Jeffrey J. Bazarian, M.D., M.P.H.

Dr. Bazarian is an emergency physician with an active concussion clinic and research program. He has served on several traumatic brain injury-related task forces and panels for the Centers for Disease Control and Prevention, the National Institutes of Health, the National Science Foundation, and the Institute of Medicine. In 2008, he worked with the Defense and Veterans Brain Injury Center to develop mild traumatic brain injury (concussion) management guidelines for returning troops.

Research

The goals of the Bazarian TBI lab are to develop neuroimaging and blood-based biomarkers of axonal injury after concussion and repetitive head hits, and to understand the pathophysiologic mechanisms of recovery. A translational research platform is used to accrue injured subjects through the Emergency Department at the University of Rochester Medical Center as well as contact athletes at the University of Rochester and the Rochester Institute of Technology. Since 2009, over 700 collegiate athletes and over 100 non-athletes have been studied using a variety of biomarkers including diffusion tensor imaging, functional MRI, serum brain proteins (such as S100B, GFAP, UCH-L1 and tau), peripheral changes in mRNA expression, the epigenome and the metabolome; computerized cognitive performance, computerized platform posturography, computerized eye-tracking, quantitative EEG. We have integrated objective measures of head impact exposure using sensor technology to understand the relationship between impact biomechanics and brain injury. The strategic use of this comprehensive array of methodologies has shed light on the effects of single and repetitive head hits on brain structure and function, setting the stage for targeted interventions to prevent and mitigate TBI-related disability.

Credentials

Specialties

Internal Medicine - American Board of Internal Medicine

Education

1987
MD | Univ. of Rochester School of Medicine and Dentistry

2002
MPH | University of Rochester School of Medicine & Dentistry

Post-doctoral Training & Residency

09/01/1987 - 06/01/1990
Residency in Internal Medicine at University of Rochester Medical Center

Awards

2018
Deborah Warden Lectureship
Sponsor: Department of Defense

2006
Faculty Mentoring Award
Sponsor: University of Rochester

2003
Ernst Sayward Award for Excellence in Community and Preventive Medicine

2000
Kluge Trauma and Emergency Medical Service Award
Sponsor: Rochester Academy of Medicine

1997
Clinical Teaching Award
Sponsor: Emergency Department Residency
Location: University of Rochester

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Patents

Patent Title: System and Method to Assess Risk of Changes to Brain White Matter Based on Head Impact Dose Equivalent Number
Patent #: 10,646,154
Issue Date: May 12, 2020
Country: United States
Invented By: Jeffrey J Bazarian, Kian Merchant-Borna

Publications

Journal Articles

4/23/2022
Bogner-Flatz V, Braunstein M, Bazarian JJ, Keil L, Richter PH, Kusmenkov T, Biberthaler P, Giese T. "Neutrophil Gene Expression Patterns in Multiple Trauma Patients Indicate Distinct Clinical Outcomes." The Journal of surgical research.. 2022 Apr 23; 277:100-109. Epub 2022 Apr 23.

3/15/2022
Stephen SJ, Hasman L, Goldenberg M, Merchant-Borna K, Kawata K, Mannix R, Bazarian JJ. "Short-Term Neurologic Manifestations of Repetitive Head Impacts Among Athletes: A Scoping Review." The Journal of head trauma rehabilitation.. 2022 Mar 15; Epub 2022 Mar 15.

1/21/2022
Vike NL, Bari S, Stetsiv K, Walter A, Newman S, Kawata K, Bazarian JJ, Martinovich Z, Nauman EA, Talavage TM, Papa L, Slobounov SM, Breiter HC. "A preliminary model of football-related neural stress that integrates metabolomics with transcriptomics and virtual reality." iScience.. 2022 Jan 21; 25(1):103483. Epub 2021 Dec 15.

Books & Chapters

2018
Chapter Title: Traumatic Brain Injury and Spinal Cord Injury
Book Title: Goldman-Cecil Medicine
Author List: Bazarian JJ, Ling G.
Published By: Elsevier 2018

2018
Chapter Title: Emergency Department Evaluation of the Concussed Athlete
Book Title: Handbook of Clinical Neurology
Author List: Wright DW, Bazarian JJ.
Published By: Elsevier 2018

2009
Chapter Title: Mild traumatic Brain Injury
Book Title: Evidence Based Emergency Medicine
Author List: Bazarian JJ; Townend W
Edited By: BH Rowe
Published By: Blackwell Publishing 2009

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