Dr. Bender is an Assistant Professor in the Division of Stroke and Cerebrovascular Disease.

Clinical interests: Dr. Bender specializes the management of ischemic and hemorrhagic stroke and underlying pathologies, including brain aneurysms, cranial and spinal vascular malformations, moyamoya disease, and carotid atherosclerosis. He offers patients both endovascular and open surgical treatments depending on individualized consideration of invasiveness, risk, and durability.

Cerebrovascular neurosurgery is one of medicine’s frontiers and Dr. Bender has introduced several new procedures to the University of Rochester, including radial angiography and intervention, middle meningeal artery embolization for subdural hematoma, and digital spinal myelography for the identification of CSF-venous fistulae. He performs traditional microsurgical aneurysm clipping, AVM resection, and direct cerebral arterial bypass. Dr. Bender also has broad experience in general neurosurgery, including spine pathology, primary and metastatic brain tumors, trigeminal neuralgia, chiari malformation, and hydrocephalus.

Research: Dr. Bender’s laboratory investigates cerebral arterial thrombus, a biospecimen to which neurosurgeons performing endovascular thrombectomy for large vessel occlusion ischemic stroke have privileged access. The lab employs mass spectrometry as an unbiased and quantitative tool to understand the proteomic makeup of stroke thrombus. This research is illuminating causes of ischemic stroke and helping developing new therapeutic strategies.

Dr. Bender also believes in the importance of rigorously analyzing clinical practice and sharing novel insights. Among his clinical research interests are: cerebral aneurysm flow diversion, mechanical thrombectomy sub-populations and interventional technique, and mobile stroke technology.

Background: Dr. Bender completed Neurological Surgery residency and a two-year enfolded Endovascular Neurosurgery fellowship at the Johns Hopkins Hospital. He grew up in Hamburg, NY and graduated summa cum laude from Yale. Dr. Bender worked for two years as a management consultant in the Chicago office of McKinsey & Co before attending medical school at Johns Hopkins.

Faculty Appointments

Assistant Professor - Department of Neurosurgery (SMD)

Assistant Professor - Department of Imaging Sciences (SMD) - Joint

Assistant Professor - Department of Neurology, Stroke Division (SMD) - Joint

Connect with Matthew T. Bender, M.D.

@mtbendermd

Credentials

Residency & Fellowship

Fellowship, Endovascular Neurosurgery, Johns Hopkins Hospital. 2016 - 2018

Residency, Neurological Surgery, Johns Hopkins Hospital. 2012 - 2019

Education

MD | Johns Hopkins University School of Medicine. 2012

Publications

Journal Articles

Association of Do-Not-Resuscitate orders and in-hospital mortality among patients undergoing cranial neurosurgery.

Zhang L, Albert GP, Pieters TA, McHugh DC, Asemota AO, Roberts DE, Hwang DY, Bender MT, George BP

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.. 2023 October 17118 :26-33. Epub 10/17/2023.

Stents for progressively symptomatic paediatric intracranial arterial dissection.

Jay CRG, Duncan AN, Ellika SK, Bender MT

Journal of neurointerventional surgery.. 2023 March 15 (3):e3. Epub 06/08/2021.

Mechanical Thrombectomy for Ischemic Stroke Secondary to Large Vessel Occlusions in Patients on Extracorporeal Membrane Oxygenation.

Kohli G, George DD, Grenga A, Santangelo G, Gosev I, Schartz D, Kessler A, Khan I, Barrus B, Gu Y, Bhalla T, Mattingly TK, Bender MT

Cerebrovascular diseases.. 2023 January 30 :1-7. Epub 01/30/2023.

Endovascular thrombectomy with or without intravenous thrombolysis in acute basilar artery occlusion ischemic stroke: A meta-analysis.

Kohli GS, Schartz D, Whyte R, Akkipeddi SM, Ellens NR, Bhalla T, Mattingly TK, Bender MT

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2022 December 31 (12):106847. Epub 10/28/2022.

