
R James White, M.D., Ph.D.
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R James White, M.D., Ph.D.
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400 Red Creek Drive, Suite 110
Rochester, NY 14623
About Me
In my laboratory, we do experiments in animals and cells in an attempt to discover entirely new ways to treat this deadly disease.
Because echocardiograms often estimate pulmonary hypertension in patients with obstructive sleep apnea and heart failure, much of my clinical practice and expertise is focused in these two common problems.
The URMC Pulmonary Hypertension group also includes my partner Dan Lachant, MD; three full time RN's, Karen Frutiger, Ali Theuer and new comer Cyndi MacDonald; a full time administrator, Jocelyn Dixon; two research technicians, Deb Haight and Jackie Bruno; and a post-doctoral research associate, Allison Light.
Professional Background
I moved to Rochester in 1997 to begin residency training in internal medicine and stayed to complete training in pulmonary and critical care. Mark Taubman mentored my early scientific career in the lab studying rat models of pulmonary hypertension and a potential pathogenic role for tissue factor, the protease which initiates blood coagulation. I still have a strong interest in bench studies of the pulmonary vasculature, but more recently I have enjoyed leadership roles in phase 2 and 3 clinical trials for PAH drug development.
Faculty Appointments
Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)
Professor - Department of Pediatrics, Cardiology (SMD) - Joint
Professor - Department of Pharmacology and Physiology (SMD) - Joint
Connect with R James White, M.D., Ph.D.
Credentials
Residency & Fellowship
Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 2000 - 2003
Residency, Internal Medicine, University of Rochester Medical Center. 1998 - 2000
Internship, Internal Medicine, University of Rochester Medical Center. 1997 - 1998
Education
MD | University of Pittsburgh School of Medicine. 1997
Awards
Parker B. Francis Fellowship in Pulmonary Biology, Francis Family Foundation 2005 - 2007
Buswell Fellowship, Department of Medicine, University of Rochester SMD 2003 - 2005
NIH Training Grant Multi-Disciplinary Training & Pulmonary Research, University of Rochester SMD 2001 - 2004
Alpha Omega Alpha, University of Pittsburgh 1996
NIH Medical Scientist Training Program, University of Pittsburgh 1990 - 1997
Phi Beta Kappa, Ohio State University 1990
Research
I am grateful for the opportunity to serve as steering committee leadership in drug development projects with United Therapeutics (oral treprostinil) and PhaseBio (VIP analogue PB1046). I also serve as a consultant providing development advice to Reata, Gilead, Bayer, and Celtaxsys. I chair the DSMB for the first randomized, placebo-controlled trial of genetically-modified, endothelial progenitor cells led by colleagues in Canada (sponsor, Northern Therapeutics).
The overall goal of my bench laboratory is to do better preclinical testing of potential novel treatment options for pulmonary arterial hypertension. Our current approach is with a rat model that recapitulates the histopathology, severe hemodynamic alterations, and right ventricular heart failure seen in advanced human disease. This rat model employs pneumonectomy (promotes contralateral lung growth) and endothelial injury (low dose monocrotaline) to cause lethal pulmonary hypertension in about 4 weeks. Our animals die earlier with a more severe phenotype, and we presented the first report of proliferative, plexiform-like lesions in 2004. We have developed a novel CT angiography to assess for vascular pruning during disease progression, and we have become expert at evaluating RV size and function with echo. We have also utilized telemetry techniques to measure pressure in awake, behaving animals. Our main recent contribution has been to establish a model severe enough that we can test new therapy approaches in animals treated with today's FDA approved agents. We believe that this sort of preclinical testing will provide the best evidence to move compounds into the clinic. Deb Haight, LVT, leads the lab work.
We hypothesize that tissue factor (the membrane bound glycoprotein which initiates coagulation) is an important contributor to disease progression, and we are actively testing small molecule inhibitors of tissue factor and thrombin as novel therapies in this devastating disease.
