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Jennifer Anolik at the bench

B Cells and Immune Diseases

Defining the role of B cells in systemic autoimmunity has been instrumental in characterizing the impact of B cell depletion (BCD) on the human immune system and establishing B cell targeted therapies. This has been a major advance in the field of immunologic disease with broad implications in rheumatoid arthritis, lupus, diabetes, malignancy, and immune deficiency.

Findings demonstrating a link between the clinical response and the immunologic reconstitution with transitional B cells was the first delineation of a B regulatory cell population in humans, greatly advancing our understanding of BCD therapy and human B cell development pathways. A prominent publication defining new populations of human transitional B cells provided further fundamental insights into the developmental process followed by human B cells, identifying a new population of human transitional B cells. Recent work has elucidated a previously unrecognized cross-talk between the B cell compartment and neutrophil driven α interferon production in the bone marrow in systemic lupus erythematosus (SLE) that alters B cell development and selection, as well as a critical role for B cells in regulation of bone homeostasis in RA.

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Jennifer H. Anolik, M.D., Ph.D.

Jennifer H. Anolik, M.D., Ph.D.
Principal Investigator

Research Projects
Lab Members
Publications

Projects

Cellular interations in the RA synovium

B Cell Roles in Rheumatoid Arthritis

Phenotypic profiles of Primary Sjogren’s (pSS) and normal control characterized by multi-parameter flow cytometry. Cluster analysis reveals two distinct cluster of pSS patients based on T and B cells.

Immunologic and Ultrasound Biomarkers in Primary Sjögren’s Syndrome

Development of Novel Treatment Approaches in SLE

Development of Novel Treatment Approaches in Systemic Lupus Erythematosus (SLE)

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Publications

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    1. Sugiarto NW
    2. Gurajala S
    3. Curtis M
    4. Eisenhaure TM
    5. Arazi A
    6. Fava A
    7. Xiao Q
    8. Mears J
    9. Rovin B
    10. Berthier CC
    11. Zhao Y
    12. Izmirly PM
    13. Barnas JL
    14. Hoover PJ
    15. Peters M
    16. Raychowdhury R
    17. Horisberger A
    18. Sakaue S
    19. Furie RA
    20. Belmont HM
    21. Hildeman DA
    22. Woodle ES
    23. Dall'Era M
    24. Putterman C
    25. Kamen DL
    26. McMahon MA
    27. Grossman J
    28. Kalunian KC
    29. Hodgin JB
    30. Payan-Schober F
    31. Apruzzese W
    32. Perlman H
    33. Cuda CM
    34. Wofsy D
    35. Guthridge JM
    36. Anolik JH
    37. James JA
    38. Rao DA
    39. Davidson A
    40. Petri MA
    41. Buyon JP
    42. Hacohen N
    43. Diamond B
    44. Raychaudhuri S
    A population-scale atlas of blood and tissue in lupus nephritis.; bioRxiv : the preprint server for biology. 2026 Apr 02.
    1. Horisberger A
    2. Griffith A
    3. Keegan J
    4. Arazi A
    5. Pulford J
    6. Murzin E
    7. Howard K
    8. Hancock B
    9. Fava A
    10. Sasaki T
    11. Ghosh T
    12. Inamo J
    13. Beuschel R
    14. Cao Y
    15. Preisinger K
    16. Gutierrez-Arcelus M
    17. Eisenhaure TM
    18. Guthridge J
    19. Hoover PJ
    20. Dall'Era M
    21. Wofsy D
    22. Kamen DL
    23. Kalunian KC
    24. Furie R
    25. Belmont M
    26. Izmirly P
    27. Clancy R
    28. Hildeman D
    29. Woodle ES
    30. Apruzzese W
    31. McMahon MA
    32. Grossman J
    33. Barnas JL
    34. Payan-Schober F
    35. Ishimori M
    36. Weisman M
    37. Kretzler M
    38. Berthier CC
    39. Hodgin JB
    40. Demeke DS
    41. Putterman C
    42. Brenner MB
    43. Anolik JH
    44. Raychaudhuri S
    45. Hacohen N
    46. James JA
    47. Davidson A
    48. Petri MA
    49. Buyon JP
    50. Diamond B
    51. Zhang F
    52. Lederer JA
    53. Rao DA
    Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis.; The Journal of clinical investigation. 2025 Jun 19.
    1. Inamo J
    2. Keegan J
    3. Griffith A
    4. Ghosh T
    5. Horisberger A
    6. Howard K
    7. Pulford JF
    8. Murzin E
    9. Hancock B
    10. Dominguez ST
    11. Gurra MG
    12. Gurajala S
    13. Jonsson AH
    14. Seifert JA
    15. Feser ML
    16. Norris JM
    17. Cao Y
    18. Apruzzese W
    19. Bridges SL
    20. Bykerk VP
    21. Goodman S
    22. Donlin LT
    23. Firestein GS
    24. Bathon JM
    25. Hughes LB
    26. Filer A
    27. Pitzalis C
    28. Anolik JH
    29. Moreland L
    30. Hacohen N
    31. Guthridge JM
    32. James JA
    33. Cuda CM
    34. Perlman H
    35. Brenner MB
    36. Raychaudhuri S
    37. Sparks JA
    38. Holers VM
    39. Deane KD
    40. Lederer J
    41. Rao DA
    42. Zhang F
    Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.; The Journal of clinical investigation; Vol 135(6). 2025 Mar 17.

Affiliations

In the News

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April 13, 2026
Mentee of Dr. Jennifer Barnas Awarded Rochester Academy of Science Student Grant

February 6, 2026
Dr. Katherine Herman Presents Medical Grand Rounds

January 23, 2026
Dr. Theresa Bingemann Presents at the AAAAI Program Directors Assembly Winter Meeting

November 21, 2025
Dr. Rangel-Moreno an International Speaker at the Research Seminars in Biological Sciences and International Biomedicine Workshop

October 22, 2025
Dr. Jennifer Anolik Presents at Upstate Medical Center Symposium

All News »

Contact Us

  Anolik Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642

 (585) 275-2891