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Jennifer Howitt Anolik, M.D., Ph.D.

Jennifer Howitt Anolik, M.D., Ph.D.

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About Me

Faculty Appointments

Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Associate Chair, Research - Department of Medicine (SMD)

Interim Chief - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Professor - Department of Microbiology and Immunology (SMD) - Joint

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Fellowship, Rheumatology, University of Rochester Medical Center. 1999 - 2001

Residency, Internal Medicine, University of Rochester Medical Center. 1997 - 1999

Internship, Internal Medicine, University of Rochester Medical Center. 1996 - 1997

Education

MD | University of Rochester School of Medicine/Dentistry. 1996

PHD | University of Rochester School of Medicine/Dentistry. Medical Biochemical Genetics. 1994

Awards

American Society for Clinical Investigation. 2015

Eisenberg Memorial Lupus Lectureship. 2008

Lawrence Kohn Senior Teaching Fellow. 2006 - 2008

Edmund Dubois Memorial Lectureship Award. 2005

Buswell Fellowship. 2003

Rheumatology Fellow Award. 2001

NIH Training Grant T32-AI07169-16. 2000 - 2002

Stuber Fellowship. 1999 - 2000

Raphael Dolin Resident Research Award. 1999

Medical Scientist Training Program Scholarship. 1994 - 1996

Stotz Fellowship. 1991 - 1992

Medical Scientist Training Program Scholarship. 1988 - 1990

Phi Beta Kappa. 1988

Sigma Xi Scientific Research Society. 1988

Outstanding Senior Chemistry Student Award. 1988

Dean's Letter of Recognition. 1988 - 1989

Summer Research Fellowship. 1987

Research

Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compa...
Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compartment, and bone cells. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Clinical Trials

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Nonbiologic Lupus Standard of Care

Lead Researcher: Jennifer Howitt Anolik MD, PhD

You may be eligible to take part in the study because you have an autoimmune disease known as “lupus.” In autoimmune diseases, the immune system sees the body’s own tissues as “foreign” and attacks itself, resulting in inflammation. Systemic lupus er...

Publications

Journal Articles

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.

Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K, Sakaue S, Nathan A, , Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, Thakar J, McDavid A, Rao DA, Anolik JH

Nature communications.. 2024 June 1115 (1):4991. Epub 06/11/2024.

The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.

Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z, , Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S

Nature communications.. 2024 May 3115 (1):4650. Epub 05/31/2024.

Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.

Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH, , Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE

Science translational medicine.. 2024 April 1016 (742):eadk3506. Epub 04/10/2024.

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.

Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z, , Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S

Nature genetics.. 2024 April 9 Epub 04/09/2024.

Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis.

Fava A, Buyon J, Magder L, Hodgin J, Rosenberg A, Demeke DS, Rao DA, Arazi A, Celia AI, Putterman C, Anolik JH, Barnas J, Dall'Era M, Wofsy D, Furie R, Kamen D, Kalunian K, James JA, Guthridge J, Atta MG, Monroy Trujillo J, Fine D, Clancy R, Belmont HM, Izmirly P, Apruzzese W, Goldman D, Berthier CC, Hoover P, Hacohen N, Raychaudhuri S, Davidson A, Diamond B, , Petri M

JCI insight.. 2024 January 239 (2)Epub 01/23/2024.

Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis.

Horisberger A, Griffith A, Keegan J, Arazi A, Pulford J, Murzin E, Howard K, Hancock B, Fava A, Sasaki T, Ghosh T, Inamo J, Beuschel R, Cao Y, Preisinger K, Gutierrez-Arcelus M, Eisenhaure TM, Guthridge J, Hoover PJ, Dall'Era M, Wofsy D, Kamen DL, Kalunian KC, Furie R, Belmont M, Izmirly P, Clancy R, Hildeman D, Woodle ES, Apruzzese W, McMahon MA, Grossman J, Barnas JL, Payan-Schober F, Ishimori M, Weisman M, Kretzler M, Berthier CC, Hodgin JB, Demeke DS, Putterman C, , Brenner MB, Anolik JH, Raychaudhuri S, Hacohen N, James JA, Davidson A, Petri MA, Buyon JP, Diamond B, Zhang F, Lederer JA, Rao DA

bioRxiv : the preprint server for biology.. 2024 January 15 Epub 01/15/2024.

