URMC / Labs / Rahman Lab / Publications Publications Rashid KSundar IKGerloff JLi DRahman I Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema.; Scientific reports; Vol 81. 2018 Jun 13. Paquette STDawes RPSundar IKRahman IBrown EBWhite PM Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.; Scientific reports; Vol 81. 2018 Apr 10. Sundar IKRashid KGerloff JRangel-Moreno JLi DRahman I Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 Apr 09. Kaur GMuthumalage TRahman I Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products.; Toxicology letters. 2018 Feb 23. Sundar IKRashid KGerloff JLi DRahman I Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema.; American journal of respiratory cell and molecular biology. 2018 Feb 15. Eddingsaas NPagano TCummings CRahman IRobinson RHensel E Qualitative Analysis of E-Liquid Emissions as a Function of Flavor Additives Using Two Aerosol Capture Methods.; International journal of environmental research and public health; Vol 152. 2018 Feb 13. Khan NASundar IKRahman I Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse.; Physiological reports; Vol 63. 2018 Feb. Javed FKellesarian SVAbduljabbar TAbduljabbar ATAkram ZVohra FRahman IRomanos GE Influence of involuntary cigarette smoke inhalation on osseointegration: a systematic review and meta-analysis of preclinical studies.; International journal of oral and maxillofacial surgery. 2017 Dec 09. Tang MJi CPallo SRahman IJohnson GVW Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.; Neurobiology of aging; Vol 63. 2017 Dec 09. Sundar IKSellix MTRahman I Redox regulation of circadian molecular clock in chronic airway diseases.; Free radical biology & medicine. 2017 Oct 31. Javed FALHarthi SSBinShabaib MSGajendra SRomanos GERahman I Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system.; Inhalation toxicology. 2017 Oct 17. Sundar IKRashid KSellix MTRahman I The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation.; Biochemical and biophysical research communications. 2017 Sep 30. Rahman IDe Cunto GSundar IKLungarella G Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice.; American journal of respiratory cell and molecular biology; Vol 573. 2017 Sep. Behrsing HHill ERaabe HTice RFitzpatrick SDevlin RPinkerton KOberdörster GWright CWieczorek RAufderheide MSteiner SKrebs TAsgharian BCorley ROldham MAdamson JLi XRahman IGrego SChu PHMcCullough SCurren R In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use.; Alternatives to laboratory animals : ATLA; Vol 453. 2017 Jul. Javed FAbduljabbar TVohra FMalmstrom HRahman IRomanos GE Comparison of Periodontal Parameters and Self-Perceived Oral Symptoms among Cigarette-Smokers, Individuals Vaping Electronic-Cigarettes and Never-Smokers: A Pilot Study.; Journal of periodontology. 2017 Jun 23. Lei WLerner CSundar IKRahman I Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III.; Scientific reports; Vol 7. 2017 Mar 03. Gerloff JSundar IKFreter RSekera ERFriedman AERobinson RPagano TRahman I Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts.; Applied in vitro toxicology; Vol 31. 2017 Mar 01. Arbat SDave MNiranjane VRahman IArbat A Analyzing the clinical profile of swine flu/influenza A H1N1 infection in central India: a retrospective study.; Virusdisease; Vol 281. 2017 Mar. Javed FKellesarian SVSundar IKRomanos GERahman I Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues.; Oral diseases. 2017 Feb 06. Lee HPark JRKim WJSundar IKRahman IPark SMYang SR Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 Feb 01. Sundar IKYin QBaier BSYan LMazur WLi DSusiarjo MRahman I DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.; Clinical epigenetics; Vol 9. 2017. Muthumalage TPrinz MAnsah KOGerloff JSundar IKRahman I Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine.; Frontiers in physiology; Vol 8. 2017. Valacchi GCervellati CEvelson PRahman I Redox regulation of inflammatory processes.; The international journal of biochemistry & cell biology; Vol 81Pt B. 2016 Dec. Sundar IKJaved FRomanos GERahman I E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts.; Oncotarget; Vol 747. 2016 Nov 22. Sundar IKRahman I Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: Implications for COPD and lung cancer.; American journal of physiology. Lung cellular and molecular physiology. 