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Guan Wu, M.D., Ph.D.

Guan Wu, M.D., Ph.D.

About Me

We are pleased to welcome Guan Wu, MD, PhD to the Department of Urology at the University of Rochester Medical Center. Dr. Wu has joined our growing research and clinical faculty, extending our knowledge and our ability to offer our patients the best care possible. Dr. Wu has been working on identif...
We are pleased to welcome Guan Wu, MD, PhD to the Department of Urology at the University of Rochester Medical Center. Dr. Wu has joined our growing research and clinical faculty, extending our knowledge and our ability to offer our patients the best care possible. Dr. Wu has been working on identifying and characterizing biochemical defects in kidney cancer cells. His laboratory is also analyzing the genetics of human kidney cancer specimens, specifically to identify tumor markers.

Dr. Wu is performing minimally invasive and robotic surgery and also sees general urology patients in our offices in Canandaigua, Clifton Springs and Rochester. He specializes in laparoscopic surgery, general urology and kidney cancer research.

Dr. Wu is a double doctorate graduate of the Beijing Medical University School of Medicine. He also completed his post-doctoral training at the University of Iowa Hospital and Strong Memorial Hospital. His dual residencies allow him to see surgical urology patients.

Faculty Appointments

Professor - Department of Urology (SMD)

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Residency, Urology, University of Rochester School of Medicine GME. 2002 - 2006

Residency, Surgery (General Surgery), University of Rochester School of Medicine GME. 2001 - 2002

Internship, Surgery (General Surgery), University of Rochester School of Medicine GME. 2000 - 2001

Education

MD | Beijing Medical University (China). 1983

Awards

China Natural Science Foundation Award. 2015

The Robert S. Davis, M.D. Faculty Teaching Award. 2011

Honorary Director of the Department of Urology. 2011

America's Top Doctor. 2011

AUA Foundation M.D. / Ph.D. Research Award. 2011

Honored Visiting Professor of the Second Medical School and Tianjin Institute of Urology. 2008 - 2008

The AUA Northeastern Section Young Investigator Award. 2007 - 2007

China Natural Science Award. 2005

Praecis Pharmaceuticals/AUA Gerald P. Murphy Scholar. 2004 - 2004

China Natural Science Award. 2003

The Pfizer Scholars in Urology Award. 1996 - 1996

Smithkline-Beecham Travel Award. 1995 - 1995

Outstanding Graduate Student Award. 1985 - 1985

Outstanding Medical Student Award. 1982 - 1982

Research

The long-term goal of Dr. Wu's research is to refine our knowledge of the biology of kidney cancer. Currently, Dr. Wu's laboratory is studying genetic defects in kidney cancer cells and how these defects cause the disease.

Dr. Wu's laboratory has been working on the proteins produced by cance...
The long-term goal of Dr. Wu's research is to refine our knowledge of the biology of kidney cancer. Currently, Dr. Wu's laboratory is studying genetic defects in kidney cancer cells and how these defects cause the disease.

Dr. Wu's laboratory has been working on the proteins produced by cancer critical genes. He and his associates are learning how the cellular and biochemical functions of these proteins cause kidney cancer to develop and progress. Dr. Wu's laboratory has identified several such complexes by purifying them from kidney cancer cell lines and by using yeast as a human protein carrier. This research is not only extending our understanding of kidney cancer, but also has broader implications for normal cell physiology.

Dr. Wu's laboratory is also analyzing the genetics of human kidney cancer specimens to look into DNA mutations. This research will be combined with the studies done with kidney cancer cell lines. Together, they will help us discover and validate new "tumor markers" (substances produced by the body that can indicate the presence of a specific cancer). This, in turn, will help us develop new ways to diagnose and treat kidney cancer.

Publications

Journal Articles

EDITORIAL COMMENT.

Gurung PMS, Messing EM, Joseph JV, Wu G

Urology.. 2020 February 136 :110-111. Epub 1900 01 01.

Incorporation and validation of clinically relevant performance metrics of simulation (CRPMS) into a novel full-immersion simulation platform for nerve-sparing robot-assisted radical prostatectomy (NS-RARP) utilizing three-dimensional printing and hydrogel casting technology.

Witthaus MW; Farooq S2; Melnyk R; Campbell T; Saba P; Mathews E; Ezzat B; Ertefaie A; Frye TP; Wu G; Rashid H; Joseph JV; Ghazi A.

