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Anthony P. Pietropaoli, M.D.

Anthony P. Pietropaoli, M.D.

Pulmonary & Critical Care Medicine

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
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About Me

Professional Background

Dr. Anthony Pietropaoli was born and raised in Rochester, NY. He graduated from the College of the Holy Cross ith a B.A. degree, majoring in English & Pre-medical studies. He attended Upstate Medical University and then moved to Pittsburgh for internship, residency, and chief residency in Internal...
Dr. Anthony Pietropaoli was born and raised in Rochester, NY. He graduated from the College of the Holy Cross ith a B.A. degree, majoring in English & Pre-medical studies. He attended Upstate Medical University and then moved to Pittsburgh for internship, residency, and chief residency in Internal Medicine. Dr. Pietropaoli spent two years practicing General Internal Medicine before making the decision to specialize in Pulmonary & Critic al Care Medicine. He completed this fellowship at the University of Rochester in 1999, joining the faculty thereafter. He has served a number of roles in the division and medical center, currently directing the Medical Intensive Care Unit, the Respiratory Therapy Department, and the Pulmonary Rehabilitation Program. His clinical interests broad, but he spends most of his clinical time on all things critical care, pleural disease, and pulmonary rehabilitation.

Certified Specialties

Critical Care Medicine - American Board of Internal Medicine

Internal Medicine - American Board of Internal Medicine

Pulmonary Disease - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Credentials

Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 1996 - 1999

Residency, Internal Medicine, University of Pittsburgh Medical Center. 1991 - 1994

Internship, Internal Medicine, University of Pittsburgh Medical Center. 1990 - 1991

Education

MD | Suny Health Science Center At Syracuse. 1990

Awards

Highland Medicine Teaching Award. 2016

Arthur W. Bauman Teaching Award (for outstanding educational contributions to the Internal Medicine Residency Program). 2015

Lawrence A. Kohn Senior Teaching Fellow Award. 2005 - 2007

America's Top Physicians. 2003 - 2005

Best Doctors in America. 2003

Arthur W. Bauman Teaching Award (for outstanding educational contributions to the Internal Medicine Residency Program). 2003

Fellow, American College of Chest Physicians. 2001

Young Leaders in Pulmonary Medicine. 2001

Selected participant, Symposium on Leadership Development in Pulmonary & Critical Care Medicine. 2001

Alpha Omega Alpha Medical Honor Society. 1990 - 2007

Research

Dr. Pietropaoli developed and leads a critical care translational research program at the University of Rochester. During this time we have enrolled over 500 critically ill patients and volunteers in our cohort studies, made new observations about the relationships between NO metabolism, red blood c...
Dr. Pietropaoli developed and leads a critical care translational research program at the University of Rochester. During this time we have enrolled over 500 critically ill patients and volunteers in our cohort studies, made new observations about the relationships between NO metabolism, red blood cell dysfunction, neutrophil dysfunction, vascular function, and clinical outcomes, and forged strong collaborations with clinical and basic science investigators across a number of university departments.

Dr. Pietropaoli also collaborates with investigators in laboratory and transfusion medicine investigating the "storage lesion" that develops in banked blood and clinical outcomes in critically ill transfusion recipients.

Dr. Pietropaoli also investigates the epidemiology of critical care medicine. He is the UR principal investigator for the Critical Illness Outcomes Study, a nationwide cohort study involving over 6,000 patients in 69 U.S. ICUs designed to examine relationships between patient characteristics, ICU characteristics, and mortality

Dr. Pietropaoli's long-term goal is to nurture the growth and productivity of this comprehensive, multidisciplinary critical care research program, promoting new discoveries that improve outcomes for our critically ill population.

Research Lab

Pietropaoli Lab

Visit Lab Website

Clinical Trials

SEVERE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME COHORT STUDY 

Lead Researcher: Anthony P Pietropaoli

An observational research study of subjects admitted to the ICU with severe SIRS (and/or sepsis). For ICU subjects enrolled, the study involves blood and urine testing and research measurements of blood flow using ultrasound. At selected time poi...

Publications

Journal Articles

SWEAT ICU-An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs.

Agarwal A, Chen JT, Coopersmith CM, Denson JL, Dickert NW, Ferrante LE, Gershengorn HB, Gosine AD, Hayward BJ, Kaur N, Khan A, Lamberton C, Landsittel D, Lyons PG, Mikkelsen ME, Nadig NR, Pietropaoli AP, Poole BR, Viglianti EM, Sevransky JE

Critical care explorations.. 2022 October 4 (10):e0774. Epub 10/13/2022.

