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Thomas Barrett, M.D.

Specialties

Otolaryngology (ENT)

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URochester Medical Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Call Center (585) 276-3000

Locations

Ear, Nose, & Throat - Rochester

Wilmot Cancer Institute
601 Elmwood Avenue, Suite G
Rochester, NY 14642

(585) 275-5823 Get Directions

About Me

Faculty Appointments

Assistant Professor - Department of Otolaryngology (SMD)

Credentials

Residency & Fellowship

Fellowship, Head and Neck-Microvascular Reconstructive Surgery, Icahn School of Medicine At Mount Sinai. 2025 - 2026

Residency, Otolaryngology, Washington University School of Medicine. 2018 - 2025

Medical School, Icahn School of Medicine at Mount Sinai. 2014 - 2018

Awards

AHNS Alando J. Ballantyne Resident Research Pilot CORE Grant. 2021 - 2022

Joseph M. Chole Humanitarian Award (2025).

Alpha Omega Alpha.

Publications

Journal Articles

Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk.

Barrett TF, Jama M, Alshalalfa M, Tharakan T, Hao Y, Klopper JP, Cavazos TB, Jackson RS, Pipkorn P, Rich JT, Zolkind PA, Adkins DR, Oppelt P, Apicelli AJ, Rammohan N, Brown TC, Puram SV, Jasim S, Harbison RA

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2026 September 175 (3):578-586. Epub 07/10/2026.

Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition.

Simkin D, Barrett TF, Zhang L, Moore MJ, Greenwald AC, Galili N, Mints M, Ramadan S, Yu V, Mullins RDZ, Zaretsky J, Bischoff P, Adkins D, Thorstad WL, Karam SD, Paniello RC, Rich JT, Jackson RS, Pipkorn P, Zolkind PA, Peng G, Harbison RA, Chernock R, Parikh AS, Puram SV, Tirosh I

Nature genetics.. 2026 September 58 (9):2240-2253. Epub 08/14/2026.

Pathologic Response After Neoadjuvant Chemoimmunotherapy in Head and Neck Squamous Cell Carcinoma.

Gomez EA, Kraft DO, Elkersh Y, Cooke PV, Sicard RM, Barrett TF, Shemtob L, Ahn S, Berger MH, Teng MS, Kirke DN, Urken M, Khan M, Chai RL, Khorsandi A, Bakst RL, Sindhu KK, Liu JT, Misiukiewicz KJ, Veremis B, Sohn SY, Brandwein MS, Pujadas E, Genden EM, Roof SA

JAMA otolaryngology-- head & neck surgery.. 2026 August 13 Epub 08/13/2026.

Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma.

Mints M, Sample RA, Parikh AS, Zaretsky JM, Qi Z, Law T, Wang F, Barrett TF, Mullins R, Reeb A, Greenwald AC, Stoller E, Ramadan S, Gerndt S, Oppelt P, Ley J, Thorstad W, Paniello RC, Rich JT, Harbison RA, Zolkind PA, Jackson RS, Pipkorn P, Adkins DR, Uppaluri R, Tirosh I, Puram SV

Cell reports. Medicine.. 2026 April 217 (4):102715. Epub 03/31/2026.

Immunotherapy Prescribing Patterns and Immune-Related Adverse Events in Patients With Head and Neck Cancer.

Peterson AM, Stwalley D, Kallogjeri D, Barrett TF, Harbison AR, Pipkorn P, Jackson RS, Puram SV, Piccirillo JF, Zolkind P

JAMA otolaryngology-- head & neck surgery.. 2026 February 19 Epub 02/19/2026.

Long-Term Outcomes of Patients With HPV+ Unknown Primary Squamous Cell Carcinoma Treated With Transoral Surgery.

Barrett TF, Boukind A, Enin K, Pipkorn P, Zolkind P, Harbison RA, Rich JT, Bockover SR, Apicelli AJ, Oppelt P, Rammohan N, Moravan MJ, Los Santos J, Gay H, Adkins DR, Thorstad WL, Puram SV, Jackson RS

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2025 December 173 (6):1414-1420. Epub 10/01/2025.

