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Jennifer Anolik at the bench

B Cells and Immune Diseases

Defining the role of B cells in systemic autoimmunity has been instrumental in characterizing the impact of B cell depletion (BCD) on the human immune system and establishing B cell targeted therapies. This has been a major advance in the field of immunologic disease with broad implications in rheumatoid arthritis, lupus, diabetes, malignancy, and immune deficiency.

Findings demonstrating a link between the clinical response and the immunologic reconstitution with transitional B cells was the first delineation of a B regulatory cell population in humans, greatly advancing our understanding of BCD therapy and human B cell development pathways. A prominent publication defining new populations of human transitional B cells provided further fundamental insights into the developmental process followed by human B cells, identifying a new population of human transitional B cells. Recent work has elucidated a previously unrecognized cross-talk between the B cell compartment and neutrophil driven α interferon production in the bone marrow in systemic lupus erythematosus (SLE) that alters B cell development and selection, as well as a critical role for B cells in regulation of bone homeostasis in RA.

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Jennifer H. Anolik, M.D., Ph.D.

Jennifer H. Anolik, M.D., Ph.D.
Principal Investigator

Research Projects
Lab Members
Publications

Projects

Cellular interations in the RA synovium

B Cell Roles in Rheumatoid Arthritis

Phenotypic profiles of Primary Sjogren’s (pSS) and normal control characterized by multi-parameter flow cytometry. Cluster analysis reveals two distinct cluster of pSS patients based on T and B cells.

Immunologic and Ultrasound Biomarkers in Primary Sjögren’s Syndrome

Development of Novel Treatment Approaches in SLE

Development of Novel Treatment Approaches in Systemic Lupus Erythematosus (SLE)

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Publications

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    1. Sugiarto NW
    2. Gurajala S
    3. Curtis M
    4. Eisenhaure TM
    5. Arazi A
    6. Fava A
    7. Xiao Q
    8. Mears J
    9. Rovin B
    10. Berthier CC
    11. Zhao Y
    12. Izmirly PM
    13. Barnas JL
    14. Hoover PJ
    15. Peters M
    16. Raychowdhury R
    17. Horisberger A
    18. Sakaue S
    19. Furie RA
    20. Belmont HM
    21. Hildeman DA
    22. Woodle ES
    23. Dall'Era M
    24. Putterman C
    25. Kamen DL
    26. McMahon MA
    27. Grossman J
    28. Kalunian KC
    29. Hodgin JB
    30. Payan-Schober F
    31. Apruzzese W
    32. Perlman H
    33. Cuda CM
    34. Wofsy D
    35. Guthridge JM
    36. Anolik JH
    37. James JA
    38. Rao DA
    39. Davidson A
    40. Petri MA
    41. Buyon JP
    42. Hacohen N
    43. Diamond B
    44. Raychaudhuri S
    A population-scale transcriptional atlas of blood and tissue in lupus nephritis.; Science translational medicine; Vol 18(863), pp. eaec0512. 2026 Aug 19.
    1. Zhang S
    2. Magder L
    3. Goldman D
    4. James JA
    5. Guthridge JM
    6. Guthridge C
    7. Izmirly P
    8. Buyon JP
    9. Belmont HM
    10. Furie RA
    11. Schwartz N
    12. Putterman C
    13. Barnas JL
    14. Anolik JH
    15. French S
    16. Dall'era M
    17. Rosenberg AZ
    18. Hodgin J
    19. Demeke DS
    20. Petri M
    21. Fava A
    Clinical, histological, and serological predictors of renal function loss in lupus nephritis.; Arthritis care & research. 2026 Apr 28.
    1. Hoover PJ
    2. Eisenhaure TM
    3. Hodgin J
    4. Apruzzese W
    5. Mears J
    6. Peters M
    7. Jones T
    8. Shah SI
    9. Kamal H
    10. Leavitt R
    11. Jackson SW
    12. Danaher P
    13. Rao DA
    14. Xiao Q
    15. Gurajala S
    16. Ai J
    17. Fava A
    18. Berthier CC
    19. Horisberger A
    20. Barnas JL
    21. Izmirly PM
    22. Belmont HM
    23. Clancy R
    24. Furie R
    25. Aranow C
    26. Guthridge JM
    27. Dall'Era M
    28. Wofsy D
    29. Kamen DL
    30. Kalunian KC
    31. McMahon MA
    32. Grossman J
    33. Payan-Schober F
    34. Hildeman DA
    35. Woodle ES
    36. Putterman C
    37. Kretzler M
    38. Clark MR
    39. Raychaudhuri S
    40. James JA
    41. Anolik JH
    42. Petri MA
    43. Buyon JP
    44. Diamond B
    45. Davidson A
    46. Hacohen N
    47. Arazi A
    Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression.; Annals of the rheumatic diseases. 2026 Apr 28.

Affiliations

In the News

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June 9, 2026
Fueling Discovery: Meet the 2026 Research and Education Pilot Awardees

May 8, 2026
Dr. Garcia-Hernandez, PhD to Receive the Women of Distinction Award

May 8, 2026
Dr. John Looney Named a JACI 2026 Outstanding Reviewer

April 13, 2026
Mentee of Dr. Jennifer Barnas Awarded Rochester Academy of Science Student Grant

February 6, 2026
Dr. Katherine Herman Presents Medical Grand Rounds

All News »

Contact Us

  Anolik Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642

 (585) 275-2891