Disparities in Lung-Protective Ventilation in the United States.

Malnoske ML, Quill CM, Barwise AK, Pietropaoli AP

Cure?us.. 2022 October 14 (10):e29834. Epub 10/02/2022.

Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality.

Trzeciak A, Mongre RK, Kim MR, Lim K, Madero RA, Parkhurst CN, Pietropaoli AP, Kim M

Frontiers in immunology.. 2022 13 :965305. Epub 08/02/2022.

Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis.

Trzeciak A, Pietropaoli AP, Kim M

Immune network.. 2020 June 20 (3):e23. Epub 06/22/2020.

Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.

Pietropaoli AP, Henrichs KF, Cholette JM, Spinelli SL, Phipps RP, Refaai MA, Blumberg N

Transfusion.. 2019 February 27 Epub 02/27/2019.

Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Gensini F, Rubenstein JS, Sweeney D, Phipps R, Spinelli SL, Refaai MA, Eaton MP, Blumberg N

Transfusion.. 2018 July 58 (7):1631-1639. Epub 03/30/2018.

0.9% NaCl (Normal Saline) - Perhaps not so normal after all?

Blumberg N, Cholette JM, Pietropaoli AP, Phipps R, Spinelli SL, Eaton MP, Noronha SA, Seghatchian J, Heal JM, Refaai MA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2018 February 57 (1):127-131. Epub 02/21/2018.

Methionine Metabolites in Patients With Sepsis.

Wexler O, Gough MS, Morgan MA, Mack CM, Apostolakos MJ, Doolin KP, Mooney RA, Arning E, Bottiglieri T, Pietropaoli AP

Journal of intensive care medicine.. 2018 January 33 (1):37-47. Epub 09/02/2016.

Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Blumberg N, Cholette JM, Schmidt AE, Phipps RP, Spinelli SL, Heal JM, Pietropaoli AP, Refaai MA, Sime PJ

Transfusion medicine reviews.. 2017 October 31 (4):252-257. Epub 05/04/2017.

Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study.

Tsang G, Insel MB, Weis JM, Morgan MA, Gough MS, Frasier LM, Mack CM, Doolin KP, Graves BT, Apostolakos MJ, Pietropaoli AP

Critical care : the official journal of the Critical Care Forum.. 2016 October 2120 (1):335. Epub 10/21/2016.

Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study.

Sevransky JE, Checkley W, Herrera P, Pickering BW, Barr J, Brown SM, Chang SY, Chong D, Kaufman D, Fremont RD, Girard TD, Hoag J, Johnson SB, Kerlin MP, Liebler J, O'Brien J, O'Keefe T, Park PK, Pastores SM, Patil N, Pietropaoli AP, Putman M, Rice TW, Rotello L, Siner J, Sajid S, Murphy DJ, Martin GS,

Critical care medicine.. 2015 October 43 (10):2076-84. Epub 1900 01 01.

Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spineli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Blumberg N

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.. 2015 March 16 (3):227-35. Epub 1900 01 01.

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent.

Lerman YV, Lim K, Hyun YM, Falkner KL, Yang H, Pietropaoli AP, Sonnenberg A, Sarangi PP, Kim M

Blood.. 2014 December 4124 (24):3515-23. Epub 10/02/2014.

Inhalation of ultrafine carbon particles alters heart rate and heart rate variability in people with type 2 diabetes.

Vora R, Zareba W, Utell MJ, Pietropaoli AP, Chalupa D, Little EL, Oakes D, Bausch J, Wiltshire J, Frampton MW

Particle and fibre toxicology.. 2014 July 1611 :31. Epub 07/16/2014.

RBC dysfunction in critical illness: driven by complement?

Pietropaoli AP, Wexler O

Critical care medicine.. 2014 May 42 (5):1323-4. Epub 1900 01 01.

Brachial artery reactivity in patients with severe sepsis: an observational study.

Wexler O, Morgan MA, Gough MS, Steinmetz SD, Mack CM, Darling DC, Doolin KP, Apostolakos MJ, Graves BT, Frampton MW, Chen X, Pietropaoli AP

Critical care : the official journal of the Critical Care Forum.. 2012 December 1216 (2):R38. Epub 12/12/2012.

Role of ?1 integrin in tissue homing of neutrophils during sepsis.

