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David Justin Nagel, M.D., Ph.D.

David Justin Nagel, M.D., Ph.D.

he/him/his

Pulmonary & Critical Care Medicine

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Appointment (585) 275-4161
Fax (585) 340-4009

About Me

As a Pulmonary and Critical Care physician, I see patients in the Medical Intensive Care Units at Strong Memorial Hospital and Highland Hospital as well as in the ambulatory clinic at Strong. In the outpatient setting, I focus on patients with interstitial lung disease, including idiopathic pulmona...
As a Pulmonary and Critical Care physician, I see patients in the Medical Intensive Care Units at Strong Memorial Hospital and Highland Hospital as well as in the ambulatory clinic at Strong. In the outpatient setting, I focus on patients with interstitial lung disease, including idiopathic pulmonary fibrosis, lung scarring related to autoimmune diseases, and sarcoidosis. I am a member of the URMC Pulmonary Fibrosis Foundation Care center and work closely with the multidisciplinary diagnostic team to allow a timely and accurate diagnosis for each patient.

Professional Background

Dr. Nagel was born in Rochester, NY and graduated from the University of Rochester with a bachelor's degree in Biology. He then attended graduate school at the University of Rochester School of Medicine and Dentistry and received his Doctor of Philosophy in the Department of Pharmacology and Physio...
Dr. Nagel was born in Rochester, NY and graduated from the University of Rochester with a bachelor's degree in Biology. He then attended graduate school at the University of Rochester School of Medicine and Dentistry and received his Doctor of Philosophy in the Department of Pharmacology and Physiology. He next attended URSMD and received his Doctor of Medicine degree in 2011. After completing his residency in Internal Medicine at Dartmouth-Hitchcock Medical Center, he stayed on as a Chief Medical resident for an additional year. He then moved back to the University of Rochester Medical Center to complete his fellowship in Pulmonary and Critical Care Medicine in 2018. He subsequently joined the Division of Pulmonary Diseases and Critical Care at URMC and is pursuing a career as an independently funded physician-scientist.

Faculty Appointments

Assistant Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Credentials

Residency & Fellowship

Fellowship, Pulmonary and Critical Care Medicine, University of Rochester Medical Center. 2015 - 2018

Residency, Internal Medicine, Dartmouth-Hitchcock Medical Center GME. 2012 - 2015

Internship, Internal Medicine, Dartmouth-Hitchcock Medical Center GME. 2011 - 2012

Education

MD | University of Rochester. 2011

Awards

RCMB Programming Committee Aprenticeship. 2021 - 2022

New Faculty Boot Camp. 2020 - 2020

Fellows Track Symposium. 2017

Fellow-in-training Member of the Cardiovascular Medicine and Surgery Network. 2016 - 2018

Department of Medicine Excellence in Teaching. 2013

Travel Award for Basic Science. 2012

Medicine Library Award. 2011

Gold Humanism Honor Society Inductee. 2010

Travel Award. 2007

Best Poster Award. 2006

Research

Dr. Nagel is an Assistant Professor in the Department of Medicine, Division of Pulmonary Diseases and Critical Care. His graduate work examined the pathogenesis of vascular smooth muscle remodeling and smooth muscle cell phenotype switching, specifically exploring the role of Phosphodiesterase 1A i...
Dr. Nagel is an Assistant Professor in the Department of Medicine, Division of Pulmonary Diseases and Critical Care. His graduate work examined the pathogenesis of vascular smooth muscle remodeling and smooth muscle cell phenotype switching, specifically exploring the role of Phosphodiesterase 1A in this process. As a pulmonologist, he has translated the skills he learned as a graduate student to examine the pathology of myofibroblast differentiation signaling as it applies to the development of pulmonary fibrosis. His fellowship research focused on the interactions between a family of proton-sensing G-Protein Coupled Receptors, the extracellular matrix, and Transforming Growth Factor-Beta dependent signaling pathways. His current work examines ways in which extracellular remodeling, specifically through elastin degradation, contribute to pulmonary fibrosis. The interstitial lung disease group is also involved in several clinical trials and was one of the nation's top enrolling institutions in the Pulmonary Fibrosis Foundation patient registry.

