URMC / Labs / Rahman Lab / Publications

Recent Publications from the Irfan Rahman Lab

1. Shaikh SB
2. Faizan MI
3. Islam KU
4. Rehan VK
5. Rahman I
PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells.; Frontiers in pharmacology; Vol 17, pp. 1779345. 2026 Feb 03.
1. Effah F
2. Sengupta M
3. Sun Y
4. Faizan MI
5. Kaur G
6. Raghu R
7. Elzein A
8. Marczylo T
9. Strongin RM
10. Rahman I
A Comparative Toxicological Evaluation of Nicotine and Its Analog 6-Methyl Nicotine in E-Cigarette Aerosol Utilizing a 3D in vitro Human Respiratory Model.; Toxicology. 2026 Jan 31.
1. Kaur G
2. Lamb T
3. Tjitropranoto A
4. Rahman I
Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs.; eLife; Vol 14. 2026 Jan 29.
1. Li D
2. Liu P
3. Rahman I
4. Zand M
5. Pryhuber G
6. Dye T
7. Goniewicz M
8. Gurkar AU
9. Königshoff M
10. Eickelberg O
11. Mora A
12. Rojas M
13. Ma Q
14. Lugo-Martinez J
15. Bar-Joseph Z
16. Lanna S
17. Finkel T
18. Xie Z
Evaluation of statistical differential analysis methods for identification of senescent cells using single-cell transcriptomics.; Cell reports methods. 2026 Jan 22.
1. Lin K
2. Sun Y
3. Raghu R
4. Suharu P
5. Effah F
6. Rahman I
Toxicity and health effects of delta-8, delta-9, and delta-10-tetrahydrocannabinol and unregulated cannabinoids in vaping products.; Toxicology reports; Vol 16, pp. 102202. 2026 Jan 08.
1. Panda K
2. Peng JY
3. Santiago MJ
4. Rahman MS
5. Shaikh SB
6. Kaur G
7. Faizan MI
8. Islam KU
9. Wang T
10. Black SM
11. Evans CM
12. Rahman I
13. Chinnapaiyan S
14. Unwalla HJ
HIV disrupts the lung molecular clock, leading to lung inflammation and features of emphysema.; Communications biology; Vol 9(1), pp. 11. 2026 Jan 05.
1. Hadley W
2. Lacagnina R
3. Rahman I
4. Casey AMH
5. Deterding R
6. Deutsch G
7. McGraw MD
Childhood Interstitial Lung Disease (chILD) Associated With Toxic Chemical Inhalation Exposures: A State-of-the-Art Review.; Pediatric pulmonology; Vol 60(12), pp. e71401. 2025 Dec.
1. Sun Y
2. Kaur G
3. Effah F
4. Friedman A
5. Rahman I
Cytotoxic and oxidative effects of commercially available propylene glycol (PG) and vegetable glycerin (VG): Common humectants in electronic cigarettes.; Toxicology reports; Vol 15, pp. 102171. 2025 Nov 21.
1. Muthumalage T
2. Rahman I
Genetic ablation of p16 leads to pulmonary remodeling, pro-senescence response, and immune modulation in mice exposed to low-dose, Sub-chronic, environmental tobacco smoke.; Inhalation toxicology. 2025 Nov 12.
1. Effah F
2. Shaikh SB
3. Chalupa D
4. Faizan MI
5. Elder A
6. Rahman I
High-resistance coils in E-cigarettes increase heavy metals leaching into aerosols to cause oxidants generation in human bronchial epithelial cells at air-liquid interface: A unique non-animal methodological approach on vaping studies.; NAM journal; Vol 1. 2025 Oct 09.
1. Ozdemir SA
2. Faizan MI
3. Kaur G
4. Shaikh SB
5. Ul Islam K
6. Rahman I
Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.; International journal of molecular sciences; Vol 26(19). 2025 Oct 04.
1. Sun Y
2. Lin K
3. Effah F
4. Barrera FC
5. Li D
6. McIntosh S
7. McGraw MD
8. Rahman I
Toxicity of Humectants Propylene Glycol and Vegetable Glycerin in Electronic Nicotine Delivery Systems.; Toxicology letters. 2025 Oct 01.
