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Jennifer Anolik at the bench

Anolik Lab

B Cells and Immune Diseases

Defining the role of B cells in systemic autoimmunity has been instrumental in characterizing the impact of B cell depletion (BCD) on the human immune system and establishing B cell targeted therapies. This has been a major advance in the field of immunologic disease with broad implications in rheumatoid arthritis, lupus, diabetes, malignancy, and immune deficiency.

Findings demonstrating a link between the clinical response and the immunologic reconstitution with transitional B cells was the first delineation of a B regulatory cell population in humans, greatly advancing our understanding of BCD therapy and human B cell development pathways. A prominent publication defining new populations of human transitional B cells provided further fundamental insights into the developmental process followed by human B cells, identifying a new population of human transitional B cells. Recent work has elucidated a previously unrecognized cross-talk between the B cell compartment and neutrophil driven α interferon production in the bone marrow in systemic lupus erythematosus (SLE) that alters B cell development and selection, as well as a critical role for B cells in regulation of bone homeostasis in RA.

Publications

    1. Bocharnikov AV
    2. Keegan J
    3. Wacleche VS
    4. Cao Y
    5. Fonseka CY
    6. Wang G
    7. Muise ES
    8. Zhang KX
    9. Arazi A
    10. Keras G
    11. Li ZJ
    12. Qu Y
    13. Gurish MF
    14. Petri M
    15. Buyon JP
    16. Putterman C
    17. Wofsy D
    18. James JA
    19. Guthridge JM
    20. Diamond B
    21. Anolik JH
    22. Mackey MF
    23. Alves SE
    24. Nigrovic PA
    25. Costenbader KH
    26. Brenner MB
    27. Lederer JA
    28. Rao DA
    PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.; JCI insight; Vol 4(20). 2019 Oct 17.
    1. Arazi A
    2. Rao DA
    3. Berthier CC
    4. Davidson A
    5. Liu Y
    6. Hoover PJ
    7. Chicoine A
    8. Eisenhaure TM
    9. Jonsson AH
    10. Li S
    11. Lieb DJ
    12. Zhang F
    13. Slowikowski K
    14. Browne EP
    15. Noma A
    16. Sutherby D
    17. Steelman S
    18. Smilek DE
    19. Tosta P
    20. Apruzzese W
    21. Massarotti E
    22. Dall'Era M
    23. Park M
    24. Kamen DL
    25. Furie RA
    26. Payan-Schober F
    27. Pendergraft WF
    28. McInnis EA
    29. Buyon JP
    30. Petri MA
    31. Putterman C
    32. Kalunian KC
    33. Woodle ES
    34. Lederer JA
    35. Hildeman DA
    36. Nusbaum C
    37. Raychaudhuri S
    38. Kretzler M
    39. Anolik JH
    40. Brenner MB
    41. Wofsy D
    42. Hacohen N
    43. Diamond B
    Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis.; Nature immunology; Vol 20(10). 2019 Oct.
    1. Dieudonné Y
    2. Gies V
    3. Guffroy A
    4. Keime C
    5. Bird AK
    6. Liesveld J
    7. Barnas JL
    8. Poindron V
    9. Douiri N
    10. Soulas-Sprauel P
    11. Martin T
    12. Meffre E
    13. Anolik JH
    14. Korganow AS
    Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.; Journal of autoimmunity; Vol 102. 2019 Aug.
    1. Arazi A
    2. Rao DA
    3. Berthier CC
    4. Davidson A
    5. Liu Y
    6. Hoover PJ
    7. Chicoine A
    8. Eisenhaure TM
    9. Jonsson AH
    10. Li S
    11. Lieb DJ
    12. Zhang F
    13. Slowikowski K
    14. Browne EP
    15. Noma A
    16. Sutherby D
    17. Steelman S
    18. Smilek DE
    19. Tosta P
    20. Apruzzese W
    21. Massarotti E
    22. Dall'Era M
    23. Park M
    24. Kamen DL
    25. Furie RA
    26. Payan-Schober F
    27. Pendergraft WF
    28. McInnis EA
    29. Buyon JP
    30. Petri MA
    31. Putterman C
    32. Kalunian KC
    33. Woodle ES
    34. Lederer JA
    35. Hildeman DA
    36. Nusbaum C
    37. Raychaudhuri S
    38. Kretzler M
    39. Anolik JH
    40. Brenner MB
    41. Wofsy D
    42. Hacohen N
    43. Diamond B
    The immune cell landscape in kidneys of patients with lupus nephritis.; Nature immunology; Vol 20(7). 2019 Jul.

View All Publications

Contact Us

  Anolik Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642