Jennifer Howitt Anolik, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 486-0901

Fax: (585) 442-3214

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Research Labs

The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity.

Lab: (585) 273-2179

Visit Lab Website

Locations

Lattimore Medical Ctr
125 Lattimore Rd.
Ste G110
Rochester, NY 14620-4159

Allergy/Immunology/Rheumatology: (585) 486-0901

Faculty Appointments

Professor - Department of Medicine , Allergy/Immunology and Rheumatology (SMD)
Professor - Department of Microbiology and Immunology (SMD) - Joint
Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Patient Care Setting

Allergy, Immunology & Rheumatology

Biography

Dr. Anolik is an adult rheumatologist who practices in the University of Rochester's Lupus Clinic. Her research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus, and B cell regulation of bone homeostasis in rheumatoid arthritis. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Research

Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compartment, and bone cells. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Credentials

Specialties

Internal Medicine
Rheumatology - American Board of Internal Medicine

Education

1988
BA | Swarthmore College
Chemistry

1994
PhD | Univ Rochester Sch Med/Dent
Biochemistry

1996
MD | Univ Rochester Sch Med/Dent
Medicine

Post-doctoral Training & Residency

07/01/1999 - 06/30/2001
Fellowship in Rheumatology at University of Rochester Medical Center - GME Office

07/01/1997 - 06/30/1999
Residency in Internal Medicine at University of Rochester Medical Center - GME Office

07/01/1996 - 06/30/1997
Internship in Internal Medicine at University of Rochester Medical Center - GME Office

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Awards

2015
American Society for Clinical Investigation

2008
Eisenberg Memorial Lupus Lectureship
Sponsor: University of MO-Columbia
Location: Columbia, MO

2006 - 2008
Lawrence Kohn Senior Teaching Fellow

2005
Edmund Dubois Memorial Lectureship Award
Sponsor: American College of Rheumatology

2003
Buswell Fellowship
Sponsor: University of Rochester Dept of Medicine
Location: Rochester, NY

2001
Rheumatology Fellow Award
Sponsor: American College of Rheumatology

2000 - 2002
NIH Training Grant T32-AI07169-16
Sponsor: University of Rochester
Location: Rochester, NY

1999 - 2000
Stuber Fellowship
Sponsor: University of Rochester
Location: Rochester, NY

1999
Raphael Dolin Resident Research Award
Sponsor: University of Rochester
Location: Rochester, NY

1994 - 1996
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1991 - 1992
Stotz Fellowship
Sponsor: University of Rochester Biochemisty Dept
Location: Rochester, NY

1988 - 1990
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1988 - 1989
Dean's Letter of Recognition
Sponsor: University of Rochester
Location: Rochester, NY

1988
Sigma Xi Scientific Research Society
Location: Swathmore College

1988
Outstanding Senior Chemistry Student Award
Sponsor: American Institutue ofChemists
Location: Swathmore College

1988
Phi Beta Kappa
Location: Swathmore College

1987
Summer Research Fellowship
Sponsor: Dana Foundation
Location: Swathmore College

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Publications

Journal Articles

12/3/2018
Sun W, Meednu N, Rosenberg A, Rangel-Moreno J, Wang V, Glanzman J, Owen T, Zhou X, Zhang H, Boyce BF, Anolik JH, Xing L. "B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation." Nature communications.. 2018 Dec 3; 9(1):5127. Epub 2018 Dec 03.

10/16/2018
Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Lee FE, Boss JM, Lund FE, Sanz I. "Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus." Immunity.. 2018 Oct 16; 49(4):725-739.e6. Epub 2018 Oct 09.

7/11/2018
Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, , Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. "Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue." Arthritis research & therapy.. 2018 Jul 11; 20(1):139. Epub 2018 Jul 11.

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Videos

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