Skip to content
Richard John Looney, M.D.

Richard John Looney, M.D.

Allergy, Immunology & Rheumatology , Pediatrics , Pediatric Allergy/Immunology

4.8 out of 5 stars
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Allergy/Immunology Appointment (585) 486-0930
Rheumatology Appointment (585) 486-0901
Administrative (585) 275-2891

Locations

Allergy, Immunology, & Rheumatology

125 Lattimore Road, Suite G-110
Rochester, NY 14620

About Me

Dr. Looney is a rheumatologist as well as an allergist and clinical immunologist with a broad interest in all aspects of these specialties. He has been at the University of Rochester for over 50 years and has been in the Allergy Immunology Rheumatology Division for over 40 years. His research has in...
Dr. Looney is a rheumatologist as well as an allergist and clinical immunologist with a broad interest in all aspects of these specialties. He has been at the University of Rochester for over 50 years and has been in the Allergy Immunology Rheumatology Division for over 40 years. His research has involved both translational research and clinical trials including the role of B cell depletion and mesenchymal stem cells in systemic lupus erythematosus. He has also worked on the role of the microbiome and infections in development of immune mediated diseases.

Certified Specialties

Allergy & Immunology - American Board of Allergy & Immunology

Infectious Disease - American Board of Internal Medicine

Internal Medicine - American Board of Internal Medicine

Rheumatology - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Dr. Stephen I. Rosenfeld and Elise A. Rosenfeld Distinguished Professorship in Allergy & Clinical Immunology - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Credentials

Residency & Fellowship

Fellowship, Allergy & Immunology, University of Rochester Medical Center. 1979 - 1984

Residency, Internal Medicine, University of Rochester Medical Center. 1977 - 1979

Internship, Internal Medicine, University of Rochester Medical Center. 1976 - 1977

Education

MD | University of Rochester School of Medicine/Dentistry. 1976

Awards

Postdoctoral Training Grant. 1983 - 1984

Postdoctoral Training Grant. 1980

Research

I have practiced Rheumatology and Allergy/Clinical Immunology on the Faculty of the University of Rochester since 1984 and was the AI Training Program Director for 19 years. Over my career about half my time has been clinical and the rest split between research, teaching and administration. Studies ...
I have practiced Rheumatology and Allergy/Clinical Immunology on the Faculty of the University of Rochester since 1984 and was the AI Training Program Director for 19 years. Over my career about half my time has been clinical and the rest split between research, teaching and administration. Studies in my early career included discovery of CD32/FcgammaRIIa and creation of the first monoclonal antibody against this FcR. Another significant contribution was the description of the effects of latent CMV on T cell subsets and the importance of taking this into account when studying aging, rheumatoid arthritis and HIV. Since the mid-1990’s I became interested in investigator-initiated trials of new agents for immune-mediated diseases, most notably one of the very first trials of B cell targeted therapy for autoimmunity (anti-CD20 for SLE). I was also PI on an investigator initiated study of a biologic for prosthetic hip loosing and the first CT imaging algorithms to quantify peri-prosthetic osteolysis. From 2003 to 2014 most of my research effort was through the NIH Autoimmunity Centers of Excellence (ACE) as a member of the steering committee and as the Clinical Director for the Rochester ACE. Through the ACE I developed and participated in numerous clinical trials, testing novel treatments for systemic autoimmune diseases. In June 2014 I was installed as the inaugural Stephen and Elise Rosenfeld Professor of Allergy and Clinical Immunology. The unrestricted funding from this Professorship has provided resources to move in new directions. Part of this funding has been used to support research on mesenchymal stem cells in SLE. These studies have been supported by a grant from the Alliance for Lupus Research on the role of IFNbeta in SLE and a Department of Defense grant on the use of senolytic drugs to target these prematurely aged cells. The Rosenfeld Professorship and NIH funding through pilot grants from the Environmental Center, as well as from the CTSI, supported studies on immune system development and the role of the microbiome in determining risk of allergic disease by comparing the Old Order Mennonites to Rochesterians.

Publications

Journal Articles

Mycophenolate mofetil withdrawal in patients with systemic lupus erythematosus: a multicentre, open-label, randomised controlled trial.

Chakravarty EF, Utset T, Kamen DL, Contreras G, McCune WJ, Aranow C, Kalunian K, Massarotti E, Clowse MEB, Rovin BH, Lim SS, Majithia V, Dall'Era M, Looney RJ, Erkan D, Saxena A, Olsen NJ, Ko K, Guthridge JM, Goldmuntz E, Springer J, D'Aveta C, Keyes-Elstein L, Barry B, Pinckney A, McNamara J, James JA

The Lancet. Rheumatology.. 2024 January 29 Epub 01/29/2024.

B Cell-Directed Therapy in Autoimmunity.

Abeles I, Palma C, Meednu N, Payne AS, Looney RJ, Anolik JH

Annual review of immunology.. 2023 November 27 Epub 11/27/2023.

Immune dysregulation.

