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Jennifer Anolik at the bench

B Cells and Immune Diseases

Defining the role of B cells in systemic autoimmunity has been instrumental in characterizing the impact of B cell depletion (BCD) on the human immune system and establishing B cell targeted therapies. This has been a major advance in the field of immunologic disease with broad implications in rheumatoid arthritis, lupus, diabetes, malignancy, and immune deficiency.

Findings demonstrating a link between the clinical response and the immunologic reconstitution with transitional B cells was the first delineation of a B regulatory cell population in humans, greatly advancing our understanding of BCD therapy and human B cell development pathways. A prominent publication defining new populations of human transitional B cells provided further fundamental insights into the developmental process followed by human B cells, identifying a new population of human transitional B cells. Recent work has elucidated a previously unrecognized cross-talk between the B cell compartment and neutrophil driven α interferon production in the bone marrow in systemic lupus erythematosus (SLE) that alters B cell development and selection, as well as a critical role for B cells in regulation of bone homeostasis in RA.

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Jennifer H. Anolik, M.D., Ph.D.

Jennifer H. Anolik, M.D., Ph.D.
Principal Investigator

Research Projects
Lab Members
Publications

Projects

Cellular interations in the RA synovium

B Cell Roles in Rheumatoid Arthritis

Phenotypic profiles of Primary Sjogren’s (pSS) and normal control characterized by multi-parameter flow cytometry. Cluster analysis reveals two distinct cluster of pSS patients based on T and B cells.

Immunologic and Ultrasound Biomarkers in Primary Sjögren’s Syndrome

Development of Novel Treatment Approaches in SLE

Development of Novel Treatment Approaches in Systemic Lupus Erythematosus (SLE)

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Publications

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View All Publications
    1. Sugiarto NW
    2. Gurajala S
    3. Curtis M
    4. Eisenhaure TM
    5. Arazi A
    6. Fava A
    7. Xiao Q
    8. Mears J
    9. Rovin B
    10. Berthier CC
    11. Zhao Y
    12. Izmirly PM
    13. Barnas JL
    14. Hoover PJ
    15. Peters M
    16. Raychowdhury R
    17. Horisberger A
    18. Sakaue S
    19. Furie RA
    20. Belmont HM
    21. Hildeman DA
    22. Woodle ES
    23. Dall'Era M
    24. Putterman C
    25. Kamen DL
    26. McMahon MA
    27. Grossman J
    28. Kalunian KC
    29. Hodgin JB
    30. Payan-Schober F
    31. Apruzzese W
    32. Perlman H
    33. Cuda CM
    34. Wofsy D
    35. Guthridge JM
    36. Anolik JH
    37. James JA
    38. Rao DA
    39. Davidson A
    40. Petri MA
    41. Buyon JP
    42. Hacohen N
    43. Diamond B
    44. Raychaudhuri S
    A population-scale transcriptional atlas of blood and tissue in lupus nephritis.; Science translational medicine; Vol 18(863), pp. eaec0512. 2026 Aug 19.
    1. Zhang S
    2. Magder L
    3. Goldman D
    4. James JA
    5. Guthridge JM
    6. Guthridge C
    7. Izmirly P
    8. Buyon JP
    9. Belmont HM
    10. Furie RA
    11. Schwartz N
    12. Putterman C
    13. Barnas JL
    14. Anolik JH
    15. French S
    16. Dall'era M
    17. Rosenberg AZ
    18. Hodgin J
    19. Demeke DS
    20. Petri M
    21. Fava A
    Clinical, histological, and serological predictors of renal function loss in lupus nephritis.; Arthritis care & research. 2026 Apr 28.
    1. Hoover PJ
    2. Eisenhaure TM
    3. Hodgin J
    4. Apruzzese W
    5. Mears J
    6. Peters M
    7. Jones T
    8. Shah SI
    9. Kamal H
    10. Leavitt R
    11. Jackson SW
    12. Danaher P
    13. Rao DA
    14. Xiao Q
    15. Gurajala S
    16. Ai J
    17. Fava A
    18. Berthier CC
    19. Horisberger A
    20. Barnas JL
    21. Izmirly PM
    22. Belmont HM
    23. Clancy R
    24. Furie R
    25. Aranow C
    26. Guthridge JM
    27. Dall'Era M
    28. Wofsy D
    29. Kamen DL
    30. Kalunian KC
    31. McMahon MA
    32. Grossman J
    33. Payan-Schober F
    34. Hildeman DA
    35. Woodle ES
    36. Putterman C
    37. Kretzler M
    38. Clark MR
    39. Raychaudhuri S
    40. James JA
    41. Anolik JH
    42. Petri MA
    43. Buyon JP
    44. Diamond B
    45. Davidson A
    46. Hacohen N
    47. Arazi A
    Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression.; Annals of the rheumatic diseases. 2026 Apr 28.

Affiliations

In the News

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October 5, 2026
Dr. Stern Awarded Allergy Action Award

June 9, 2026
Fueling Discovery: Meet the 2026 Research and Education Pilot Awardees

May 8, 2026
Dr. Garcia-Hernandez, PhD to Receive the Women of Distinction Award

May 8, 2026
Dr. John Looney Named a JACI 2026 Outstanding Reviewer

April 13, 2026
Mentee of Dr. Jennifer Barnas Awarded Rochester Academy of Science Student Grant

All News »

Contact Us

  Anolik Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642

 (585) 275-2891