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Matthew D. McGraw, M.D.

Matthew D. McGraw, M.D.

Pediatrics, Pediatric Pulmonology

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
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About Me

Dr. McGraw's primary goal as a pediatric pulmonologist is to provide excellent care for all children and adolescents with underlying lung disease. He sees all patients with pediatric lung diseases including but not limited to cystic fibrosis, chronic lung disease of prematurity, and asthma. The pri...
Dr. McGraw's primary goal as a pediatric pulmonologist is to provide excellent care for all children and adolescents with underlying lung disease. He sees all patients with pediatric lung diseases including but not limited to cystic fibrosis, chronic lung disease of prematurity, and asthma. The primary focus of his basic science is better understanding the mechanisms of rare lung diseases, such as childhood interstitial lung disease (chILD) and bronchiolitis obliterans (BO), in order to identify new medical therapies.

Professional Background

Inherent of Dr. McGraw's practice is providing thoughtful, evidence-based, family-centered care to all children and families. His primary goal is to promote the greatest developmentally appropriate growth and potential of all children, consistent with the mission of the University of Rochester's Dep...
Inherent of Dr. McGraw's practice is providing thoughtful, evidence-based, family-centered care to all children and families. His primary goal is to promote the greatest developmentally appropriate growth and potential of all children, consistent with the mission of the University of Rochester's Department of Pediatrics. He works collaboratively with parents, primary and other care providers to achieve the best outcomes for children and adolescents with underlying lung disease.

Faculty Appointments

Assistant Professor - Department of Pediatrics, Pulmonology (SMD)

George Washington Goler Chair in Pediatrics - Department of Pediatrics (SMD)

Credentials

Residency & Fellowship

Fellowship, Pediatric Pulmonology, University of Colorado Hospital- GME. 2015 - 2018

Residency, Pediatrics, University of Virginia-Radiology GME. 2013 - 2015

Internship, Pediatrics, University of Virginia-Radiology GME. 2012 - 2013

Education

MD | SUNY Upstate College of Health Professions. 2012

Awards

Mechanisms of Basal Cell Dysfunction in Chemical-induced Bronchiolitis Obliterans. 2022 - 2026

Furth Award. 2020 - 2021

KL2 Award. 2020 - 2022

NIH Loan Repayment Program. 2019 - 2023

Best Research Poster, Junior Faculty. 2018

Society of Toxicology's Donald E. Gardner Inhalation Toxicology Education Award 2017. 2017

NIH T32 Training Grant, University of Colorado SOM, 2016 –2018. 2016 - 2018

Mulholland Resident and Fellow Teaching Award, Honorable Mention, 2015. 2015

American Academy of Pediatrics, Resident CATCH Implementation Grant, 2014 – 2015. 2014 - 2015

University of Virginia Pediatrics Resident Teaching Award, 2014 & 2015. 2014 - 2015

Gold Humanism Honor Society. 2011 - 2012

Bucknell University Department of Biomedical Engineering, Magna Cum Laude. 2008

Tau Beta Pi Engineering Honor Society. 2007 - 2008

Bucknell University Dean's List. 2005 - 2008

Research

Dr. McGraw's research involves understanding the mechanisms of aberrant airway epithelial repair after inhalation injuries. The primary pediatric lung disease studied is bronchiolitis obliterans (BO), a devastating and often progressive fibrotic lung disease characterized by progressive luminal nar...
Dr. McGraw's research involves understanding the mechanisms of aberrant airway epithelial repair after inhalation injuries. The primary pediatric lung disease studied is bronchiolitis obliterans (BO), a devastating and often progressive fibrotic lung disease characterized by progressive luminal narrowing and obliteration of the small airways, or bronchioles. Despite BO's high morbidity and mortality, very little is known about its pathogenesis, and even less is available in terms of prevention, intervention and treatment.

Inhalation agents used to study the mechanisms of aberrant airway epithelial repair include sulfur mustard (SM), a chemical warfare inhalation agent, and diacetyl, a volatile chemical in many flavorings. Both of these inhalation agents can cause bronchiolitis obliterans in children.

Basic science techniques include: small animal model development; primary airway epithelial cell isolation; flow sorting; 3D cell culture; single cell RNA sequencing.

Research Lab

Publications

Journal Articles

Rat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures.

Day NJ, Wang J, Johnston CJ, Kim SY, Olson HM, House EL, Attah IK, Clair GC, Qian WJ, McGraw MD

American journal of physiology. Lung cellular and molecular physiology.. 2023 March 7 Epub 03/07/2023.

The E-cigarette or Vaping Product Use-Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report.