1. Li S
2. Agudelo Garcia PA
3. Aliferis C
4. Becich MJ
5. Calyeca J
6. Cosgrove BD
7. Elisseeff J
8. Farzad N
9. Fertig EJ
10. Glass C
11. Gu L
12. Hu Q
13. Ji Z
14. Königshoff M
15. LeBrasseur NK
16. Li D
17. Ma A
18. Ma Q
19. Menon V
20. Mitchell JT
21. Mora AL
22. Nagaraj S
23. Nelson AC
24. Niedernhofer LJ
25. Rojas M
26. Taha HB
27. Wang J
28. Wang S
29. Wu PH
30. Xie J
31. Xu M
32. Yu M
33. Zhang X
34. Zhao Y
35. Adams PD
36. Aguayo-Mazzucato C
37. Baker DJ
38. Benz C
39. Bernlohr DA
40. Bueno M
41. Chen J
42. Childs BG
43. Chuang JH
44. Chung D
45. Dileepan M
46. Ding L
47. Dong M
48. Duncan F
49. Enninful A
50. Flynn WF
51. Franco AC
52. Furman D
53. Garovic V
54. Halene S
55. Herman AB
56. Hertzel AV
57. Iwasaki K
58. Jeon H
59. Kang JW
60. Karmakar S
61. Kirkland JL
62. Korstanje R
63. Kummerfeld E
64. Lee JH
65. Liu Y
66. Lu Y
67. Lugo-Martinez J
68. Martini H
69. Melov S
70. Musi N
71. Passos JF
72. Peters ST
73. Rahman I
74. Ramasamy R
75. Rindone AN
76. Robbins PD
77. Robson P
78. Rodriguez-Lopez J
79. Rosas L
80. Rosenthal N
81. Schafer MJ
82. Schilling B
83. Schmidt EL
84. Schneider K
85. Sengupta K
86. Shu J
87. So PTC
88. Sun L
89. Tchkonia T
90. Teneche MG
91. Vanegas N
92. Wang J
93. Xie J
94. Yin S
95. Zhang K
96. Zhu Q
97. Fan R
Advancing biological understanding of cellular senescence with computational multiomics.; Nature genetics. 2025 Sep 15.
1. Quinones Tavarez Z
2. Ossip DJ
3. Li D
4. Croft DP
5. Rahman I
6. Wojtovich AP
Microbiota-Influenced Toxicological Responses in Caenorhabditis elegans Exposed to Strawberry and Menthol E-Liquids.; microPublication biology; Vol 2025. 2025 Aug 11.
1. Kaur G
2. Lamb T
3. Tjitropranoto A
4. Rahman I
Single-cell transcriptomics identifies an increased Ly6G- neutrophil population and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs.; bioRxiv : the preprint server for biology. 2025 Aug 07.
1. Lin W
2. Hill T
3. Stroup AM
4. Sarles SE
5. Ogura T
6. Augustine F
7. O'Sullivan S
8. Rahman I
9. Robinson R
10. Jabba SV
11. Nuss C
12. Hensel E
Chemosensory Tobacco Product Toxicology Part 2: Toxicological Testing, Assays, and State of the Science.; Toxicological sciences : an official journal of the Society of Toxicology. 2025 Jul 24.
1. Lin W
2. Hill T
3. Stroup AM
4. Sarles SE
5. Ogura T
6. Augustine F
7. O'Sullivan S
8. Rahman I
9. Robinson R
10. Jabba SV
11. Nuss C
12. Hensel E
Chemosensory Tobacco Product Toxicology Part 1: Sensory Mechanisms.; Toxicological sciences : an official journal of the Society of Toxicology. 2025 Jul 24.
1. Ma A
2. Cheng H
3. Vanegas NDP
4. Ghobashi A
5. Chen H
6. Rodriguez J
7. Rosas L
8. Wang C
9. Shao J
10. Jiang Y
11. Wang X
12. Rahman I
13. Lugo-Martinez J
14. Li D
15. Pryhuber GS
16. Bar-Joseph Z
17. Eickelberg O
18. Königshoff M
19. Chung D
20. Chen R
21. Finkel T
22. Mora A
23. Rojas M
24. Ma Q
An Intrinsic-hoc Framework for Heterogeneous Cellular Senescence Elucidation Using Deep Graph Representation Learning and Experimental Validation.; bioRxiv : the preprint server for biology. 2025 Jul 04.