Long A, Kleiner A, Looney RJ

The Journal of allergy and clinical immunology.. 2023 January 151 (1):70-80. Epub 1900 01 01.

Quantitative glycoproteomics of human milk and association with atopic disease.

Holm M, Saraswat M, Joenväärä S, Seppo A, Looney RJ, Tohmola T, Renkonen J, Renkonen R, Järvinen KM

PloS one.. 2022 May 1317 (5):e0267967. Epub 05/13/2022.

Biomarkers of Development of Immunity and Allergic Diseases in Farming and Non-farming Lifestyle Infants: Design, Methods and 1 Year Outcomes in the "Zooming in to Old Order Mennonites" Birth Cohort Study.

Järvinen KM, Davis EC, Bevec E, Jackson CM, Pizzarello C, Catlin E, Klein M, Sunkara A, Diaz N, Miller J, Martina CA, Thakar J, Seppo AE, Looney RJ,

Frontiers in pediatrics.. 2022 10 :916184. Epub 07/06/2022.

B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-? in Systemic Lupus Erythematosus.

Barnas JL, Albrecht J, Meednu N, Alzamareh DF, Baker C, McDavid A, Looney RJ, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 October 27 Epub 10/27/2021.

Steroid Allergy in a Patient With Behçet's Disease.

Harrison BM, Looney RJ, Williams ZR, DiLoreto DA

Ophthalmic surgery, lasers & imaging retina.. 2021 August 52 (8):447-449. Epub 08/01/2021.

Infant Gut Microbiome Is Enriched with Bifidobacteria longumssp. infantisin Old Order Mennoniteswith Traditional Farming Lifestyle.

Seppo AE, Bu K, Jumabaeva M, Thakar J, Choudhury R, Yonemitsu C, Bode L, Martina CA, Allen M, Tamburini S, Piras E, Wallach DS, Looney RJ, Clemente JC, Järvinen KM

Allergy.. 2021 April 27 Epub 04/27/2021.

Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition.

Seppo AE, Choudhury R, Pizzarello C, Palli R, Fridy S, Rajani PS, Stern J, Martina C, Yonemitsu C, Bode L, Bu K, Tamburini S, Piras E, Wallach DS, Allen M, Looney RJ, Clemente JC, Thakar J, Järvinen KM

Frontiers in immunology.. 2021 12 :741513. Epub 10/11/2021.

IFN signaling inhibits osteogenesis in human SLE bone marrow.

Gao L, Liesveld J, Anolik J, Mcdavid A, Looney RJ

Lupus.. 2020 June 9 :961203320930088. Epub 06/09/2020.

B cell targeted therapies in autoimmune disease.

Barnas JL, Looney RJ, Anolik JH

Current opinion in immunology.. 2019 December 61 :92-99. Epub 11/14/2019.

Cell Senescence in Lupus.

Gao L, Slack M, Barnas JL, McDavid A, Anolik J, Looney RJ

Current rheumatology reports.. 2019 May 2321 (7):32. Epub 05/23/2019.

Cell Senescence in Lupus.

Gao L, Slack M, McDavid A, Anolik J, Looney RJ

Current rheumatology reports.. 2019 January 1421 (2):1. Epub 01/14/2019.

Failure of B Cell Tolerance in CVID.

Richardson CT, Slack MA, Dhillon G, Marcus CZ, Barnard J, Palanichamy A, Sanz I, Looney RJ, Anolik JH

Frontiers in immunology.. 2019 10 :2881. Epub 12/10/2019.

Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis.

Gomez Mendez LM, Cascino MD, Garg J, Katsumoto TR, Brakeman P, Dall'Era M, Looney RJ, Rovin B, Dragone L, Brunetta P

Clinical journal of the American Society of Nephrology : CJASN.. 2018 October 813 (10):1502-1509. Epub 08/08/2018.

Prevalence of allergic disease in Old Order Mennonites in New York.

Martina C, Looney RJ, Marcus C, Allen M, Stahlhut R

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2016 November 117 (5):562-563.e1. Epub 09/06/2016.

Treatment of systemic lupus erythematosus patients with the BAFF antagonist "peptibody" blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials.

Stohl W, Merrill JT, Looney RJ, Buyon J, Wallace DJ, Weisman MH, Ginzler EM, Cooke B, Holloway D, Kaliyaperumal A, Kuchimanchi KR, Cheah TC, Rasmussen E, Ferbas J, Belouski SS, Tsuji W, Zack DJ

Arthritis research & therapy.. 2015 August 2017 :215. Epub 08/20/2015.

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.

Adlowitz DG, Barnard J, Biear JN, Cistrone C, Owen T, Wang W, Palanichamy A, Ezealah E, Campbell D, Wei C, Looney RJ, Sanz I, Anolik JH

PloS one.. 2015 10 (6):e0128269. Epub 06/05/2015.

Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study.

Rovin BH, Furie R, Latinis K, Looney RJ, Fervenza FC, Sanchez-Guerrero J, Maciuca R, Zhang D, Garg JP, Brunetta P, Appel G,

Arthritis and rheumatism.. 2012 April 64 (4):1215-26. Epub 01/09/2012.

