URMC / Labs / Takimoto Lab / Publications

Recent Publications from the Takimoto Lab

1. Schmierer J
2. Lutz M
3. Takimoto T
Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations.; Journal of virology. 2025 Dec 23.
1. Schmierer J
2. Takimoto T
Functional Analysis of GRSF1 in the Nuclear Export and Translation of Influenza A Virus mRNAs.; Viruses; Vol 16(7). 2024 Jul 16.
1. Hardy K
2. Lutz M
3. Takimoto T
Human coronavirus NL63 nsp1 induces degradation of RNA polymerase II to inhibit host protein synthesis.; PLoS pathogens; Vol 20(6), pp. e1012329. 2024 Jun 20.
1. Lutz M
2. Schmierer J
3. Takimoto T
Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1.; Communications biology; Vol 5(1), pp. 1102. 2022 Jan 17.
1. Raymonda MH
2. Ciesla JH
3. Monaghan M
4. Leach J
5. Asantewaa G
6. Smorodintsev-Schiller LA
7. Lutz MM
8. Schafer XL
9. Takimoto T
10. Dewhurst S
11. Munger J
12. Harris IS
Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro.; Virology; Vol 566. 2021 Nov 27.
1. Kurebayashi Y
2. Bajimaya S
3. Watanabe M
4. Lim N
5. Lutz M
6. Dunagan M
7. Takimoto T
Human parainfluenza virus type 1 regulates cholesterol biosynthesis and establishes quiescent infection in human airway cells.; PLoS pathogens; Vol 17(9). 2021 Sep.
1. Dunagan MM
2. Hardy K
3. Takimoto T
Impact of Influenza A Virus Shutoff Proteins on Host Immune Responses.; Vaccines; Vol 9(6). 2021 Jun 10.
1. Genoyer E
2. Kulej K
3. Hung CT
4. Thibault PA
5. Azarm K
6. Takimoto T
7. Garcia BA
8. Lee B
9. Lakdawala S
10. Weitzman MD
11. López CB
The Viral Polymerase Complex Mediates the Interaction of Viral Ribonucleoprotein Complexes with Recycling Endosomes during Sendai Virus Assembly.; mBio; Vol 11(4). 2020 Aug 25.
1. Scaggs Huang F
2. Bernstein DI
3. Slobod KS
4. Portner A
5. Takimoto T
6. Russell CJ
7. Meagher M
8. Jones BG
9. Sealy RE
10. Coleclough C
11. Branum K
12. Dickey M
13. Buschle K
14. McNeal M
15. Makowski M
16. Nakamura A
17. Hurwitz JL
Safety and immunogenicity of an intranasal sendai virus-based vaccine for human parainfluenza virus type I and respiratory syncytial virus (SeVRSV) in adults.; Human vaccines & immunotherapeutics. 2020 Aug 04.
1. Lutz Iv MM
2. Dunagan MM
3. Kurebayashi Y
4. Takimoto T
Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses.; Viruses; Vol 12(4). 2020 Mar 26.
1. Chaimayo C
2. Dunagan M
3. Hayashi T
4. Santoso N
5. Takimoto T
Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity.; PLoS pathogens; Vol 14(11). 2018 Nov 29.
1. Bajimaya S
2. Frankl T
3. Hayashi T
4. Takimoto T
Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses.; Virology; Vol 510. 2017 Jul 24.
1. Russell CJ
2. Jones BG
3. Sealy RE
4. Surman SL
5. Mason JN
6. Hayden RT
7. Tripp RA
8. Takimoto T
9. Hurwitz JL
A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge.; Virology; Vol 509. 2017 Jun 09.
1. Chaimayo C
2. Hayashi T
3. Underwood A
4. Hodges E
5. Takimoto T
Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 protein.; Virology; Vol 505. 2017 May.
1. Bajimaya S
2. Hayashi T
3. Frankl T
4. Bryk P
5. Ward B
6. Takimoto T
Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses.; Virology; Vol 501. 2017 Jan 15.