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.

Kang JB, Shen AZ, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta KA, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K, , Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Luo Y, Sakaue S, Raychaudhuri S

Nature genetics.. 2023 November 30 Epub 11/30/2023.

B Cell-Directed Therapy in Autoimmunity.

Abeles I, Palma C, Meednu N, Payne AS, Looney RJ, Anolik JH

Annual review of immunology.. 2023 November 27 Epub 11/27/2023.

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, Nayar S, Rangel-Moreno J, Meednu N, Marks KE, Mantel I, Kang JB, Rumker L, Mears J, Slowikowski K, Weinand K, Orange DE, Geraldino-Pardilla L, Deane KD, Tabechian D, Ceponis A, Firestein GS, Maybury M, Sahbudin I, Ben-Artzi A, Mandelin AM, Nerviani A, Lewis MJ, Rivellese F, Pitzalis C, Hughes LB, Horowitz D, DiCarlo E, Gravallese EM, Boyce BF, , Moreland LW, Goodman SM, Perlman H, Holers VM, Liao KP, Filer A, Bykerk VP, Wei K, Rao DA, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S

Nature.. 2023 November 8 Epub 11/08/2023.

Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.

Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford J, Murzin E, Hancock B, Jonsson AH, Seifert J, Feser ML, Norris JM, Cao Y, Apruzzese W, Louis Bridges S, Bykerk V, Goodman S, Donlin L, Firestein GS, Perlman H, Bathon JM, Hughes LB, Tabechian D, Filer A, Pitzalis C, Anolik JH, Moreland L, Guthridge JM, James JA, Brenner MB, Raychaudhuri S, Sparks JA, Michael Holers V, Deane KD, Lederer JA, Rao DA, Zhang F

bioRxiv : the preprint server for biology.. 2023 July 4 Epub 07/04/2023.

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis.

Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Zhu Z, , Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S

bioRxiv : the preprint server for biology.. 2023 April 8 Epub 04/08/2023.

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium.

Dunlap G, Wagner A, Meednu N, Zhang F, Jonsson AH, Wei K, Sakaue S, Nathan A, , Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, McDavid A, Rao DA, Anolik JH

bioRxiv : the preprint server for biology.. 2023 March 21 Epub 03/21/2023.

Mapping the dynamic genetic regulatory architecture of genes at single-cell resolution.

Kang JB, Shen AZ, Sakaue S, Luo Y, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta K, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K, , Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Raychaudhuri S

medRxiv : the preprint server for health sciences.. 2023 March 20 Epub 03/20/2023.

Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.

Kenney HM, Rangel-Moreno J, Peng Y, Chen KL, Bruno J, Embong A, Pritchett E, Fox JI, Becerril-Villanueva E, Gamboa-Domínguez A, Quataert S, Muthukrishnan G, Wood RW, Korman BD, Anolik JH, Xing L, Ritchlin CT, Schwarz EM, Wu CL

Frontiers in immunology.. 2023 14 :1237498. Epub 08/25/2023.

Granzyme K CD8 T cells form a core population in inflamed human tissue.

Jonsson AH, Zhang F, Dunlap G, Gomez-Rivas E, Watts GFM, Faust HJ, Rupani KV, Mears JR, Meednu N, Wang R, Keras G, Coblyn JS, Massarotti EM, Todd DJ, Anolik JH, McDavid A, , Wei K, Rao DA, Raychaudhuri S, Brenner MB

Science translational medicine.. 2022 June 1514 (649):eabo0686. Epub 06/15/2022.

Prominent B cell signature differentiates discoid from subacute cutaneous lupus erythematosus.

Lerman I, Bawany F, Whitt W, Esaa F, Yon J, Babkowski N, Rapp MB, Scott GA, Anolik JH, Richardson CT

The Journal of investigative dermatology.. 2022 May 17 Epub 05/17/2022.