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.

Ichikawa HT, Conley T, Muchamuel T, Jiang J, Lee S, Owen T, Barnard J, Nevarez S, Goldman BI, Kirk CJ, Looney RJ, Anolik JH

Arthritis and rheumatism.. 2012 February 64 (2):493-503. Epub 1900 01 01.

Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor.

Kobie JJ, Zheng B, Bryk P, Barnes M, Ritchlin CT, Tabechian DA, Anandarajah AP, Looney RJ, Thiele RG, Anolik JH, Coca A, Wei C, Rosenberg AF, Feng C, Treanor JJ, Lee FE, Sanz I

Arthritis research & therapy.. 2011 13 (6):R209. Epub 12/16/2011.

Human basophils express amphiregulin in response to T cell-derived IL-3.

Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR

The Journal of allergy and clinical immunology.. 2010 December 126 (6):1260-6.e4. Epub 10/30/2010.

Connective tissue diseases: Translating the effects of BAFF in SLE.

Marston B, Looney RJ

Nature reviews. Rheumatology.. 2010 September 6 (9):503-4. Epub 1900 01 01.

A perspective on B-cell-targeting therapy for SLE.

John Looney R, Anolik J, Sanz I

Modern rheumatology. 2010 February 20 (1):1-10. Epub 08/08/2009.

Immunization responses in rheumatoid arthritis patients treated with rituximab: results from a controlled clinical trial.

Bingham CO, Looney RJ, Deodhar A, Halsey N, Greenwald M, Codding C, Trzaskoma B, Martin F, Agarwal S, Kelman A

Arthritis and rheumatism.. 2010 January 62 (1):64-74. Epub 1900 01 01.

Hydroxychloroquine-induced myopathy.

Kwon JB, Kleiner A, Ishida K, Godown J, Ciafaloni E, Looney RJ

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.. 2010 January 16 (1):28-31. Epub 1900 01 01.

Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets.

Anolik JH, Looney RJ, Lund FE, Randall TD, Sanz I

Immunologic research.. 2009 December 45 (2-3):144-58. Epub 04/07/2009.

Macrophage activation syndrome: serological markers and treatment with anti-thymocyte globulin.

Coca A, Bundy KW, Marston B, Huggins J, Looney RJ

Clinical immunology : the official journal of the Clinical Immunology Society.. 2009 July 132 (1):10-8. Epub 03/17/2009.

Novel human transitional B cell populations revealed by B cell depletion therapy.

Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, Looney RJ, Sanz I, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 May 15182 (10):5982-93. Epub 1900 01 01.

Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae.

Brown RJ, Rother KI, Artman H, Mercurio MG, Wang R, Looney RJ, Cowen EW

Archives of dermatology.. 2009 January 145 (1):63-6. Epub 1900 01 01.

Update on the use of rituximab for intractable rheumatoid arthritis.

Looney RJ

Open access rheumatology : research and reviews.. 2009 1 :83-94. Epub 06/26/2009.

Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus.

Albert D, Dunham J, Khan S, Stansberry J, Kolasinski S, Tsai D, Pullman-Mooar S, Barnack F, Striebich C, Looney RJ, Prak ET, Kimberly R, Zhang Y, Eisenberg R

Annals of the rheumatic diseases.. 2008 December 67 (12):1724-31. Epub 02/04/2008.

Is rituximab suitable for use as a first-line biologic therapy for RA?

Kleiner A, Looney RJ

Nature clinical practice. Rheumatology.. 2008 November 4 (11):574-5. Epub 09/09/2008.

Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome.

Mehta LR, Samuelsson MK, Kleiner AK, Goodman AD, Anolik JH, Looney RJ, Schwid SR

Multiple sclerosis : clinical and laboratory research.. 2008 April 14 (3):425-7. Epub 01/21/2008.

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

Nicholas MW, Dooley MA, Hogan SL, Anolik J, Looney J, Sanz I, Clarke SH

Clinical immunology : the official journal of the Clinical Immunology Society.. 2008 February 126 (2):189-201. Epub 1900 01 01.

The effects of rituximab on immunocompetency in patients with autoimmune disease.

Looney RJ, Srinivasan R, Calabrese LH

Arthritis and rheumatism.. 2008 January 58 (1):5-14. Epub 1900 01 01.

Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae

Brown, RJ.; Rother, KI.; Mercurio, MG.; Wang, R.; Looney, RJ.; Cowen, EW.

Archives of Dermatology. 2008; .

Commentary: rituximab as first line therapy for rheumatoid arthritis

Kleiner, A.; Looney, RJ.

Nature Clinical Practice in Rheumatology. 2008; .

Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).

Reddy MB, Looney RJ, Utell MJ, Plotzke KP, Andersen ME

Toxicological sciences : an official journal of the Society of Toxicology.. 2007 October 99 (2):422-31. Epub 07/14/2007.

