Louis S. Constine, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-2171

Office: (585) 275-5622

Fax: (585) 275-1531

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Locations

James P. Wilmot Cancer Center
601 Elmwood Ave
Rochester, NY 14642

Faculty Appointments

Professor - Department of Radiation Oncology (SMD)
Philip Rubin Professorship in Radiation Oncology - Department of Radiation Oncology (SMD)

Patient Care Settings

Cancer, Radiation Oncology

Biography

I am a radiation oncologist with clinical and scientific expertise is in lymphomas, sarcomas, all pediatric malignancies, and the broad area of survivorship that includes the acute and chronic effects of chemotherapy and radiation therapy on normal tissues. I am fortunate to spend my life striving to help patients with cancer, optimizing their quality of life and curing them when possible.

My professional life is guided by my words: "For the survivor of cancer, the world is full and each day is a celebration; For the physician, each patient is an inspiration; For the person with cancer, each day is precious and must be faced with courage."

Conditions I Treat
- Lymphomas
- Sarcomas
- Pediatric hematology and oncology (including central nervous system cancer)
- Long term side effects of chemotherapy and radiation therapy

Professional Background

Louis S. Constine, MD, FASTRO, FACR is Professor of Radiation Oncology and Pediatrics and Vice Chair of the Department of Radiation Oncology. He is also the Director of the James P. Wilmot Cancer Institute Judy DiMarzo Survivorship Program. After graduating from Stanford University, and the Johns Hopkins University School of Medicine, he trained in pediatrics, pediatric oncology, and radiation oncology, and has board certification in these areas. He is a member of numerous societies including The American Society of Radiation Oncology, the Radiation Research Society, the American Society of Clinical Oncology, and the American Society of Hematology. He was awarded fellowships in the American Society of Radiation Oncology in 2008, and in the American College of Radiology in 2018.

Research

Dr. Constine is the Radiation Chair of the Lymphoma Committee in the Southwest Oncology Group. He is on the core committees for the Children’s Oncology Group Survivorship Guidelines, the International Survivorship Harmonization Guidelines, previously was on the American Society of Clinical Oncology Survivorship Advisory Group, and he leads the Pediatric Quantitative Analysis of Normal Tissue Effects in the Clinic ASTRO/AAPM initiative. He serves on the Children’s Oncology Group Late Effects Steering Committee, is senior advisor for the COG Hodgkin Lymphoma Committee, and is on the executive committee of the Radiation Oncology Committee (leading an effort to compile normal tissue dose constraints for protocols). He has been an investigator on several grants including an ROI evaluating long-term cardiac toxicities in Hodgkin lymphoma survivors. He is a member of the steering committee for the NCI-supported Childhood Cancer Survivorship Study. He was a member of a four-person United Nations task force collating the adverse effects of radiation on children; he discussed their 240-page document at the UN international headquarters (Vienna) in 5/2012 and again in 5/2013 and it was internationally distributed. Other international efforts included his core membership on an International Atomic Energy Agency initiative to develop pediatric radiation oncology in low-income countries. Additional activities include membership on task forces for the American Heart Association on cardiotoxicity, and the National Council on Radiation Protection Scientific Committee on “Second Primary Cancers and Cardiovascular Disease after Radiation Therapy.” Dr. Constine has authored (co-authored) edited more than 50 book chapters (including the 6th edition of Pediatric Radiation Oncology- British Medical Book Award), edited eight books and ~250 original and invited reports.

Credentials

Education

1973
MD | Johns Hopkins University School of Medicine (USA)

Post-doctoral Training & Residency

07/01/1978 - 06/30/1981
Residency in Radiation Oncology at Stanford University Medical Center

07/01/1976 - 06/30/1978
Fellowship in Pediatric Hematology-Oncology at Seattle Children's Hospital

07/01/1975 - 06/30/1976
Residency in Pediatrics at Stanford University Medical Center

07/01/1973 - 06/30/1975
Internship in Internal Medicine at H Lee Moffitt Cancer Center & Research Institute (United States of America)

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Awards

2018
Fellow
Sponsor: American College of Radiology (ACR)

2018
Educator of the Year
Sponsor: Association of Residents in Radiation Oncology

2017 - Present
Albert Nelson Marquis Lifetime Achievement Award
Sponsor: Marquis Who's Who

2017
Medical Book Awards: High Commendation (Oncology)
Sponsor: British Medical Association

2017
America's Most Honored Professionals--Top 1%
Sponsor: The American Registry

2014
Anna Meadows Distinguished Lecturer in Pediatric Oncology Survivorship
Sponsor: University of Pennsylvania

2013 - Present
Philip Rubin Professor of Radiation Oncology and Pediatrics
Sponsor: Department of Radiation Oncology
Location: University of Rochester

