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Projects

Development of Novel Antiviral Compounds Targeting Host Genes

Development of Novel Antiviral Compounds Targeting Host GenesThe cellular machineries and pathways are utilized by viruses. Small-molecule compounds targeting host genes would serve as new generation of antiviral reagents.

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Host Machineries Regulating HIV Transcription and Latency

Host Machineries Regulating HIV Transcription and LatencyThrough the comprehensive functional genomic screens, we identified host proteins that potently suppress HIV transcription and promote its latency, including BRD4 and FACT (SUPT16H and SSRP1) proteins.

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Lytic and Latent Replication of Gammaherpesviruses (EBV and KSHV)

Lytic and Latent Replication of Gammaherpesviruses (EBV and KSHV)Gammaherpesviruses (EBV and KSHV) are key viral determinants of AIDS-related malignancy. Our earlier proteomic studies identified a set of key host factors that involve in lytic and latent replication of gammaherpesviruses (EBV and KSHV), including TIP60.

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Systems Biology Tools To Study Host-Virus Interaction: Functional Genomic Screens

Systems Biology Tools To Study Host-Virus Interaction: Functional Genomic ScreensTo produce a comprehensive map of host-virus interactions, we applied a screening strategy to complete parallel siRNA screens using multiple orthologous RNAi reagents (MORR).

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Systems Biology Tools To Study Host-Virus Interaction: Development And Use Of Proteomics

Systems Biology Tools To Study Host-Virus Interaction: Development And Use Of ProteomicsTo understand host-virus relationships, it is indispensable to globally study their protein interactions since viruses usually encode limited genes and highly depend on host machineries to replicate.

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