Patents
Treatment of Pulmonary Hypertension Using An Agent that Inhibits a Tissue Factor Pathway
Issue date: October 22, 2013
Patent #: 8,563,511
Country: United States
Inventors: Mark B Taubman, R. James White
Treatment of Pulmonary Hypertension Using an Agent that Inhibits a Tissue Factor Pathway
Issue date: July 15, 2015
Patent #: 1799243
Country: Europe
Inventors: Mark B Taubman, R. James White
Treatment of Pulmonary Hypertension Using An Agent that Inhibits a Tissue Factor Pathway
Issue date: July 15, 2015
Patent #: FR1799243
Country: France
Inventors: Mark B Taubman, R. James White
Treatment of Pulmonary Hypertension Using An Agent that Inhibits a Tissue Factor Pathway
Issue date: July 15, 2015
Patent #: DE1799243
Country: Germany
Inventors: Mark B Taubman, R. James White
Treatment of Pulmonary Hypertension Using An Agent that Inhibits a Tissue Factor Pathway
Issue date: July 15, 2015
Patent #: GB1799243
Country: United Kingdom
Inventors: Mark B Taubman, R. James White
Publications
Journal Articles
Fauvel C, White RJ, Vanderpool RR, Badagliacca R, Tobore T, Rahman M, Vizza CD, Lin S, Everett AD, Visovatti SH, Benza RL
Chest.. 2023 September 12 Epub 09/12/2023.
Fling C, De Marco T, Kime NA, Lammi MR, Oppegard LJ, Ryan JJ, Ventetuolo CE, White RJ, Zamanian RT, Leary PJ,
Annals of the American Thoracic Society.. 2023 September 8 Epub 09/08/2023.
Benza RL, Gomberg-Maitland M, Farber HW, Vizza CD, Broderick M, Holdstock L, Nelsen AC, Deng C, Rao Y, White RJ
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.. 2022 August 15 Epub 08/15/2022.
Lachant D, Kennedy E, Derenze B, Light A, Lachant M, White RJ
Chest.. 2022 June 28 Epub 06/28/2022.
Chang KY, Duval S, Badesch DB, Bull TM, Chakinala MM, De Marco T, Frantz RP, Hemnes A, Mathai SC, Rosenzweig EB, Ryan JJ, Thenappan T,
Journal of the American Heart Association.. 2022 April 27 :e024969. Epub 04/27/2022.
Rahaghi FF, Balasubramanian VP, Bourge RC, Burger CD, Chakinala MM, Eggert MS, Elwing JM, Feldman J, King C, Klinger JR, Mathai SC, McConnell JW, Palevsky HI, Restrepo-Jaramillo R, Safdar Z, Sager JS, Sood N, Sulica R, White RJ, Hill NS
Pulmonary circulation.. 2022 April 12 (2):e12055. Epub 04/07/2022.
Lachant D, Light A, Hannon K, Abbas F, Lachant M, White RJ
European heart journal. Digital health.. 2022 March 3 (1):90-97. Epub 11/02/2021.
Khan A, White RJ, Meyer G, Pulido Zamudio TR, Jerjes-Sanchez C, Johnson D, Grover R, Broderick M, Ousmanou A, Holdstock L, Michelakis E
Respiratory medicine.. 2022 January 19193 :106744. Epub 01/19/2022.
Arevalo C, White RJ, Lachant D
Respiratory medicine case reports.. 2022 37 :101646. Epub 04/09/2022.
Vizza CD, Lang IM, Badagliacca R, Benza RL, Rosenkranz S, White RJ, Adir Y, Andreassen AK, Balasubramanian V, Bartolome S, Blanco I, Bourge RC, Carlsen J, Conde Camacho RE, D'Alto M, Farber HW, Frantz RP, Ford HJ, Ghio S, Gomberg-Maitland M, Naeije R, Orfanos SE, Oudiz RJ, Perrone SV, Shlobin OA, Simon MA, Torres F, Wang KY, Yacoub MH, Liu Y, Golden G, Matsubara H
American journal of respiratory and critical care medicine.. 2021 December 14 Epub 12/14/2021.