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S, Donlin LT, Raychauduri S, Bombardieri M, Pitzalis C, Orange DE, , McDavid A, Anolik JH

Cell reports.. 2022 May 339 (5):110766. Epub 1900 01 01.

Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival.

Rangel-Moreno J, Garcia-Hernandez ML, Owen T, Barnard J, Becerril-Villanueva E, Kashyap T, Argueta C, Gamboa-Dominguez A, Tamir S, Landesman Y, Goldman BI, Ritchlin CT, Anolik JH

Arthritis & rheumatology.. 2022 March 25 Epub 03/25/2022.

Urine Proteomics and Renal Single Cell Transcriptomics Implicate IL-16 in Lupus Nephritis.

Fava A, Rao DA, Mohan C, Zhang T, Rosenberg A, Fenaroli P, Belmont HM, Izmirly P, Clancy R, Monroy Trujillo J, Fine D, Arazi A, Berthier CC, Davidson A, James JA, Diamond B, Hacohen N, Wofsy D, Raychaudhuri S, Apruzzese W, , Buyon J, Petri M

Arthritis & rheumatology.. 2021 November 16 Epub 11/16/2021.

B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-? in Systemic Lupus Erythematosus.

Barnas JL, Albrecht J, Meednu N, Alzamareh DF, Baker C, McDavid A, Looney RJ, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 October 27 Epub 10/27/2021.

Activated peripheral blood B cells in rheumatoid arthritis and relationship to anti-TNF treatment and response: randomized clinical trial for anti-TNF effects on B cells.

Meednu N, Barnard J, Callahan K, Coca A, Marston B, Thiele R, Tabechian D, Bolster M, Curtis J, Mackay M, Graf J, Keating R, Smith E, Boyle K, Keyes-Elstein L, Welch B, Goldmuntz E, Anolik JH

Arthritis & rheumatology.. 2021 August 4 Epub 08/04/2021.

IFN- and TNF- drive a + + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.

Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, , Donlin LT, Raychaudhuri S

bioRxiv : the preprint server for biology.. 2020 August 5 Epub 08/05/2020.

Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.

Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E

Science.. 2020 July 17369 (6501):320-325. Epub 1900 01 01.

Notch signalling drives synovial fibroblast identity and arthritis pathology.

Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB

Nature.. 2020 April 22 Epub 04/22/2020.

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.

Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Eun-Hyung Lee F, Boss JM, Lund FE, Sanz I

Immunity.. 2020 January 1452 (1):203. Epub 1900 01 01.

B cell targeted therapies in autoimmune disease.

Barnas JL, Looney RJ, Anolik JH

Current opinion in immunology.. 2019 December 61 :92-99. Epub 11/14/2019.

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis.

Mensah KA, Chen JW, Schickel JN, Isnardi I, Yamakawa N, Vega-Loza A, Anolik JH, Gatti RA, Gelfand EW, Montgomery RR, Horowitz MC, Craft JE, Meffre E

Science translational medicine.. 2019 November 2011 (519)Epub 1900 01 01.

PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.

Bocharnikov AV, Keegan J, Wacleche VS, Cao Y, Fonseka CY, Wang G, Muise ES, Zhang KX, Arazi A, Keras G, Li ZJ, Qu Y, Gurish MF, Petri M, Buyon JP, Putterman C, Wofsy D, James JA, Guthridge JM, Diamond B, Anolik JH, Mackey MF, Alves SE, Nigrovic PA, Costenbader KH, Brenner MB, Lederer JA, Rao DA,

JCI insight.. 2019 October 174 (20)Epub 10/17/2019.

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis.

Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B,

Nature immunology.. 2019 October 20 (10):1404. Epub 1900 01 01.

Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

Dieudonné Y, Gies V, Guffroy A, Keime C, Bird AK, Liesveld J, Barnas JL, Poindron V, Douiri N, Soulas-Sprauel P, Martin T, Meffre E, Anolik JH, Korganow AS

Journal of autoimmunity.. 2019 August 102 :150-158. Epub 05/10/2019.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S

Nature immunology.. 2019 July 20 (7):928-942. Epub 05/06/2019.

The immune cell landscape in kidneys of patients with lupus nephritis.

Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B,

Nature immunology.. 2019 July 20 (7):902-914. Epub 06/17/2019.

Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.

Gao L, OConnell M, Allen M, Liesveld J, McDavid A, Anolik JH, Looney RJ

Cytokine.. 2019 May 29 :154725. Epub 05/29/2019.

Failure of B Cell Tolerance in CVID.

Richardson CT, Slack MA, Dhillon G, Marcus CZ, Barnard J, Palanichamy A, Sanz I, Looney RJ, Anolik JH

Frontiers in immunology.. 2019 10 :2881. Epub 12/10/2019.

B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.

Sun W, Meednu N, Rosenberg A, Rangel-Moreno J, Wang V, Glanzman J, Owen T, Zhou X, Zhang H, Boyce BF, Anolik JH, Xing L

Nature communications.. 2018 December 39 (1):5127. Epub 12/03/2018.

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.

Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Lee FE, Boss JM, Lund FE, Sanz I

Immunity.. 2018 October 1649 (4):725-739.e6. Epub 10/09/2018.

Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, , Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH

Arthritis research & therapy.. 2018 July 1120 (1):139. Epub 07/11/2018.

Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.

Gies V, Schickel JN, Jung S, Joublin A, Glauzy S, Knapp AM, Soley A, Poindron V, Guffroy A, Choi JY, Gottenberg JE, Anolik JH, Martin T, Soulas-Sprauel P, Meffre E, Korganow AS

JCI insight.. 2018 March 83 (5)Epub 03/08/2018.

Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers.

Bird AK, Chang M, Barnard J, Goldman BI, Meednu N, Rangel-Moreno J, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2017 July 15199 (2):458-466. Epub 06/05/2017.

Inhibition of G Protein ?? Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.

Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH

Arthritis & rheumatology.. 2016 September 68 (9):2244-56. Epub 1900 01 01.

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis.

Meednu N, Zhang H, Owen T, Sun W, Wang V, Cistrone C, Rangel-Moreno J, Xing L, Med B, Anolik JH

Arthritis & rheumatology.. 2016 April 68 (4):805-16. Epub 1900 01 01.

New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome.

Bird AK, Meednu N, Anolik JH

Current opinion in rheumatology.. 2015 September 27 (5):461-7. Epub 1900 01 01.

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.

Adlowitz DG, Barnard J, Biear JN, Cistrone C, Owen T, Wang W, Palanichamy A, Ezealah E, Campbell D, Wei C, Looney RJ, Sanz I, Anolik JH

PloS one.. 2015 10 (6):e0128269. Epub 06/05/2015.

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-?B.

Zhang H, Hilton MJ, Anolik JH, Welle SL, Zhao C, Yao Z, Li X, Wang Z, Boyce BF, Xing L

The Journal of clinical investigation.. 2014 July 124 (7):3200-14. Epub 06/02/2014.

Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.

Wang W, Rangel-Moreno J, Owen T, Barnard J, Nevarez S, Ichikawa HT, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 April 1192 (7):3011-20. Epub 02/26/2014.

Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus.

Palanichamy A, Bauer JW, Yalavarthi S, Meednu N, Barnard J, Owen T, Cistrone C, Bird A, Rabinovich A, Nevarez S, Knight JS, Dedrick R, Rosenberg A, Wei C, Rangel-Moreno J, Liesveld J, Sanz I, Baechler E, Kaplan MJ, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 February 1192 (3):906-18. Epub 12/30/2013.

Quantitative proteomics of parotid saliva in primary Sjögren's syndrome.

Ambatipudi KS, Swatkoski S, Moresco JJ, Tu PG, Coca A, Anolik JH, Gucek M, Sanz I, Yates JR, Melvin JE

Proteomics.. 2012 October 12 (19-20):3113-20. Epub 09/10/2012.

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.

Ichikawa HT, Conley T, Muchamuel T, Jiang J, Lee S, Owen T, Barnard J, Nevarez S, Goldman BI, Kirk CJ, Looney RJ, Anolik JH

Arthritis and rheumatism.. 2012 February 64 (2):493-503. Epub 1900 01 01.

Treatment targets in systemic lupus erythematosus: biology and clinical perspective.