1. Muthumalage T
2. Sarles E
3. Wang Q
4. Hensel E
5. Hill T
6. Rahman I
7. Robinson R
8. Stroup AM
9. Thongphanh K
10. Miller LA
In Vitro assessments of ENDS toxicity in the respiratory tract: Are we there yet?; NAM journal; Vol 1. 2025 Apr 03.
1. Akhtar A
2. Shakir M
3. Ansari MS
4. Divya
5. Faizan MI
6. Chauhan V
7. Singh A
8. Alam R
9. Azmi I
10. Sharma S
11. Pracha M
12. Uddin IM
13. Bashir U
14. Shahni SN
15. Chaudhuri R
16. Albogami S
17. Ganguly R
18. Sagar S
19. Singh VP
20. Kharya G
21. Srivastava AK
22. Mabalirajan U
23. Roy SS
24. Rahman I
25. Ahmad T
Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity.; Cell reports. Medicine; Vol 6(3), pp. 102021. 2025 Mar 18.
1. Effah F
2. Sun Y
3. Lin K
4. Rahman I
A comparative toxicological evaluation of emerging nicotine analogs 6-methyl nicotine and nicotinamide: a scoping review.; Archives of toxicology. 2025 Feb 12.
1. Effah F
2. Sun Y
3. Friedman A
4. Rahman I
Emerging Nicotine Analog 6-Methyl Nicotine Increases Reactive Oxygen Species in Aerosols and Cytotoxicity in Human Bronchial Epithelial Cells.; Toxicology letters. 2025 Jan 31.
1. Li D
2. Xie Z
3. Shaikh SB
4. Rahman I
Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users.; Scientific reports; Vol 15(1), pp. 2714. 2025 Jan 21.
1. Faizan MI
2. Kaur G
3. Shaikh SB
4. Effah F
5. Unwalla H
6. Rahman I
Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice.; Physiological reports; Vol 13(2), pp. e70199. 2025 Jan.
1. Hasanaj E
2. Beaulieu D
3. Wang C
4. Hu Q
5. Bueno M
6. Sembrat JC
7. Pineda RH
8. Melo-Narvaez MC
9. Cardenes N
10. Yanwu Z
11. Yingze Z
12. Lafyatis R
13. Morris A
14. Mora A
15. Rojas M
16. Li D
17. Rahman I
18. Pryhuber GS
19. Lehmann M
20. Alder J
21. Gurkar A
22. Finkel T
23. Ma Q
24. Póczos B
25. Bar-Joseph Z
26. Eickelberg O
27. Königshoff M
SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms.; bioRxiv : the preprint server for biology. 2024 Dec 22.
1. Panda K
2. Santiago MJ
3. Rahman MS
4. Ghorai S
5. Black SM
6. Rahman I
7. Unwalla HJ
8. Chinnapaiyan S
HIV-1 Tat Protein and Cigarette Smoke Mediated ADAM17 Upregulation Can Lead to Impaired Mucociliary Clearance.; Cells; Vol 13(23). 2024 Dec 05.
1. Shaikh SB
2. Balaya RDA
3. Dagamajalu S
4. Bhandary YP
5. Unwalla H
6. Prasad TSK
7. Rahman I
A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence.; Cell communication and signaling : CCS; Vol 22(1), pp. 544. 2024 Nov 14.
1. Rahman MS
2. Ghorai S
3. Panda K
4. Santiago MJ
5. Aggarwal S
6. Wang T
7. Rahman I
8. Chinnapaiyan S
9. Unwalla HJ
Dr. Jekyll or Mr. Hyde: The multifaceted roles of miR-145-5p in human health and disease.; Non-coding RNA research; Vol 11, pp. 22-37. 2024 Nov 10.
1. Nguyen ND
2. Rosas L
3. Khaliullin T
4. Jiang P
5. Hasanaj E
6. Ovando-Ricardez JA
7. Bueno M
8. Rahman I
9. Pryhuber GS
10. Li D
11. Ma Q
12. Finkel T
13. Königshoff M
14. Eickelberg O
15. Rojas M
16. Mora AL
17. Lugo-Martinez J
18. Bar-Joseph Z
scDOT: optimal transport for mapping senescent cells in spatial transcriptomics.; Genome biology; Vol 25(1), pp. 288. 2024 Nov 08.
