URochester Medicine / Labs / Nichols Lab / Publications

Publications

1. Chafouleas ZJ
2. Ackerman JE
3. Loiselle AE
4. Nichols AEC
The Cellular Basis of Fibrotic Tendon Healing: Now in Higher Definition.; American journal of physiology. Cell physiology. 2026 Mar 17.
1. Nichols AEC
2. Benoodt L
3. Adjei-Sowah E
4. Jerreld K
5. Kollar A
6. Ketonis C
7. Loiselle AE
Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatially-dependent manner.; Nature communications; Vol 16(1), pp. 5448. 2025 Jul 01.
1. Rodenhouse A
2. Smolyak G
3. Adjei-Sowah E
4. Adhikari N
5. Muscat S
6. Okutani T
7. Ketonis C
8. Nichols AEC
9. Kottmann RM
10. Loiselle AE
Ogerin induced activation of Gpr68 alters tendon healing.; FASEB bioAdvances; Vol 7(5), pp. e70008. 2025 Apr 03.
1. Adjei-Sowah E
2. Lecaj E
3. Adhikari N
4. Sensini C
5. Nichols AEC
6. Buckley MR
7. Loiselle AE
Loss of Cochlin drives impairments in tendon structure and function.; Matrix biology plus; Vol 25, pp. 100168. 2025 Feb 15.
1. Muscat S
2. Nichols AEC
Leveraging in vivo animal models of tendon loading to inform tissue engineering approaches.; Frontiers in bioengineering and biotechnology; Vol 12, pp. 1449372. 2024 Oct 07.
1. Smolyak G
2. Rodenhouse A
3. Nichols AEC
4. Ketonis C
5. Loiselle AE
Pharmacological antagonism of Ccr2+ cell recruitment to facilitate regenerative tendon healing.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024 Oct 01.
1. Adjei-Sowah E
2. Chandrasiri I
3. Xiao B
4. Liu Y
5. Ackerman JE
6. Soto C
7. Nichols AEC
8. Nolan K
9. Benoit DSW
10. Loiselle AE
Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing.; Science advances; Vol 10(25), pp. eadn2332. 2024 Jun 19.
1. Korcari A
2. Nichols AEC
3. Buckley MR
4. Loiselle AE
Correction: Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.; eLife; Vol 13. 2024 Jan 03.
1. Adjei-Sowah E
2. Chandrasiri I
3. Xiao B
4. Liu Y
5. Ackerman JE
6. Soto C
7. Nichols AEC
8. Nolan K
9. Benoit DSW
10. Loiselle AE
Development of a Nanoparticle-Based Tendon-Targeting Drug Delivery System to Pharmacologically Modulate Tendon Healing.; bioRxiv : the preprint server for biology. 2023 Nov 30.
1. Ackerman JE
2. Adjei-Sowah E
3. Korcari A
4. Muscat SN
5. Nichols AEC
6. Buckley MR
7. Loiselle AE
Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.; bioRxiv : the preprint server for biology. 2023 Jul 21.
1. Nichols AEC
2. Wagner NW
3. Ketonis C
4. Loiselle AE
Epitenon-derived cells comprise a distinct progenitor population that contributes to both tendon fibrosis and regeneration following acute injury.; bioRxiv : the preprint server for biology. 2023 Feb 01.
1. Korcari A
2. Nichols AEC
3. Buckley MR
4. Loiselle AE
Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.; eLife; Vol 12. 2023 Jan 19.
1. Ackerman JE
2. Muscat SN
3. Adjei-Sowah E
4. Korcari A
5. Nichols AEC
6. Buckley MR
7. Loiselle AE
Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.; Matrix biology : journal of the International Society for Matrix Biology. 2023 Jan 13.
1. Ackerman JE
2. Best KT
3. Muscat SN
4. Pritchett EM
5. Nichols AEC
6. Wu CL
7. Loiselle AE
Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function.; Cell reports; Vol 41(8), pp. 111706. 2022 Nov 22.
1. Muscat S
2. Nichols AEC
3. Gira E
4. Loiselle AE
CCR2 is expressed by tendon resident macrophage and T cells, while CCR2 deficiency impairs tendon healing via blunted involvement of tendon-resident and circulating monocytes/macrophages.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 36(11), pp. e22607. 2022 Nov.
