Jennifer Howitt Anolik, M.D., Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 486-0901

Fax: (585) 442-3214

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Research Labs

The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity.

Visit The lab focuses on mechanisms of B cell tolerance in systemic lupus, bone marrow B cell development, and B cell regulation by the innate immune system and of the bone compartment in lupus and rheumatoid arthritis. Both translational approaches and murine models are utilized to study the diversity of B cell roles in systemic autoimmunity. Lab Website

Locations

400 Red Creek Dr
Suite 240
Rochester, NY 14623

Faculty Appointments

Professor - Department of Medicine , Allergy/Immunology and Rheumatology (SMD)
Associate Chair, Research - Department of Medicine (SMD)
Interim Chief - Department of Medicine , Allergy/Immunology and Rheumatology (SMD)
Professor - Department of Microbiology and Immunology (SMD) - Joint
Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Patient Care Settings

Allergy, Immunology & Rheumatology, Hospital Medicine

Biography

Dr. Anolik is an adult rheumatologist who practices in the University of Rochester's Lupus Clinic. Her research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus, and B cell regulation of bone homeostasis in rheumatoid arthritis. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Research

Dr. Anolik's research interests include the role of B cells in the pathophysiology of human systemic lupus, the study of new immuno-modulatory treatments for lupus and rheumatoid arthritis, and autoantibody independent functions for B cells including interaction with T cells, the innate immune compartment, and bone cells. As part of the research group at the University of Rochester she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. She has also pioneered the use of tonsil and bone marrow biopsy as a means of probing immune dysregulation in autoimmune diseases, including SLE and RA.

Credentials

Education

1994
PHD | University of Rochester School of Medicine/Dentistry
Medical Biochemical Genetics

1996
MD | University of Rochester School of Medicine/Dentistry

Post-doctoral Training & Residency

07/01/1999 - 06/30/2001
Fellowship in Rheumatology at University of Rochester Medical Center

07/01/1997 - 06/30/1999
Residency in Internal Medicine at University of Rochester Medical Center

07/01/1996 - 06/30/1997
Internship in Internal Medicine at University of Rochester Medical Center

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Awards

2015
American Society for Clinical Investigation

2008
Eisenberg Memorial Lupus Lectureship
Sponsor: University of MO-Columbia
Location: Columbia, MO

2006 - 2008
Lawrence Kohn Senior Teaching Fellow

2005
Edmund Dubois Memorial Lectureship Award
Sponsor: American College of Rheumatology

2003
Buswell Fellowship
Sponsor: University of Rochester Dept of Medicine
Location: Rochester, NY

2001
Rheumatology Fellow Award
Sponsor: American College of Rheumatology

2000 - 2002
NIH Training Grant T32-AI07169-16
Sponsor: University of Rochester
Location: Rochester, NY

1999 - 2000
Stuber Fellowship
Sponsor: University of Rochester
Location: Rochester, NY

1999
Raphael Dolin Resident Research Award
Sponsor: University of Rochester
Location: Rochester, NY

1994 - 1996
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1991 - 1992
Stotz Fellowship
Sponsor: University of Rochester Biochemistry Dept
Location: Rochester, NY

1988 - 1990
Medical Scientist Training Program Scholarship
Sponsor: NIH
Location: University of Rochester

1988 - 1989
Dean's Letter of Recognition
Sponsor: University of Rochester
Location: Rochester, NY

1988
Sigma Xi Scientific Research Society
Location: Swathmore College

1988
Outstanding Senior Chemistry Student Award
Sponsor: American Institute of Chemists
Location: Swathmore College

1988
Phi Beta Kappa
Location: Swathmore College

1987
Summer Research Fellowship
Sponsor: Dana Foundation
Location: Swathmore College

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Publications

Journal Articles

7/4/2023
Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford J, Murzin E, Hancock B, Jonsson AH, Seifert J, Feser ML, Norris JM, Cao Y, Apruzzese W, Louis Bridges S, Bykerk V, Goodman S, Donlin L, Firestein GS, Perlman H, Bathon JM, Hughes LB, Tabechian D, Filer A, Pitzalis C, Anolik JH, Moreland L, Guthridge JM, James JA, Brenner MB, Raychaudhuri S, Sparks JA, Michael Holers V, Deane KD, Lederer JA, Rao DA, Zhang F. "Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis." bioRxiv : the preprint server for biology.. 2023 Jul 4; Epub 2023 Jul 04.

4/8/2023
Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Zhu Z, , Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S. "The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis." bioRxiv : the preprint server for biology.. 2023 Apr 8; Epub 2023 Apr 08.

3/21/2023
Dunlap G, Wagner A, Meednu N, Zhang F, Jonsson AH, Wei K, Sakaue S, Nathan A, , Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, McDavid A, Rao DA, Anolik JH. "Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium." bioRxiv : the preprint server for biology.. 2023 Mar 21; Epub 2023 Mar 21.

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