Vaccine responses in patients with rheumatoid arthritis.

Ravikumar R, Anolik J, Looney RJ

Current rheumatology reports.. 2007 October 9 (5):407-15. Epub 1900 01 01.

Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy.

Anolik JH, Barnard J, Owen T, Zheng B, Kemshetti S, Looney RJ, Sanz I

Arthritis and rheumatism.. 2007 September 56 (9):3044-56. Epub 1900 01 01.

New and promising treatments for rheumatoid arthritis.

Looney RJ, Stohl W

The American journal of orthopedics.. 2007 July 36 (7 Suppl):18-23. Epub 1900 01 01.

Guidelines for assessing immunocompetency in clinical trials for autoimmune diseases.

Looney RJ, Diamond B, Holers VM, Levesque MC, Moreland L, Nahm MH, St Clair EW,

Clinical immunology : the official journal of the Clinical Immunology Society.. 2007 June 123 (3):235-43. Epub 02/27/2007.

Will targeting B cells be the answer for Sjögren's syndrome?

Looney RJ

Arthritis and rheumatism.. 2007 May 56 (5):1371-7. Epub 1900 01 01.

B cell depletion therapy in autoimmune diseases.

Sanz I, Anolik JH, Looney RJ

Frontiers in bioscience : a journal and virtual library.. 2007 January 112 :2546-67. Epub 01/01/2007.

Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy

Anolik, JH.; Barnard, J.; Owen, T; Zheng, B; Kemshetti, S.; Looney, RJ.; Sanz, I.

Arthritis & Rheumatism. 2007; 56(9): 3004-3056.

Nicholas, M.W.; Dooley, M.S.; Hogan, S.; Anolik, J.; Looney, R.J.; Sanz, I.; Clarke, S.H.

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

2007; 56: 3004-3056.

Vaccine responses in patients with rheumatoid arthritis

Ravikumar, R.; Anolik, J.; Looney, R.

Current Rheumatology Reports. 2007; 9(5): 407-415.

B cell depletion therapy in systemic rheumatic diseases: different strokes for different folks?

Stohl W, Looney RJ

Clinical immunology : the official journal of the Clinical Immunology Society.. 2006 October 121 (1):1-12. Epub 05/11/2006.

Autoimmunity and bone.

Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT

Annals of the New York Academy of Sciences.. 2006 April 1068 :275-83. Epub 1900 01 01.

New therapies for systemic lupus erythematosus: cellular targets.

Looney RJ, Anolik J, Sanz I

Rheumatic diseases clinics of North America.. 2006 February 32 (1):201-15, xi. Epub 1900 01 01.

Periprosthetic osteolysis: an immunologist's update.

Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ

Current opinion in rheumatology.. 2006 January 18 (1):80-7. Epub 1900 01 01.

Autoimmunity and bone

Schwarz, EM.; Looney, RJ.; Drissi, H.; O'Keefe, RJ.; Boyce, BF.; Zing, L.; Ritchlin, CT.

Annals of the New York Academy of Science. 2006; 1068: 275-283.

B cell-targeted therapy for rheumatoid arthritis: an update on the evidence

Looney, R.J.

Drugs. 2006; 66: 325-339.

Use of intravenous immunoglobulin G (IVIG).

Looney RJ, Huggins J

Best practice & research. Clinical haematology.. 2006 19 (1):3-25. Epub 1900 01 01.

B cell-targeted therapy for rheumatoid arthritis: an update on the evidence.

Looney RJ

Drugs.. 2006 66 (5):625-39. Epub 1900 01 01.

The therapeutic potential of anti-CD20 "what do B-cells do?".

Eisenberg R, Looney RJ

Clinical immunology : the official journal of the Clinical Immunology Society.. 2005 December 117 (3):207-13. Epub 09/19/2005.

Discovering that B cells are important in rheumatoid arthritis.

Looney RJ

The Journal of rheumatology.. 2005 November 32 (11):2067-9. Epub 1900 01 01.

Receptor activator of nuclear kappa ligand and osteoprotegerin: where are we now and what about future treatment uses?

Schwarz, EM.; O'Keefe, RJ.; Zing, L.; Looney, RJ.; Ritchlin, CT.

Current Opinion in Orthopedics. 2005; 16: 370-375.

Treatment of SLE with anti-CD20 monoclonal antibody.

Looney RJ, Anolik J, Sanz I

Current directions in autoimmunity. 2005 8 :193-205. Epub 1900 01 01.

Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus.

Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I

Arthritis and rheumatism.. 2004 November 50 (11):3580-90. Epub 1900 01 01.

Allergen immunotherapy.

Huggins JL, Looney RJ

American family physician.. 2004 August 1570 (4):689-96. Epub 1900 01 01.

B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab.

Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I

Arthritis and rheumatism.. 2004 August 50 (8):2580-9. Epub 1900 01 01.

A successful challenge in a patient with vancomycin-induced linear IgA dermatosis.

Joshi S, Scott G, Looney RJ

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2004 July 93 (1):101-3. Epub 1900 01 01.