1. Kaur G
2. Wang Q
3. Tjitropranoto A
4. Unwalla H
5. Rahman I
Cold ischemia time alters cell-type specific senescence leading to loss of cellular integrity in mouse lungs.; Experimental lung research; Vol 50(1), pp. 184-198. 2024 Oct 20.
1. Shaikh SB
2. Rahman I
Cav1 Scaffolding Domain Peptide (CSP7): A Novel Target for Idiopathic Pulmonary Fibrosis.; American journal of respiratory cell and molecular biology. 2024 Sep 18.
1. Orfin RH
2. Ramos Santiago JW
3. Decena Soriano R
4. Romero Acosta E
5. Bermudez D
6. Rodriguez YL
7. Li D
8. Rahman I
9. McIntosh S
10. Ossip DJ
11. Cupertino AP
12. Cartujano-Barrera F
Kick Vaping: Feasibility, acceptability, and preliminary impact of a vaping cessation text messaging intervention for Latino young adults.; Journal of ethnicity in substance abuse. 2024 Aug 28.
1. Santiago MJ
2. Chinnapaiyan S
3. Panda K
4. Rahman MS
5. Ghorai S
6. Lucas JH
7. Black SM
8. Rahman I
9. Unwalla HJ
MicroRNA mediated suppression of airway lactoperoxidase by TGF-β1 and cigarette smoke promotes airway inflammation.; Journal of inflammation (London, England); Vol 21(1), pp. 31. 2024 Aug 27.
1. Santiago MJ
2. Chinnapaiyan S
3. Panda K
4. Rahman MS
5. Ghorai S
6. Rahman I
7. Black SM
8. Liu Y
9. Unwalla HJ
Altered Host microRNAomics in HIV Infections: Therapeutic Potentials and Limitations.; International journal of molecular sciences; Vol 25(16). 2024 Aug 13.
1. Kassem NOF
2. Strongin RM
3. Stroup AM
4. Brinkman MC
5. El-Hellani A
6. Erythropel HC
7. Etemadi A
8. Goniewicz ML
9. Hansen EG
10. Kassem NO
11. Li D
12. Liles S
13. Noël A
14. Rezk-Hanna M
15. Wang Q
16. Rahman I
Toxicity of Waterpipe Tobacco Smoking: The Role of Flavors, Sweeteners, Humectants, and Charcoal.; Toxicological sciences : an official journal of the Society of Toxicology. 2024 Jul 22.
1. Quinones Tavarez Z
2. Croft DP
3. Li D
4. Gill SR
5. Wojtovich AP
6. Rahman I
7. Ossip DJ
Fruit flavors in electronic cigarettes (ECIGs) are associated with nocturnal dry cough: A population longitudinal analysis.; PloS one; Vol 19(6), pp. e0306467. 2024 Jun 28.
1. Muthumalage T
2. Noel A
3. Thanavala Y
4. Alcheva A
5. Rahman I
Challenges in current inhalable tobacco toxicity assessment models: A narrative review.; Tobacco induced diseases; Vol 22. 2024 Jun 10.
1. Lucas JH
2. Wang Q
3. Pang C
4. Rahman I
Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice.; The Science of the total environment. 2024 Jun 04.
1. Lucas JH
2. Wang Q
3. Meehan Atrash J
4. Pang C
5. Rahman I
Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice.; Toxicological sciences : an official journal of the Society of Toxicology. 2024 Jun 03.