Rebuli ME, Rose JJ, Noël A, Croft DP, Benowitz NL, Cohen AH, Goniewicz ML, Larsen BT, Leigh N, McGraw MD, Melzer AC, Penn AL, Rahman I, Upson D, Crotty Alexander LE, Ewart G, Jaspers I, Jordt SE, Kligerman S, Loughlin CE, McConnell R, Neptune ER, Nguyen TB, Pinkerton KE, Witek TJ

Annals of the American Thoracic Society.. 2023 January 20 (1):1-17. Epub 1900 01 01.

Disruption of proteostasis causes IRE1 mediated reprogramming of alveolar epithelial cells.

Katzen J, Rodriguez L, Tomer Y, Babu A, Zhao M, Murthy A, Carson P, Barrett M, Basil MC, Carl J, Leach JP, Morley M, McGraw MD, Mulugeta S, Pelura T, Rosen G, Morrisey EE, Beers MF

Proceedings of the National Academy of Sciences of the United States of America.. 2022 October 25119 (43):e2123187119. Epub 10/17/2022.

Diacetyl Inhalation Impairs Airway Epithelial Repair in Mice Infected with Influenza A Virus.

McGraw MD, Yee M, Kim SY, Dylag AM, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2022 September 6 Epub 09/06/2022.

Post-translational modifications to hemidesmosomes in human airway epithelial cells following diacetyl exposure.

Kim SY, McGraw MD

Scientific reports.. 2022 June 1312 (1):9738. Epub 06/13/2022.

Noninvasive systemic biomarkers of e-cigarette or vaping use-associated lung injury: a pilot study.

Podguski S, Kaur G, Muthumalage T, McGraw MD, Rahman I

ERJ open research.. 2022 April 8 (2)Epub 04/04/2022.

Reduced Plasma Phosphatidylethanolamines in E-cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI).

McGraw MD, Croft DP, Nacca NE, Rahman I

Pediatric pulmonology.. 2022 February 28 Epub 02/28/2022.

An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue.

Lukowski JK, Olson H, Velickovic M, Wang J, Kyle JE, Kim YM, Williams SM, Zhu Y, Huyck HL, McGraw MD, Poole C, Rogers L, Misra R, Alexandrov T, Ansong C, Pryhuber GS, Clair G, Adkins JN, Carson JP, Anderton CR

Frontiers in molecular biosciences.. 2022 9 :1022775. Epub 11/16/2022.

Diacetyl Vapor Inhalation Induces Mixed, Granulocytic Lung Inflammation with Increased CD4CD25 T Cells in the Rat.

House EL, Kim SY, Johnston CJ, Groves AM, Hernady E, Misra RS, McGraw MD

Toxics.. 2021 December 209 (12)Epub 12/20/2021.

Proteomic Analysis of Human Lung Development.

Clair G, Bramer LM, Misra R, McGraw MD, Bhattacharya S, Kitzmiller JA, Feng S, Danna VG, Bandyopadhyay G, Bhotika H, Huyck HL, Deutsch GH, Mariani TJ, Carson J, Whitsett JA, Pryhuber GS, Adkins JN, Ansong C

American journal of respiratory and critical care medicine.. 2021 November 9 Epub 11/09/2021.

Fibrin Airway Cast Obstruction: Experience, Classification and Treatment Guideline from Denver.

Liptzin DR, McGraw MD, Houin PR, Veress LA

Pediatric pulmonology.. 2021 October 29 Epub 10/29/2021.

Weight loss in adolescents presenting with EVALI.

Nacca N, McGraw MD, Croft DP, Kalininskiy A

Pediatric pulmonology.. 2021 June 8 Epub 06/08/2021.

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD

Archives of toxicology.. 2021 May 24 Epub 05/24/2021.

E-cigarette exposures, respiratory tract infections, and impaired innate immunity: a narrative review.

Kalininskiy A, Kittel J, Nacca NE, Misra RS, Croft DP, McGraw MD

Pediatric medicine.. 2021 February 4 Epub 02/28/2021.

Protein thiol oxidation in the rat lung following e-cigarette exposure.

Wang J, Zhang T, Johnston CJ, Kim SY, Gaffrey MJ, Chalupa D, Feng G, Qian WJ, McGraw MD, Ansong C

Redox biology.. 2020 October 1037 :101758. Epub 10/10/2020.

Face Coverings in a Pandemic.

McGraw MD, Achanta S, Castner J, Gold DR, Hines SE, Redlich CA, Sockrider MM

American journal of respiratory and critical care medicine.. 2020 September 1202 (5):P17-P18. Epub 1900 01 01.

Reply to: Lipid Laden Macrophages Are Not Diagnostic of PAP Syndrome and Can Indicate Lung Injury.

Israel AK, McGraw MD, Agrawal T

American journal of respiratory and critical care medicine.. 2020 July 16 Epub 07/16/2020.

Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN

Toxicology letters.. 2020 June 1325 :25-33. Epub 02/26/2020.

Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure.

McGraw MD, Kim SY, White CW, Veress LA

Annals of the New York Academy of Sciences.. 2020 May 14 Epub 05/14/2020.