B cells as therapeutic targets for rheumatic diseases.

Looney RJ, Anolik J, Sanz I

Current opinion in rheumatology.. 2004 May 16 (3):180-5. Epub 1900 01 01.

Computed tomography to assess pelvic lysis after total hip replacement.

Claus AM, Totterman SM, Sychterz CJ, Tamez-Peña JG, Looney RJ, Engh CA

Clinical orthopaedics and related research.. 2004 May (422):167-74. Epub 1900 01 01.

Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L

Arthritis and rheumatism.. 2004 January 50 (1):265-76. Epub 1900 01 01.

RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis

Ritchlin, CT.; Schwarz, EM.; O'Keefe, RJ.; Looney, RJ.

Journal of Musculoskeletal Neuronal Interaction. 2004; 4: 276-284.

B lymphocytes in systemic lupus erythematosus: lessons from therapy targeting B cells.

Looney RJ, Anolik J, Sanz I

Lupus.. 2004 13 (5):381-90. Epub 1900 01 01.

Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo.

Schwarz EM, Campbell D, Totterman S, Boyd A, O'Keefe RJ, Looney RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 November 21 (6):1049-55. Epub 1900 01 01.

B cell depletion therapy in systemic lupus erythematosus.

Anolik J, Sanz I, Looney RJ

Current rheumatology reports.. 2003 October 5 (5):350-6. Epub 1900 01 01.

Down-regulation of CD20 on B cells upon CD40 activation.

Anolik J, Looney RJ, Bottaro A, Sanz I, Young F

European journal of immunology.. 2003 September 33 (9):2398-409. Epub 1900 01 01.

The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus.

Anolik JH, Campbell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ

Arthritis and rheumatism.. 2003 February 48 (2):455-9. Epub 1900 01 01.

Treating human autoimmune disease by depleting B cells.

Looney RJ

Annals of the rheumatic diseases.. 2002 October 61 (10):863-6. Epub 1900 01 01.

Effect of aging on cytokine production in response to respiratory syncytial virus infection.

Looney RJ, Falsey AR, Walsh E, Campbell D

The Journal of infectious diseases.. 2002 March 1185 (5):682-5. Epub 02/14/2002.

Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear

Looney,R. J.; Boyd,A.; Totterman,S.; Seo,G. S.; Tamez-Pena,J.; Campbell,D.; Novotny,L.; Olcott,C.; Martell,J.; Hayes,F. A.; O'Keefe,R. J.; Schwarz,E. M.

Arthritis Research (Print). 2002; 4(1): 59,63.

Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear.

Looney RJ, Boyd A, Totterman S, Seo GS, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM

Arthritis research.. 2002 4 (1):59-63. Epub 10/03/2001.

Response of C-reactive protein and serum amyloid A to influenza A infection in older adults.

Falsey AR, Walsh EE, Francis CW, Looney RJ, Kolassa JE, Hall WJ, Abraham GN

The Journal of infectious diseases.. 2001 April 1183 (7):995-9. Epub 02/23/2001.

Hepatitis B immunization of healthy elderly adults: relationship between naïve CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant.

Looney RJ, Hasan MS, Coffin D, Campbell D, Falsey AR, Kolassa J, Agosti JM, Abraham GN, Evans TG

Journal of clinical immunology.. 2001 January 21 (1):30-6. Epub 1900 01 01.

Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components

Pollice,P. F.; Rosier,R. N.; Looney,R. J.; Puzas,J. E.; Schwarz,E. M.; O'Keefe,R. J.

Journal of Bone and Joint Surgery. American volume. 2001; : 1057,1061.

Effects of interleukin-15 on in vitro human T cell proliferation and activation.

Hasan MS, Kallas EG, Thomas EK, Looney J, Campbell M, Evans TG

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.. 2000 February 20 (2):119-23. Epub 1900 01 01.

Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis

Schwarz,E. M.; Looney,R. J.; O'Keefe,R. J.

Arthritis Research (Print). 2000; 2(3): 165,168.

Comparison of respiratory syncytial virus humoral immunity and response to infection in young and elderly adults.

Falsey AR, Walsh EE, Looney RJ, Kolassa JE, Formica MA, Criddle MC, Hall WJ

Journal of medical virology.. 1999 October 59 (2):221-6. Epub 1900 01 01.

Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis.

Hooper M, Kallas EG, Coffin D, Campbell D, Evans TG, Looney RJ

The Journal of rheumatology.. 1999 July 26 (7):1452-7. Epub 1900 01 01.

Expansion of the CD57 subset of CD8 T cells in HIV-1 infection is related to CMV serostatus.

Evans TG, Kallas EG, Luque AE, Menegus M, McNair C, Looney RJ

AIDS.. 1999 June 1813 (9):1139-41. Epub 1900 01 01.

Role of cytomegalovirus in the T cell changes seen in elderly individuals.