Marian V, Anolik JH

Arthritis research & therapy.. 2012 14 Suppl 4 (Suppl 4):S3. Epub 11/30/2012.

B cell immunology for the clinician.

Marcus C, Dhillon G, Anolik JH

The Pediatric infectious disease journal.. 2011 February 30 (2):158-60. Epub 1900 01 01.

Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor.

Kobie JJ, Zheng B, Bryk P, Barnes M, Ritchlin CT, Tabechian DA, Anandarajah AP, Looney RJ, Thiele RG, Anolik JH, Coca A, Wei C, Rosenberg AF, Feng C, Treanor JJ, Lee FE, Sanz I

Arthritis research & therapy.. 2011 13 (6):R209. Epub 12/16/2011.

Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus.

Bekar KW, Owen T, Dunn R, Ichikawa T, Wang W, Wang R, Barnard J, Brady S, Nevarez S, Goldman BI, Kehry M, Anolik JH

Arthritis and rheumatism.. 2010 August 62 (8):2443-57. Epub 1900 01 01.

B cells in the pathogenesis and treatment of rheumatoid arthritis.

Marston B, Palanichamy A, Anolik JH

Current opinion in rheumatology.. 2010 May 22 (3):307-15. Epub 1900 01 01.

B-cell biology and related therapies in systemic lupus erythematosus.

Ahmed S, Anolik JH

Rheumatic diseases clinics of North America.. 2010 February 36 (1):109-30, viii-ix. Epub 1900 01 01.

Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets.

Anolik JH, Looney RJ, Lund FE, Randall TD, Sanz I

Immunologic research.. 2009 December 45 (2-3):144-58. Epub 04/07/2009.

Novel human transitional B cell populations revealed by B cell depletion therapy.

Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, Looney RJ, Sanz I, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 May 15182 (10):5982-93. Epub 1900 01 01.

Two negative randomized controlled trials in lupus: now what?

Coca A, Anolik JH

F1000 medicine reports. 2009 May 81 Epub 05/08/2009.

Novel populations of human transitional B cells revealed by B cell depletion therapy

Palanichamy, A.; Barnard, J.; Zheng, B.; Owen, T.; Quach, T.; Wei, C.; Looney, R.J.; Sanz, I.; Anolik, J.H.

Journal of Immunology. 2009; .

Two negative randomized controlled trials in lupus: now what? Faculty of 1000 invited commentary

Coca, A.; Anolik, J.

2009; .

Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets

Anolik, J.; Looney, R.J.; Lund, F.; Randall, T.; Sanz, I.

Immunologic Research. 2009; .

Targeted biologic approaches to the treatment of systemic vasculitis.

Coca A, Anolik JH

Clinical reviews in allergy & immunology.. 2008 October 35 (1-2):79-87. Epub 1900 01 01.

Neuromyelitis optica spectrum disorder in a patient with systemic lupus erythematosus and anti-phospholipid antibody syndrome.

Mehta LR, Samuelsson MK, Kleiner AK, Goodman AD, Anolik JH, Looney RJ, Schwid SR

Multiple sclerosis : clinical and laboratory research.. 2008 April 14 (3):425-7. Epub 01/21/2008.

Phenotypic and functional heterogeneity of human memory B cells.

Sanz I, Wei C, Lee FE, Anolik J

Seminars in immunology.. 2008 February 20 (1):67-82. Epub 02/06/2008.

Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks.

Anolik JH, Ravikumar R, Barnard J, Owen T, Almudevar A, Milner EC, Miller CH, Dutcher PO, Hadley JA, Sanz I

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 January 15180 (2):688-92. Epub 1900 01 01.

Profound hypogammaglobulinemia 7 years after treatment for indolent lymphoma

Walker, AR.; Kleiner, A.; Rich, L.; Conners, C.; Fisher, RI.; Anolik, JH.; Friedberg, JW.

Cancer Investigations. 2008; 26(4): 431-433.

Coca, A.; Anolik, J.

Targeted Biologic Approaches to the Treatment

Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy.

Anolik JH, Barnard J, Owen T, Zheng B, Kemshetti S, Looney RJ, Sanz I

Arthritis and rheumatism.. 2007 September 56 (9):3044-56. Epub 1900 01 01.