Wang S, Zhu G, Jiang D, Rhen J, Li X, Liu H, Lyu Y, Tsai P, Rose Y, Nguyen T, White RJ, Pryhuber GS, Mariani TJ, Li C, Mohan A, Xu Y, Pang J
Hypertension.. 2021 November 5 :HYPERTENSIONAHA12016065. Epub 11/05/2021.
Newcomb G, Wilson BL, White RJ, Goldman B, Lachant NA, Lachant DJ
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.. 2021 October 27 :107392. Epub 10/27/2021.
Arevalo C, White RJ, Le T, Lachant D
Respiratory medicine.. 2021 September 4188 :106596. Epub 09/04/2021.
Rosenkranz S, Feldman J, McLaughlin VV, Rischard F, Lange TJ, White RJ, Peacock AJ, Gerhardt F, Ebrahimi R, Brooks G, Satler C, Frantz RP,
The Lancet. Respiratory medicine.. 2021 August 20 Epub 08/20/2021.
Lachant D, Roto D, Rappaport S, Prasad P, Lachant N, White RJ
Thrombosis research.. 2021 July 3205 :40-43. Epub 07/03/2021.
Bernstein DN, Cliburn JA, Lachant DJ, White RJ, Hammert WC
Hand : official journal of the American Association for Hand Surgery.. 2021 March 31 :1558944721999727. Epub 03/31/2021.
Hoeper MM, Al-Hiti H, Benza RL, Chang SA, Corris PA, Gibbs JSR, Grünig E, Jansa P, Klinger JR, Langleben D, McLaughlin VV, Meyer GMB, Ota-Arakaki J, Peacock AJ, Pulido T, Rosenkranz S, Vizza CD, Vonk-Noordegraaf A, White RJ, Chang M, Kleinjung F, Meier C, Paraschin K, Ghofrani HA, Simonneau G,
The Lancet. Respiratory medicine.. 2021 March 24 Epub 03/24/2021.
Min J, Badesch D, Chakinala M, Elwing J, Frantz R, Horn E, Klinger J, Lammi M, Mazimba S, Sager J, Shlobin O, Simon M, Thenappan T, Grinnan D, Ventetuolo C, Al-Naamani N,
American journal of respiratory and critical care medicine.. 2021 March 15203 (6):761-764. Epub 1900 01 01.
Zamanian RT, Badesch D, Chung L, Domsic RT, Medsger T, Pinckney A, Keyes-Elstein L, D'Aveta C, Spychala M, White RJ, Hassoun PM, Torres F, Sweatt AJ, Molitor JA, Khanna D, Maecker H, Welch B, Goldmuntz E, Nicolls MR,
American journal of respiratory and critical care medicine.. 2021 March 2 Epub 03/02/2021.
Lachant DJ, Bach C, Fe A, White RJ, Lachant NA
ERJ open research.. 2021 January 7 (1)Epub 02/01/2021.
Lachant DJ, Lachant NA, Kouides P, Rappaport S, Prasad P, White RJ
Journal of thrombosis and haemostasis : JTH.. 2020 October 18 (10):2640-2645. Epub 08/24/2020.
DesJardin JT, Kolaitis NA, Kime N, Kronmal RA, Benza RL, Elwing JM, Lammi MR, McConnell JW, Presberg KW, Sager JS, Shlobin OA, De Marco T,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.. 2020 September 39 (9):945-953. Epub 05/16/2020.
Xue C, Senchanthisai S, Sowden M, Pang J, White J, Berk BC
Hypertension.. 2020 August 24 :HYPERTENSIONAHA11914013. Epub 08/24/2020.
Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, Yee M, O'Reilly MA, Morrell C, Ritchlin CT, Schwarz EM, Korman BD
Arthritis & rheumatology.. 2020 May 10 Epub 05/10/2020.