1. Bajimaya S
2. Hayashi T
3. Takimoto T
Rescue of Sendai Virus from Cloned cDNA.; Methods in molecular biology (Clifton, N.J.); Vol 1602. 2017.
1. Hayashi T
2. Chaimayo C
3. McGuinness J
4. Takimoto T
Critical role of the PA-X C-terminal domain of influenza A virus on its subcellular localization and shutoff activity.; Journal of virology. 2016 May 25.
1. Stone R
2. Hayashi T
3. Bajimaya S
4. Hodges E
5. Takimoto T
Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses.; Virology; Vol 487. 2016 Jan.
1. Hayashi T
2. Chaimayo C
3. Takimoto T
Impact of influenza PA-X on host response.; Oncotarget; Vol 6(23). 2015 Aug 14.
1. Hayashi T
2. Wills S
3. Bussey KA
4. Takimoto T
Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures.; Journal of virology; Vol 89(15). 2015 Aug.
1. Hayashi T
2. MacDonald LA
3. Takimoto T
Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses.; Journal of virology; Vol 89(12). 2015 Jun.
1. Fukushima K
2. Takahashi T
3. Ueyama H
4. Takaguchi M
5. Ito S
6. Oishi K
7. Minami A
8. Ishitsubo E
9. Tokiwa H
10. Takimoto T
11. Suzuki T
Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase.; FEBS letters; Vol 589(11). 2015 May 8.
1. Zhan X
2. Slobod KS
3. Jones BG
4. Sealy RE
5. Takimoto T
6. Boyd K
7. Surman S
8. Russell CJ
9. Portner A
10. Hurwitz JL
Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats.; International immunology; Vol 27(5). 2015 May.
1. Fukushima K
2. Takahashi T
3. Ito S
4. Takaguchi M
5. Takano M
6. Kurebayashi Y
7. Oishi K
8. Minami A
9. Kato T
10. Park EY
11. Nishimura H
12. Takimoto T
13. Suzuki T
Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 3.; Virology; Vol 464-465. 2014 Sep.
1. Bialas KM
2. Bussey KA
3. Stone RL
4. Takimoto T
Specific nucleoprotein residues affect influenza virus morphology.; Journal of virology; Vol 88(4). 2014 Feb.
1. Desmet EA
2. Bussey KA
3. Stone R
4. Takimoto T
Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis.; Journal of virology; Vol 87(6). 2013 Mar.
1. Stone R
2. Takimoto T
Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly.; PloS one; Vol 8(4). 2013.
1. Noronha JM
2. Liu M
3. Squires RB
4. Pickett BE
5. Hale BG
6. Air GM
7. Galloway SE
8. Takimoto T
9. Schmolke M
10. Hunt V
11. Klem E
12. García-Sastre A
13. McGee M
14. Scheuermann RH
Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.; Journal of virology; Vol 86(10). 2012 May.
1. MacDonald LA
2. Aggarwal S
3. Bussey KA
4. Desmet EA
5. Kim B
6. Takimoto T
Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies.; Virology; Vol 426(1). 2012 Apr 25.
1. Jones BG
2. Sealy RE
3. Rudraraju R
4. Traina-Dorge VL
5. Finneyfrock B
6. Cook A
7. Takimoto T
8. Portner A
9. Hurwitz JL
Sendai virus-based RSV vaccine protects African green monkeys from RSV infection.; Vaccine; Vol 30(5). 2012 Jan 20.
1. Bialas KM
2. Desmet EA
3. Takimoto T
Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro.; PloS one; Vol 7(11). 2012.
1. Aggarwal S
2. Dewhurst S
3. Takimoto T
4. Kim B
Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.; The Journal of biological chemistry; Vol 286(40). 2011 Oct 7.