1. Nichols AEC
2. Muscat SN
3. Miller SE
4. Green LJ
5. Richards MS
6. Loiselle AE
Impact of isolation method on cellular activation and presence of specific tendon cell subpopulations during in vitro culture.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 35(7), pp. e21733. 2021 Jul.
1. Rezvani SN
2. Nichols AEC
3. Grange RW
4. Dahlgren LA
5. Brolinson PG
6. Wang VM
A novel murine muscle loading model to investigate Achilles musculotendinous adaptation.; Journal of applied physiology (Bethesda, Md. : 1985); Vol 130(4), pp. 1043-1051. 2021 Feb 11.
1. Best KT
2. Korcari A
3. Mora KE
4. Nichols AE
5. Muscat SN
6. Knapp E
7. Buckley MR
8. Loiselle AE
Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis.; eLife; Vol 10. 2021 Jan 22.
1. Best KT
2. Nichols AEC
3. Knapp E
4. Hammert WC
5. Ketonis C
6. Jonason JH
7. Awad HA
8. Loiselle AE
NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.; Science signaling; Vol 13(658). 2020 Nov 17.
1. Best KT
2. Studentsova V
3. Ackerman JE
4. Nichols AEC
5. Myers M
6. Cobb J
7. Knapp E
8. Awad HA
9. Loiselle AE
Effects of Tamoxifen on Tendon Homeostasis and Healing: Considerations for the use of Tamoxifen-Inducible Mouse Models.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2020 Jun 02.
1. Nichols AEC
2. Oh I
3. Loiselle AE
Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 38(1), pp. 13-22. 2019 Jun 24.
1. Ackerman JE
2. Nichols AE
3. Studentsova V
4. Best KT
5. Knapp E
6. Loiselle AE
Cell non-autonomous functions of S100a4 drive fibrotic tendon healing.; eLife; Vol 8. 2019 May 24.
1. Khatibzadeh SM
2. Menarim BC
3. Nichols AEC
4. Werre SR
5. Dahlgren LA
Urinary Bladder Matrix Does Not Improve Tenogenesis in an In Vitro Equine Model.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 37(8), pp. 1848-1859. 2019 May 15.
1. Polly SS
2. Nichols AEC
3. Donnini E
4. Inman DJ
5. Scott TJ
6. Apple SM
7. Werre SR
8. Dahlgren LA
Adipose-Derived Stromal Vascular Fraction and Cultured Stromal Cells as Trophic Mediators for Tendon Healing.; Journal of orthopaedic research : official publication of the Orthopaedic Research Society; Vol 37(6), pp. 1429-1439. 2019 Apr 29.
1. Nichols AEC
2. Best KT
3. Loiselle AE
The Cellular basis of fibrotic tendon healing: challenges and opportunities.; Translational research : the journal of laboratory and clinical medicine. 2019 Feb 08.
1. Nichols AEC
2. Settlage RE
3. Werre SR
4. Dahlgren LA
Novel roles for scleraxis in regulating adult tenocyte function.; BMC cell biology; Vol 19(1), pp. 14. 2018 Aug 07.
1. Nichols AEC
2. Werre SR
3. Dahlgren LA
Transient Scleraxis Overexpression Combined with Cyclic Strain Enhances Ligament Cell Differentiation.; Tissue engineering. Part A; Vol 24(19-20), pp. 1444-1455. 2018 May 10.
1. Sawyere DM
2. Lanz OI
3. Dahlgren LA
4. Barry SL
5. Nichols AC
6. Werre SR
Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum.; Veterinary surgery : VS; Vol 45(5), pp. 582-6. 2016 Jul.
1. Peterson TR
2. Sengupta SS
3. Harris TE
4. Carmack AE
5. Kang SA
6. Balderas E
7. Guertin DA
8. Madden KL
9. Carpenter AE
10. Finck BN
11. Sabatini DM
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.; Cell; Vol 146(3), pp. 408-20. 2011 Aug 05.
1. Liu GH
2. Qu J
3. Carmack AE
4. Kim HB
5. Chen C
6. Ren H
7. Morris AJ
8. Finck BN
9. Harris TE
Lipin proteins form homo- and hetero-oligomers.; The Biochemical journal; Vol 432(1), pp. 65-76. 2010 Nov 15.