Approaches to and outcomes of intra-arterial tPA in embolectomy for large vessel occlusion.

Kohli GS, Whyte R, Schartz D, Rahmani R, Ellens NR, Susa ST, Bhalla T, Mattingly TK, Bender MT

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2022 October 31 (10):106717. Epub 08/19/2022.

Reversal of Advanced Directives in Neurologic Emergencies.

McHugh DC, George BP, Bender MT, Horowitz RK, Kaufman DC, Holloway RG, Roberts DE

The Neurohospitalist.. 2022 October 12 (4):651-658. Epub 06/15/2022.

Observation versus intervention for Borden type I intracranial dural arteriovenous fistula: A pooled analysis of 469 patients.

Schartz D, Rahmani R, Gunturi A, Kohli GS, Akkipeddi SMK, Ellens NR, Romiyo P, Kessler A, Bhalla T, Mattingly TK, Bender MT

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.. 2022 September 13 :15910199221127070. Epub 09/13/2022.

Impact of aspiration catheter size on clinical outcomes in aspiration thrombectomy.

Schartz D, Ellens N, Kohli GS, Rahmani R, Akkipeddi SMK, Colby GP, Hui F, Bhalla T, Mattingly T, Bender MT

Journal of neurointerventional surgery.. 2022 August 2 Epub 08/02/2022.

Management of postoperative cervical pseudomeningocele with percutaneous aspiration and epidural blood patch.

Schartz DA, Ismail RF, Rahman AA, Bender MT, Westesson PL, Mesfin A, Kessler A

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.. 2022 July 11 :15910199221113714. Epub 07/11/2022.

Endovascular Therapy is Effective for Large Vessel Occlusion Despite Concurrent Cancer.

Mattingly TK, Risco JE, Burch JE, Whyte R, Kohli GS, Susa S, Bhalla T, Bender MT

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2022 June 31 (6):106439. Epub 03/18/2022.

A Meta-analysis of Combined Aspiration Catheter and Stent Retriever versus Stent Retriever Alone for Large-Vessel Occlusion Ischemic Stroke.

Schartz DA, Ellens NR, Kohli GS, Akkipeddi SMK, Colby GP, Bhalla T, Mattingly TK, Bender MT

AJNR. American journal of neuroradiology.. 2022 April 43 (4):568-574. Epub 03/17/2022.

Major complications of dural venous sinus stenting for idiopathic intracranial hypertension: case series and management considerations.

Townsend RK, Jost A, Amans MR, Hui F, Bender MT, Satti SR, Maurer R, Liu K, Brinjikji W, Fargen KM

Journal of neurointerventional surgery.. 2022 January 14 (1)Epub 04/28/2021.

Mobile Stroke Unit Operational Metrics: Institutional Experience, Systematic Review and Meta-Analysis.

Ellens NR, Schartz D, Rahmani R, Akkipeddi SMK, Kelly AG, Benesch CG, Parker SA, Burgett JL, Proper D, Pilcher WH, Mattingly TK, Grotta JC, Bhalla T, Bender MT

Frontiers in neurology. 2022 13 :868051. Epub 05/09/2022.

Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy.

Bender MT, Mattingly TK, Rahmani R, Proper D, Burnett WA, Burgett JL, LEsperance J, Cushman JT, Pilcher WH, Benesch CG, Kelly AG, Bhalla T

Stroke and vascular neurology.. 2021 December 24 Epub 12/24/2021.

Noncurative microsurgery for cerebral aneurysms: a systematic review and meta-analysis of wrapping, residual, and recurrence rates.

Schartz D, Mattingly TK, Rahmani R, Ellens N, Akkipeddi SMK, Bhalla T, Bender MT

Journal of neurosurgery.. 2021 November 19 :1-11. Epub 11/19/2021.

