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Serra-Moreno Lab

Welcome to the Serra-Moreno Lab

The Serra-Moreno lab opens September 1, 2020. If you are interested in joining the lab or learning more, please contact Dr. Serra-Moreno.

The Serra-Moreno lab studies the mechanisms by which Human Immunodeficiency Virus (HIV) and its close relative Simian Immunodeficiency Virus (SIV) circumvent the barriers of the innate immunity in their respective hosts and cause Acquired Immunodeficiency Syndrome (AIDS). Current projects in the lab are investigating the interplay between HIV/SIV and the cellular factors Tetherin/BST2, BCA2 and autophagy. 

Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS), a disease that has caused 36 million deaths, and is considered the worst human pandemic of the last 50 years. Although current treatments are effective at keeping HIV to undetectable levels, they are unable to eliminate this virus from infected cells. Therefore, there is a critical need to find strategies to eradicate HIV. The research program in the Serra-Moreno lab focuses on understanding how HIV overcomes the innate immune barriers in its target cells to establish a chronic infection, with the goal of using this information to find new avenues for therapeutic intervention.

Ruth Serra-Moreno

Ruth Serra-Moreno, Ph.D.
Principal Investigator

Selected Publications

Colomer-Lluch, M. and Serra-Moreno R. 2017. BCA2/RABRING7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα. J Virol. 2017 March 29; 91(8).

Arias, J., Colomer-Lluch, M, von Bredow, B., Greene, J., MacDonald, J., O'Connor, D., Serra-Moreno, R., and Evans, D. 2016. Tetherin Antagonism by HIV-1 Group M Nef Proteins. J Virol. Sept. 2016 (JVI01465-16R1). PMID: 27654287    

Colomer-Lluch, M., Gollahon L.S. and Serra-Moreno R. 2016. Anti-HIV factors: targeting each step of HIV's replication cycle. Curr. HIV. Res. 2016; 14(3):175-182

Serra-Moreno, R. 2014. The end of Nef's tether. Trends Microbiol. Dec; 22(12):662-664. PMCID: PMC4258156.

Nityanandam, R. and Serra-Moreno, R. 2014. BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in a tetherin-independent manner. PLoS Pathogens. May 22;10(5):e1004151.

Serra-Moreno, R*., Zimmermann, K., Stern, L.J., and Evans, D.T. 2013. Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis. PLoS Pathogens. July;9(7):e1003487. *corresponding author

Serra-Moreno, R., and Evans D.T. 2012. Adaptation of Human and Simian Immunodeficiency Viruses for Resistance to Tetherin/BST-2. Current HIV Research. Jun;10(4):277-82.

Serra-Moreno, R., Jia, B., Breed, M., Alvarez, X., and Evans, D.T. 2011. Compensatory changes in gp41 restore resistance to tetherin in a pathogenic nef-deleted SIV. Cell Host & Microbe. Jan 20; 9(1): 46-57.

Evans, D.T., Serra-Moreno, R., Singh, R.K., and Guatelli, J.C. 2010. BST2/Tetherin: a new component of the innate response to enveloped viruses. Trends Microbiol. Sep 18(9): 388-396.

Jia, B*., Serra-Moreno, R*., Neidermyer, W., Rahmberg, A., Mackey, J., Fofana, I.B., Johnson, W.E., Westmoreland, S.,  and Evans, D. 2009. Species-specificity Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2. PLoS Pathog. May;5(5):e1000429. Epub 2009 May 15. *Both authors collaborated equally in this work.

Serra-Moreno R., Jofre J. and Muniesa M. 2008. The CI repressors of Shiga toxin-converting prophages are involved in coinfection of Escherichia coli strains, which causes a down regulation in the production of Shiga toxin 2. J Bacteriol. Jul;190(13):4722-35. Epub 2008 May 

Serra-Moreno R., Jofre J. and Muniesa M. 2007. Insertion site occupancy by stx2 bacteriophages depends on the locus availability of the host strain chromosome. J Bacteriol. Sep;189(18):6645-54. Epub 2007 Jul 20.

Serra-Moreno R., Acosta S., Hernalsteens J.P., Jofre J. and Muniesa M. 2006. Use of the lambda Red recombinase system to produce recombinant prophages carrying antibiotic resistance genes. BMC Mol Biol. Sep 19;7:31

View All Publications

Contact Us

  Serra-Moreno Lab
601 Elmwood Ave
Rochester, NY 14642