BJU Int. 2020; .

Lasers versus bipolar technology in the transurethral treatment of benign prostatic enlargement: a systematic review and meta-analysis of comparative studies.

Gu C; Zhou N; Gurung P; Kou Y;, Luo Y; Wang Y; Zhou H; Zhen C; Yang J; Tian F; Wu G.

World J Urol. 2020; .

Robot-assisted Placement of Pelvic Tissue Expander for Radiation After Prostatectomy and Cystectomy for Treatment of Prostate Cancer Biochemical Recurrence.

Quarrier SO;, Matloubieh JE; Wu G.

Urology. 2019; .

Metastatic prostate cancer mimicking a subdural hematoma: A case report and literature review.

Nunno A; Johnson MD; Wu G; Li YM.

J Clin Neurosci. 2018; .

Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial.

Messing EM; Tangen CM; Lerner SP; Sahasrabudhe DM;Koppie TM; Wood DP Jr; Mack PC; Svatek RS; Evans CP; Hafez KS; Culkin DJ; Brand TC; Karsh LI; Holzbeierlein JM; Wilson SS; Wu G; Plets M; Vogelzang NJ; Thompson IM Jr.

JAMA. 2018; .

The role of urinary cytology when diagnostic workup is suspicious for upper tract urothelial carcinoma but tumour biopsy is nonconfirmatory.

Horovitz D; Meng Y; Joseph JV; Feng C; Wu G; Rashid H;, Messing EM.

PLoS One. 2017; .

Robotic management of genito-urinary injuries from obstetrical and gynecological operations: a multi-institutional report of outcomes

Gellhaus, P,Rilly C, Llukani E, Lee Z, Rashid H, Ghazi, A, Joseph J, Wu G, Eun D, Boris R.

BJU Int. 2015; 115(3):430-6.

Effectiveness and safety of extended duration prophylaxis for venous thromboembolism in major urologic oncology surgery

Kukreja J, Levey HR, Scosyrev E, Kiernan M, Berrondo C, McNamee C, Wu G, Joseph J, Ghazi A, Rashid H, Dozier A, Messing EM.

Uro Oncol. 2015; 3(9):387.

Robot-assisted laparoscopic repair of vesicovaginal fistulas-a single center experience in 10 patients

Agrawal V, Kucherov V, Bendana E, Joseph J, Rashid H, Wu G.

Urology. 2015; 86(2):276-82.

Unilateral hypoplastic kidney and ureter associated with diverse mesonephric remnant hyperplasia

Xiao GQ, Jerome JG, Wu G.

Am J Clin Exp Urol. 2015; 3(2): 107-11.

Bladder cancer incidence and mortality in patients treated with radiation for uterine cancer

Kukreja JB, Scosyrev E, Messing EM, Wu G.

BJU Int. 2014; 114(6):844-51.

Folliculin-deficient renal cancer cells exhibit higher radiosensitivity through autophagic cell death

Zhang Q, Si S, Schoen S, Jin XB, Chen J, Wu G.

J Urol. 2014; 191(6): 1880-8.

Overall survival after partial versus radical nephrectomy for a small real mass: a systemic review of observational studies

Scosyrev E, Wu K, Levey H, Beckham C, Agrawal V, Wu G, Messing EM.

Urology Practice. 2014; 1: 27-34.

Preoperative fiducial coil placement facilitates robot-assisted laparoscopic excision of retroperitoneal small solitary metastasis of kidney cancer

Agrawal V, Sharma A, Wu G.

Urology. 2014; 84(5): e21-2.

International robotic radical cystectomy consortium: a way forward

Raza SJ, Field E, Kibel AS, Mottrie A, Weizer Az, Wagner A, Hermal AK, Scherr DS, Schanne F, Gaboardi F, Wu G, Peabody JO, Koauk J, Redorta JP, Pattaras JG, Rha KH, Richstone L, Balbay MD, Menon M Hayn M, Stoeckle M, Wiklund P, Dasgupta P, Pruthi R, Ghavamian R, Khan S, Siemer, S Maatman T, Wilson T, Poulakis V, Wilding G, Guru KA.

Indian J Urol. 2014; 30 (3): 314-7.

Robotic repair of post-cystectomy ureteroileal anastomotic strictures: Techniques for success

Tobis S, Houman J, Mastrodenato, K, Rashid H, Wu G.

