature communications; Vol 10(1). 2019 Feb 18.
1. Molinarolo S
2. Lee S
3. Leisle L
4. Lueck JD
5. Granata D
6. Carnevale V
7. Ahern CA
Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel.; The Journal of biological chemistry; Vol 293(14). 2018 Apr 06.
1. Infield DT
2. Lueck JD
3. Galpin JD
4. Galles GD
5. Ahern CA
Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte.; Scientific reports; Vol 8(1). 2018 Mar 26.
1. Leisle L
2. Chadda R
3. Lueck JD
4. Infield DT
5. Galpin JD
6. Krishnamani V
7. Robertson JL
8. Ahern CA
Cellular encoding of Cy dyes for single-molecule imaging.; eLife; Vol 5. 2016 Jan 12.
1. Lueck JD
2. Mackey AL
3. Infield DT
4. Galpin JD
5. Li J
6. Roux B
7. Ahern CA
Atomic mutagenesis in ion channels with engineered stoichiometry.; eLife; Vol 5. 2016 Jan 06.
1. Beedle AM
2. Turner AJ
3. Saito Y
4. Lueck JD
5. Foltz SJ
6. Fortunato MJ
7. Nienaber PM
8. Campbell KP
Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy.; The Journal of clinical investigation; Vol 122(9). 2012 Sep.
1. Loy RE
2. Lueck JD
3. Mostajo-Radji MA
4. Carrell EM
5. Dirksen RT
Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy.; PloS one; Vol 7(11). 2012.
1. Han R
2. Frett EM
3. Levy JR
4. Rader EP
5. Lueck JD
6. Bansal D
7. Moore SA
8. Ng R
9. Beltrán-Valero de Bernabé D
10. Faulkner JA
11. Campbell KP
Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.; The Journal of clinical investigation; Vol 120(12). 2010 Dec.
1. Lueck JD
2. Rossi AE
3. Thornton CA
4. Campbell KP
5. Dirksen RT
Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle.; The Journal of general physiology; Vol 136(6). 2010 Dec.
1. Wheeler TM
2. Sobczak K
3. Lueck JD
4. Osborne RJ
5. Lin X
6. Dirksen RT
7. Thornton CA
Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.; Science (New York, N.Y.); Vol 325(5938). 2009 Jul 17.
1. Kimura T
2. Lueck JD
3. Harvey PJ
4. Pace SM
5. Ikemoto N
6. Casarotto MG
7. Dirksen RT
8. Dulhunty AF
Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.; Cell calcium; Vol 45(3). 2009 Mar.
1. Wheeler TM
2. Lueck JD
3. Swanson MS
4. Dirksen RT
5. Thornton CA
Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.; The Journal of clinical investigation; Vol 117(12). 2007 Dec.
1. Lueck JD
2. Lungu C
3. Mankodi A
4. Osborne RJ
5. Welle SL
6. Dirksen RT
7. Thornton CA
Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1.; American journal of physiology. Cell physiology; Vol 292(4). 2007 Apr.
1. Lueck JD
2. Mankodi A
3. Swanson MS
4. Thornton CA
5. Dirksen RT
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.; The Journal of general physiology; Vol 129(1). 2007 Jan.
1. Chelu MG
2. Goonasekera SA
3. Durham WJ
4. Tang W
5. Lueck JD
6. Riehl J
7. Pessah IN
8. Zhang P
9. Bhattacharjee MB
10. Dirksen RT
11. Hamilton SL
Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 20(2). 2006 Feb.
1. Kimura T
2. Nakamori M
3. Lueck JD
4. Pouliquin P
5. Aoike F
6. Fujimura H
7. Dirksen RT
8. Takahashi MP
9. Dulhunty AF
10. Sakoda S
Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1.; Human molecular genetics; Vol 14(15). 2005 Aug 1.