Xenopus laevis Research Resource for Immunobiology
Ever since it was discovered that X. laevis could easily be induced to breed in the laboratory by injecting human gonadotrophin, this anuran amphibian has become the model of choice for research in all sorts of biological fields ranging from early developmental biology and metamorphosis to behavior and immunity. In particular, evolutionary distance of X. laevis from mammals permits distinguishing species-specific adaptation from more conserved features of the immune system.
The University of Rochester is home to the world's most comprehensive resource specializing in the use of the amphibian Xenopus laevis for biomedical and immunological research. Several genetically-defined inbred strains and clones are available for study. The facility also maintains and develops research tools such as transgenic animals, monoclonal antibodies, cell lines, DNA libraries and molecular probes. The resource includes a satellite facility devoted to study infectious diseases caused by iridovirus. Technical assistance, education and training are also provided. The resource is supported by the National Institute of Allergy and Infectious Diseases (NIH/NIAID).