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The Nichols Lab

Adult tissue homeostasis is a continuous, dynamic process that is must be tightly regulated by proper cellular responses to external stimuli to maintain tissue integrity. Identification of the specific mechanisms that facilitate appropriate cellular responses is crucial to understanding how cells maintain homeostasis, or importantly, how failure to do so can lead to tissue degeneration and injury. The overall goal of our research is to identify the signaling pathways and mechanisms that govern homeostasis in mechanically active tissues.

We are particularly interested in how altered cell-cell communications affect cell fate in the context of tendon pathology and adaptation. The ultimate goal of this research is the identification of cell-type specific therapeutic targets for intervention that will ultimately result in improved healing outcomes for tendinopathies either by halting tissue degeneration, promoting regeneration of the native tendon matrix, or through the creation of more bio-identical tissue engineered replacements.

Anne E. Nichols, Ph.D.

Anne E. Nichols, Ph.D.
Principal Investigator


Epitenon Vessel

The Identity, Function, and Fate of Epitenon-Derived Progenitor Cells in Tendon Healing

Cell Connections

Epitenon-Tenocyte Mechanotransduction in Tendon Homeostasis and Adaptation

Tendon Pain

The Origins of Pain in Injured Tendons

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Contact Us

  Nichols Lab
SMD 1-7574
601 Elmwood Ave
Rochester, NY 14642