A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus.

Wei C, Anolik J, Cappione A, Zheng B, Pugh-Bernard A, Brooks J, Lee EH, Milner EC, Sanz I

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 May 15178 (10):6624-33. Epub 1900 01 01.

B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny.

Anolik JH, Friedberg JW, Zheng B, Barnard J, Owen T, Cushing E, Kelly J, Milner EC, Fisher RI, Sanz I

Clinical immunology : the official journal of the Clinical Immunology Society.. 2007 February 122 (2):139-45. Epub 09/27/2006.

B cell depletion therapy in autoimmune diseases.

Sanz I, Anolik JH, Looney RJ

Frontiers in bioscience : a journal and virtual library.. 2007 January 112 :2546-67. Epub 01/01/2007.

Vaccine responses in patients with rheumatoid arthritis

Ravikumar, R.; Anolik, JH.; Looney, RH.

Current Rheumatology Reports. 2007; 9: 407-415.

B cell biology and dysfunction in SLE

Anolik, JH.

Bulliten of the New York University Hospital of Joint Disease. 2007; 65: 182-186.

B cell biology and dysfunction in SLE.

Anolik JH

Bulletin of the NYU hospital for joint diseases. 2007 65 (3):182-6. Epub 1900 01 01.

New therapies for systemic lupus erythematosus: cellular targets.

Looney RJ, Anolik J, Sanz I

Rheumatic diseases clinics of North America.. 2006 February 32 (1):201-15, xi. Epub 1900 01 01.

B cell targeted therapy for systemic lupus erythematosus

Sabahi, R.; Anolik, JH.

Drugs. 2006; 66: 1.

B-cell-targeted therapy for systemic lupus erythematosus.

Sabahi R, Anolik JH

Drugs.. 2006 66 (15):1933-48. Epub 1900 01 01.

Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.

Cappione A, Anolik JH, Pugh-Bernard A, Barnard J, Dutcher P, Silverman G, Sanz I

The Journal of clinical investigation.. 2005 November 115 (11):3205-16. Epub 10/06/2005.

New treatments for SLE: cell-depleting and anti-cytokine therapies.

Anolik JH, Aringer M

Best practice & research. Clinical rheumatology.. 2005 October 19 (5):859-78. Epub 1900 01 01.

Human innate B cells: a link between host defense and autoimmunity?

Milner EC, Anolik J, Cappione A, Sanz I

Springer seminars in immunopathology.. 2005 March 26 (4):433-52. Epub 01/05/2005.

New treatments for SLE: Cell -depleting and anti-cytokine therapies

Anolik, JH.; Aringer, M.

Best Practices and Research Clinical Rheumatology. 2005; 19(5): 859.

Reconstitution of the adult B cell repertoire after treatment with rituximab.

Sanz I, Anolik J

Arthritis research & therapy.. 2005 7 (5):175-6. Epub 07/22/2005.

Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus.

Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I

Arthritis and rheumatism.. 2004 November 50 (11):3580-90. Epub 1900 01 01.

B cells in human and murine systemic lupus erythematosus.

Anolik J, Sanz I

Current opinion in rheumatology.. 2004 September 16 (5):505-12. Epub 1900 01 01.

B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab.

Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I

Arthritis and rheumatism.. 2004 August 50 (8):2580-9. Epub 1900 01 01.

B cells as therapeutic targets for rheumatic diseases.

Looney RJ, Anolik J, Sanz I

Current opinion in rheumatology.. 2004 May 16 (3):180-5. Epub 1900 01 01.

Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes.

Cappione AJ, Pugh-Bernard AE, Anolik JH, Sanz I

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 April 1172 (7):4298-307. Epub 1900 01 01.

B lymphocytes in systemic lupus erythematosus: lessons from therapy targeting B cells.

Looney RJ, Anolik J, Sanz I

Lupus.. 2004 13 (5):381-90. Epub 1900 01 01.

B cell depletion therapy in systemic lupus erythematosus.

Anolik J, Sanz I, Looney RJ

Current rheumatology reports.. 2003 October 5 (5):350-6. Epub 1900 01 01.