Sarangi PP, Hyun YM, Lerman YV, Pietropaoli AP, Kim M

Shock.. 2012 August 38 (3):281-7. Epub 1900 01 01.

The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis.

Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP

Critical care medicine.. 2011 June 39 (6):1351-8. Epub 1900 01 01.

Vascular effects of ultrafine particles in persons with type 2 diabetes.

Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW

Environmental health perspectives.. 2010 December 118 (12):1692-8. Epub 09/07/2010.

Gender differences in mortality in patients with severe sepsis or septic shock.

Pietropaoli AP, Glance LG, Oakes D, Fisher SG

Gender medicine.. 2010 October 7 (5):422-37. Epub 1900 01 01.

Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis.

Morgan MA, Frasier LM, Stewart JC, Mack CM, Gough MS, Graves BT, Apostolakos MJ, Doolin KP, Darling DC, Frampton MW, Pietropaoli AP

Critical care medicine.. 2010 April 38 (4):1069-77. Epub 1900 01 01.

Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects.

Shah AP, Pietropaoli AP, Frasier LM, Speers DM, Chalupa DC, Delehanty JM, Huang LS, Utell MJ, Frampton MW

Environmental health perspectives.. 2008 March 116 (3):375-80. Epub 1900 01 01.

Smokers have reduced nitric oxide production by conducting airways but normal levels in the alveoli.

Pietropaoli AP, Perillo IB, Perkins PT, Frasier LM, Speers DM, Frampton MW, Utell MJ, Hyde RW

Inhalation toxicology.. 2007 May 19 (6-7):533-41. Epub 1900 01 01.

Smokers have reduced nitric oxide production by conducting airways but normal levels in the alveoli

Pietropaoli, AP; IB Perillo; PT Perkins; LM Frasier; DM Speers; MW Frampton; MJ Utell; MW Frampton; RW Hyde.

Inhal. Toxicol.19(6-7): 533-541. 2007; 19(6-7): 533-541.

Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans.

Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ

Environmental health perspectives.. 2006 January 114 (1):51-8. Epub 1900 01 01.

Changes in markers of epithelial permeability and inflammation in chronic smokers switching to a nonburning tobacco device (Eclipse)

Stewart JC; Hyde RW; Boscia J; Chow MY; O'Mara RE; Perillo I; Pietropaoli A; Smith CJ; Torres A; Utell MJ; Frampton MW.

Nicotine & Tobacco Research. 2006; 8(6): 773-783.

Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles.

Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ

Inhalation toxicology.. 2004 16 Suppl 1 :59-72. Epub 1900 01 01.

Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans.

Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE, Utell MJ, Frampton MW

Journal of applied physiology.. 2001 November 91 (5):1931-40. Epub 1900 01 01.

Exhaled nitric oxide does not provide a marker of vascular endothelial function in healthy humans.

Pietropaoli AP, Perkins PT, Perillo IB, Hyde RW

American journal of respiratory and critical care medicine.. 2000 June 161 (6):2113-4. Epub 1900 01 01.

Pathologic quiz case: infection in a patient with a cervical arteriovenous malformation.

Riesenfeld EP, Shan Y, Pietropaoli AP

Archives of pathology & laboratory medicine.. 2000 March 124 (3):466-8. Epub 1900 01 01.

Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans.

Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, Hyde RW

Journal of applied physiology.. 1999 October 87 (4):1532-42. Epub 1900 01 01.

Rate of nitric oxide production by lower alveolar airways of human lungs.

Geigel EJ, Hyde RW, Perillo IB, Torres A, Perkins PT, Pietropaoli AP, Frasier LM, Frampton MW, Utell MJ

Journal of applied physiology.. 1999 January 86 (1):211-21. Epub 1900 01 01.

Books

Toxicology of the Lung (2005)

Chapter: "Human Clinical Studies of Airborne Pollutants"

Authors: Frampton, MW, Pietropaoli, AP, Morrow, PE, Utell, MJ

Publisher: CRC Press, Taylor & Francis Group, Boca Raton 2005

Principles of Gender Specific Medicine (2004)

Chapter: "Gender Differences in the Sepsis Syndrome: Clinical Evidence and Potential Mechanisms"

Authors: Pietropaoli, AP

Publisher: Elsevier Academic Press, San Diego 2004

The ICU Manual (2001)

Chapter: "Approach to Mechanical Ventilation"

Authors: Pietropaoli, AP

Publisher: McGraw-HIll, New York 2001

Ratings & Reviews

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