Looney RJ, Falsey A, Campbell D, Torres A, Kolassa J, Brower C, McCann R, Menegus M, McCormick K, Frampton M, Hall W, Abraham GN

Clinical immunology : the official journal of the Clinical Immunology Society.. 1999 February 90 (2):213-9. Epub 1900 01 01.

Patterns of cytokine production in psoriatic synovium.

Ritchlin C, Haas-Smith SA, Hicks D, Cappuccio J, Osterland CK, Looney RJ

The Journal of rheumatology.. 1998 August 25 (8):1544-52. Epub 1900 01 01.

Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects.

Looney RJ, Frampton MW, Byam J, Kenaga C, Speers DM, Cox C, Mast R, Klykken PC, Morrow PE, Utell MJ

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 August 44 (2):214-20. Epub 1900 01 01.

Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: implications for tolerance and immunotherapy.

Wei C, Willis RA, Tilton BR, Looney RJ, Lord EM, Barth RK, Frelinger JG

Proceedings of the National Academy of Sciences of the United States of America.. 1997 June 1094 (12):6369-74. Epub 1900 01 01.

Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone

Torres,A.; Utell,M. J.; Morow,P. E.; Voter,K. Z.; Whitin,J. C.; Cox,C.; Looney,R. J.; Speers,D. M.; Tsai,Y.; Frampton,M. W.

American Journal of Respiratory and Critical Care Medicine : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1997; 156: 728,736.

Regulation of IgE and cytokine production by cAMP: implications for extrinsic asthma.

Fedyk ER, Adawi A, Looney RJ, Phipps RP

Clinical immunology and immunopathology.. 1996 November 81 (2):101-13. Epub 1900 01 01.

Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes.

Wei C, Storozynsky E, McAdam AJ, Yeh KY, Tilton BR, Willis RA, Barth RK, Looney RJ, Lord EM, Frelinger JG

Cancer immunology, immunotherapy : CII.. 1996 July 42 (6):362-8. Epub 1900 01 01.

Allergic reactions to cyclophosphamide: delayed clinical expression associated with positive immediate skin tests to drug metabolites in five patients.

Popescu NA, Sheehan MG, Kouides PA, Loughner JE, Condemi JJ, Looney RJ, Leddy JP

The Journal of allergy and clinical immunology.. 1996 January 97 (1 Pt 1):26-33. Epub 1900 01 01.

Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles

Blaine,T. A.; Rosier,R. N.; Puzas,J. E.; Looney,R. J.; Reynolds,P. R.; Reynolds,S. D.; O'Keefe,R. J.

Journal of Bone and Joint Surgery. American volume. 1996; 78(8): 1181,1192.

Environmentally induced asthma.

Utell MJ, Looney RJ

Toxicology letters.. 1995 December 82-83 :47-53. Epub 1900 01 01.

CD40 expression by human fibroblasts.

Fries KM, Sempowski GD, Gaspari AA, Blieden T, Looney RJ, Phipps RP

Clinical immunology and immunopathology.. 1995 October 77 (1):42-51. Epub 1900 01 01.

Costimulatory activity of human synovial fibroblasts.

Looney RJ, Hooper M, Pudiak D

The Journal of rheumatology.. 1995 October 22 (10):1820-4. Epub 1900 01 01.

Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis.

Fries KM, Blieden T, Looney RJ, Sempowski GD, Silvera MR, Willis RA, Phipps RP

Clinical immunology and immunopathology.. 1994 September 72 (3):283-92. Epub 1900 01 01.

Protein tyrosine phosphorylation triggered by human Fc gamma RII.

Liu Z, Pudiak D, Looney RJ

Biochemical and biophysical research communications.. 1994 June 15201 (2):829-34. Epub 1900 01 01.

Cytokine production by mite-specific T cells from donors with mild atopic disease.

Looney RJ, Pudiak D, Rosenfeld SI

The Journal of allergy and clinical immunology.. 1994 February 93 (2):476-83. Epub 1900 01 01.

Accumulation of interferon gamma-producing TH1 helper T cells in nasal polyps

Miller,C. H.; Pudiak,D. R.; Hatem,F.; Looney,R. J.

Otolaryngology and head and neck surgery. 1994; 111(1): 51,58.

Expression of membrane antigens on human alveolar macrophages after exposure to nitrogen dioxide

Gavras, JB.; Frampton, MW.; Ryan, DH.; Levy, PC; Looney, RJ.; Cox, C.; Morrow, PE.; Utell, MJ.

Inhalation Toxicology. 1994; 6: 633-647.

Structure and function of human and mouse Fc gamma RII.

Looney RJ

Blood cells. 1993 19 (2):353-9. Epub 1900 01 01.

Characterization of human alveolar macrophage Fc gamma receptor III: a transmembrane glycoprotein that is shed under in vitro culture conditions

Levy,P. C.; Utell,M. J.; Fleit,H. B.; Roberts,N. J.,Jr; Ryan,D. H.; Looney,R. J.

American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1991; 5(4): 307,314.

Alveolar and peritoneal macrophages bear three distinct classes of Fc receptors for IgG.

