URochester Medicine / Labs / Ovitt Lab / Publications

Recent Publications

1. Uchida H
2. Maruyama EO
3. Takano T
4. Aure MH
5. Glasner MF
6. Soares ZG
7. Faustoferri RC
8. Thomas VK
9. Makarenkova HP
10. Yule DI
11. Ovitt CE
Ascl3+ ionocytes in murine salivary gland ducts are innervated sensory cells that display unique calcium signalling characteristics and contribute to the composition of saliva.; The Journal of physiology. 2026 Feb 20.
1. Piraino LR
2. Chen CY
3. Mereness JA
4. Dunman PM
5. Ovitt CE
6. Benoit DSW
7. DeLouise LA
Salivary gland tissue chip screening identifies candidate radioprotective drugs.; Communications medicine; Vol 5(1), pp. 420. 2025 Oct 09.
1. Uchida H
2. Maruyama EO
3. Takano T
4. Aure MH
5. Glasner MF
6. Guerra Soares Z
7. Faustoferii R
8. Thomas K
9. Makarenkova EP
10. Yule DI
11. Ovitt CE
Ascl3+ ionocytes in murine salivary gland ducts are innervated sensory cells that display unique calcium signaling characteristics and contribute to the composition of saliva.; bioRxiv : the preprint server for biology. 2025 Sep 02.
1. Gao X
2. Mukaibo T
3. Wei X
4. Faustoferri RC
5. Oei MS
6. Hwang SK
7. Yan AJ
8. Melvin JE
9. Ovitt CE
Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands.; Developmental biology. 2024 Feb 02.
1. Muñoz M
2. Acevedo A
3. Ovitt CE
4. Luitje ME
5. Maruyama EO
6. Catalán MA
CFTR expression in human salivary gland acinar cells.; American journal of physiology. Cell physiology. 2024 Jan 29.
1. Mereness JA
2. Piraino L
3. Chen CY
4. Moyston T
5. Song Y
6. Shubin A
7. DeLouise LA
8. Ovitt CE
9. Benoit DSW
Slow hydrogel matrix degradation enhances salivary gland mimetic phenotype.; Acta biomaterialia. 2023 May 05.
1. Song Y
2. Uchida H
3. Sharipol A
4. Piraino L
5. Mereness JA
6. Ingalls MH
7. Rebhahn J
8. Newlands SD
9. DeLouise LA
10. Ovitt CE
11. Benoit DSW
Author Correction: Development of a functional salivary gland tissue chip with potential for high-content drug screening.; Communications biology; Vol 5(1). 2022 Mar 30.
1. Uchida H
2. Ingalls MH
3. Maruyama EO
4. Johnston CJ
5. Hernady E
6. Faustoferri RC
7. Ovitt CE
Short-term and bystander effects of radiation on murine submandibular glands.; Disease models & mechanisms. 2022 Jan 20.
1. Song Y
2. Sharipol A
3. Uchida H
4. Ingalls MH
5. Piraino L
6. Mereness JA
7. Moyston T
8. DeLouise LA
9. Ovitt CE
10. Benoit DSW
Encapsulation of Primary Salivary Gland Acinar Cell Clusters and Intercalated Ducts (AIDUCs) within Matrix Metalloproteinase (MMP)-Degradable Hydrogels to Maintain Tissue Structure and Function.; Advanced healthcare materials. 2022 Jan 06.
1. Uchida H
2. Ovitt CE
Novel impacts of saliva with regard to oral health.; The Journal of prosthetic dentistry. 2021 Jun 14.
1. Song Y
2. Uchida H
3. Sharipol A
4. Piraino L
5. Mereness JA
6. Ingalls MH
7. Rebhahn J
8. Newlands SD
9. DeLouise LA
10. Ovitt CE
11. Benoit DSW
Author Correction: Development of a functional salivary gland tissue chip with potential for high-content drug screening.; Communications biology; Vol 4(1). 2021 Apr 30.
1. Song Y
2. Uchida H
3. Sharipol A
4. Piraino L
5. Mereness JA
6. Ingalls MH
7. Rebhahn J
8. Newlands SD
9. DeLouise LA
10. Ovitt CE
11. Benoit DSW
Development of a functional salivary gland tissue chip with potential for high-content drug screening.; Communications biology; Vol 4(1). 2021 Mar 19.
1. Luitje ME
2. Israel AK
3. Cummings MA
4. Giampoli EJ
5. Allen PD
6. Newlands SD
7. Ovitt CE
Long-term maintenance of acinar cells in human submandibular glands after radiation therapy.; International journal of radiation oncology, biology, physics. 2020 Nov 09.
