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Sandhya Khurana, M.D.
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About Me

Interests: Difficult and Severe Asthma

Professional Background

Dr. Sandhya Khurana is an adult pulmonary and critical care physician with a specialized focus in management of severe and difficult asthma. She completed her training in Pulmonary and Critical Care Medicine at Thomas Jefferson University in 2003 where her research focus was 'airway remodeling in as...
Dr. Sandhya Khurana is an adult pulmonary and critical care physician with a specialized focus in management of severe and difficult asthma. She completed her training in Pulmonary and Critical Care Medicine at Thomas Jefferson University in 2003 where her research focus was 'airway remodeling in asthma'. She joined the faculty at University of Rochester in 2008 and helped develop a multidisciplinary state-of-the-art severe asthma program. She is the Director of the Mary Parkes Center for Asthma, Allergy & Pulmonary Care.

Dr. Khurana's clinical and research interests include comprehensive multidisciplinary management of severe asthma. She believes in a patient-centered team-based approach to management of this complex condition. She has expertise in application of novel therapies for severe asthma including new monoclonal antibodies. She is the site principal investigator in multicenter clinical trials evaluating new treatments in asthma. She is a co-investigator in the SOAR (Study Of Asthma in Rochester) asthma registry focused on characterization of asthma using non-invasive biomarkers.

Dr. Khurana has chaired asthma-focused sessions and participated as faculty at national and international meetings. Dr. Khurana was invited to participate in the 2015 WHO strategic meeting for management of chronic respiratory diseases in Geneva, Switzerland. She is the past Chair of Airway Disorders NetWork of the American College of Chest Physicians. She has also served on the American Thoracic Society/European Respiratory Society's joint task-force on severe asthma. Dr. Khurana has co-authored several peer-reviewed papers on severe asthma and is the editor of a textbook on 'difficult asthma'.

Certified Specialties

Critical Care Medicine - American Board of Internal Medicine

Pulmonary Disease - American Board of Internal Medicine

Sleep Medicine - American Board of Internal Medicine

Faculty Appointments

Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Director, Mary Parkes Center - Department of Medicine, Pulmonary Diseases and Critical Care (SMD) - Joint


Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, Thomas Jefferson University Hospital & Medical College. 2000 - 2003

Residency, Internal Medicine, State University of NY Health Science Center/Brooklyn. 1997 - 2000

Internship, Internal Medicine, State University of NY Health Science Center/Brooklyn. 1996 - 1997


MBBS | University College of Medical Sciences-Delhi (India). 1992


Clinical Trials

American Lung Association Lung Health Cohort ALA LHC

Lead Researcher: Sandhya Khurana

Because lung function reaches its peak level between the ages of 25-35 years old, we are beginning our study with people only in this age range. If you are in this age range and have no history of chronic (i.e. long-lasting) lung diseases - other tha...


Journal Articles

Update on Asthma Biology.

Georas SN, Khurana S

The Journal of allergy and clinical immunology.. 2024 February 8 Epub 02/08/2024.

Diagnostic Impact of a Race-Composite Pulmonary Function Test Results Interpretation Strategy.

Connolly MJ, Donohue PA, Palli R, Khurana S, Cai X, Georas SN

Chest.. 2023 June 17 Epub 06/17/2023.

Pulmonary Embolism Diagnosed During Endobronchial Ultrasound in a Patient With Major Trauma.

Maeda T, Fe A, Khurana S, Nead M

Cure?us.. 2023 February 15 (2):e35273. Epub 02/21/2023.

Heterogeneity of Treatment Response to Asthma.

Maeda T, Khurana S

Advances in experimental medicine and biology.. 2023 1426 :143-161. Epub 1900 01 01.

The effects of a deep breathing maneuver on standard airwave oscillometry measurements.

Donohue P, Love NC, Connolly M, Khurana S, Georas SN

Respiratory medicine and research.. 2022 December 683 :100985. Epub 12/06/2022.

Use of biologics for the treatment of moderate-to-severe asthma: the age of personalized medicine.

Mustafa SS, Patrawala S, Khurana S

Current opinion in pulmonary medicine.. 2022 February 7 Epub 02/07/2022.

Use of fractional exhaled nitric oxide to guide the treatment of asthma and chronic cough.

Sandhya Khurana.

Journal of Precision Respiratory Medicine. 2022; 5(1): 1-4.

Oral corticosteroid-sparing effects of mepolizumab in severe eosinophilic asthma: evidence from randomized controlled trials and real-world studies.

Casale TB, Burnette A, Bourdin A, Howarth P, Hahn B, Stach-Klysh A, Khurana S

Therapeutic advances in respiratory disease.. 2022 16 :17534666221107313. Epub 1900 01 01.

Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline.

Khatri SB, Iaccarino JM, Barochia A, Soghier I, Akuthota P, Brady A, Covar RA, Debley JS, Diamant Z, Fitzpatrick AM, Kaminsky DA, Kenyon NJ, Khurana S, Lipworth BJ, McCarthy K, Peters M, Que LG, Ross KR, Schneider-Futschik EK, Sorkness CA, Hallstrand TS,

American journal of respiratory and critical care medicine.. 2021 November 15204 (10):e97-e109. Epub 1900 01 01.

Asthma Biologics: Real-World Effectiveness, Impact of Switching Biologics and Predictors of Response.

Abbas F, Georas S, Cai X, Khurana S

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2021 September 2 Epub 09/02/2021.

Mediastinal pancreatic pseudocyst masquerading as diffuse alveolar haemorrhage.

