Pulmonary Disease and Pathologic Processes in the Lung
The Sime Lab research focuses include:
- Chronic lung inflammation due to inhalation of tobacco smoke and indoor air pollution, and novel strategies to mitigate inflammation and promote resolution
- Novel strategies to inhibit pulmonary fibrosis by targeting the myofibroblast.
Inhalation of tobacco smoke and indoor air pollution can lead to chronic lung diseases such as chronic obstructive pulmonary disease (COPD). We are interested in studying the mechanisms by which smoke exposure leads to lung disease, and are implementing novel mitigation strategies to promote resolution of lung inflammation. We utilize a state-of-the-art smoking facility located in the MRBX for smoking exposure studies.
Lung scarring, or pulmonary fibrosis, can be caused by environmental exposures such as silica, asbestos, and radiation, or develop of unknown reasons (Idiopathic pulmonary fibrosis). We are interested in studying the cellular mechanisms involved in the pathogenesis of pulmonary fibrosis to identify novel therapeutic targets.