1. Shubin AD
2. Sharipol A
3. Felong TJ
4. Weng PL
5. Schutrum BE
6. Joe DS
7. Aure MH
8. Benoit DSW
9. Ovitt CE
Stress or injury induces cellular plasticity in salivary gland acinar cells.; Cell and tissue research. 2020 Jan 04.
1. Weng PL
2. Luitje ME
3. Ovitt CE
Cellular Plasticity in Salivary Gland Regeneration.; Oral diseases. 2019 Sep 27.
1. Ingalls MH
2. Hollomon AJ
3. Newlands SD
4. McDavid AN
5. Ovitt CE
Intrinsic Mitotic Activity Supports the Human Salivary Gland Acinar Cell Population.; FEBS letters. 2019 Sep 20.
1. Weng PL
2. Aure MH
3. Ovitt CE
Concise Review: A critical evaluation of criteria used to define salivary gland stem cells.; Stem cells (Dayton, Ohio). 2019 Jun 07.
1. Varghese JJ
2. Hansen ME
3. Sharipol A
4. Ingalls MH
5. Ormanoski MA
6. Newlands SD
7. Ovitt CE
8. Benoit DSW
Salivary gland cell aggregates are derived from self-organization of acinar lineage cells.; Archives of oral biology; Vol 97. 2018 Oct 22.
1. Weng PL
2. Aure MH
3. Maruyama T
4. Ovitt CE
Limited Regeneration of Adult Salivary Glands after Severe Injury Involves Cellular Plasticity.; Cell reports; Vol 24(6). 2018 Aug 07.
1. Varghese JJ
2. Schmale IL
3. Hansen ME
4. Newlands SD
5. Benoit DSW
6. Ovitt CE
Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation.; Journal of visualized experiments : JoVE. 2018 May 04.
1. Varghese JJ
2. Schmale IL
3. Wang Y
4. Hansen ME
5. Newlands SD
6. Ovitt CE
7. Benoit DSW
Retroductal Nanoparticle Injection to the Murine Submandibular Gland.; Journal of visualized experiments : JoVE. 2018 May 03.
1. Varghese JJ
2. Schmale IL
3. Mickelson D
4. Hansen ME
5. Newlands SD
6. Benoit DSW
7. Korshunov VA
8. Ovitt CE
Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection.; Journal of dental research. 2018 Apr 01.
1. Gao X
2. Oei MS
3. Ovitt CE
4. Sincan M
5. Melvin JE
Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse.; Physiological genomics; Vol 50(4). 2018 Apr 01.
1. Malcolm DW
2. Varghese JJ
3. Sorrells JE
4. Ovitt CE
5. Benoit DSW
The Effects of Biological Fluids on Colloidal Stability and siRNA Delivery of a pH-Responsive Micellar Nanoparticle Delivery System.; ACS nano. 2017 Dec 12.
1. Shubin AD
2. Felong TJ
3. Schutrum BE
4. Joe DS
5. Ovitt CE
6. Benoit DS
Encapsulation of primary salivary gland cells in enzymatically degradable poly(ethylene glycol) hydrogels promotes acinar cell characteristics.; Acta biomaterialia. 2016 Dec 27.
1. Weng PL
2. Vinjamuri M
3. Ovitt CE
Ascl3 transcription factor marks a distinct progenitor lineage for non-neuronal support cells in the olfactory epithelium.; Scientific reports; Vol 6. 2016 Dec 02.
1. Maruyama EO
2. Aure MH
3. Xie X
4. Myal Y
5. Gan L
6. Ovitt CE
Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands.; PloS one; Vol 11(1). 2016.
1. Aure MH
2. Arany S
3. Ovitt CE
Salivary Glands: Stem Cells, Self-duplication, or Both?; Journal of dental research; Vol 94(11). 2015 Nov.
1. Shubin AD
2. Felong TJ
3. Graunke D
4. Ovitt CE
5. Benoit DS
Development of poly(ethylene glycol) hydrogels for salivary gland tissue engineering applications.; Tissue engineering. Part A; Vol 21(11-12). 2015 Jun.
1. Aure MH
2. Konieczny SF
3. Ovitt CE
Salivary gland homeostasis is maintained through acinar cell self-duplication.; Developmental cell; Vol 33(2). 2015 Apr 20.
1. Arany S
2. Benoit DS
3. Dewhurst S
4. Ovitt CE
Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 21(6). 2013 Jun.
