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Robert M. Kottmann, M.D.

Robert M. Kottmann, M.D.

Pulmonary & Critical Care Medicine, Internal Medicine

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Office (585) 275-4161
Fax (585) 340-4009

Locations

Pulmonary Clinic

601 Elmwood Avenue, 3rd Floor
Rochester, NY 14642

(585) 275-4161 Get Directions

About Me

Faculty Appointments

Associate Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Credentials

Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 2004 - 2007

Residency, Internal Medicine, University of Rochester Medical Center. 2002 - 2004

Internship, Internal Medicine, University of Rochester Medical Center. 2001 - 2002

Education

MD | Jefferson Medical College. 2001

Research

Research Lab

Clinical Trials

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis,,A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis

Lead Researcher: Robert M Kottmann

You are being asked to be in this research study because you have idiopathic pulmonary fibrosis (IPF). This means that you have scarring of the lungs from an unknown cause. The scarring makes it hard for the lungs to get oxygen into the blood, which ...

Patents

LDH Inhibitors as Treatment for Fibrosis and for Fibrotic-Related Disorders

Issue date: September 05, 2017

Patent #: 9,750,761

Country: United States

Inventors: Robert Matthew Kottmann, Richard P Phipps, Patricia Janet Sime

Method and Apparatus to Diagnose the Metatstatic or Progressive Potential of Cancer, Fibrosis and other Diseases

Issue date: September 08, 2020

Patent #: 10,765,376

Country: United States

Inventors: Edward Brown III, Kathleen Burke, Robert Matthew Kottmann, Seth W Perry, Jesse W Sharpe, Patricia Janet Sime

Publications

Journal Articles

Association between weight loss and mortality in idiopathic pulmonary fibrosis.

Kalininskiy A, Rackow AR, Nagel D, Croft D, McGrane-Minton H, Kottmann RM

Respiratory research.. 2022 December 2423 (1):377. Epub 12/24/2022.

The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA Activity.

Rackow AR, Nagel DJ, Zapas G, Clough RS, Sime PJ, Kottmann RM

International journal of molecular sciences.. 2022 October 823 (19)Epub 10/08/2022.

Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis.

Nagel DJ, Rackow AR, Ku WY, Bell TJ, Sime PJ, Kottmann RM

Cells.. 2022 August 1611 (16)Epub 08/16/2022.

miR-338-3p Blocks TGF?-Induced Myofibroblast Differentiation through the Induction of PTEN.

Rackow AR, Judge JL, Woller CF, Sime PJ, Kottmann RM

American journal of physiology. Lung cellular and molecular physiology.. 2022 January 5 Epub 01/05/2022.

Ogerin mediated inhibition of TGF-?(1) induced myofibroblast differentiation is potentiated by acidic pH.

Bell TJ, Nagel DJ, Woeller CF, Kottmann RM

PloS one.. 2022 17 (7):e0271608. Epub 07/28/2022.

The effect of air pollution on the transcriptomics of the immune response to respiratory infection.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN

Scientific reports.. 2021 September 3011 (1):19436. Epub 09/30/2021.

The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops.

Rackow AR, Nagel DJ, McCarthy C, Judge J, Lacy S, Freeberg MAT, Thatcher TH, Kottmann RM, Sime PJ

The European respiratory journal.. 2020 September 17 Epub 09/17/2020.

Reinterpreting Evidence of Rheumatoid Arthritis-Associated Interstitial Lung Disease to Understand Etiology.

Wu EK, Ambrosini RD, Kottmann RM, Ritchlin CT, Schwarz EM, Rahimi H

Current rheumatology reviews.. 2019 January 15 Epub 01/15/2019.

The clinical impact of pneumocystis and viral PCR testing on bronchoalveolar lavage in immunosuppressed patients.

Lachant DJ, Croft DP, McGrane Minton H, Hardy DJ, Prasad P, Kottmann RM

Respiratory medicine.. 2018 December 145 :35-40. Epub 10/22/2018.

Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.

Judge JL, Nagel DJ, Owens KM, Rackow A, Phipps RP, Sime PJ, Kottmann RM

PloS one.. 2018 13 (5):e0197936. Epub 05/24/2018.

Development of an accurate and sensitive method for lactate analysis in exhaled breath condensate by LC MS/MS.