Management of HPV+ head and neck squamous cell carcinoma with unknown primary in the era of treatment de-escalation.

Barrett TF, Apicelli AJ, Ramadan S, Pipkorn P, Zolkind P, Rich JT, Harbison RA, Thorstad W, Gay H, Rammohan N, Moravan MJ, Los Santos J, Oppelt P, Adkins D, Jackson RS, Puram SV

Oral oncology.. 2025 October 169 :107631. Epub 08/30/2025.

A hybrid epithelial/mesenchymal state in head and neck cancer: A biomarker for survival with differential prognosis by self-reported race.

Mazul AL, Barrett TF, Colditz G, Parikh AS, Ramadan S, Zevallos JP, Rich JT, Harbison RA, Jackson RS, Pipkorn P, Zolkind P, Tirosh I, Puram SV

Med.. 2024 July 125 (7):826-831.e3. Epub 06/19/2024.

Inherent Bias in Large Language Models: A Random Sampling Analysis.

Ayoub NF, Balakrishnan K, Ayoub MS, Barrett TF, David AP, Gray ST

Mayo Clinic proceedings. Digital health.. 2024 June 2 (2):186-191. Epub 04/11/2024.

Promising New Diagnostic and Treatment Modalities for Allergic Rhinitis: What's Coming Next?

Barrett TF, Roland LT

Otolaryngologic clinics of North America.. 2024 April 57 (2):243-251. Epub 09/16/2023.

Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state.

Barrett TF, Patel B, Khan SM, Mullins RDZ, Yim AKY, Pugazenthi S, Mahlokozera T, Zipfel GJ, Herzog JA, Chicoine MR, Wick CC, Durakovic N, Osbun JW, Shew M, Sweeney AD, Patel AJ, Buchman CA, Petti AA, Puram SV, Kim AH

Nature communications.. 2024 January 1215 (1):478. Epub 01/12/2024.

Evidence-Based Medicine for Mandible Fracture Repair: Current Controversies and Future Opportunities.

Barrett T, Chi J

Facial plastic surgery : FPS.. 2023 June 39 (3):214-219. Epub 01/05/2023.

Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours.

Gavish A, Tyler M, Greenwald AC, Hoefflin R, Simkin D, Tschernichovsky R, Galili Darnell N, Somech E, Barbolin C, Antman T, Kovarsky D, Barrett T, Gonzalez Castro LN, Halder D, Chanoch-Myers R, Laffy J, Mints M, Wider A, Tal R, Spitzer A, Hara T, Raitses-Gurevich M, Stossel C, Golan T, Tirosh A, Suvà ML, Puram SV, Tirosh I

Nature.. 2023 June 618 (7965):598-606. Epub 05/31/2023.

Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma.

Puram SV, Mints M, Pal A, Qi Z, Reeb A, Gelev K, Barrett TF, Gerndt S, Liu P, Parikh AS, Ramadan S, Law T, Mroz EA, Rocco JW, Adkins D, Thorstad WL, Gay HA, Ding L, Paniello RC, Pipkorn P, Jackson RS, Wang X, Mazul A, Chernock R, Zevallos JP, Silva-Fisher J, Tirosh I

Nature genetics.. 2023 April 55 (4):640-650. Epub 04/03/2023.

Epithelial-Mesenchymal Plasticity in Tumor Immune Evasion.

Mullins RDZ, Pal A, Barrett TF, Heft Neal ME, Puram SV

Cancer research.. 2022 July 582 (13):2329-2343. Epub 1900 01 01.

Anatomic variants of the subscapular-thoracodorsal arterial system: A radiologic analysis of 200 arterial systems.

Barrett TF, Orlowski H, Rich J, Jackson RS, Pipkorn P, Puram SV

Oral oncology.. 2022 February 125 :105682. Epub 01/05/2022.