1. Arany S
2. Xu Q
3. Hernady E
4. Benoit DS
5. Dewhurst S
6. Ovitt CE
Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures.; Journal of cellular biochemistry; Vol 113(6). 2012 Jun.
1. Rugel-Stahl A
2. Elliott ME
3. Ovitt CE
Ascl3 marks adult progenitor cells of the mouse salivary gland.; Stem cell research; Vol 8(3). 2012 May.
1. Arany S
2. Catalán MA
3. Roztocil E
4. Ovitt CE
Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration.; Developmental biology; Vol 353(2). 2011 May 15.
1. Lan Y
2. Liu H
3. Ovitt CE
4. Jiang R
Generation of Osr1 conditional mutant mice.; Genesis (New York, N.Y. : 2000); Vol 49(5). 2011 May.
1. Liu W
2. Watson SS
3. Lan Y
4. Keene DR
5. Ovitt CE
6. Liu H
7. Schweitzer R
8. Jiang R
The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis.; Molecular and cellular biology; Vol 30(20). 2010 Oct.
1. Gao Y
2. Lan Y
3. Ovitt CE
4. Jiang R
Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development.; Developmental biology; Vol 328(2). 2009 Apr 15.
1. Bullard T
2. Koek L
3. Roztocil E
4. Kingsley PD
5. Mirels L
6. Ovitt CE
Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands.; Developmental biology; Vol 320(1). 2008 Aug 1.
1. Lan Y
2. Wang Q
3. Ovitt CE
4. Jiang R
A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development.; Genesis (New York, N.Y. : 2000); Vol 45(10). 2007 Oct.
1. Chen J
2. Bush JO
3. Ovitt CE
4. Lan Y
5. Jiang R
The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.; Genesis (New York, N.Y. : 2000); Vol 45(8). 2007 Aug.
1. Nakamoto T
2. Srivastava A
3. Romanenko VG
4. Ovitt CE
5. Perez-Cornejo P
6. Arreola J
7. Begenisich T
8. Melvin JE
Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells.; American journal of physiology. Regulatory, integrative and comparative physiology; Vol 292(6). 2007 Jun.
1. Begenisich T
2. Nakamoto T
3. Ovitt CE
4. Nehrke K
5. Brugnara C
6. Alper SL
7. Melvin JE
Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.; The Journal of biological chemistry; Vol 279(46). 2004 Nov 12.
1. Lan Y
2. Ovitt CE
3. Cho ES
4. Maltby KM
5. Wang Q
6. Jiang R
Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis.; Development (Cambridge, England); Vol 131(13). 2004 Jul.
1. Schmidt D
2. Ovitt CE
3. Anlag K
4. Fehsenfeld S
5. Gredsted L
6. Treier AC
7. Treier M
The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance.; Development (Cambridge, England); Vol 131(4). 2004 Feb.
1. Ronfani L
2. Ferraguti M
3. Croci L
4. Ovitt CE
5. Schöler HR
6. Consalez GG
7. Bianchi ME
Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2.; Development (Cambridge, England); Vol 128(8). 2001 Apr.
1. De Felice M
2. Ovitt C
3. Biffali E
4. Rodriguez-Mallon A
5. Arra C
6. Anastassiadis K
7. Macchia PE
8. Mattei MG
9. Mariano A
10. Schöler H
11. Macchia V
12. Di Lauro R
A mouse model for hereditary thyroid dysgenesis and cleft palate.; Nature genetics; Vol 19(4). 1998 Aug.
1. Brehm A
2. Ovitt CE
3. Schöler HR
Oct-4: more than just a POUerful marker of the mammalian germline?; APMIS : acta pathologica, microbiologica, et immunologica Scandinavica; Vol 106(1). 1998 Jan.
1. Bertocchini F
2. Ovitt CE
3. Conti A
4. Barone V
5. Schöler HR
6. Bottinelli R
7. Reggiani C
8. Sorrentino V
Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.; The EMBO journal; Vol 16(23). 1997 Dec 1.
1. Yeom YI
2. Fuhrmann G
3. Ovitt CE
4. Brehm A
5. Ohbo K
6. Gross M
7. Hübner K
8. Schöler HR
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.; Development (Cambridge, England); Vol 122(3). 1996 Mar.
1. Ludwig T
2. Munier-Lehmann H
3. Bauer U
4. Hollinshead M
5. Ovitt C
6. Lobel P
7. Hoflack B
Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.; The EMBO journal; Vol 13(15). 1994 Aug 1.