1. Bussey KA
2. Desmet EA
3. Mattiacio JL
4. Hamilton A
5. Bradel-Tretheway B
6. Bussey HE
7. Kim B
8. Dewhurst S
9. Takimoto T
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.; Journal of virology; Vol 85(14). 2011 Jul.
1. Noble E
2. Mathews DH
3. Chen JL
4. Turner DH
5. Takimoto T
6. Kim B
Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.; The Journal of biological chemistry; Vol 286(26). 2011 Jul 1.
1. Guo H
2. Santiago F
3. Lambert K
4. Takimoto T
5. Topham DJ
T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.; Journal of virology; Vol 85(1). 2011 Jan.
1. Desmet EA
2. Hollenbaugh JA
3. Sime PJ
4. Wright TW
5. Topham DJ
6. Sant AJ
7. Takimoto T
8. Dewhurst S
9. Maggirwar SB
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.; Virology; Vol 400(2). 2010 May 10.
1. Bussey KA
2. Bousse TL
3. Desmet EA
4. Kim B
5. Takimoto T
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.; Journal of virology; Vol 84(9). 2010 May.
1. Aggarwal S
2. Bradel-Tretheway B
3. Takimoto T
4. Dewhurst S
5. Kim B
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.; PloS one; Vol 5(4). 2010.
1. Chambers R
2. Takimoto T
Trafficking of Sendai virus nucleocapsids is mediated by intracellular vesicles.; PloS one; Vol 5(6). 2010.
1. Chambers R
2. Takimoto T
Antagonism of innate immunity by paramyxovirus accessory proteins.; Viruses; Vol 1(3). 2009 Dec.
1. Chambers R
2. Takimoto T
Host specificity of the anti-interferon and anti-apoptosis activities of parainfluenza virus P/C gene products.; The Journal of general virology; Vol 90(Pt 8). 2009 Aug.
1. Bradel-Tretheway BG
2. Kelley Z
3. Chakraborty-Sett S
4. Takimoto T
5. Kim B
6. Dewhurst S
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.; The Journal of general virology; Vol 89(Pt 12). 2008 Dec.
1. Zhan X
2. Slobod KS
3. Krishnamurthy S
4. Luque LE
5. Takimoto T
6. Jones B
7. Surman S
8. Russell CJ
9. Portner A
10. Hurwitz JL
Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections.; Vaccine; Vol 26(27-28). 2008 Jun 25.
1. Zhan X
2. Hurwitz JL
3. Krishnamurthy S
4. Takimoto T
5. Boyd K
6. Scroggs RA
7. Surman S
8. Portner A
9. Slobod KS
Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B.; Vaccine; Vol 25(52). 2007 Dec 17.
1. Brown SA
2. Hurwitz JL
3. Zirkel A
4. Surman S
5. Takimoto T
6. Alymova I
7. Coleclough C
8. Portner A
9. Doherty PC
10. Slobod KS
A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein.; Journal of virology; Vol 81(22). 2007 Nov.
1. Bousse T
2. Chambers RL
3. Scroggs RA
4. Portner A
5. Takimoto T
Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment.; Virus research; Vol 121(1). 2006 Oct.
1. Bousse T
2. Takimoto T
Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein.; Journal of virology; Vol 80(18). 2006 Sep.
1. Krishnamurthy S
2. Takimoto T
3. Scroggs RA
4. Portner A
Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines.; Journal of virology; Vol 80(11). 2006 Jun.
1. Alymova IV
2. Portner A
3. Takimoto T
4. Boyd KL
5. Babu YS
6. McCullers JA
The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae.; Antimicrobial agents and chemotherapy; Vol 49(1). 2005 Jan.
1. Takimoto T
2. Hurwitz JL
3. Zhan X
4. Krishnamurthy S
5. Prouser C
6. Brown B
7. Coleclough C
8. Boyd K
9. Scroggs RA
10. Portner A
11. Slobod KS
Recombinant Sendai virus as a novel vaccine candidate for respiratory syncytial virus.; Viral immunology; Vol 18(2). 2005.