Jennifer Howitt Anolik, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 486-0901

Fax: (585) 442-3214

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Research Labs

The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity.

Visit The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity. Lab Website

Locations

Lattimore Medical Center Allergy/Immunology/Rheumatology
125 Lattimore Rd, Ste G110
Rochester, NY 14620-4159

Allergy/Immunology/Rheumatology: (585) 486-0901

Faculty Appointments

Professor - Department of Medicine , Allergy/Immunology and Rheumatology (SMD)
Associate Chair, Research - Department of Medicine (SMD)
Professor - Department of Microbiology and Immunology (SMD) - Joint
Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Patient Care Setting

Allergy, Immunology & Rheumatology

Biography

Dr. Anolik is an adult rheumatologist who practices in the University of Rochester's Lupus Clinic. Her research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus, and B cell regulation of bone homeostasis in rheumatoid arthritis. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Research

Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compartment, and bone cells. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Credentials

Specialties

Internal Medicine
Rheumatology - American Board of Internal Medicine

Education

1994
Ph.D | Univ. of Rochester School of Medicine and Dentistry
Biochemistry

1996
MD | Univ. of Rochester School of Medicine and Dentistry

Post-doctoral Training & Residency

07/01/1999 - 06/30/2001
Fellowship in Rheumatology at University of Rochester Medical Center

07/01/1997 - 06/30/1999
Residency in Internal Medicine at University of Rochester Medical Center

07/01/1996 - 06/30/1997
Internship in Internal Medicine at University of Rochester Medical Center

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Awards

2015
American Society for Clinical Investigation

2008
Eisenberg Memorial Lupus Lectureship
Sponsor: University of MO-Columbia
Location: Columbia, MO

2006 - 2008
Lawrence Kohn Senior Teaching Fellow

2005
Edmund Dubois Memorial Lectureship Award
Sponsor: American College of Rheumatology

2003
Buswell Fellowship
Sponsor: University of Rochester Dept of Medicine
Location: Rochester, NY

2001
Rheumatology Fellow Award
Sponsor: American College of Rheumatology

2000 - 2002
NIH Training Grant T32-AI07169-16
Sponsor: University of Rochester
Location: Rochester, NY

1999 - 2000
Stuber Fellowship
Sponsor: University of Rochester
Location: Rochester, NY

1999
Raphael Dolin Resident Research Award
Sponsor: University of Rochester
Location: Rochester, NY

1994 - 1996
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1991 - 1992
Stotz Fellowship
Sponsor: University of Rochester Biochemistry Dept
Location: Rochester, NY

1988 - 1990
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1988 - 1989
Dean's Letter of Recognition
Sponsor: University of Rochester
Location: Rochester, NY

1988
Sigma Xi Scientific Research Society
Location: Swathmore College

1988
Outstanding Senior Chemistry Student Award
Sponsor: American Institute of Chemists
Location: Swathmore College

1988
Phi Beta Kappa
Location: Swathmore College

1987
Summer Research Fellowship
Sponsor: Dana Foundation
Location: Swathmore College

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Publications

Journal Articles

8/4/2021
Meednu N, Barnard J, Callahan K, Coca A, Marston B, Thiele R, Tabechian D, Bolster M, Curtis J, Mackay M, Graf J, Keating R, Smith E, Boyle K, Keyes-Elstein L, Welch B, Goldmuntz E, Anolik JH. "Activated peripheral blood B cells in rheumatoid arthritis and relationship to anti-TNF treatment and response: randomized clinical trial for anti-TNF effects on B cells." Arthritis & rheumatology.. 2021 Aug 4; Epub 2021 Aug 04.

8/5/2020
Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, , Donlin LT, Raychaudhuri S. "IFN- and TNF- drive a + + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation." . 2020 Aug 5; Epub 2020 Aug 05.

7/17/2020
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E. "Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition." Science.. 2020 Jul 17; 369(6501):320-325.

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