URMC / Labs / Takimoto Lab / Publications Publications Chaimayo CHayashi TUnderwood AHodges ETakimoto T (2017 May). Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 protein. Virology. Bajimaya SHayashi TFrankl TBryk PWard BTakimoto T (2017 Jan 15). Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses. Virology. Hayashi TChaimayo CMcGuinness JTakimoto T (2016 May 25). Critical role of the PA-X C-terminal domain of influenza A virus on its subcellular localization and shutoff activity. Journal of virology. Stone RHayashi TBajimaya SHodges ETakimoto T (2016 Jan). Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses. Virology. Hayashi TChaimayo CTakimoto T (2015 Aug 14). Impact of influenza PA-X on host response. Oncotarget. Hayashi TWills SBussey KATakimoto T (2015 Aug). Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures. Journal of virology. Hayashi TMacDonald LATakimoto T (2015 Jun). Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses. Journal of virology. Fukushima KTakahashi TUeyama HTakaguchi MIto SOishi KMinami AIshitsubo ETokiwa HTakimoto TSuzuki T (2015 May 8). Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. FEBS letters. Zhan XSlobod KSJones BGSealy RETakimoto TBoyd KSurman SRussell CJPortner AHurwitz JL (2015 May). Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats. International immunology. Bialas KMBussey KAStone RLTakimoto T (2014 Feb). Specific nucleoprotein residues affect influenza virus morphology. Journal of virology. Desmet EABussey KAStone RTakimoto T (2013 Mar). Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis. Journal of virology. Stone RTakimoto T (2013). Critical role of the fusion protein cytoplasmic tail sequence in parainfluenza virus assembly. PloS one. Noronha JMLiu MSquires RBPickett BEHale BGAir GMGalloway SETakimoto TSchmolke MHunt VKlem EGarcía-Sastre AMcGee MScheuermann RH (2012 May). Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction. Journal of virology. MacDonald LAAggarwal SBussey KADesmet EAKim BTakimoto T (2012 Apr 25). Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies. Virology. Jones BGSealy RERudraraju RTraina-Dorge VLFinneyfrock BCook ATakimoto TPortner AHurwitz JL (2012 Jan 20). Sendai virus-based RSV vaccine protects African green monkeys from RSV infection. Vaccine. Bialas KMDesmet EATakimoto T (2012). Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro. PloS one. Aggarwal SDewhurst STakimoto TKim B (2011 Oct 7). Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex. The Journal of biological chemistry. Bussey KADesmet EAMattiacio JLHamilton ABradel-Tretheway BBussey HEKim BDewhurst STakimoto T (2011 Jul). PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. Journal of virology. Noble EMathews DHChen JLTurner DHTakimoto TKim B (2011 Jul 1). Biophysical analysis of influenza A virus RNA promoter at physiological temperatures. The Journal of biological chemistry. Guo HSantiago FLambert KTakimoto TTopham DJ (2011 Jan). T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model. Journal of virology. Desmet EAHollenbaugh JASime PJWright TWTopham DJSant AJTakimoto TDewhurst SMaggirwar SB (2010 May 10). Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology. Bussey KABousse TLDesmet EAKim BTakimoto T (2010 May). PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. Journal of virology. Aggarwal SBradel-Tretheway BTakimoto TDewhurst SKim B (2010). Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. PloS one. Chambers RTakimoto T (2010). Trafficking of Sendai virus nucleocapsids is mediated by intracellular vesicles. PloS one. Chambers RTakimoto T (2009 Dec). Antagonism of innate immunity by paramyxovirus accessory proteins. Viruses. Chambers RTakimoto T (2009 Aug). Host specificity of the anti-interferon and anti-apoptosis activities of parainfluenza virus P/C gene products. The Journal of general virology. Bradel-Tretheway BGKelley ZChakraborty-Sett STakimoto TKim BDewhurst S (2008 Dec). The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit. The Journal of general virology. Zhan XSlobod KSKrishnamurthy SLuque LETakimoto TJones BSurman SRussell CJPortner AHurwitz JL (2008 Jun 25). Sendai virus recombinant vaccine expressing hPIV-3 HN or F elicits protective immunity and combines with a second recombinant to prevent hPIV-1, hPIV-3 and RSV infections. Vaccine. Zhan XHurwitz JLKrishnamurthy STakimoto TBoyd KScroggs RASurman SPortner ASlobod KS (2007 Dec 17). Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Vaccine. Brown SAHurwitz JLZirkel ASurman STakimoto TAlymova IColeclough CPortner ADoherty PCSlobod KS (2007 Nov). A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted human immunodeficiency virus type 1 envelope glycoprotein. Journal of virology. Bousse TChambers RLScroggs RAPortner ATakimoto T (2006 Oct). Human parainfluenza virus type 1 but not Sendai virus replicates in human respiratory cells despite IFN treatment. Virus research. Bousse TTakimoto T (2006 Sep). Mutation at residue 523 creates a second receptor binding site on human parainfluenza virus type 1 hemagglutinin-neuraminidase protein. Journal of virology. Krishnamurthy STakimoto TScroggs RAPortner A (2006 Jun). Differentially regulated interferon response determines the outcome of Newcastle disease virus infection in normal and tumor cell lines. Journal of virology. Alymova IVPortner ATakimoto TBoyd KLBabu YSMcCullers JA (2005 Jan). The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae. Antimicrobial agents and chemotherapy. Takimoto THurwitz JLZhan XKrishnamurthy SProuser CBrown BColeclough CBoyd KScroggs RAPortner ASlobod KS (2005). Recombinant Sendai virus as a novel vaccine candidate for respiratory syncytial virus. Viral immunology. Bousse TLTaylor GKrishnamurthy SPortner ASamal SKTakimoto T (2004 Dec). Biological significance of the second receptor binding site of Newcastle disease virus hemagglutinin-neuraminidase protein. Journal of virology. Takimoto TPortner A (2004 Dec). Molecular mechanism of paramyxovirus budding. Virus research. Takimoto THurwitz JLColeclough CProuser CKrishnamurthy SZhan XBoyd KScroggs RABrown BNagai YPortner ASlobod KS (2004 Jun). Recombinant Sendai virus expressing the G glycoprotein of respiratory syncytial virus (RSV) elicits immune protection against RSV. Journal of virology. Alymova IVTaylor GTakimoto TLin THChand PBabu YSLi CXiong XPortner A (2004 May). Efficacy of novel hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 against human parainfluenza viruses in vitro and in vivo. Antimicrobial agents and chemotherapy. Zaitsev Vvon Itzstein MGroves DKiefel MTakimoto TPortner ATaylor G (2004 Apr). Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion. Journal of virology. Takimoto TTaylor GLConnaris HCCrennell SJPortner A (2002 Dec). Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion. Journal of virology. Bousse TMatrosovich TPortner AKato ANagai YTakimoto T (2002 Aug). The long noncoding region of the human parainfluenza virus type 1 f gene contributes to the read-through transcription at the m-f gene junction. Journal of virology. Connaris HTakimoto TRussell RCrennell SMoustafa IPortner ATaylor G (2002 Feb). Probing the sialic acid binding site of the hemagglutinin-neuraminidase of Newcastle disease virus: identification of key amino acids involved in cell binding, catalysis, and fusion. Journal of virology. Takimoto TMurti KGBousse TScroggs RAPortner A (2001 Dec). Role of matrix and fusion proteins in budding of Sendai virus. Journal of virology. Bousse TTakimoto TMatrosovich TPortner A (2001 May 10). Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity. Virology. Suzuki TPortner AScroggs RAUchikawa MKoyama NMatsuo KSuzuki YTakimoto T (2001 May). Receptor specificities of human respiroviruses. Journal of virology. Coronel ECTakimoto TMurti KGVarich NPortner A (2001 Feb). Nucleocapsid incorporation into parainfluenza virus is regulated by specific interaction with matrix protein. Journal of virology. Crennell STakimoto TPortner ATaylor G (2000 Nov). Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nature structural biology. Takimoto TBousse TPortner A (2000 Sep). Molecular cloning and expression of human parainfluenza virus type 1 L gene. Virus research. Takimoto TTaylor GLCrennell SJScroggs RAPortner A (2000 Apr 25). Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein. Virology.