J Laparoendosc Adv Surg Tech A. 2013; 23(6): 526-9.

The impact of frozen section analysis during partial nephrectomy on surgical margin status and tumor recurrence: A clinicopathologic study of 433 cases

Venigalla, S, Wu G, Miyamoto.

Clinical Genitourinary Cancer. 2013; 11(4):527-36.

Analysis of a large single-center experience with robot-assisted pyeloplasty

Tobis S, Venigalla S, Scosyrev E, Lloyd LG, Golijanin D, Joseph JV, Rashid H, Wu G.

Int J Urol. 2013; 20(2): 230-4.

Statin use and the risk of biochemical recurrence of prostate cancer after definitive local therapy

Scosyrev E, Donsky H, Tobis S, Wu G, Joseph J, Rashid H, Messing.

BJU Int. 2013; E111(3 Pt B): E71-7.

The Birt-Hogg-Dube tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis

Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li W.

Hum Mol Genet. 2013; 22(2): 284-99.

Role of frozen section analysis of surgical margins during robot-assisted laparoscopic radical prostatectomy: A 2,631-case experience

Kakiuchi Y, Choy B, Gordetsky J, Izumi K, Wu G, Rashid H, Joseph J, Miyamoto.

Hum Pathology. 2013; 44(8):1556-62.

Robot-assisted transumbilical laparoscopic single-site (R-LESS) pyeloplasty: Technique and perioperative outcomes

Tobis S, Houman J, Thomer M, Rashid H, Wu G.

J Laparoendosc Adv Surg Tech A. 2013; 23(8):702-6.

Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells

Zhang Q, Si S, Schoen S, Jin XB, Chen J, Wu G.

J Exp Clin Cancer Res. 2013; 32:99.

Non-bladder cancer mortality in patients with urothelial cancer of the bladder

Scosyrev E, Wu G, Golijanin D, Messing EM.

Urol Oncol. 2013; 20(2):230-4.

The burden of bladder cancer in men and women: analysis of the years of life lost

Scosyrev E, Golijanin D, Wu G, Messing EM.

BJU Int. 2012; 109(1): 57-62.

Prostate cancer in the elderly: Frequency of advanced disease at presentation and disease-specific mortality

Scosyrev E, Messing EM, Mohile S, Golijanin D, Wu G.

Cancer. 2012; 118(12): 3062-70.

Robot-assisted laparoscopic partial nephrectomy: Review of the first 100 cases from a single institution

Tobis S, Venigalla S, Knopf JK, Scosyrev E, Erturk E, Golijanin D, Joseph JV, Rashid H, Wu G.

J Robotic Surg. 2012; 6(2): 139-47.

Pelvic Angiomyolipoma

Nicholson TM, Lloyd GL, Wu G.

Urology. 2012; 79(2): 15-6.

Identifying additional lymph nodes in radical cystectomy specimens

Gordetsky J, Scosyrev E, Rashid H, Wu G, Silvers C, Golijanin D, Messing EM, Yao J.

Modern Pathology. 2012; 25(1): 140-144.

Near infrared fluorescence imaging following intravenous indocyanine green: initial clinical experience with open partial and radical nephrectomy of renal cortical tumors

Tobis S, Knopf JK, Marshall J, Cardin A, Silvers CR, Wood RR, Reeder JE, Erturk E, Yao J, Singer E, Madeb R, Rashid H, Wu G, Messing EM, Golijanin D.

Urology. 2012; 79(4): 958-964.

Mixed epithelial and stromal tumor of the kidney in a 14-year-old boy

Choy B, Gordetsky J, Varghese M, Lloyd G.L., Wu G, Miyamoto, H.

Urologia Internationalis. 2012; (88): 247-248.

Robot-assisted and pure laparoscopic partial nephrectomy with near infrared fluorescence imaging

Tobis S, Knopf JK, Silvers CR, Messing EM, Yao J, Rashid H, Wu G, Golijanin D.

Journal of Endourology. 2012; 26(7): 797-802.

Prostate-specific antigen screening for prostate cancer and the risk of overt metastatic disease at presentation: analysis of trends over time

Scosyrev E, Wu G, Mohile S, Messing EM.

Cancer. 2012; 118(23): 5768-5776.

Prostate-specific antigen testing in older men in the United States: Data from the behavioral risk factor surveillance system

Scosyrev E, Wu G, Golijanin D, Messing EM.