2012 - 2013
Patient- and Family-Centered ICARE High Performance Award
Sponsor: University of Rochester Medical Center
Location: Rochester, NY

2011
Educator of the Year
Sponsor: Association of Residents in Radiation Oncology

2010
Merit Award: PDQ Pediatric Treatment Editorial Board
Sponsor: National Institutes of Health

2008
Fellow
Location: American Society for Therapeutic Radiology and Oncology (ASTRO)

2008
Make a Difference Award
Sponsor: Melissa's Living Legacy Teen Cancer Foundation
Location: Rochester, NY

2007 - Present
America's Top Doctors for Cancer
Sponsor: America's Best Doctors

2007 - Present
Best Doctor
Sponsor: BestDoctors.com

2005
Philip Rubin-Mayer Mitchell Teaching Award
Location: University of Rochester Department of Radiation Oncology

2004
Ring of Fire Award
Location: Camp Good Days and Special Times

2001
Philip Rubin-Mayer Mitchell Teaching Award
Location: University of Rochester Department of Radiation Oncology

2001
Jacob Gitelman Award
Location: Cancer Action

1997
Philip Rubin-Mayer Mitchell Teaching Award
Location: University of Rochester Department of Radiation Oncology

1983 - 1986
Junior Faculty Fellowship Award
Location: American Cancer Society

1983
Teddy Award
Location: Camp Good Days and Special Times

1969
Graduation with Distinction
Location: Stanford University

1969
Beta Kappa

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Clinical Trials

Phase II Study of Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma

Lead Researcher: Louis S Constine

This phase II study will evaluate whether a reduction in radiation dose and field size will maintain a high rate of local control while minimizing the risk of acute and late toxicity . Hypothesis: The radiation dose and treatment volume can be safely reduced from 30 Gy to 20 Gy while maintaining high rates of local control in patients who had a negative PET-CT scan following rituximab - containing chemotherapy.

View Study Details

Publications

Journal Articles

2023
Milano MT; Vargo JA; Yorke ED; Ronckers CM; Kremer LC; Chafe SMJ; van Santen HM; Marks LB; Bentzen SM; Constine LS; Vogelius IR. "Primary hypothyroidism in childhood cancer survivors treated with radiotherapy: A PENTEC comprehensive review". Int J Radiat Oncol Biol Phys. 2023; in press.

2023
Constine LS; Olch AJ; Jackson A; Hua C-H; Ronckers C; Milano MT; Marcus KJ; Yorke E; Hodgson D; Howell R; Hudson M; Williams J; Marples B; Kremer L; Marks LB; Bentzen SM. "Pediatric Normal Tissue Effects in the Clinic (PENTEC): an international collaboration to assess normal tissue radiation dose-volume-response relationships for children with cancer". Int J Radiat Oncol Biol Phys. 2023; in press.

2023
Milgrom SA; van Luijk P; Pino R; Ronckers CM; Kremer LC; Gidley PW; Grosshans DR; Laskar S; Okcu MF; Constine LS; Paulino AC. "Salivary and Dental Complications in Childhood Cancer Survivors Treated With Radiation Therapy to the Head and Neck: A Pediatric Normal Tissue Effects in the Clinic (PENTEC) Comprehensive Review ." Int J Radiat Oncol Biol Phys. 2023; in press.

Books & Chapters

2021
Chapter Title: Pediatric Hodgkin Lymphoma
Book Title: Clinical Radiation Oncology
Author List: Roberts KB; Hoppe BS, Kelly KM; Constine LS
Edited By: Tepper JE; Foote RL; Michalski JM
Published By: Elsevier 2021 in Philadelphia

2021
Chapter Title: Late Effects After Radiation
Book Title: Clinical Radiation Oncology
Author List: Milano MT; Marks LB; Constine LS
Edited By: Tepper JE; Foote RL; Michalski JM
Published By: Elsevier 2021 in Philadelphia

2018
Chapter Title: Hypopituitarism
Book Title: Adult CNS Radiation Oncology
Author List: Hardy S; Milano MT; Shafiq I; Vates GE; Constine LS
Published By: Springer 2018 in New York, NY

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Videos

SECOND OPINION | Late Effects of Cancer Treatment | APT | Full Episode

SECOND OPINION | Late Effects of Cancer Treatments | APT | Webisode