Combined Pipeline Embolization Device with Endoscopic Endonasal Fascia Lata/Muscle Graft Repair as a Salvage Technique for Treatment of Iatrogenic Carotid Artery Pseudoaneurysm.

Liu A, Rincon-Torroella J, Bender MT, McDougall CG, Tufaro AP, London NR, Coon AL, Reh DD, Gallia GL

Journal of neurological surgery reports.. 2021 October 82 (4):e43-e48. Epub 12/01/2021.

Complications of transradial versus transfemoral access for neuroendovascular procedures: a meta-analysis.

Schartz D, Akkipeddi SMK, Ellens N, Rahmani R, Kohli GS, Bruckel J, Caplan JM, Mattingly TK, Bhalla T, Bender MT

Journal of neurointerventional surgery.. 2021 September 3 Epub 09/03/2021.

Stents for progressively symptomatic paediatric intracranial arterial dissection.

Jay CRG, Duncan AN, Ellika SK, Bender MT

BMJ case reports.. 2021 May 3114 (5)Epub 05/31/2021.

Aging Patient Population With Ruptured Aneurysms: Trend Over 28 Years.

Feghali J, Gami A, Rapaport S, Bender MT, Jackson CM, Caplan JM, McDougall CG, Huang J, Tamargo RJ

Neurosurgery.. 2021 February 1688 (3):658-665. Epub 1900 01 01.

Twisting: Incidence and Risk Factors of an Intraprocedural Challenge Associated With Pipeline Flow Diversion of Cerebral Aneurysms.

Bender MT, Young RW, Zarrin DA, Campos JK, Caplan JM, Huang J, Tamargo RJ, Lin LM, Colby GP, Coon AL

Neurosurgery.. 2020 December 1588 (1):25-35. Epub 1900 01 01.

Absence of Ischemic Injury after Sacrificing the Superior Petrosal Vein during Microvascular Decompression.

Xia Y, Kim TY, Mashouf LA, Patel KK, Xu R, Casaos J, Choi J, Kim ES, Hung AL, Wu A, Garzon-Muvdi T, Bender MT, Jackson CM, Bettegowda C, Lim M

Operative neurosurgery.. 2020 March 118 (3):316-320. Epub 1900 01 01.

Aspirin Monotherapy in Flow Diversion of Selected Internal Carotid Artery Aneurysms.

Bender MT, Zarrin DA, Jiang B, Campos JK, Lin LM, Young RW, Colby GP, Coon AL

World neurosurgery.. 2020 February 134 :580-583. Epub 06/26/2019.

Precision of VerifyNow P2Y12 Assessment of Clopidogrel Response in Patients Undergoing Cerebral Aneurysm Flow Diversion.

Bender MT, Zarrin DA, Campos JK, Jiang B, Chandra A, Vo CD, Caplan JM, Huang J, Tamargo RJ, Lin LM, Colby GP, Coon AL

Neurosurgery.. 2019 October 185 (4):543-549. Epub 1900 01 01.

Commentary: Radial Artery Access for Treatment of Posterior Circulation Aneurysms Using the Pipeline Embolization Device: Case Series.

Bender MT, Colby GP, Coon AL

Operative neurosurgery.. 2019 October 117 (4):E139-E140. Epub 1900 01 01.

Flow diversion covering the M1 origin as a last resort.

Lin LM, Bender MT, Colby GP, Jiang B, Campos JK, Zarrin DA, Young RWC, Xu R, Caplan JM, Huang J, Tamargo RJ, Coon AL

Stroke and vascular neurology.. 2019 September 4 (3):141-147. Epub 12/19/2018.

Commentary: Comparison of Pipeline Embolization Device and Flow Re-Direction Endoluminal Device Flow Diverters for Internal Carotid Artery Aneurysms: A Propensity-Score Matched Cohort Study.

Bender MT, Colby GP, Coon AL

Neurosurgery.. 2019 August 185 (2):E256-E257. Epub 1900 01 01.

Multiple pipeline twists encountered during treatment of a symptomatic fusiform ICA aneurysm.