Anderson CL, Looney RJ, Culp DJ, Ryan DH, Fleit HB, Utell MJ, Frampton MW, Manganiello PD, Guyre PM

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 July 1145 (1):196-201. Epub 1900 01 01.

An 80,000-kd glycoprotein cell surface antigen found only on nonhematopoietic cells in human bone marrow.

Iyer J, Duerst RE, Looney JN, Humphries RK, Abboud CN, Frantz CN

Experimental hematology.. 1990 June 18 (5):384-9. Epub 1900 01 01.

Human alveolar macrophage FcR-mediated cytotoxicity. Heteroantibody- versus conventional antibody-mediated target cell lysis.

Levy PC, Looney RJ, Shen L, Graziano RF, Fanger MW, Roberts NJ, Ryan DH, Utell MJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 May 15144 (10):3693-700. Epub 1900 01 01.

Fc gamma R-mediated killing by eosinophils.

Graziano RF, Looney RJ, Shen L, Fanger MW

The Journal of immunology : official journal of the American Association of Immunologists.. 1989 January 1142 (1):230-5. Epub 1900 01 01.

Structural polymorphism of the human platelet Fc gamma receptor.

Looney RJ, Anderson CL, Ryan DH, Rosenfeld SI

The Journal of immunology : official journal of the American Association of Immunologists.. 1988 October 15141 (8):2680-3. Epub 1900 01 01.

Expression of IgG Fc receptors in myeloid leukemic cell lines. Effect of colony-stimulating factors and cytokines.

Liesveld JL, Abboud CN, Looney RJ, Ryan DH, Brennan JK

The Journal of immunology : official journal of the American Association of Immunologists.. 1988 March 1140 (5):1527-33. Epub 1900 01 01.

Human Fc gamma receptors: stable inter-donor variation in quantitative expression on platelets correlates with functional responses.

Rosenfeld SI, Ryan DH, Looney RJ, Anderson CL, Abraham GN, Leddy JP

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 May 1138 (9):2869-73. Epub 1900 01 01.

Structural polymorphism of the human monocyte 40 kilodalton Fc receptor for IgG.

Anderson CL, Ryan DH, Looney RJ, Leary PC

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 April 1138 (7):2254-6. Epub 1900 01 01.

Immunoglobulin G Fc receptors of human leukocytes.

Anderson CL, Looney RJ

Methods in enzymology.. 1987 150 :524-36. Epub 1900 01 01.

Role of the Vi antigen of Salmonella typhi in resistance to host defense in vitro.

Looney RJ, Steigbigel RT

The Journal of laboratory and clinical medicine.. 1986 November 108 (5):506-16. Epub 1900 01 01.

The valence for ligand of the human mononuclear phagocyte 72 kD high-affinity IgG Fc receptor is one.

O'Grady JH, Looney RJ, Anderson CL

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 October 1137 (7):2307-10. Epub 1900 01 01.

Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line.

Anderson CL, Guyre PM, Whitin JC, Ryan DH, Looney RJ, Fanger MW

The Journal of biological chemistry.. 1986 September 25261 (27):12856-64. Epub 1900 01 01.

The low affinity 40,000 Fc gamma receptor and the transferrin receptor can be alternative or simultaneous target structures on cells sensitive for natural killing.

Perl A, Looney RJ, Ryan DH, Abraham GN

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 June 15136 (12):4714-20. Epub 1900 01 01.

Identification of a second class of IgG Fc receptors on human neutrophils. A 40 kilodalton molecule also found on eosinophils.

Looney RJ, Ryan DH, Takahashi K, Fleit HB, Cohen HJ, Abraham GN, Anderson CL

The Journal of experimental medicine.. 1986 April 1163 (4):826-36. Epub 1900 01 01.

Human monocytes and U937 cells bear two distinct Fc receptors for IgG.

Looney RJ, Abraham GN, Anderson CL

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 March 1136 (5):1641-7. Epub 1900 01 01.

The V kappa IIIb light chain sub-subgroup. II. Isotype expression in acquired hypogammaglobulinaemia and as a function of age.

Moynihan JA, Looney RJ, Abraham GN

Immunology.. 1986 February 57 (2):325-7. Epub 1900 01 01.

Human leukocyte IgG Fc receptors

Anderson, CL.; Looney, RJ.

Immunology Today. 1986; 7: 264-266.

Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes.

Rosenfeld SI, Looney RJ, Leddy JP, Phipps DC, Abraham GN, Anderson CL

The Journal of clinical investigation.. 1985 December 76 (6):2317-22. Epub 1900 01 01.

Two distinct classes of IgG Fc receptors on a human monocyte line (U937) defined by differences in binding of murine IgG subclasses at low ionic strength.

Jones DH, Looney RJ, Anderson CL

The Journal of immunology : official journal of the American Association of Immunologists.. 1985 November 135 (5):3348-53. Epub 1900 01 01.

The VKIIIb light chain sub-subgroup: restricted association with mu heavy chain in normal human serum.