A Unique Case of Secondary Pulmonary Alveolar Proteinosis Following E-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI).

Israel AK, Velez MJ, Staicu SA, Ambrosini R, McGraw M, Agrawal T

American journal of respiratory and critical care medicine.. 2020 May 11 Epub 05/11/2020.

Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).

Muthumalage T, Friedman MR, McGraw MD, Ginsberg G, Friedman AE, Rahman I

Toxics.. 2020 April 38 (2)Epub 04/03/2020.

Understanding the Asthmatic Response to an Experimental Rhinovirus Infection: Exploring the Effects of Blocking IgE.

Heymann PW, Platts-Mills TA, Woodfolk JA, Borish L, Murphy DD, Carper HT, Conaway MR, Steinke JW, Muehling L, Gerald TW, Kennedy JL, Irani AM, McGraw MD, Early SV, Wheatley LM, Adams AP, Turner RB

The Journal of allergy and clinical immunology.. 2020 February 1 Epub 02/01/2020.

E-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach.

Croft DP, McGraw MD, Navarette KA, Marraffa J, Ginsberg G, Nacca NE, Bach CT, Kalininskiy A

The Lancet. Respiratory medicine.. 2019 December 7 (12):1017-1026. Epub 11/08/2019.

Marijuana medusa: The many pulmonary faces of marijuana inhalation in adolescent males.

McGraw MD, Houser GH, Galambos C, Wartchow EP, Stillwell PC, Weinman JP

Pediatric pulmonology.. 2018 December 53 (12):1619-1626. Epub 10/23/2018.

Developmental Origins of Chronic Lung Diseases. Mechanical Stretch, Micro-RNAs, and Hydrogels.

McGraw MD, Sherlock LG, Bailey KL, Abman SH

American journal of respiratory cell and molecular biology.. 2018 August 59 (2):267-270. Epub 1900 01 01.

The use of light's criteria in hospitalized children with a pleural effusion of unknown etiology.

McGraw MD, Robison K, Kupfer O, Brinton JT, Stillwell PC

Pediatric pulmonology.. 2018 August 53 (8):1101-1106. Epub 05/27/2018.

Reply to: Comment on "Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats".

McGraw MD, Veress LA

American journal of respiratory cell and molecular biology.. 2018 August 59 (2):274-275. Epub 1900 01 01.

Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats.

McGraw MD, Dysart MM, Hendry-Hofer TB, Houin PR, Rioux JS, Garlick RB, Loader JE, Smith R, Paradiso DC, Holmes WW, Anderson DR, White CW, Veress LA

American journal of respiratory cell and molecular biology.. 2018 June 58 (6):696-705. Epub 1900 01 01.

Oxygen Administration Improves Survival but Worsens Cardiopulmonary Functions in Chlorine-exposed Rats.

Okponyia OC, McGraw MD, Dysart MM, Garlick RB, Rioux JS, Murphy AL, Roe GB, White CW, Veress LA

American journal of respiratory cell and molecular biology.. 2018 January 58 (1):107-116. Epub 1900 01 01.

Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard.

McGraw MD, Osborne CM, Mastej EJ, Di Paola JA, Anderson DR, Holmes WW, Paradiso DC, Garlick RB, Hendry-Hofer TB, Rancourt RC, Smith RW, Burns C, Roe GB, Rioux JS, White CW, Veress LA

Toxicological sciences : an official journal of the Society of Toxicology.. 2017 October 1159 (2):461-469. Epub 1900 01 01.

Uremic pleuritis: A case report and review of recurrent exudative pleural effusions in children.

McGraw MD, Galambos C, Stillwell PC

Pediatric pulmonology.. 2017 September 52 (9):E52-E54. Epub 04/25/2017.

From the Cover: ImpairedProliferation and Differentiation of the Conducting Airway Epithelium Associated With Bronchiolitis Obliterans After Sulfur Mustard Inhalation Injury in Rats.

McGraw MD, Rioux JS, Garlick RB, Rancourt RC, White CW, Veress LA

Toxicological sciences : an official journal of the Society of Toxicology.. 2017 June 1157 (2):399-409. Epub 1900 01 01.

Inner-city asthma: special considerations for management.

Dutmer CM, McGraw MD, Liu AH

Current opinion in allergy and clinical immunology.. 2016 April 16 (2):148-56. Epub 1900 01 01.

Activation of human neutrophil Mac-1 by anion substitution.

Lomakina E, Knauf PA, Schultz JB, Law FY, McGraw MD, Waugh RE

Blood cells, molecules & diseases.. 2009 42 (3):177-84. Epub 02/25/2009.

E-cigarette exposures, respiratory tract infections, and impaired innate immunity: a narrative review

Kalininskiy, A.; Kittel J; Nacca NE; Misra RS; Croft DP; McGraw MD.

Pediatric Medicine. .

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