Lemay M, Korman B, Hammert W, White RJ, Lachant D
Clinical and experimental rheumatology.. 2020 April 15 Epub 04/15/2020.
White RJ, Lachant DJ
Chest.. 2020 April 157 (4):761-763. Epub 1900 01 01.
White RJ, Jerjes-Sanchez C, Bohns Meyer GM, Pulido T, Sepulveda P, Wang KY, Grünig E, Hiremath S, Yu Z, Gangcheng Z, Yip WLJ, Zhang S, Khan A, Deng CQ, Grover R, Tapson VF,
American journal of respiratory and critical care medicine.. 2020 March 15201 (6):707-717. Epub 1900 01 01.
Nikkho S, Fernandes P, White RJ, Deng CC, Farber HW, Corris PA
Pulmonary circulation.. 2020 10 (4):2045894020941491. Epub 07/20/2020.
Lachant DJ, Light A, Offen M, Adams J, White RJ
Pulmonary circulation.. 2020 10 (4):2045894020972572. Epub 12/09/2020.
Lachant DJ, Light AN, Mackin ML, Schwartz RG, White RJ
Annals of the American Thoracic Society.. 2019 November 4 Epub 11/04/2019.
Bush K, Barbosa H, Farooq S, Weisenthal SJ, Trayhan M, White RJ, Noyes EI, Ghoshal G, Zand MS
Infection control and hospital epidemiology.. 2019 October 28 :1-7. Epub 10/28/2019.
Lachant DJ, Meoli DF, Haight D, Staicu S, Akers S, Glickman S, Ambrosini R, Champion HC, White RJ
American journal of physiology. Lung cellular and molecular physiology.. 2019 October 1317 (4):L445-L455. Epub 07/19/2019.
White RJ, Vonk-Noordegraaf A, Rosenkranz S, Oudiz RJ, McLaughlin VV, Hoeper MM, Grünig E, Ghofrani HA, Chakinala MM, Barberà JA, Blair C, Langley J, Frost AE
Respiratory research.. 2019 September 1220 (1):208. Epub 09/12/2019.
White RJ, Parikh K, Allen R, Feldman J, Jerjez-Sanchez C, Pan L, Keogh AM, Vizza CD, Shapiro SM, Gordon K, Broderick M, Bartolome S
Pulmonary circulation.. 2019 July 10 :2045894019866335. Epub 07/10/2019.
Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, Ross RVM, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Noordegraaf AV, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, , ,
The Lancet. Respiratory medicine.. 2018 December 5 Epub 12/05/2018.
Burger CD, Ozbay AB, Lazarus HM, Riehle E, Montejano LB, Lenhart G, White RJ
Journal of managed care & specialty pharmacy.. 2018 August 24 (8):834-842. Epub 02/13/2018.
White RJ, Wilkins MR
Circulation.. 2018 May 29137 (22):2390-2392. Epub 1900 01 01.
Lachant DJ, Meoli DF, Haight D, Lyons JA, Swarthout RF, White RJ
Experimental lung research.. 2018 February 44 (1):51-61. Epub 01/30/2018.
Light A, Heininger A, Wessman K, Frutiger K, White RJ
Pain medicine : the official journal of the American Academy of Pain Medicine.. 2017 December 118 (12):2515-2517. Epub 1900 01 01.
Rahaghi FF, Feldman JP, Allen RP, Tapson V, Safdar Z, Balasubramanian VP, Shapiro S, Mathier MA, Elwing JM, Chakinala MM, White RJ
Pulmonary circulation.. 2017 March 7 (1):167-174. Epub 03/21/2017.
Chakinala MM, Feldman JP, Rischard F, Mathier M, Broderick M, Leedom N, Laliberte K, White RJ
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.. 2017 February 36 (2):193-201. Epub 06/24/2016.
