The cellular machineries and pathways are utilized by viruses. Small-molecule compounds targeting host genes would serve as new generation of antiviral reagents.
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Through the comprehensive functional genomic screens, we identified host proteins that potently suppress HIV transcription and promote its latency, including BRD4 and FACT (SUPT16H and SSRP1) proteins.
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Gammaherpesviruses (EBV and KSHV) are key viral determinants of AIDS-related malignancy. Our earlier proteomic studies identified a set of key host factors that involve in lytic and latent replication of gammaherpesviruses (EBV and KSHV), including TIP60.
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To produce a comprehensive map of host-virus interactions, we applied a screening strategy to complete parallel siRNA screens using multiple orthologous RNAi reagents (MORR).
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To understand host-virus relationships, it is indispensable to globally study their protein interactions since viruses usually encode limited genes and highly depend on host machineries to replicate.
Learn more about Systems Biology Tools To Study Host-Virus Interaction: Development And Use Of Proteomics