1. Suryadevara V
2. Hudgins AD
3. Rajesh A
4. Pappalardo A
5. Karpova A
6. Dey AK
7. Hertzel A
8. Agudelo A
9. Rocha A
10. Soygur B
11. Schilling B
12. Carver CM
13. Aguayo-Mazzucato C
14. Baker DJ
15. Bernlohr DA
16. Jurk D
17. Mangarova DB
18. Quardokus EM
19. Enninga EAL
20. Schmidt EL
21. Chen F
22. Duncan FE
23. Cambuli F
24. Kaur G
25. Kuchel GA
26. Lee G
27. Daldrup-Link HE
28. Martini H
29. Phatnani H
30. Al-Naggar IM
31. Rahman I
32. Nie J
33. Passos JF
34. Silverstein JC
35. Campisi J
36. Wang J
37. Iwasaki K
38. Barbosa K
39. Metis K
40. Nernekli K
41. Niedernhofer LJ
42. Ding L
43. Wang L
44. Adams LC
45. Ruiyang L
46. Doolittle ML
47. Teneche MG
48. Schafer MJ
49. Xu M
50. Hajipour M
51. Boroumand M
52. Basisty N
53. Sloan N
54. Slavov N
55. Kuksenko O
56. Robson P
57. Gomez PT
58. Vasilikos P
59. Adams PD
60. Carapeto P
61. Zhu Q
62. Ramasamy R
63. Perez-Lorenzo R
64. Fan R
65. Dong R
66. Montgomery RR
67. Shaikh S
68. Vickovic S
69. Yin S
70. Kang S
71. Suvakov S
72. Khosla S
73. Garovic VD
74. Menon V
75. Xu Y
76. Song Y
77. Suh Y
78. Dou Z
79. Neretti N
SenNet recommendations for detecting senescent cells in different tissues.; Nature reviews. Molecular cell biology. 2024 Jun 03.
1. Sun Y
2. Prabhu P
3. Rahman R
4. Li D
5. McIntosh S
6. Rahman I
e-Cigarette Tobacco Flavors, Public Health, and Toxicity: Narrative Review.; Online journal of public health informatics; Vol 16, pp. e51991. 2024 May 27.
1. Kassem NOF
2. Strongin RM
3. Stroup AM
4. Brinkman MC
5. El-Hellani A
6. Erythropel HC
7. Etemadi A
8. Exil V
9. Goniewicz ML
10. Kassem NO
11. Klupinski TP
12. Liles S
13. Muthumalage T
14. Noël A
15. Peyton DH
16. Wang Q
17. Rahman I
18. Valerio LG
A review of the toxicity of ingredients in e-cigarettes, including those ingredients having the FDA's "Generally Recognized as Safe (GRAS)" regulatory status for use in food.; Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2024 May 24.
1. Strongin RM
2. Sharma E
3. Erythropel HC
4. Kassem NOF
5. Noël A
6. Peyton DH
7. Rahman I
Chemical and physiological interactions between e-liquid constituents: cause for concern?; Tobacco control. 2024 Apr 24.
1. Sun Y
2. Prabhu P
3. Li D
4. McIntosh S
5. Rahman I
Vaping: Public Health, Social Media, and Toxicity.; Online journal of public health informatics; Vol 16, pp. e53245. 2024 Apr 11.
1. Orfin RH
2. Uceda V
3. Gardner C
4. Estrada B
5. Tamayo E
6. Hernández-Torres R
7. Li D
8. Rahman I
9. McIntosh S
10. Ossip DJ
11. Cupertino AP
12. Cartujano-Barrera F
Recruiting Latino young adults into a vaping cessation study via social media: Feasibility and cost analysis.; Tobacco prevention & cessation; Vol 10. 2024 Apr 09.
1. Chandy M
2. Hill T
3. Jimenez-Tellez N
4. Wu JC
5. Sarles SE
6. Hensel E
7. Wang Q
8. Rahman I
9. Conklin DJ
Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: "What Are the Tools Needed for the Job?" and "Do We Have Them?".; Cardiovascular toxicology. 2024 Mar 31.
1. El-Hellani A
2. Adeniji A
3. Erythropel HC
4. Wang Q
5. Lamb T
6. Mikheev VB
7. Rahman I
8. Stepanov I
9. Strongin RM
10. Wagener TL
11. Brinkman MC
Comparison of emissions across tobacco products: A slippery slope in tobacco control.; Tobacco induced diseases; Vol 22. 2024 Mar 30.
1. Kaur G
2. Sohanur Rahman M
3. Shaikh S
4. Panda K
5. Chinnapaiyan S
6. Santiago Estevez M
7. Xia L
8. Unwalla H
9. Rahman I
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities.; Biochemical pharmacology. 2024 Mar 29.
1. Wang Q
2. Goracci C
3. Sundar IK
4. Rahman I
Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis.; Journal of inflammation (London, England); Vol 21(1), pp. 9. 2024 Mar 20.
1. Li D
2. Xie Z
3. Shaikh SB
4. Rahman I
Abnormal expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users.; Research square. 2024 Jan 24.