I primarily treat patients with pulmonary hypertension, heart failure, and pulmonary embolus (blood clots in the lung). My goal is to improve and provide access to care for patients with pulmonary vascular disease across New York and central Pennsylvania. We are a nationally accredited PHA (Pulmonary Hypertension Association) Comprehensive Care Center with an outpatient clinic and inpatient service at Strong Memorial Hospital. The URMC Pulmonary Hypertension group consists of my partner and mentor Jim White, MD,PhD; clinical/research nurse (Andrew Mintz); two research technicians (Deborah Haight and Jackie Bruno); a full time administrator (Monique Johnson); a research study coordinator (Michael Lachant) and a post-doctoral research associate (Allison Light PhD). We are involved with multiple pharmaceutical clinical trials, translational research, and laboratory research. Our pulmonary hypertension group has collaborated with the Pulmonary Hypertension Association to create a how to safely exercise videos series.

https://phassociation.org/patients/living-with-ph/exercise-and-ph/

https://phassociation.org/portfolio-items/exercise-and-pulmonary-rehab-in-ph/?portfolioCats=23550

Faculty Appointments

Associate Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Associate Professor - Center for Health and Technology - Joint

Credentials

Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 2014 - 2017

Residency, Internal Medicine, University of Rochester Medical Center. 2012 - 2014

Internship, Internal Medicine, University of Rochester Medical Center. 2011 - 2012

Education

DO | Philadelphia College of Osteopathic Medicine. 2011

Awards

NHLBI: K23. 2024 - 2028

United Therapeutics Investigator Initiated. 2024 - 2027

Medidata Investigator Initiated. 2022 - 2026

Chest Foundation Grant. 2022 - 2023

KL2 Scholar Award. 2021 - 2023

Jenesis Innovative Researcher Award. 2021 - 2023

United Therapeutics Investigator Initiated. 2020 - 2024

Entelligence Young Investigator Award. 2018 - 2019

Research

I have two areas of active research trying to personalize pulmonary vascular disease.

The first is using digital technology to measure changes in heart rate during the 6-minute walk test (submaximal exercise). We have found this measurement (Cardiac Effort) to be more reproducible than walk distance alone and correlates extremely well with right ventricular function. We are exploring other outcomes associated with this measurement. We are also looking at changes in actigraphy as a marker of treatment response. The other area of research is evaluating baseline and changes in vascular and coagulation parameters to better phenotype and characterize treatment strategies.

Publications

Journal Articles

Peak steps to measure ''capacity for activity'': Actigraphy in the ADAPT registry with oral treprostinil.

Lachant D, Gagermeier J, Seaman S, Wang A, Broderick M, White RJ

JHLT open.. 2025 May 8 :100219. Epub 01/23/2025.

The frequency and predictors of pulmonary rehabilitation referrals among patients with pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry.

Bailey M, Frantz R, Minhas J, Cascino T, Burger C, Shlobin O, Sager J, Raval A, Lammi M, Runo J, Thenappan T, De Marco T, Ravichandran A, Safdar Z, Lachant D, Badesch D, Yung D, DuBrock H

Chest.. 2025 April 28 Epub 04/28/2025.

Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension.

Clark HL, Lachant D, Light AN, Haight D, Lopia S, Mackman N, White RJ

JHLT open.. 2025 February 7 :100178. Epub 11/06/2024.

Heart Rate Variability in Pulmonary Arterial Hypertension.

Gyawali B, Roto D, Lachant M, White RJ, Lachant D

Pulmonary circulation.. 2025 January 15 (1):e70048. Epub 02/08/2025.

Unsupervised Exercise in Interstitial Lung Disease: A Delphi Study to Develop a Consensus Preparticipation Screening Tool for Lymphangioleiomyomatosis.

Child CE, Ho LA, Lachant D, Gupta N, Moss J, Jones A, Krishna R, Holland AE, Han MK, McCarthy C, Ataya A, Baqir M, Dilling D, Swigris J, Swenson ER, Brown MB

Chest.. 2024 November 166 (5):1108-1123. Epub 07/16/2024.