Moynihan JA, Looney RJ, Abraham GN

Immunology.. 1985 February 54 (2):207-13. Epub 1900 01 01.

The Fc portion of intact IgG blocks stimulation of human PBMC by anti-T3.

Looney RJ, Abraham GN

The Journal of immunology : official journal of the American Association of Immunologists.. 1984 July 133 (1):154-6. Epub 1900 01 01.

Books

Functional Tissue Engineering (2004)

Chapter: Assessment of the performance of engineered tissues in human requires the development of high sensitivity and quantitative outcome measures

Authors: O'Keefe, RJ; Totterman, S; Schwarz, EM; Looney, RJ; Seo, GS; Tamez-Pena, J; Boyd, A; Bukata, S; Monu, J; Parker, K

Publisher: Springer 2004

Immunologic Disorders in Infants and Children (2004)

Chapter: The B cell System

Authors: Insel, R; Looney, RJ

Publisher: abc 2004

Textbook of Pulmonary Medicine (2003)

Chapter: Occupational Asthma and Industrial Bronchitis

Authors: RJ Looney, MJ Utell

Publisher: Lippincott Raven Publishers 2003

Textbook of Pulmonary Medicine (1998)

Chapter: Occupational Asthma and Industrial Bronchitis

Authors: RJ Looney, MJ Utell

Publisher: Lippincott Raven Publishers 1998

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.

Ratings

During this visit, did this provider spend enough time with you?

4.7 stars

During this visit, did this provider show respect for what you had to say?

4.8 stars

During this visit, did this provider give you easy to understand information about these health questions or concerns?

4.8 stars

During this visit, did this provider listen carefully to you?

4.8 stars

During this visit, did this provider explain things in a way that was easy to understand?

4.8 stars

Patient Comments

5.0 stars

All good

Mar 27, 2024

Dr. Looney is fantastic. He listens and takes his time to explain.

Mar 27, 2024

5.0 stars

Dr. Looney is one of the best!

Feb 15, 2024

Dr Looney is always a concerned physician who wants to be sure his patient understands what is happening with them.

Dec 01, 2023

5.0 stars

Dr. Looney is excellent at putting medical puzzle pieces in place. Excellent

Oct 18, 2023

5.0 stars

Dr.Looney is one of the best physicians I have ever had. I totally trust him with my care. He is very knowledgable and personable.

Oct 03, 2023

Dr. Looney is very easy to talk with, answering all my questions and concerns.

Sep 06, 2023

5.0 stars

Dr. Looney is an incredible specialist!! Immunologist!! I would not have been up waking around, if I had not been referred to him for my disease!

Aug 15, 2023

5.0 stars

Dr. Looney was very easy to discuss health and mobility issues with which I am very concerned at this point. He arranged for certain tests. All the personnel involved were professional, kind and polite. The atmosphere and building was quiet, clean, safe and secure, professional.

Aug 08, 2023

5.0 stars

Yes I would recommend it to my friends

Jul 13, 2023

5.0

Dr Looney is the best!

Jul 13, 2023

5.0

Dr. Looney is ver personable, listened , really listened to my concerns.

Jul 09, 2023

5.0

Dr. Looney showed me respect and reassurance. ALWAYS a positive experience. So blessed to have him for my care!

Jun 14, 2023

5.0

Dr. Looney is an amazing doctor. It is rare to find someone so knowledgeable and kind. He is top-notch.

Jun 08, 2023

5.0

We feel fortunate to be under Dr. Looney's care. My daughter has autism and learning disabilities, and can be unwilling to cooperate at times. But the doctor is so kind and soft-spoken that he typically obtains the information he needs.

Jun 01, 2023

2.2

Provider lacks empathy and seems dismissive

May 03, 2023

3.0

Excellent doctor [...]

Apr 15, 2023

5.0

RARE QUALITY MD - VERY APPRECIATED EXPERTISE AND COMMUNICATION "SYLE". EXCELLENT FOLLOW UP,

Mar 30, 2023

4.2

Dr Looney is the best

Jan 12, 2023

5.0

Dr. Looney explained everything, and educated us on reasons for condition - EXCELLENT dr.

Dec 20, 2022

5.0

Appreciated the thorough old-fashioned approach. Unlike many physicians now, who are obligated to focus on the EMR, he actually did the history by listening and taking notes on a sheet of paper as it should be. Too many physicians are forced by the health care system to be data-entry clerks and typists rather than physicians, and Dr Looney fortunately does NOT do that. That should be the goal of UR medicine for all physicians.

Dec 07, 2022

1.8

Dismissive and rushed me out the door. I left feeling worse than when I came. I will only see my regular allergist after this visit.

Sep 01, 2022

5.0

We're grateful for all good experiences.

Aug 27, 2022

5.0

Dr Looney an excellent Dr

Jul 05, 2022

5.0

My team of doctors communicated with each other and got me in immediately after assessing my condition.

Jun 13, 2022

5.0

Dr. Looney is fantastic! Very considerate & explained everything.

Apr 18, 2022

5.0

Very good

Apr 07, 2022