Jackson TC, Zhang YV, Sime PJ, Phipps RP, Kottmann RM

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.. 2017 September 11061-1062 :468-473. Epub 07/24/2017.

Nasopharyngeal viral PCR in immunosuppressed patients and its association with virus detection in bronchoalveolar lavage by PCR.

Lachant DJ, Croft DP, McGrane Minton H, Prasad P, Kottmann RM

Respirology : official journal of the Asian Pacific Society of Respirology.. 2017 August 22 (6):1205-1211. Epub 04/05/2017.

The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.

Judge JL, Lacy SH, Ku WY, Owens KM, Hernady E, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM

Radiation research.. 2017 July 188 (1):35-43. Epub 05/02/2017.

Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.

Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2017 April 56 (4):453-464. Epub 1900 01 01.

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.

Kottmann RM, Trawick E, Judge JL, Wahl LA, Epa A, Owens KM, Thatcher TH, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2015 December 1309 (11):L1305-12. Epub 09/25/2015.

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.

Judge JL, Owens KM, Pollock SJ, Woeller CF, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM

American journal of physiology. Lung cellular and molecular physiology.. 2015 October 15309 (8):L879-87. Epub 08/07/2015.

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.

Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2015 October 15309 (8):L888-901. Epub 08/21/2015.

Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung.

Kottmann RM, Sharp J, Owens K, Salzman P, Xiao GQ, Phipps RP, Sime PJ, Brown EB, Perry SW

Respiratory research.. 2015 May 2716 :61. Epub 05/27/2015.

Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI.

Jones KM, Randtke EA, Howison CM, Cárdenas-Rodríguez J, Sime PJ, Kottmann MR, Pagel MD

Molecular imaging and biology.. 2015 April 17 (2):177-84. Epub 1900 01 01.

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-? Induced Myofibroblast Differentiation via Prostaglandin E2.

Epa AP, Thatcher TH, Pollock SJ, Wahl LA, Lyda E, Kottmann RM, Phipps RP, Sime PJ

PloS one.. 2015 10 (8):e0135266. Epub 08/06/2015.

Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.

Olsen KC, Epa AP, Kulkarni AA, Kottmann RM, McCarthy CE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ

American journal of respiratory cell and molecular biology.. 2014 April 50 (4):737-47. Epub 1900 01 01.

New light is shed on the enigmatic origin of the lung myofibroblast.

Rosas IO, Kottman RM, Sime PJ

American journal of respiratory and critical care medicine.. 2013 October 1188 (7):765-6. Epub 1900 01 01.

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ

PloS one.. 2013 8 (5):e63798. Epub 05/31/2013.

Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-?.

Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ

American journal of respiratory and critical care medicine.. 2012 October 15186 (8):740-51. Epub 08/23/2012.

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE

American journal of respiratory cell and molecular biology.. 2012 May 46 (5):687-94. Epub 01/12/2012.

Transglutaminase 2 and its role in pulmonary fibrosis.

Olsen KC, Sapinoro RE, Kottman RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ

American journal of respiratory and critical care medicine.. 2011 September 15184 (6):699-707. Epub 06/23/2011.

Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients.

Kottmann RM, Kelly J, Lyda E, Gurell M, Stalica J, Ormsby W, Moon K, Trawick D, Sime PJ

Thorax.. 2011 September 66 (9):823. Epub 09/13/2010.

Metastatic papillary thyroid carcinoma and severe airflow obstruction.

Manganaris C, Wittlin S, Xu H, Gurell M, Sime P, Kottmann RM

Chest.. 2010 September 138 (3):738-42. Epub 1900 01 01.

Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.

Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2009 November 297 (5):L912-9. Epub 09/04/2009.

Determinants of initiation and progression of idiopathic pulmonary fibrosis.

Kottmann RM, Hogan CM, Phipps RP, Sime PJ

Respirology : official journal of the Asian Pacific Society of Respirology.. 2009 September 14 (7):917-33. Epub 1900 01 01.

Exogenous lipoid pneumonia: an unexpected complication of substance abuse.

Gurell MN, Kottmann RM, Xu H, Sime PJ

Annals of internal medicine.. 2008 September 2149 (5):364-5. Epub 1900 01 01.

The Role of PPARs in Lung Fibrosis.

Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ

PPAR research. 2007 2007 :71323. Epub 1900 01 01.