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Mahlon Johnson Lab

Mahlon D. Johnson, M.D., Ph.D.

Ph.D. 1984
University of Tennessee College of Medicine

M.D. 1981
University of Tennessee College of Medicine

Director, Neuropathology at the Department of Pathology and Laboratory Medicine

Department of Pathology and Laboratory Medicine

Research Overview

The Mahlon Johnson Laboratory studies the biology of the leptomeninges and the pathogenesis of meningiomas. The lab is attempting to identify targets for novel chemotherapies for meningiomas.

The lab has been mapping numerous signaling pathways that regulate leptomeningeal and meningioma proliferation and apoptosis. The interactions between leptomeninges, cerebrospinal fluid and the dura in meningioma development are also of interest.

Recent Publications

Johnson MD. "Transforming growth factor ? family in the pathogenesis of meningiomas." World neurosurgery.. 2017 Mar 23; Epub 2017 Mar 23.

Johnson MD, O'Connell M, Walter K. "STAT3 activation and risk of recurrence in meningiomas." Oncol Lett. 2017; 13: 2432-2436.

Johnson MD, O'Connell M, Walter K, Silberstein H. "mTOR activation is increased in pilocytic astrocytomas from older adults compared with children." Surgical neurology international. 2017 8:85. Epub 2017 May 26.

Johnson MD, Reeder JE, O'Connell M. "APOBEC3B expression in human leptomeninges and meningiomas." Oncology letters.. 2016 Dec 0; 12(6):5344-5348. Epub 2016 Nov 10.

Towner JE, Johnson MD, Li YM. "Intraventricular Hemangiopericytoma: A Case Report and Literature Review." World neurosurgery.. 2016 May 0; 89:728.e5-728.e10. Epub 2016 Feb 01.

Johnson MD; Reeder JE; O'Connell M. "p38MAPK activation and DUSP10 expression in meningiomas." Journal of clinical neuroscience. 2016; 30: 110-4.

Manuylova E, Calvi LM, Hastings C, Vates GE, Johnson MD, Cave WT, Shafiq I. "Late presentation of acromegaly in medically controlled prolactinoma patients." Endocrinology, diabetes & metabolism case reports.. 2016 2016Epub 2016 Oct 17.

Johnson MD. "Do mesothelin/MUC16 interactions facilitate adenocarcinoma metastases to intracranial meningiomas?" Surgical neurology international. 2016 7(Suppl 41):S1049-S1052. Epub 2016 Dec 21