Electronically delivered rehabilitation after acute pulmonary embolism is safe and improves quality of life.

Lachant D, Haight D, Roto D, Williams A, Norton K, White RJ

The European respiratory journal.. 2024 September 64 (3)Epub 09/05/2024.

Pulmonary perfusion defects or residual vascular obstruction and persistent symptoms after pulmonary embolism: a systematic review and meta-analysis.

Cimini LA, Luijten D, Barco S, Ghanima W, Jervan Ø, Kahn SR, Konstantinides S, Lachant D, Nakano Y, Ninaber M, van Es J, van Mens T, Vonk Noordegraaf A, Becattini C, Klok FA

ERJ open research.. 2024 July 10 (4)Epub 07/29/2024.

Cardiac effort and 6-min walk distance correlate with stroke volume measured by cardiac magnetic resonance imaging.

Lachant DJ, Lachant MD, Haight D, White RJ

Pulmonary circulation.. 2024 April 14 (2):e12355. Epub 04/01/2024.

Risk scores as a surrogate in pulmonary arterial hypertension: a different lens.

White RJ, Lachant DJ, Benza RL

The Lancet. Respiratory medicine.. 2024 March 12 (3):e9-e10. Epub 1900 01 01.

Peak steps: Capacity for activity improves after adding approved therapy in pulmonary arterial hypertension.

Lachant D, Light A, Lachant M, Annis J, Hemnes A, Brittain E, James White R

Pulmonary circulation.. 2023 July 13 (3):e12285. Epub 09/10/2023.

Pulmonary Hypertension: How to Best Treat the Different Scleroderma Phenotypes?

Korman BD, Lachant DJ, Castelino FV

Rheumatic diseases clinics of North America.. 2023 May 49 (2):345-357. Epub 1900 01 01.

Evaluation of Clinical Recovery After Surgical Treatment for Hand Ischemia From Vasospastic and Occlusive Disease Using PROMIS.

Bernstein DN, Cliburn JA, Lachant DJ, White RJ, Hammert WC

Hand : official journal of the American Association for Hand Surgery.. 2023 January 18 (1):15-21. Epub 03/31/2021.

Cardiac Effort to Compare Clinic and Remote 6-Minute Walk Testing in Pulmonary Arterial Hypertension.

Lachant D, Kennedy E, Derenze B, Light A, Lachant M, White RJ

Chest.. 2022 December 162 (6):1340-1348. Epub 06/28/2022.

Comparison of chest- and wrist-based actigraphy in pulmonary arterial hypertension.

Lachant D, Light A, Hannon K, Abbas F, Lachant M, White RJ

European heart journal. Digital health.. 2022 March 3 (1):90-97. Epub 11/02/2021.

An untapped resource: characteristics of thrombus recovered from intermediate or high risk pulmonary embolus patients.

Newcomb G, Wilson BL, White RJ, Goldman B, Lachant NA, Lachant DJ

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.. 2022 57 :107392. Epub 10/27/2021.

Transitioning selexipag to oral treprostinil in patients with pulmonary artery hypertension.

Arevalo C, White RJ, Lachant D

Respiratory medicine case reports.. 2022 37 :101646. Epub 04/09/2022.

Vasodilator use in precapillary pulmonary hypertension with end stage kidney disease: A single center experience.

Arevalo C, White RJ, Le T, Lachant D

Respiratory medicine.. 2021 November 188 :106596. Epub 09/04/2021.

Resting heart rate as a surrogate for improvement in intermediate risk pulmonary embolus patients?

Roto D, Lachant NA, James White R, Lachant DJ

Respiratory medicine.. 2021 October 187 :106578. Epub 08/17/2021.

Venous thromboembolism associates with SARS-CoV-2 more than seasonal influenza.

Lachant D, Roto D, Rappaport S, Prasad P, Lachant N, White RJ

Thrombosis research.. 2021 September 205 :40-43. Epub 07/03/2021.