Young RW, Bender MT, Colby GP, Coon AL

BMJ case reports.. 2019 July 412 (7)Epub 07/04/2019.

Tiny Pipes: 67 Cases of Flow Diversion for Aneurysms in Distal Vessels Measuring Less Than 2.0 mm.

Bender MT, Zarrin DA, Campos JK, Lin LM, Huang J, Caplan JM, Tamargo RJ, Colby GP, Coon AL

World neurosurgery.. 2019 July 127 :e193-e201. Epub 03/13/2019.

Retrosigmoid approach for glycerin rhizotomy in the treatment of trigeminal neuralgia without overt arterial compression: updated case series.

Kim TY, Jackson CM, Xia Y, Mashouf LA, Patel KK, Kim ES, Hung AL, Wu A, Garzon-Muvdi T, Bender MT, Bettegowda C, Lee JYK, Lim M

Journal of neurosurgery.. 2019 March 8132 (4):1227-1233. Epub 03/08/2019.

Tandem cervical carotid stenting for stenosis with flow diversion embolisation for the treatment of intracranial aneurysms.

Campos JK, Lin LM, Beaty NB, Bender MT, Jiang B, Zarrin DA, Coon AL

Stroke and vascular neurology.. 2019 March 4 (1):43-47. Epub 12/17/2018.

Flow Diversion of Posterior Circulation Cerebral Aneurysms: A Single-Institution Series of 59 Cases.

Bender MT, Colby GP, Jiang B, Lin LM, Campos JK, Xu R, Westbroek EM, Vo CD, Zarrin DA, Caplan JM, Huang J, Tamargo RJ, Coon AL

Neurosurgery.. 2019 January 184 (1):206-216. Epub 1900 01 01.

Declining complication rates with flow diversion of anterior circulation aneurysms after introduction of the Pipeline Flex: analysis of a single-institution series of 568 cases.

Colby GP, Bender MT, Lin LM, Beaty N, Caplan JM, Jiang B, Westbroek EM, Varjavand B, Campos JK, Huang J, Tamargo RJ, Coon AL

Journal of neurosurgery.. 2018 December 1129 (6):1475-1481. Epub 1900 01 01.

Augmenting Occlusion Outcomes Through Pipeline with Adjunctive Coiling.

Bender MT, Colby GP, Coon AL

World neurosurgery.. 2018 December 120 :403-404. Epub 10/03/2018.

Pipeline-assisted coil embolization of a large middle cerebral artery pseudoaneurysm in a 9-month-old infant: experience from the youngest flow diversion case.

Colby GP, Jiang B, Bender MT, Beaty NB, Westbroek EM, Xu R, Lin LM, Campos JK, Tamargo RJ, Huang J, Cohen AR, Coon AL

Journal of neurosurgery. Pediatrics.. 2018 November 122 (5):532-540. Epub 1900 01 01.

Small Aneurysms Account for the Majority and Increasing Percentage of Aneurysmal Subarachnoid Hemorrhage: A 25-Year, Single Institution Study.

Bender MT, Wendt H, Monarch T, Beaty N, Lin LM, Huang J, Coon A, Tamargo RJ, Colby GP

Neurosurgery.. 2018 October 183 (4):692-699. Epub 1900 01 01.

Pipeline Embolization for Salvage Treatment of Previously Stented Residual and Recurrent Cerebral Aneurysms.

Bender MT, Vo CD, Jiang B, Campos JK, Zarrin DA, Xu R, Westbroek EM, Caplan JM, Huang J, Tamargo RJ, Lin LM, Colby GP, Coon AL

Interventional neurology.. 2018 October 7 (6):359-369. Epub 06/01/2018.

Single-stage flow diversion with adjunctive coiling for cerebral aneurysm: outcomes and technical considerations in 72 cases.

