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Inna Hughes, M.D., Ph.D.

Inna Hughes, M.D., Ph.D.


Neurology , Pediatrics , Child Neurology

5 out of 5 stars
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients



Epilepsy Center

601 Elmwood Avenue, Box 673
Rochester, NY 14642

Pediatric Neurology

200 East River Road, 3rd Floor
Rochester, NY 14623

About Me

Certified Specialties

Epilepsy - American Board of Psychiatry & Neurology

Neurology with Special Qualification in Child Neurology - American Board of Psychiatry & Neurology

Faculty Appointments

Associate Professor - Department of Neurology, Epilepsy (SMD)

Associate Professor - Department of Pediatrics (SMD) - Joint


Residency & Fellowship

Fellowship, Epilepsy, University of Rochester Medical Center. 2014 - 2015

Residency, University of Rochester Medical Center. 2009 - 2012

Internship, Pediatrics, Golisano Children's Hospital-University of Rochester. 2007 - 2009


MD | Washington University School of Medicine. 2007


Upstate New York Regional Champions. 2011

Alpha Omega Alpha Society. 2011

Spencer T and Ann W. Olin Medical Scientist Fellow. 2007

Merlie Fine Sciences Travel Award. 2004

Viktor Hamburger Award. 2004

Graduate Student Presentation Award. 2004

Ruth L. Kirschstein National Research Service Award Individual Fellowship. 2004 - 2007

Honors in Biology, Magna cum Laude. 1999

Medical Scientist Training Program grant. 1999 - 2003

Minority Undergraduate Summer Internship Program. 1998

Acceleration to Excellence Scholarship. 1995 - 1997


Journal Articles

Seizure Frequency Process and Outcome Quality Measures: Quality Improvement in Neurology.

Munger Clary H, Josephson SA, Franklin G, Herman ST, Hopp JL, Hughes I, Meunier L, Moura LMVR, Parker-McFadden B, Pugh MJ, Schultz R, Spanaki MV, Bennett A, Baca C

Neurology.. 2022 April 598 (14):583-590. Epub 1900 01 01.

Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD.

Poliquin S, Hughes I, Shen W, Mermer F, Wang J, Mack T, Xu D, Kang JQ

Experimental neurology.. 2021 May 4 :113723. Epub 05/04/2021.

Quality improvement in neurology: Epilepsy Quality Measurement Set 2017 update.

Patel AD, Baca C, Franklin G, Herman ST, Hughes I, Meunier L, Moura LMVR, Munger Clary H, Parker-McFadden B, Pugh MJ, Schultz RJ, Spanaki MV, Bennett A, Josephson SA

Neurology.. 2018 October 3091 (18):829-836. Epub 10/03/2018.

Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses.

Hurle B, Marques-Bonet T, Antonacci F, Hughes I, Ryan JF, Comparative Sequencing Program N, Eichler EE, Ornitz DM, Green ED

BMC evolutionary biology. 2011 January 2411 :23. Epub 01/24/2011.

The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.

Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BP, Keller-Peck C, Heuckeroth RO

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 January 2730 (4):1523-38. Epub 1900 01 01.

Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members.

Hughes I, Binkley J, Hurle B, Green ED, , Sidow A, Ornitz DM

BMC evolutionary biology. 2008 February 68 :41. Epub 02/06/2008.

Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.

Hughes I, Saito M, Schlesinger PH, Ornitz DM

Proceedings of the National Academy of Sciences of the United States of America.. 2007 July 17104 (29):12023-8. Epub 07/02/2007.

Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development.

Hughes I, Thalmann I, Thalmann R, Ornitz DM

Brain research.. 2006 May 261091 (1):58-74. Epub 03/09/2006.

Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti.

Thalmann I, Hughes I, Tong BD, Ornitz DM, Thalmann R

Electrophoresis.. 2006 April 27 (8):1598-608. Epub 1900 01 01.

Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio.

Hughes I, Blasiole B, Huss D, Warchol ME, Rath NP, Hurle B, Ignatova E, Dickman JD, Thalmann R, Levenson R, Ornitz DM

Developmental biology.. 2004 December 15276 (2):391-402. Epub 1900 01 01.

GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration.

Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM, Milbrandt J

Neuron.. 2004 November 1844 (4):623-36. Epub 1900 01 01.

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.


During this visit, did this provider spend enough time with you?

5.0 stars

During this visit, did this provider show respect for what you had to say?

5.0 stars

During this visit, did this provider give you easy to understand information about these health questions or concerns?

4.9 stars

During this visit, did this provider listen carefully to you?

5.0 stars

During this visit, did this provider explain things in a way that was easy to understand?

4.9 stars

Patient Comments

5.0 stars

Inna Hughes is the best neurologist! She cares deeply for me and wants me to live the best life I can.

Sep 23, 2023

5.0 stars

Every time we have visit or communication w/ Dr. Hughes is outstanding! Only regret is, we didn't find her years ago.

Jun 28, 2023

5.0 stars

We ALWAYS receive exceptional care, concern and communication with Dr. Hughes.

May 30, 2023

5.0 stars

Dr. Hughes is the best and I am very thankful that she is taking care of my son.

Apr 04, 2023

My doctor is very nice

Mar 17, 2023

5.0 stars

Best dr. we have ever seen or dealt with for our daughter.

Mar 14, 2023

5.0 stars

Very good doctor.

Dec 07, 2022

5.0 stars

You need a category beyond "very good". There is no adequate description for the care we receive from Dr. Hughes. "Rock Star" might be close. She's brilliant, well-informed, anticipates our current concerns prior to us walking in the door and has researched answers ahead of time. She clearly reviewed our most recent medical history because she started off by saying "I see the surgery went well" referencing a spinal surgery at another hospital, in another city, that had nothing to do with her treatment of Billy. How often does that happen when you see a doctor? Usually you spend the first 5 minutes catching them up on what's going on- Dr. Hughes does that PRIOR to you walking in the door. She is AMAZING. I have complete trust and faith in her knowledge and advise. She has changed our son's life in ways that are so positive, words cannot do it justice.

Sep 29, 2022

She is in excellent provided who really have giving my daughter the best care

Apr 19, 2022

Dr. Inna Hughes has been part of our NEURO Care team for the past decade. She is fabulous and we drive from over an hour a way to see her. The telemed option for this appointment was fabulous as she was able to provide the same super care without the drive transporting our medically complex kiddo to the office. [...]

Apr 13, 2022