Direct oral anticoagulant therapy in patients with morbid obesity after intermediate- or high-risk pulmonary emboli.

Lachant DJ, Bach C, Fe A, White RJ, Lachant NA

ERJ open research.. 2021 January 7 (1)Epub 02/01/2021.

Asymptomatic necrotizing myositis in a young male with progressive interstitial lung disease.

Baah S, Gorgone M, Lachant D

Respiratory medicine case reports.. 2021 32 :101374. Epub 03/02/2021.

Chronic therapeutic anticoagulation is associated with decreased thrombotic complications in SARS-CoV-2 infection.

Lachant DJ, Lachant NA, Kouides P, Rappaport S, Prasad P, White RJ

Journal of thrombosis and haemostasis : JTH.. 2020 October 18 (10):2640-2645. Epub 08/24/2020.

Selexipag Use in Clinical Practice: Mind the Gap.

White RJ, Lachant DJ

Chest.. 2020 April 157 (4):761-763. Epub 1900 01 01.

Heart Rate Expenditure Correlates with Right Ventricular Function.

Lachant DJ, Light AN, Mackin ML, Schwartz RG, White RJ

Annals of the American Thoracic Society.. 2020 March 17 (3):372-375. Epub 1900 01 01.

Combination of treprostinil with sympathectomy and vascular reconstruction to treat recurrent digital ulcer disease.

Lemay M, Korman B, Hammert W, White RJ, Lachant D

Clinical and experimental rheumatology.. 2020 38 Suppl 125 (3):176-177. Epub 04/15/2020.

Clinical and imaging outcomes after intermediate- or high-risk pulmonary embolus.

Lachant D, Bach C, Wilson B, Chengazi V, Goldman B, Lachant N, Pietropaoli A, Cameron S, James White R

Pulmonary circulation.. 2020 10 (3):2045894020952019. Epub 09/21/2020.

Heart rate monitoring improves clinical assessment during 6-min walk.

Lachant DJ, Light A, Offen M, Adams J, White RJ

Pulmonary circulation.. 2020 10 (4):2045894020972572. Epub 12/09/2020.

Chronic thromboembolic pulmonary hypertension is a clot you cannot swat.

Bishop GJ, Gorski J, Lachant D, Cameron SJ

Journal of vascular surgery cases and innovative techniques.. 2019 December 5 (4):402-405. Epub 09/17/2019.

Combination therapy improves vascular volume in female rats with pulmonary hypertension.

Lachant DJ, Meoli DF, Haight D, Staicu S, Akers S, Glickman S, Ambrosini R, Champion HC, White RJ

American journal of physiology. Lung cellular and molecular physiology.. 2019 October 1317 (4):L445-L455. Epub 07/19/2019.

CMV Encephalitis/Radiculitis: The Difficulty in Diagnosing in an Intubated Patient.

Newcomb G, Mariuz P, Lachant D

Case reports in critical care.. 2019 2019 :8067648. Epub 02/18/2019.

The clinical impact of pneumocystis and viral PCR testing on bronchoalveolar lavage in immunosuppressed patients.

Lachant DJ, Croft DP, McGrane Minton H, Hardy DJ, Prasad P, Kottmann RM

Respiratory medicine.. 2018 December 145 :35-40. Epub 10/22/2018.

Low dose monocrotaline causes a selective pulmonary vascular lesion in male and female pneumonectomized rats.

Lachant DJ, Meoli DF, Haight D, Lyons JA, Swarthout RF, White RJ

Experimental lung research.. 2018 February 44 (1):51-61. Epub 01/30/2018.

Nasopharyngeal viral PCR in immunosuppressed patients and its association with virus detection in bronchoalveolar lavage by PCR.

Lachant DJ, Croft DP, McGrane Minton H, Prasad P, Kottmann RM

Respirology : official journal of the Asian Pacific Society of Respirology.. 2017 August 22 (6):1205-1211. Epub 04/05/2017.