Bender MT, Jiang B, Campos JK, Lin LM, Beaty N, Vo CD, Zarrin DA, Caplan JM, Huang J, Tamargo RJ, Colby GP, Coon AL

Journal of neurointerventional surgery.. 2018 September 10 (9):843-850. Epub 05/25/2018.

Immediate and Long-Term Outcomes of Microvascular Decompression for Mixed Trigeminal Neuralgia.

Wu A, Doshi T, Hung A, Garzon-Muvdi T, Bender MT, Bettegowda C, Lim M

World neurosurgery.. 2018 September 117 :e300-e307. Epub 06/12/2018.

Procedural complexity independent of P2Y12 reaction unit (PRU) values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms.

Jiang B, Bender MT, Westbroek EM, Campos JK, Lin LM, Xu R, Tamargo RJ, Huang J, Colby GP, Coon AL

Stroke and vascular neurology.. 2018 September 3 (3):169-175. Epub 04/21/2018.

47 Consecutive Cases of Pipeline Flex Flow Diversion Utilizing a Novel Large-Bore Intracranial Intermediate Catheter: Nuances and Institutional Experience with the Syphontrak.

Lin LM, Jiang B, Bender MT, Westbroek EM, Campos JK, Tamargo RJ, Huang J, Coon AL, Colby GP

Interventional neurology.. 2018 April 7 (3-4):153-163. Epub 02/06/2018.

Pipeline Flex Embolization of Flow-Related Aneurysms Associated with Arteriovenous Malformations: A Case Report.

Beaty NB, Campos JK, Colby GP, Lin LM, Bender MT, Xu R, Coon AL

Interventional neurology.. 2018 April 7 (3-4):164-170. Epub 02/03/2018.

Abciximab (ReoPro) Dosing Strategy for the Management of Acute Intraprocedural Thromboembolic Complications during Pipeline Flow Diversion Treatment of Intracranial Aneurysms.

Lin LM, Jiang B, Campos JK, Beaty NB, Bender MT, Tamargo RJ, Huang J, Colby GP, Coon AL

Interventional neurology.. 2018 April 7 (5):218-232. Epub 02/27/2018.

Predictors of cerebral aneurysm persistence and occlusion after flow diversion: a single-institution series of 445 cases with angiographic follow-up.

Bender MT, Colby GP, Lin LM, Jiang B, Westbroek EM, Xu R, Campos JK, Huang J, Tamargo RJ, Coon AL

Journal of neurosurgery.. 2018 March 30130 (1):259-267. Epub 1900 01 01.

Use of a next-generation multi-durometer long guide sheath for triaxial access in flow diversion: experience in 95 consecutive cases.

Lin LM, Bender MT, Colby GP, Beaty NB, Jiang B, Campos JK, Huang J, Tamargo RJ, Coon AL

Journal of neurointerventional surgery.. 2018 February 10 (2):137-142. Epub 07/14/2017.

Safety Assessment of Endovascular Treatment of Cerebral Aneurysms in Patients with Fibromuscular Dysplasia.

Bender MT, Hurtado C, Jiang B, Campos JK, Huang J, Tamargo RJ, Lin LM, Coon AL, Colby GP

Interventional neurology.. 2018 February 7 (1-2):110-117. Epub 12/16/2017.

P2Y12 hyporesponse (PRU>200) is not associated with increased thromboembolic complications in anterior circulation Pipeline.

Bender MT, Lin LM, Colby GP, Lubelski D, Huang J, Tamargo RJ, Coon AL

Journal of neurointerventional surgery.. 2017 October 9 (10):978-981. Epub 09/06/2016.

Shifting Treatment Paradigms for Ruptured Aneurysms from Open Surgery to Endovascular Therapy Over 25 Years.

Bender MT, Wendt H, Monarch T, Lin LM, Jiang B, Huang J, Coon AL, Tamargo RJ, Colby GP

World neurosurgery.. 2017 October 106 :919-924. Epub 07/20/2017.

