URMC / Labs / Rahman Lab / Publications Publications Lei WLerner CSundar IKRahman I (2017 Mar 03). Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III. Scientific reports. Gerloff JSundar IKFreter RSekera ERFriedman AERobinson RPagano TRahman I (2017 Mar 01). Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts. Applied in vitro toxicology. Javed FKellesarian SVSundar IKRomanos GERahman I (2017 Feb 06). Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues. Oral diseases. Lee HPark JRKim WJSundar IKRahman IPark SMYang SR (2017 Feb 01). Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Sundar IKYin QBaier BSYan LMazur WLi DSusiarjo MRahman I (2017). DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clinical epigenetics. Valacchi GCervellati CEvelson PRahman I (2016 Dec). Redox regulation of inflammatory processes. The international journal of biochemistry & cell biology. Sundar IKJaved FRomanos GERahman I (2016 Nov 22). E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts. Oncotarget. Sundar IKRahman I (2016 Oct 28). Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: Implications for COPD and lung cancer. American journal of physiology. Lung cellular and molecular physiology. Ahmad TSundar IKTormos AMLerner CAGerloff JYao HRahman I (2016 Aug 25). Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology. Lerner CASundar IKRahman I (2016 Jul 26). Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD. The international journal of biochemistry & cell biology. Lerner CARutagarama PAhmad TSundar IKElder ARahman I (2016 Jun 22). Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts. Biochemical and biophysical research communications. Pagano TDiFrancesco AGSmith SBGeorge JWink GRahman IRobinson RJ (2016 May). Determination of Nicotine Content and Delivery in Disposable Electronic Cigarettes Available in the United States by Gas Chromatography-Mass Spectrometry. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. Javed FAl-Kheraif AARahman IMillan-Luongo LTFeng CYunker MMalmstrom HRomanos GE (2016 Feb). Comparison of Clinical and Radiographic Periodontal Status Between Habitual Water-Pipe Smokers and Cigarette Smokers. Journal of periodontology. Lerner CALei WSundar IKRahman I (2016). Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury. Frontiers in pharmacology. Yao HSundar IKHuang YGerloff JSellix MTSime PJRahman I (2015 Dec). Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. American journal of respiratory cell and molecular biology. Sundar IKYao HSellix MTRahman I (2015 Nov 15). Circadian molecular clock in lung pathophysiology. American journal of physiology. Lung cellular and molecular physiology. Sundar IKYao HSellix MTRahman I (2015 Sep). Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases. American journal of respiratory cell and molecular biology. Ahmad TSundar IKLerner CAGerloff JTormos AMYao HRahman I (2015 Jul). Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Lerner CASundar IKWatson RMElder AJones RDone DKurtzman ROssip DJRobinson RMcIntosh SRahman I (2015 Mar). Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols. Environmental pollution (Barking, Essex : 1987). Sundar IKAhmad TYao HHwang JWGerloff JLawrence BPSellix MTRahman I (2015). Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD. Scientific reports. Lerner CASundar IKYao HGerloff JOssip DJMcIntosh SRobinson RRahman I (2015). Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PloS one. Yao HSundar IKAhmad TLerner CGerloff JFriedman AEPhipps RPSime PJMcBurney MWGuarente LRahman I (2014 May 1). SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. American journal of physiology. Lung cellular and molecular physiology. Sundar IKNevid MZFriedman AERahman I (2014 Feb 7). Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer. Journal of proteome research. Hwang JWSundar IKYao HSellix MTRahman I (2014 Jan). Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Sundar IKYao HHuang YLyda ESime PJSellix MTRahman I (2014). Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. PloS one. Jo CGundemir SPritchard SJin YNRahman IJohnson GV (2014). Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. Nature communications. Gilels FPaquette STZhang JRahman IWhite PM (2013 Nov 20). Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. Yao HHwang JWSundar IKFriedman AEMcBurney MWGuarente LGu WKinnula VLRahman I (2013 Nov 1). SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. American journal of physiology. Lung cellular and molecular physiology. Hwang JWYao HCaito SSundar IKRahman I (2013 Aug). Redox regulation of SIRT1 in inflammation and cellular senescence. Free radical biology & medicine. Sundar IKYao HRahman I (2013 May 20). Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxidants & redox signaling. Biswas SHwang JWKirkham PARahman I (2013). Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. Current medicinal chemistry. Yao HSundar IKGorbunova VRahman I (2013). P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence. PloS one. Yao HRahman I (2012 Nov 15). Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochemical pharmacology. Yao HRahman I (2012 Oct 1). Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. American journal of physiology. Lung cellular and molecular physiology. Yao HChung SHwang JWRajendrasozhan SSundar IKDean DAMcBurney MWGuarente LGu WRönty MKinnula VLRahman I (2012 Jun). SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. The Journal of clinical investigation. Rahman IMacNee W (2012 Jun). Antioxidant pharmacological therapies for COPD. Current opinion in pharmacology. Rahman I (2012 May). Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochimica et biophysica acta. Rahman IKinnula VLGorbunova VYao H (2012 May). SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Preventive medicine. Rahman IKinnula VL (2012 May). Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease. Expert review of clinical pharmacology. Sundar IKChung SHwang JWLapek JDBulger MFriedman AEYao HDavie JRRahman I (2012). Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes. PloS one. Nadtochiy SMYao HMcBurney MWGu WGuarente LRahman IBrookes PS (2011 Oct). SIRT1-mediated acute cardioprotection. American journal of physiology. Heart and circulatory physiology. Hwang JWRajendrasozhan SYao HChung SSundar IKHuyck HLPryhuber GSKinnula VLRahman I (2011 Jul 15). FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. Journal of immunology (Baltimore, Md. : 1950). Yao HRahman I (2011 Jul 15). Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicology and applied pharmacology. Sundar IKMullapudi NYao HSpivack SDRahman I (2011 Jul). Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics. Current opinion in pulmonary medicine. Londhe VASundar IKLopez BMaisonet TMYu YAghai ZHRahman I (2011 May). Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung. Pediatric research. Sundar IKHwang JWWu SSun JRahman I (2011 Mar 4). Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochemical and biophysical research communications. Nadtochiy SMRedman ERahman IBrookes PS (2011 Feb 15). Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovascular research. Chung SSundar IKHwang JWYull FEBlackwell TSKinnula VLBulger MYao HRahman I (2011). NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. PloS one. Sundar IKRahman I (2011). Vitamin d and susceptibility of chronic lung diseases: role of epigenetics. Frontiers in pharmacology. Mortaz EMasjedi MRRahman I (2011). Outcome of Smoking Cessation on Airway Remodeling and Pulmonary Inflammation in COPD Patients. Tanaffos.