Down-regulation of CD20 on B cells upon CD40 activation.

Anolik J, Looney RJ, Bottaro A, Sanz I, Young F

European journal of immunology.. 2003 September 33 (9):2398-409. Epub 1900 01 01.

The relationship of FcgammaRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus.

Anolik JH, Campbell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ

Arthritis and rheumatism.. 2003 February 48 (2):455-9. Epub 1900 01 01.

Posttransfusion purpura secondary to an alloantibody reactive with HPA-5a (Br(b)).

Anolik JH, Blumberg N, Snider J, Francis CW

Transfusion.. 2001 May 41 (5):633-6. Epub 1900 01 01.

Multifocal Staphylococcus aureus infection originating from the sacroiliac joint in a patient with rheumatoid arthritis.

Anolik JH, Wildy K, Cohn SE, Marquardt JD, Totterman S, Zwillich SH

The Journal of rheumatology.. 2001 January 28 (1):217-20. Epub 1900 01 01.

A 40 year old woman with destructive arthritis and severe interstitial lung disease

Anolik, JH.; Ritchlin, C.

AML Interactions. 2000; .

Effect of isotretinoin therapy on natural killer cell activity in patients with xeroderma pigmentosum.

Anolik JH, Di Giovanna JJ, Gaspari AA

The British journal of dermatology.. 1998 February 138 (2):236-41. Epub 1900 01 01.

Effects of multiple estrogen responsive elements, their spacing, and location on estrogen response of reporter genes.

Sathya G, Li W, Klinge CM, Anolik JH, Hilf R, Bambara RA

Molecular endocrinology.. 1997 December 11 (13):1994-2003. Epub 1900 01 01.

Stability of the ligand-estrogen receptor interaction depends on estrogen response element flanking sequences and cellular factors.

Anolik JH, Klinge CM, Brolly CL, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1996 December 59 (5-6):413-29. Epub 1900 01 01.

Cooperative binding of estrogen receptor to DNA depends on spacing of binding sites, flanking sequence, and ligand

Anolik,J. H.; Klinge,C. M.; Hilf,R.; Bambara,R. A.

Biochemistry (John Wiley & Sons). 1995; 34(8): 2511,2520.

Estrogen receptor interaction with estrogen response element (ERE) DNA: Role of ligand, ERE spacing, flanking sequences

Anolik, JA.

1994; .

Differential impact of flanking sequences on estradiol- vs 4-hydroxytamoxifen-liganded estrogen receptor binding to estrogen responsive element DNA.

Anolik JH, Klinge CM, Bambara RA, Hilf R

The Journal of steroid biochemistry and molecular biology.. 1993 December 46 (6):713-30. Epub 1900 01 01.

Physical and conformational properties of a synthetic leader peptide from bovine serum albumin

Shinnar, AE.; Anolik, JH.; Johnson, DA.; Lobl, TJ.

Proceedings of the Eleventh American Peptide Symposium. 1990; .

Expansion of transitional B cells in human SLE

Palanichamy, A.; Barnard, J.; Zheng, B.; Wei, C.; Owen, T.; Cushing, E.; Campbell, D.; Kemshetti, S.; Looney, R.J.; Sanz, I.; Anolik, J.H.

In Preparation. .

Treatment with anti-CD20 prevents and reverses murine lupus

Bekar, K.; Owen, T.; Dunn, R.; Kehry, M.; Anolik, J.H.

In preparation. .

Immunologic effects of BAFF antagonism in the treatment of human SLE

Sabahi, R.; Owen, T.; Barnard, J.; Cushing, E.; Looney, R.J.; Sanz, I.; Anolik, J.H.

In preparation. .

Interferon activation in human SLE bone marrow inhibits B cell lymphopoiesis

Barnard, J.; Palanichamy, A.; Bauer, J.W.; Koeuth, T.; Baechler, E.C.; Anolik, J.H.

In preparation. .

TLR9 stimulation adversely impacts B cell depletion and reconstitution in the mouse

Wang, R.; Owen, T.; Bekar, K.; Anolik, J.

In preparation. .

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