Rescue Treatment with Pipeline Embolization for Postsurgical Clipping Recurrences of Anterior Communicating Artery Region Aneurysms.

Lin LM, Iyer RR, Bender MT, Monarch T, Colby GP, Huang J, Tamargo RJ, Coon AL

Interventional neurology.. 2017 October 6 (3-4):135-146. Epub 03/04/2017.

Endovascular flow diversion for treatment of anterior communicating artery region cerebral aneurysms: a single-center cohort of 50 cases.

Colby GP, Bender MT, Lin LM, Beaty N, Huang J, Tamargo RJ, Coon AL

Journal of neurointerventional surgery.. 2017 July 9 (7):679-685. Epub 01/27/2017.

Use of the 0.027-inch VIA microcatheter for delivery of Pipeline Flex: a technical note.

Lin LM, Colby GP, Bender MT, Xu R, Huang J, Tamargo RJ, Coon AL

Journal of neurointerventional surgery.. 2017 July 9 (7):689-693. Epub 02/01/2017.

Staged curative treatment of a complex direct carotid-cavernous fistula with a large arterial defect and an 'oversized' internal carotid artery.

Bender MT, Lin LM, Coon AL, Colby GP

BMJ case reports.. 2017 June 142017 Epub 06/14/2017.

Efficacy of primary microvascular decompression versus subsequent microvascular decompression for trigeminal neuralgia.

Theodros D, Rory Goodwin C, Bender MT, Zhou X, Garzon-Muvdi T, De la Garza-Ramos R, Abu-Bonsrah N, Mathios D, Blitz AM, Olivi A, Carson B, Bettegowda C, Lim M

Journal of neurosurgery.. 2017 May 126 (5):1691-1697. Epub 07/15/2016.

Utilization of a Novel, Multi-Durometer Intracranial Distal Access Catheter: Nuances and Experience in 110 Consecutive Cases of Aneurysm Flow Diversion.

Colby GP, Lin LM, Xu R, Beaty N, Bender MT, Jiang B, Huang J, Tamargo RJ, Coon AL

Interventional neurology.. 2017 March 6 (1-2):90-104. Epub 02/03/2017.

Aneurysm treatment practice patterns for newly appointed dual-trained cerebrovascular/endovascular neurosurgeons: Comparison of open surgical to neuroendovascular procedures in the first 2 years of academic practice.

Jiang B, Bender MT, Hasjim B, Hsu FPK, Tamargo RJ, Huang J, Colby GP, Coon AL, Lin LM

Surgical neurology international.. 2017 8 :154. Epub 07/25/2017.

Percutaneous Procedures for the Treatment of Trigeminal Neuralgia.

Wang JY, Bender MT, Bettegowda Ch

Neurosurgery clinics of North America.. 2016 July 27 (3):277-95. Epub 1900 01 01.

Post-hemorrhagic hydrocephalus presenting as cauda equina syndrome in a patient with spinal dysraphism.

Bender MT, Colby GP, Huang J

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.. 2016 April 26 :159-61. Epub 12/07/2015.

Reduced CSF leak in complete calvarial reconstructions of microvascular decompression craniectomies using calcium phosphate cement.

Eseonu CI, Goodwin CR, Zhou X, Theodros D, Bender MT, Mathios D, Bettegowda C, Lim M

Journal of neurosurgery.. 2015 December 123 (6):1476-9. Epub 07/31/2015.

Glycerol rhizotomy and radiofrequency thermocoagulation for trigeminal neuralgia in multiple sclerosis.

Bender MT, Pradilla G, Batra S, See AP, James C, Pardo CA, Carson BS, Lim M

Journal of neurosurgery.. 2013 February 118 (2):329-36. Epub 11/02/2012.

Surgical treatment of pediatric trigeminal neuralgia: case series and review of the literature.

Bender MT, Pradilla G, James C, Raza S, Lim M, Carson BS

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.. 2011 December 27 (12):2123-9. Epub 10/01/2011.

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