Clinical Challenge: Osteoradionecrosis in a Fibular Free Flap Reconstruction of the Maxilla.

Barrett TF, Rich JT, Pipkorn P

Facial plastic surgery & aesthetic medicine.. 2022 24 (6):487-488. Epub 03/30/2022.

Partial EMT in head and neck cancer biology: a spectrum instead of a switch.

Pal A, Barrett TF, Paolini R, Parikh A, Puram SV

Oncogene.. 2021 August 40 (32):5049-5065. Epub 07/08/2021.

The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database.

Barrett TF, Mazul AL, Stepan KO, Wood CB, Paniello RC, Zevallos JP, Massa S, Jackson RS, Schmitt NC, Zenga J, Kang SY, Pipkorn P, Rich JT, Puram SV

Oral oncology.. 2021 July 118 :105330. Epub 05/12/2021.

Low-risk human papilloma virus positive oropharyngeal cancer with one positive lymph node: Equivalent outcomes in patients treated with surgery and radiation therapy versus surgery alone.

Sample RA, Wood CB, Mazul AL, Barrett TF, Paniello RC, Rich JT, Kang SY, Zevallos J, Daly MD, Thorstad WL, Chen SY, Pipkorn P, Jackson RS, Puram SV

Head & neck.. 2021 June 43 (6):1759-1768. Epub 02/15/2021.

Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma.

Qi Z, Liu Y, Mints M, Mullins R, Sample R, Law T, Barrett T, Mazul AL, Jackson RS, Kang SY, Pipkorn P, Parikh AS, Tirosh I, Dougherty J, Puram SV

Cancers.. 2021 March 1113 (6)Epub 03/11/2021.

Duration of radiation therapy is associated with worse survival in head and neck cancer.

Mazul AL, Stepan KO, Barrett TF, Thorstad WL, Massa S, Adkins DR, Daly MD, Rich JT, Paniello RC, Pipkorn P, Zevallos JP, Jackson RS, Kang SY, Puram SV

Oral oncology.. 2020 September 108 :104819. Epub 05/30/2020.

Single-cell sequencing and its applications in head and neck cancer.

Qi Z, Barrett T, Parikh AS, Tirosh I, Puram SV

Oral oncology.. 2019 December 99 :104441. Epub 11/02/2019.

Brain metastasis from squamous cell carcinoma of the head and neck: a review of the literature in the genomic era.

Barrett TF, Gill CM, Miles BA, Iloreta AMC, Bakst RL, Fowkes M, Brastianos PK, Bederson JB, Shrivastava RK

Neurosurgical focus.. 2018 June 44 (6):E11. Epub 1900 01 01.

Technical Note: Preemptive Surgical Revision of Impending Deep Brain Stimulation Hardware Erosion.

Barrett TF, Rasouli JJ, Taub P, Kopell BH

World neurosurgery.. 2018 March 111 :41-46. Epub 12/16/2017.

First Application of 7-T Magnetic Resonance Imaging in Endoscopic Endonasal Surgery of Skull Base Tumors.

Barrett TF, Dyvorne HA, Padormo F, Pawha PS, Delman BN, Shrivastava RK, Balchandani P

World neurosurgery.. 2017 July 103 :600-610. Epub 03/27/2017.

Strengthening value-based medication management in a free clinic for the uninsured: Quality interventions aimed at reducing costs and enhancing adherence.

Arao RK, O'Connor MY, Barrett T, Chockalingam L, Khan F, Kumar A, Leader A, Leven E, Power JR, Shuham B, Rifkin R, Thomas D, Meah Y, Shah BJ

BMJ open quality.. 2017 6 (2):e000069. Epub 10/31/2017.

Application of Ultrahigh Field Magnetic Resonance Imaging in the Treatment of Brain Tumors: A Meta-Analysis.

Barrett TF, Sarkiss CA, Dyvorne HA, Lee J, Balchandani P, Shrivastava RK

World neurosurgery.. 2016 February 86 :450-65. Epub 09/25/2015.

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