Hoeper MM, McLaughlin VV, Barberá JA, Frost AE, Ghofrani HA, Peacock AJ, Simonneau G, Rosenkranz S, Oudiz RJ, White RJ, Miller KL, Langley J, Harris JH, Blair C, Rubin LJ, Vachiery JL
The Lancet. Respiratory medicine.. 2016 November 4 (11):894-901. Epub 10/11/2016.
White RJ, Rao Y
American journal of respiratory and critical care medicine.. 2016 June 15193 (12):1434-6. Epub 1900 01 01.
White RJ
American journal of respiratory and critical care medicine.. 2016 May 15193 (10):1084-6. Epub 1900 01 01.
Crosby A, Soon E, Jones FM, Southwood MR, Haghighat L, Toshner MR, Raine T, Horan I, Yang P, Moore S, Ferrer E, Wright P, Ormiston ML, White RJ, Haight DA, Dunne DW, Morrell NW
American journal of respiratory and critical care medicine.. 2015 December 1192 (11):1355-65. Epub 1900 01 01.
Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Grünig E, Oudiz RJ, Vonk-Noordegraaf A, White RJ, Blair C, Gillies H, Miller KL, Harris JH, Langley J, Rubin LJ,
The New England journal of medicine.. 2015 August 27373 (9):834-44. Epub 1900 01 01.
Schlosser K, McIntyre LA, White RJ, Stewart DJ
PloS one.. 2015 10 (5):e0127443. Epub 05/26/2015.
Lannan KL, Phipps RP, White RJ
Drug discovery today.. 2014 August 19 (8):1230-5. Epub 04/18/2014.
White RJ, Lannan KL, Phipps RP
Drug discovery today.. 2014 August 19 (8):1226-9. Epub 04/21/2014.
White RJ, Levin Y, Wessman K, Heininger A, Frutiger K
Pulmonary circulation.. 2013 September 3 (3):611-21. Epub 11/18/2013.
White RJ, Torres F, Allen R, Jerjes C, Pulido T, Yehle D, Howell M, Laliberte K, Marier J, Tapson VF
Journal of cardiovascular pharmacology.. 2013 June 61 (6):474-81. Epub 1900 01 01.
White RJ, Morrell NW
Circulation.. 2012 October 9126 (15):1818-20. Epub 1900 01 01.
Friedman SM, White RJ, Finkelstein SM, Kellam J, Allen EF, Sip AK, Stanton R
Geriatric orthopaedic surgery & rehabilitation.. 2012 September 3 (3):135-40. Epub 1900 01 01.
Ferrantino M, White RJ
Expert opinion on pharmacotherapy.. 2011 November 12 (16):2583-93. Epub 1900 01 01.
Yee M, White RJ, Awad HA, Bates WA, McGrath-Morrow SA, O'Reilly MA
The American journal of pathology.. 2011 June 178 (6):2601-10. Epub 05/06/2011.
Levin YD, White RJ
Drugs of today.. 2011 February 47 (2):145-56. Epub 1900 01 01.
Meoli DF, White RJ
Canadian journal of physiology and pharmacology.. 2010 August 88 (8):830-9. Epub 1900 01 01.
White RJ, Hiremath J
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.. 2010 July 29 (7):826-7. Epub 05/14/2010.
Meoli DF, White RJ
American journal of physiology. Lung cellular and molecular physiology.. 2009 October 297 (4):L706-14. Epub 07/31/2009.
Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC
Circulation.. 2009 March 24119 (11):1524-32. Epub 03/09/2009.
Gough MS, White RJ
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.. 2009 January 15 (1):30-6. Epub 1900 01 01.
White RJ, Meoli DF, Swarthout RF, Kallop DY, Galaria II, Harvey JL, Miller CM, Blaxall BC, Hall CM, Pierce RA, Cool CD, Taubman MB
American journal of physiology. Lung cellular and molecular physiology.. 2007 September 293 (3):L583-90. Epub 06/22/2007.
White RJ, Galaria II, Harvey J, Blaxall BC, Cool CD, Taubman MB
Chest.. 2005 December 128 (6 Suppl):612S-613S. Epub 1900 01 01.