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URMC / Microbiology & Immunology / Xenopus Laevis / Models to Study / Transfer & Transplantation

Transfer & Transplantation

Our laboratory maintains several inbred X. laevis with different MHC homozygous genotype, as well as several different MHC-defined isogenetic clones. These clones were generated by gynogenesis between X. laevis and X. gilli or X. mueleri (Kobel & Du Pasquier, 1975). These clones and inbred strains permit classic adoptive transfer and transplantation manipulations as in mice (Robert et al., 2004). Unlike mice, they also permit transfer of tissues and cells between larva and adult (Robert et al., 2004).

Inbred MHC-defined Strains And Isogenetic Clones (Gynogenesis)

Strains/Clones Name (MHC genotypes)
Partially Inbred, MHC homozygous strains F, J, A8(r/r), K, G
Isogenetic X. laevis/gilli (LG) clones with identical
heterozygous (a/c) MHC bu different minor H genotype
LG-6 LG-7 LG-15
MHC-disparate LG isogenetic clones LG-3 (b/d), LG-5 (b/c)
Isogenetic X. laevis/mulleri (LM) clones LM3 (w/y)