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Jennifer Howitt Anolik, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 486-0901

Fax: (585) 442-3214

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity.

Visit The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity. Lab Website

Faculty Appointments

Patient Care Setting

Allergy, Immunology & Rheumatology

Biography

Dr. Anolik is an adult rheumatologist who practices in the University of Rochester's Lupus Clinic. Her research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus, and B cell regulation of bone homeostasis in rheumatoid arthritis. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Research

Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compartment, and bone cells. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Credentials

Specialties

  • Internal Medicine
  • Rheumatology - American Board of Internal Medicine

Education

1994
Ph.D | Univ. of Rochester School of Medicine and Dentistry
Biochemistry

1996
MD | Univ. of Rochester School of Medicine and Dentistry

Post-doctoral Training & Residency

07/01/1999 - 06/30/2001
Fellowship in Rheumatology at University of Rochester Medical Center

07/01/1997 - 06/30/1999
Residency in Internal Medicine at University of Rochester Medical Center

07/01/1996 - 06/30/1997
Internship in Internal Medicine at University of Rochester Medical Center

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Awards

2015
American Society for Clinical Investigation

2008
Eisenberg Memorial Lupus Lectureship
Sponsor: University of MO-Columbia
Location: Columbia, MO

2006 - 2008
Lawrence Kohn Senior Teaching Fellow

2005
Edmund Dubois Memorial Lectureship Award
Sponsor: American College of Rheumatology

2003
Buswell Fellowship
Sponsor: University of Rochester Dept of Medicine
Location: Rochester, NY

2001
Rheumatology Fellow Award
Sponsor: American College of Rheumatology

2000 - 2002
NIH Training Grant T32-AI07169-16
Sponsor: University of Rochester
Location: Rochester, NY

1999 - 2000
Stuber Fellowship
Sponsor: University of Rochester
Location: Rochester, NY

1999
Raphael Dolin Resident Research Award
Sponsor: University of Rochester
Location: Rochester, NY

1994 - 1996
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1991 - 1992
Stotz Fellowship
Sponsor: University of Rochester Biochemistry Dept
Location: Rochester, NY

1988 - 1990
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1988 - 1989
Dean's Letter of Recognition
Sponsor: University of Rochester
Location: Rochester, NY

1988
Sigma Xi Scientific Research Society
Location: Swathmore College

1988
Outstanding Senior Chemistry Student Award
Sponsor: American Institute of Chemists
Location: Swathmore College

1988
Phi Beta Kappa
Location: Swathmore College

1987
Summer Research Fellowship
Sponsor: Dana Foundation
Location: Swathmore College

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Clinical Trials

A Double-Blind, Placebo-Controlled Randomized, Multicenter Study to Assess Changes in Omega-3 Index in Erythrocytes and Health Benefit After 24 Weeks of Daily Consumption of AKBM-3031 (Omega-3 Phospholipids From Krill), Followed by a 24 Week Open-Label Extension, in Patients With Systemic Lupus Erythematosus (SLE)

Lead Researcher: Jennifer Howitt Anolik MD, PhD

A randomized, double-blind controlled, multicenter study in SLE patients given AKBM-3031 or placebo for 24 weeks (randomized period) and followed by an open label extension (OLE) treatment with AKBM-3031 for the next 24 weeks. Patients will be maintained on stable doses of background medications, except for glucocorticoids. Decreases in doses of glucocorticoids will be encouraged during the first 20 weeks of both the randomized and open label extension portions of the trial. Stable doses of glucocorticoids and other background medications are required during weeks 20-22 and 44-48. If indicated by the PI, brief increases in corticosteroids are permitted during the first 20 weeks of both the blinded and open label extension portion of the trial. The increase in prednisone (or equivalent) dose is limited to 2X the back-ground level to a maximum of 20 mg/day for a maximum of 1 week (7 days) or to a single administration of intravenous methylprednisolone or equivalent at a maximum dose of 500mg. Stable doses of glucocorticoids and other background medications are required during weeks 20-22 and 44-48

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Med/AIR Subject Database and Tissue Repository

Lead Researcher: Jennifer Howitt Anolik MD, PhD

Autoimmune diseases affect the immune system and are typically chronic conditions in which the immune system has an overactive response against substances and tissues that are normally present in the body. How autoimmunity develops, progresses, induces immunological abnormalities and leads to disease remains largely unknown, producing the need for further research. However, because the necessary samples are unique and somewhat rare, the ability to do research can at times be hindered. One purpose of this protocol is to establish a database that will serve as both a contact and research database. Subjects who are currently participating in one of our studies as well as those who are interested in participating in future research at the University of Rochester will be consented so that we may store their personal information in a division database. We will also store data collected during the conduct of IRB approved studies which reference this protocol. Healthy controls and individuals with diseases affecting the immune system may be consented and enrolled into this protocol.

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Publications

Journal Articles

7/17/2020
Chen JW, Rice TA, Bannock JM, Bielecka AA, Strauss JD, Catanzaro JR, Wang H, Menard LC, Anolik JH, Palm NW, Meffre E. "Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition." Science.. 2020 Jul 17; 369(6501):320-325.

4/22/2020
Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB. "Notch signalling drives synovial fibroblast identity and arthritis pathology." Nature.. 2020 Apr 22; Epub 2020 Apr 22.

1/14/2020
Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Eun-Hyung Lee F, Boss JM, Lund FE, Sanz I. "Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus." Immunity.. 2020 Jan 14; 52(1):203.

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Videos

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First New Lupus Drug in 50 Years: What Promise Might it Hold?

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Pop Star Brings Disease to Spotlight