Patents
Patent Title: Patient Information Forms for FSHD (Facioscapulohumeral Muscular Dystrophy), DM (Myotonic Dystrophy), and Unaffected Blood Relatives of Individuals with FSH
Patent #: TXu 1-790-681
Issue Date: Nov 16, 2011
Country: United States
Invented By:
Michael McDermott, Richard T Moxley, III, Al-Rabi N Tawil, Charles A Thornton
Patent Title: Nucleic Acid Binding Compounds and Methods of Use
Patent #: 9,212,205
Issue Date: Dec 15, 2015
Country: United States
Invented By:
Peter Gareiss, Brian R McNaughton, Benjamin Locke Miller, Krzysztof Sobczak, Charles A Thornton, Joseph E Wedekind
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 6698740
Issue Date: May 01, 2020
Country: Japan
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 3031920
Issue Date: Aug 21, 2019
Country: Europe
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: AT3031920
Issue Date: Aug 21, 2019
Country: Austria
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: BE3031920
Issue Date: Aug 21, 2019
Country: Belgium
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: DK3031920
Issue Date: Aug 21, 2019
Country: Denmark
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: FI3031920
Issue Date: Aug 21, 2019
Country: Finland
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: FR3031920
Issue Date: Aug 21, 2019
Country: France
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: DE3031920
Issue Date: Aug 21, 2019
Country: Germany
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: IE3031920
Issue Date: Aug 21, 2019
Country: Ireland
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: IT3031920
Issue Date: Aug 21, 2019
Country: Italy
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: NL3031920
Issue Date: Aug 21, 2019
Country: Netherlands
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: NO3031920
Issue Date: Aug 21, 2019
Country: Norway
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: ES3031920
Issue Date: Aug 21, 2019
Country: Spain
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: SE3031920
Issue Date: Aug 21, 2019
Country: Sweden
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: CH3031920
Issue Date: Aug 21, 2019
Country: Switzerland/Liechtenstein
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: GB3031920
Issue Date: Aug 21, 2019
Country: United Kingdom
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: PL3031920
Issue Date: Aug 21, 2019
Country: Poland
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: HR3031920
Issue Date: Aug 21, 2019
Country: Croatia
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 10-1900770
Issue Date: Sep 14, 2018
Country: Korea, Republic of
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 223962
Issue Date: Jun 30, 2018
Country: Israel
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 6343308
Issue Date: May 25, 2018
Country: Japan
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 9,765,338
Issue Date: Sep 19, 2017
Country: United States
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 5981428
Issue Date: Aug 05, 2016
Country: Japan
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: ZL201180035573.2
Issue Date: Aug 03, 2016
Country: China, People's Republic of
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Modulation of Dystrophia Myotonica-Protein Kinase (DMPK) Expression
Patent #: 2011282217
Issue Date: Mar 17, 2016
Country: Australia
Invented By:
C.Frank Bennett, Seng H Cheng, Susan M Freier, Andrew Leger, Robert A Macleod, Sanjay K Pandey, Charles A Thornton, Bruce M Wentworth, Thurman M Wheeler
Patent Title: Methods and Compositions for Treatment of Myotonia
Patent #: 7,964,570
Issue Date: Jun 21, 2011
Country: United States
Invented By:
Rahul N Kanadia, Maurice S Swanson, Charles A Thornton
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
Patent #: 2,981,308
Issue Date: Dec 22, 2020
Country: Canada
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
Patent #: 6259000
Issue Date: Dec 15, 2017
Country: Japan
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
Patent #: 2,664,189
Issue Date: Nov 21, 2017
Country: Canada
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
Patent #: HK1182447
Issue Date: Jun 30, 2017
Country: Hong Kong
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
Patent #: 9,371,527
Issue Date: Jun 21, 2016
Country: United States
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Dystrophy
Patent #: 5926475
Issue Date: Apr 28, 2016
Country: Japan
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
Patent #: 2014216025
Issue Date: Mar 23, 2017
Country: Australia
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
Patent #: 2560001
Issue Date: Apr 13, 2016
Country: Europe
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
Patent #: GB2560001
Issue Date: Apr 13, 2016
Country: United Kingdom
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy for Myotonic Distrophy
Patent #: 2007297535
Issue Date: Sep 04, 2014
Country: Australia
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy
Patent #: 3034083
Issue Date: Dec 09, 2020
Country: Europe
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy
Patent #: FR3034083
Issue Date: Dec 09, 2020
Country: France
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy
Patent #: DE3034083
Issue Date: Dec 09, 2020
Country: Germany
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
Patent Title: Compositions and Methods Related to Protein Displacement Therapy
Patent #: GB3034083
Issue Date: Dec 09, 2020
Country: United Kingdom
Invented By:
Jill W Miller, Robert J Osborne, Krzysztof Sobczak, Maurice S Swanson, Charles A Thornton, Thurman M Wheeler
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Publications
Journal Articles
6/1/2023
Cisco LA, Sipple MT, Edwards KM, Thornton CA, Lueck JD. "Combinatorial chloride and calcium channelopathy in myotonic dystrophy." bioRxiv : the preprint server for biology.. 2023 Jun 1; Epub 2023 Jun 01.
3/2023
Thornton CA, Moxley RT, Eichinger K, Heatwole C, Mignon L, Arnold WD, Ashizawa T, Day JW, Dent G, Tanner MK, Duong T, Greene EP, Herbelin L, Johnson NE, King W, Kissel JT, Leung DG, Lott DJ, Norris DA, Pucillo EM, Schell W, Statland JM, Stinson N, Subramony SH, Xia S, Bishop KM, Bennett CF. "Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial." The Lancet. Neurology.. 2023 Mar; 22(3):218-228.
7/1/2022
Hamel JI, McDermott MP, Hilbert JE, Martens WB, Luebbe E, Tawil R, Moxley RT, Thornton CA. "Milestones of progression in myotonic dystrophy type 1 and type 2." Muscle & nerve.. 2022 Jul 1; Epub 2022 Jul 01.
Books & Chapters
2011
Chapter Title: Myotonic Dystrophy
Book Title: Muscle: Fundamental Biology and Mechanisms and Disease
Author List: Thornton, CA
Edited By: Hill JA, Stull JT, Sweeney HL, Olson, EN
Published By: Elsevier 2011
2009
Chapter Title: Myotonic Dystrophy
Book Title: Disorders of Voluntary Muscle
Author List: Day J, Thornton C
Edited By: Karpati G, Hilton-Jones D, Bushbby K, Griggs RC
Published By: Cambridge University Press 2009 in Cambridge UK
2006
Chapter Title: The RNA-Mediated Disease Process in Myotonic Dystrophy
Book Title: Genetic Instabilities and Neurological Diseases
Author List: Thornton CA, Swanson MS, Cooper TA
Edited By: Wells R, Ashizawa T
Published By: Elsevier 2006 in San Diego, CA
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