Legionella micdadei: A Forgotten Etiology of Growing Cavitary Nodules: A Case Report and Literature Review.

Lachant D, Prasad P

Case reports in pulmonology.. 2015 2015 :535012. Epub 09/15/2015.

Meningococcemia Presenting as a Myocardial Infarction.

Lachant D, Trawick D

Case reports in critical care.. 2015 2015 :953826. Epub 11/11/2015.

Novel oral anticoagulants after gastric bypass surgery: Caveat emptor

Lachant DJ, Uraizee I, Gupta R, Pedulla AJ.

International Journal of Case Reports and Images. 2013; 4(11): 663-665.

Methicillin Resistant Staphylococcus aureus Prostatic Abscess with Bacteremia.

Lachant DJ, Apostolakos M, Pietropaoli A

Case reports in infectious diseases.. 2013 2013 :613961. Epub 12/24/2013.

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.

Ratings

Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)

4.9

Likelihood of recommending this care provider to others

4.9

Explanations the care provider gave you about your problem or condition

4.9

Care provider's efforts to include you in decisions about your care

4.9

Concern the care provider showed for your questions or worries

4.9

Patient Comments

5.0

Dr. Lachant is the greatest! He listens to everything I say and makes me feel so calm and not at all stressed out. He Is so knowledgeable and also caring. He is wonderful!

Jan 11, 2025

5.0

The very best care I could ask for!

Nov 28, 2024

5.0

Outstanding. My doctor was thorough, highly professional and very competent in the provision of care.

Aug 30, 2024

5.0

Dr Lachant and staff have always provided me with exceptional service.

Aug 29, 2024

5.0

I find Dr Lachant to be caring, knowledgeable, and responsive .

Aug 11, 2024

5.0

I requested Dr Lachant based on a previous illness. I would not like to see anyone else.

Aug 01, 2024

5.0

It was a 1st virtual visit, but was extremely pleased with the knowledge of Dr LaChant

May 09, 2024

5.0

Like him a lot very good

Apr 20, 2024

5.0

This Dr has helped me a lot

Mar 22, 2024

5.0

I would recommend you people to anyone.

Mar 15, 2024

5.0

Dr. Lachant is very thorough,caring, and helpful

Feb 15, 2024

5.0

My experience with Dr. Lachant have been very beneficial. He's an excellent physician.

Oct 06, 2023

5.0

Dr. Lachant is very caring & thorough.

Aug 30, 2023

5.0

Dr. Is very knowledgeable and caring.

Aug 25, 2023

5.0

Great experience.

Aug 02, 2023

5.0

Doctor is very good. I been seeing him for 4 or 5 years. Wouldn't go anywhere else.

Jun 14, 2023

5.0

Everything about the dr. is exceptional.

Nov 28, 2022

5.0

Dr. Lachant is very thorough & helpful.

Nov 21, 2022

5.0

Love them all.

Sep 29, 2022

4.6

The best!!

Sep 02, 2022

5.0

First time visit with Dr. Lachant. He is a thorough, caring professional. I was lucky to get him first time through. Highly recommend Dr. Lachant.

Aug 15, 2022

Excellent physician, I have a rare Illness and Dr. Lachant gives me complete confidence on my treatment

Aug 05, 2022

5.0

I would recommend Dr. Lachant to everyone.

Aug 01, 2022

5.0

Dr. Dan Lachant is the best!

May 18, 2022

Dr. Lachant is very caring and he is very good at explaining treatments and medications. I have full trust in his ability for my healthcare.

May 10, 2022

5.0

Dr. Lachant is a very caring and passionate doctor. He shows genuine concern for my health and well fare.

Mar 22, 2022

5.0

I have a memory problem he gave me a lot of info on paper & verbally and I also had him explain to my sister in law/and he did gladly which made me fill relaxed/& sure I was getting the best care because they cared enough to make sure I understood and could relax.

Mar 08, 2022