Assembly of the mycobacterial peptidoglycan
Mycobacterial mutant unable to maintain normal morphology during stationary phase.
Our current research activities focus on understanding the genetics and biochemistry of peptidoglycan biosynthesis in Mycobacterium tuberculosis and related mycobacteria with the goal of identifying new targets that can be translated into the development of novel anti-tuberculosis drugs.
Our studies focus on three aspects of the peptidoglycan of mycobacteria: The formation of novel, non-classical cross links in the cell wall, the maintenance of peptidoglycan during non-replicating conditions, and the interaction of beta-lactam antibiotics with the peptidoglycan machinery
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