BJU Int. 2012; 110(10): 1485-90.

Regulation of RACK1 by the VHL tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness

He X, Wang J, Messing EM, Wu G.

Oncogene. 2011; 30 (5): 535-547.

The impact of robotics on treatment of localized prostate cancer and resident education in Rochester, New York

Madeb R, Golijanin, D, Knopf JK, Kowalczyk J, Feng C, Rashid H, Wu G, Eichel L, Valvo JR.

J Endourology. 2011; 25 (4).

Near infrared fluorescence imaging for the da Vinci Si Surgical System: Initial clinical experience with robot-assisted laparoscopic partial nephrectomy for renal cortical tumors

Tobis S, Knopf JK, Silvers C, Yao J, Rashid H, Wu G, Golijanin D.

J Urol. 2011; 186(1): 47-52.

Non-bladder cancer mortality in patients with urothelial cancer of the bladder

Scosyrev E, Golijanin D, Wu G, Messing EM.

Urol Oncol. 2011; .

Ureteritis Cystica: A radiologic pathologic correlation

Rothschild JG, Wu G.

J Clinical Imaging Science. 2011; 1(1): 23.

Single incision nephrectomy in an 8-year-old child using umbilical laparoendoscopic single-site surgery

Stoddard D, Marshall J, Wu G, Rashid H.

Can J Urol. 2010; 17 (3): 5226-8.

Midline crossing and Slit responsiveness of commissural axons require USP33

Yuasa-Kawada J, Kinoshita-Kawada M, Wu G, Rao Y, Wu JY.

Nat Neurosci. 2009; 12 (9): 1087-9.

Antopol-Goldman lesion of the kidney diagnosed by radiology: A case report of observation. Acta Radiologica

Cardin AL, Marshall J, Bhatt S, Erturk E, Wu G, Dogra VS.

2008; 49 (6): 715-7.

The VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1?

Li Z, Wang D, Messing EM, Wu G.

EMBO Reports. 2005; 6: 373-378.

The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the HGF-induced Erk-Elk-1-SRE pathway

Wang D, Li Z, Messing EM, Wu G.

J Biol Chem. 2005; 280: 16393-16401.

Analysis of two single nucleotide polymorphisms and loss of heterozygosity of the VHL gene in Chinese patients with sporadic renal cell carcinoma

Ning L, Gong K, Na X, Wu G, Na, YQ.

Chin Med J. 2005; 118: 1291-1294.

Laparoscopic radical prostatectomy following laparoscopic bilateral mesh hernia repair

Joseph JV, Madeb R, Wu G, Vicente I, Erturk E.

JSLS. 2005; E9: 368-9.

A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling

Wang D, Li Z, Schoen SR, Messing EM, Wu G.

Biochem Biophys Res Commun. 2004; 313: 320-326.

Expression of Ron proto-oncogene in renal oncocytoma and chromophobe renal cell carcinoma

Patton KD, Tretiakova MS, Yao JL, Papavero V, Huo L, Adley BP, Wu G, Huang J, Pins MR, Teh BT, Yang XJ.

Am J Surg Path. 2004; 28: 1045-1050.

The VHL protein recruits a novel KRAB-A domain protein to corepress HIF-1? transcriptional activity

Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G.

EMBO J. 2003; 22: 1857-1867.

Over production of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1? expression in renal cell carcinoma

Na X, Wu G, Ryan CK, Schoen SR, di Sant'Agnese PA, Messing EM.

Journal of Urology. 2003; 170: 588-592.

Deubiquitination of type 2 iodothyronine deiodinase by pVHL-interacting enzymes regulates thyroid hormone activation

Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BCG, Harney GW, Li Z, Wu G, Bianco A.

J Clin Invest. 2003; 112: 189-196.

Identification of the RNA polymerase II subunit HsRPB7 as a novel target of the von Hippel-Lindau protein

Na X, Duan HO, Messing EM, Schoen SR, Ryan CK, di Sant'Agnese PA, Golemis EA, Wu G.

EMBO J. 2003; 22: 4249-4259.

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G.

J Biol Chem. 2002; 277: 4656-4662.

Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study

Hsing AW, Chokkalingam AP, Gao YT, Wu G, Wang X, Deng J, Chen J, Sesterhenn IA, Mostofi FK, Chiang T, Chen YL, Stanczyk FZ, Chang C.

Cancer Epidemiol Biomarkers Prev. 2002; 11: 337-341.