2016 Oct 28. Ahmad TSundar IKTormos AMLerner CAGerloff JYao HRahman I Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease.; American journal of respiratory cell and molecular biology. 2016 Aug 25. Lerner CASundar IKRahman I Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD.; The international journal of biochemistry & cell biology. 2016 Jul 26. Lerner CARutagarama PAhmad TSundar IKElder ARahman I Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts.; Biochemical and biophysical research communications. 2016 Jun 22. Pagano TDiFrancesco AGSmith SBGeorge JWink GRahman IRobinson RJ Determination of Nicotine Content and Delivery in Disposable Electronic Cigarettes Available in the United States by Gas Chromatography-Mass Spectrometry.; Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco; Vol 185. 2016 May. Javed FAl-Kheraif AARahman IMillan-Luongo LTFeng CYunker MMalmstrom HRomanos GE Comparison of Clinical and Radiographic Periodontal Status Between Habitual Water-Pipe Smokers and Cigarette Smokers.; Journal of periodontology; Vol 872. 2016 Feb. Lerner CALei WSundar IKRahman I Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury.; Frontiers in pharmacology; Vol 7. 2016. Yao HSundar IKHuang YGerloff JSellix MTSime PJRahman I Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.; American journal of respiratory cell and molecular biology; Vol 536. 2015 Dec. Sundar IKYao HSellix MTRahman I Circadian molecular clock in lung pathophysiology.; American journal of physiology. Lung cellular and molecular physiology; Vol 30910. 2015 Nov 15. Sundar IKYao HSellix MTRahman I Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases.; American journal of respiratory cell and molecular biology; Vol 533. 2015 Sep. Ahmad TSundar IKLerner CAGerloff JTormos AMYao HRahman I Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 297. 2015 Jul. Lerner CASundar IKWatson RMElder AJones RDone DKurtzman ROssip DJRobinson RMcIntosh SRahman I Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols.; Environmental pollution (Barking, Essex : 1987); Vol 198. 2015 Mar. Sundar IKAhmad TYao HHwang JWGerloff JLawrence BPSellix MTRahman I Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.; Scientific reports; Vol 4. 2015. Lerner CASundar IKYao HGerloff JOssip DJMcIntosh SRobinson RRahman I Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung.; PloS one; Vol 102. 2015. Yao HSundar IKAhmad TLerner CGerloff JFriedman AEPhipps RPSime PJMcBurney MWGuarente LRahman I SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.; American journal of physiology. Lung cellular and molecular physiology; Vol 3069. 2014 May 1. Sundar IKNevid MZFriedman AERahman I Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer.; Journal of proteome research; Vol 132. 2014 Feb 7. Hwang JWSundar IKYao HSellix MTRahman I Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 281. 2014 Jan. Sundar IKYao HHuang YLyda ESime PJSellix MTRahman I Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis.; PloS one; Vol 92. 2014. Jo CGundemir SPritchard SJin YNRahman IJohnson GV Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.; Nature communications; Vol 5. 2014. Gilels FPaquette STZhang JRahman IWhite PM Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 3347. 2013 Nov 20. Yao HHwang JWSundar IKFriedman AEMcBurney MWGuarente LGu WKinnula VLRahman I SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.; American journal of physiology. Lung cellular and molecular physiology; Vol 3059. 2013 Nov 1. Hwang JWYao HCaito SSundar IKRahman I Redox regulation of SIRT1 in inflammation and cellular senescence.; Free radical biology & medicine; Vol 61. 2013 Aug. Sundar IKYao HRahman I Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases.; Antioxidants & redox signaling; Vol 1815. 2013 May 20. Biswas SHwang JWKirkham PARahman I Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.; Current medicinal chemistry; Vol 2012. 2013. Yao HSundar IKGorbunova VRahman I P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence.; PloS one; Vol 811. 2013. Yao HRahman I Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.; Biochemical pharmacology; Vol 8410. 2012 Nov 15.