Publications

Journal Articles

Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis.

Nagel DJ, Rackow AR, Ku WY, Bell TJ, Sime PJ, Kottmann RM

Cells.. 2022 August 1611 (16)Epub 08/16/2022.

Ogerin mediated inhibition of TGF-?(1) induced myofibroblast differentiation is potentiated by acidic pH.

Bell TJ, Nagel DJ, Woeller CF, Kottmann RM

PloS one.. 2022 17 (7):e0271608. Epub 07/28/2022.

The effect of air pollution on the transcriptomics of the immune response to respiratory infection.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN

Scientific reports.. 2021 September 3011 (1):19436. Epub 09/30/2021.

The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops.

Rackow AR, Nagel DJ, McCarthy C, Judge J, Lacy S, Freeberg MAT, Thatcher TH, Kottmann RM, Sime PJ

The European respiratory journal.. 2020 September 17 Epub 09/17/2020.

Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.

Judge JL, Nagel DJ, Owens KM, Rackow A, Phipps RP, Sime PJ, Kottmann RM

PloS one.. 2018 13 (5):e0197936. Epub 05/24/2018.

Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.

Cai Y, Nagel DJ, Zhou Q, Li F, Pi X, Knight P, Yan C

Circulation research.. 2015 March 27116 (7):1120-32. Epub 01/21/2015.

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.

Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C

Arteriosclerosis, thrombosis, and vascular biology.. 2011 March 31 (3):616-23. Epub 12/09/2010.

A model of ischemia and reperfusion increases JNK activity, inhibits the association of BAD and 14-3-3, and induces apoptosis of rabbit spinal neurocytes.

Fan J, Xu G, Nagel DJ, Hua Z, Zhang N, Yin G

Neuroscience letters.. 2010 April 12473 (3):196-201. Epub 02/24/2010.

GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions.

Zhang N, Cai W, Ma Y, Yin G, Nagel DJ, Berk BC

Cell biology international.. 2009 December 1634 (1):41-7. Epub 12/16/2009.

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.

Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe JI, Yan C

Circulation research.. 2009 November 6105 (10):956-64. Epub 09/24/2009.

Ischemic preconditioning suppresses apoptosis of rabbit spinal neurocytes by inhibiting ASK1-14-3-3 dissociation.

Yang C, Ren Y, Liu F, Cai W, Zhang N, Nagel DJ, Yin G

Neuroscience letters.. 2008 August 29441 (3):267-71. Epub 06/18/2008.

Activation of ASK1 during reperfusion of ischemic spinal cord.

Wang P, Cao X, Nagel DJ, Yin G

Neuroscience letters.. 2007 March 30415 (3):248-52. Epub 01/27/2007.

Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.

Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C

Circulation research.. 2006 March 3198 (6):777-84. Epub 03/02/2006.

Books

Non-invasive Mechanical Ventilation in Anesthesiology and Peri-operative Medicine (2021)

Chapter: Key Anesthesiology Determinants in Ventilator-dependent Patients and Home Non-invasive Ventilation Users

Authors: DJ Nagel, AR Rackow, RM Kottmann

Publisher: Nova Science, Hauppauge NY 2021

Respiratory Ventilation Strategies in Acute and Chronic Respiratory Failure in Idiopathic Pulmonary Diseases. A Practical Approach (2020)

Chapter: Acute Respiratory Failure in Chronic Interstitial Lung Disease

Authors: Baah S, Nagel DJ, Kalininskiy A, Kottmann RM

Publisher: Nova Science, Hauppague NY 2020

Cyclic Nucleotide Phosphodiesterases in Health and Disease (2005)

Chapter: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Disease

Authors: Yan C, Nagel DJ, Jeon KI

Publisher: CRC Press, Taylor and Francis Group, Boca Raton 2005