Clark HL, Illipparambil LC, Khurana S

BMJ case reports.. 2021 July 114 (7)Epub 07/01/2021.

How I do it: Managing corticosteroid-related co-morbidities in severe asthma.

Sood V, Rogers L, Khurana S

Chest.. 2021 May 18 Epub 05/18/2021.

A multi-stakeholder Delphi consensus core outcome set for clinical trials in moderate-to-severe asthma (coreASTHMA).

Tejwani V, Chang HY, Tran AP, Naber JA, Gutzwiller FS, Winders TA, Khurana S, Sumino K, Mosnaim G, Moloney RM,

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2021 March 26 Epub 03/26/2021.

Asthma-Chronic Obstructive Pulmonary Disease Overlap.

Sharma S, Khurana S, Federman AD, Wisnivesky J, Holguin F

Immunology and allergy clinics of North America.. 2020 November 40 (4):565-573. Epub 1900 01 01.

Management of severe asthma: summary of the European Respiratory Society/American Thoracic Society task force report.

Khurana S, Bush A, Holguin F

Breathe.. 2020 June 16 (2):200058. Epub 1900 01 01.

Long-term Safety and Clinical Benefit of Mepolizumab in Patients With the Most Severe Eosinophilic Asthma: The COSMEX Study.

Khurana S, Brusselle GG, Bel EH, FitzGerald JM, Masoli M, Korn S, Kato M, Albers FC, Bradford ES, Gilson MJ, Price RG, Humbert M

Clinical therapeutics.. 2019 October 41 (10):2041-2056.e5. Epub 08/22/2019.

Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline.

Holguin F, Cardet JC, Chung KF, Diver S, Ferreira DS, Fitzpatrick A, Gaga M, Kellermeyer L, Khurana S, Knight S, McDonald VM, Morgan RL, Ortega VE, Rigau D, Subbarao P, Tonia T, Adcock IM, Bleecker ER, Brightling C, Boulet LP, Cabana M, Castro M, Chanez P, Custovic A, Djukanovic R, Frey U, Frankemolle B, Gibson P, Hamerlijnck D, Jarjour N, Konno S, Shen H, Vitary C, Bush A

The European respiratory journal.. 2019 September 26 Epub 09/26/2019.

Distinct asthma phenotypes with low maximal attainment of lung function on cluster analysis.

Bhargava S, Holla AD, Jayaraj BS, Praveena AS, Ravi S, Khurana S, Mahesh PA

The Journal of asthma : official journal of the Association for the Care of Asthma.. 2019 September 3 :1-12. Epub 09/03/2019.

Association of depressive symptoms with health status and markers of uncontrolled severe asthma.

Khurana S, Lyness JM, Mallett S, Nelsen LM, Prazma CM, Albers FC, Forshag M, Llanos JP, Yancey SW, Ortega HG

Allergy and asthma proceedings :. 2019 July 140 (4):230-239. Epub 1900 01 01.

Pulmonary Function Testing and Cardiopulmonary Exercise Testing: An Overview.

Krol K, Morgan MA, Khurana S

The Medical clinics of North America.. 2019 May 103 (3):565-576. Epub 1900 01 01.

Systematic Approach to Asthma of Varying Severity.

Khurana S, Jarjour NN

Clinics in chest medicine.. 2019 March 40 (1):59-70. Epub 12/19/2018.

Tiotropium reduces airflow obstruction in asthma patients, independent of body mass index.

Khurana S, Paggiaro P, Buhl R, Bernstein JA, Haddon J, Unseld A, Engel M, Casale TB, Dixon AE

The journal of allergy and clinical immunology. In practice.. 2019 7 (7):2425-2428.e7. Epub 03/19/2019.

Anesthetic Considerations for Patients Undergoing Bronchial Thermoplasty.

Saran JS, Kreso M, Khurana S, Nead M, Larj M, Karan S

Anesthesia and analgesia.. 2018 May 126 (5):1575-1579. Epub 1900 01 01.

Mepolizumab treatment in patients with severe eosinophilic asthma.

Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P,

The New England journal of medicine.. 2014 September 25371 (13):1198-207. Epub 09/08/2014.

Modulation of vasodilator-stimulated phosphoprotein in vivo in human epithelial cells by segmental allergen challenge and beta2-agonist therapy.

Hastie AT, Batra V, Khurana S, Carpenter KA, Cirelli R, Zangrilli JG, Peters SP

Chest.. 2003 March 123 (3 Suppl):377S. Epub 1900 01 01.

Concentration of cytokines and growth factors in BAL fluid after allergen challenge in asthmatics and their effect on alpha-smooth muscle actin and collagen III synthesis by human lung fibroblasts.

Batra V, Khurana S, Musani AI, Hastie AT, Carpenter KA, Zangrilli JG, Peters SP

Chest.. 2003 March 123 (3 Suppl):398S-9S. Epub 1900 01 01.

Twenty-first century tobacco use: it is not just a risk factor anymore

S. Khurana, V. Batra, F. Leone.

Respiratory Medicine. 2003; 97(4): 295-301.


Difficult to Treat Asthma: Clinical Essentials (2020)

Authors: Editors Sandhya Khurana and Fernando Holguin

Publisher: Springer Nature 2020

Difficult to treat asthma:clinical essentials (2020)

Chapter: High-Risk Asthma Clinic: Putting It All Together

Authors: Navitha Ramesh & Sandhya Khurana

Publisher: Springer Nature 2020

Ratings & Reviews

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