Brian James Blyth, M.D.

Dr. Blyth is currently a Associate Professor of Clinical Emergency Medicine.

Dr. Blyth is currently a Associate Professor of Clinical Emergency Medicine.

The research efforts of the Blyth laboratory focus on traumatic brain injury. The overarching goal of our laboratory is to reduce the morbidity and mortality associated with traumatic brain injury. To accomplish this goal we rely on a translational approach: both clinical and basic studies are us...

The research efforts of the Blyth laboratory focus on traumatic brain injury. The overarching goal of our laboratory is to reduce the morbidity and mortality associated with traumatic brain injury. To accomplish this goal we rely on a translational approach: both clinical and basic studies are used to identify and solve relevant research questions that might lead to improved therapeutics for this disease. Ultimately, promising therapies are tested for efficacy through clinical trials. Laboratory resources include a repository of patient samples collected through a multicenter research network that includes six medical centers located throughout upstate New York with 300,000 patient visits per year. Data and clinical samples collected through this network are housed at a central repository located within the laboratory. Physically, the laboratory consists of state of the art bench research facilities within the Center for Neural Development and Disease at the University of Rochester Medical Center. We utilize patient based studies as well as cell culture and animal models of disease. Several mouse and rat models of traumatic brain injury are utilized. Relevant questions are identified through studies of large numbers of human patients and examined in detail in animal models. Mechanistic insights gleaned through this approach may then allow for novel therapeutics that can then be developed for clinical trials.