Suppression of androgen receptor transactivation by Pyk2 via interaction an phosphorylation of the ARA55 coregulator

Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C.

J Biol Chem. 2002; 277: 15426-15431.

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor

Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G.

Biochem Biophys Res Commun. 2002; 294: 700-709.

Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM

Wang D, Li Z, Messing EM, Wu G.

J Biol Chem. 2002; 277: 36216-36222.

Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells

Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T Yang Y Guo Y Chang C.

J Biol Chem. 2001; 276: 40417-40423.

Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China

Hsing AW, Gao YT, Wu G, Wang X, Deng J, Chen YL, Sesterhenn IA, Mostofi FK, Benichou J, Chang C.

Cancer Res. 2000; 60: 5111-5116.

Characterization of the cell-specific expression of parathyroid hormone-related protein in normal and neoplastic prostate tissue

Wu G, Iwamura M, di Sant'Agnese PA, Cockett ATK, Gershagen S.

Urology. 1998; 51 (5A Suppl): 110-120.

Cloning and Characterization of the alpha 1-Antichymotrypsin produced by human prostate tissue

Wu G, Lilja H, Cockett ATK, Gershagen S.

Prostate. 1998; 34: 155-161.

Calcitonin receptor mRNA expression in the human prostate

Wu G, Burzon D, di Sant'Agnese PA, Schoen SR, Deftos LJ, Gershagen S, Cockett ATK.

Urology. 1996; 47: 376-381.

The characterization of chromosomal rearrangements by a combined strategy: chromosome microdissection, polymerase chain reaction (PCR), and reverse and forward chromosome painting in a patient with myelodysplastic syndrome (MDS)

Xu J, Cedrone E, Roberts M, Wu G, Gershagen S, Wang N.

Cancer Genetics and Cytogenetics. 1995; 83: 105-110.

Parathyroid hormone-related protein is expressed by prostatic neuroendocrine cells

Iwamura M, Wu G, Abrahamsson PA, di Sant'Agnese PA, Cockett ATK, Deftos LJ.

Urology. 1994; 43: 667-674.

Parathyroid hormone-related protein: A potential autocrine growth regulator in prostate cancer cell lines

Iwamura M, Abrahamsson PA, Foss KA, Wu G, Cockett ATK, Deftos LJ.

Urology. 1994; 43: 675-679.

Overexpression of human epidermal growth factor receptor and c-erbB-2 by neuroendocrine cells in normal prostatic tissue

Iwamura M, di Sant'Agnese PA, Wu G, Benning CM, Cockett ATK, Gershagen S.

Urology. 1994; 43: 838-843.

Production of parathyroid hormone-related protein in benign and malignant prostate

Jiborn T, Gershagen S, Iwamura M, Wu G, Deftos LJ, Abrahamsson PA.

Scandinavian Journal of Urology and Nephrology. 1994; 28, suppl. no. 164: 37-38.

Immunohistochemical localization of Parathyroid hormone-related protein in human prostate cancer

Iwamura M, di Sant'Agnese PA, Wu G, Benning MC, Cockett ATK, Deftos LJ, Abrahamsson.

PACancer Res. 1993; 53: 1724-1726.

Clinical significance of multiple random mucosal biopsies in patients with bladder cancer

Gu F, Wu G, Na Y, Liang Y, Zhu M, Li W, Ma W.

Chinese J Surg. 1990; 28: 181.

Flow cytofluorometric DNA analysis in fresh bladder barbotage specimens and its correlations between cytology and mitotic index

Song L, Wang N, Huang Y, Ma W, Wu G, Song P, Xiu S.

Chinese J Surg. 1990; 28: 318.

NK cell activities in superficial bladder cancer patients before and after treatment with BCG

Xu L, Huang Y, Yang C, Wu G.

J Beijing Medical University. 1990; 22: 113.

Cytological diagnosis of prostatic carcinoma by transrectal prostatic aspiration biopsy

Ma W, Wang N, Wu G, Xu J.

Chinese J Surg. 1989; 27: 660.

Books

Advances in Imaging-Guided Urologic Surgery (2014)

Chapter: Fluorescence Image-Guided Robotic Surgery

Authors: Joseph Liao and Li-Ming Su, Wu G.

Publisher: Springer, New York 2014

Locations

699 South Main St, Ste 6, Canandaigua Commons
Canandaigua, NY 14424-2208