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Mark W. Frampton, M.D.

Pulmonary

Contact Information

Phone Numbers

Appointment: (585) 275-4161

Administrative: (585) 275-4861

Office: (585) 275-4161

Fax: (585) 273-1171

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Biography

Professional Background

Dr. Mark Frampton is Professor Emeritus of Medicine in Pulmonary and Critical Care at the University of Rochester Medical Center. He received his MD from New York University School of Medicine and then trained in Internal Medicine at Buffalo General Hospital. After nine years of private practice in Williamson, New York, he completed Pulmonary and Critical Care training at the University of Rochester, and then joined the faculty. His research focuses on the human health effects of air pollution. His studies use both environmental chamber and mouthpiece exposure systems to examine the effects of particle and gaseous pollutant exposure on lung function, airway inflammation, and cardiovascular function. Inhalation of the gaseous pollutant, ozone, has been linked with cardiovascular effects. Dr. Frampton directed the University of Rochester Medical Center's participation in the first multi-center clinical study of ozone exposure, Multicenter Ozone Exposure study in oldEr Subjects (MOSES), funded by the Health Effects Institute. Data from these human clinical studies of exposure to air pollutants help to elucidate the mechanisms responsible for pollutant health effects, and assist in establishing rational air quality standards. Dr. Frampton directed the NIH-funded training program in pulmonary research at the Medical Center for several years. He is former director the Pulmonary Function Laboratory at Strong Memorial Hospital, and currently serves as the Associate Director of the Clinical Research Center at the University of Rochester. Dr. Frampton continues to see outpatients with pulmonary disease, and to teach Pulmonary and Critical Care trainees. He has a special interest in tuberculosis, having directed the Wayne County Tuberculosis Clinic for more than 30 years, and has been caring for patients with tuberculosis infection and disease at the Monroe County Health Department for more than 25 years.

Research

Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. Gaseous and particulate contaminants in that air gain access to the body with each breath, and may have both short and long-term effects on human health. Our ongoing studies examine the effects of particle exposure on lung function, airway inflammation, and cardiovascular function. Utilizing both environmental chamber and mouthpiece exposure systems, subjects are exposed to environmentally relevant concentrations of pollutants, with or without exercise. Respiratory and systemic effects are determined using measures of lung function, examination for markers of inflammation in exhaled air, characterization of blood leukocyte and platelet responses using 3-color flow cytometry, and detailed cardiovascular monitoring. Ultrafine particles (UFP, <100 nm diameter) may be particularly important with regard to cardiovascular effects because of their potential for evading clearance mechanisms and entering the lung interstitium and vascular space. We have demonstrated in healthy nonsmokers that inhalation of low concentrations of UFP causes changes in leukocyte expression of adhesion molecules, and reductions in the pulmonary diffusing capacity, that are consistent with altered endothelial function. The elderly and people with underlying vascular disease, such as diabetics, may be more susceptible to vascular effects of particle exposure because of impaired endothelial function and increased risk for atherosclerosis. Our studies explore the hypothesis that inhalation of ultrafine particles alters endothelial function in healthy and susceptible people. Endothelial dysfunction is critically linked to the pathogenesis of atherosclerotic vascular disease. Data from these human clinical studies of exposure to air pollutants help to elucidate the mechanisms responsible for pollutant health effects, and assist in establishing rational air quality standards.

Credentials

Faculty Appointments

Specialties

  • Critical Care Medicine
  • Internal Medicine - American Board of Internal Medicine
  • Pulmonary Disease - American Board of Internal Medicine

Education

1973
MD | New York Univ Sch Medicine
Medicine

1965-1969
| California State University, Long Beach
Mathematics, Microbiology

Post-doctoral Training & Residency

07/01/1973 - 06/30/1974
Internship in Internal Medicine at Buffalo General Hospital

07/01/1974 - 06/30/1976
Residency in Internal Medicine at Buffalo General Hospital

07/01/1985 - 06/30/1988
Fellowship in Internal Medicine: Pulmonary Disease and Critical Care Medicine at University of Rochester Medical Center

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Awards

1974 - Present
Fellow, American College of Physicians

Publications

Journal Articles

12/1/2016
Ettensohn DB, Frampton MW, Nichols JE, Roberts NJ. "Human Alveolar Macrophages May Not Be Susceptible to Direct Infection by a Human Influenza Virus." The Journal of infectious diseases.. 2016 Dec 1; 214(11):1658-1665. Epub 2016 Sep 06.

8/2016
Wang M, Utell MJ, Schneider A, Zareba W, Frampton MW, Oakes D, Hopke PK, Wiltshire J, Kane C, Peters A, Breitner S, Chalupa D, Rich DQ. "Does total antioxidant capacity modify adverse cardiac responses associated with ambient ultrafine, accumulation mode, and fine particles in patients undergoing cardiac rehabilitation?" Environmental research.. 2016 Aug 0; 149:15-22. Epub 2016 May 10.

2016
Becerra AZ, Georas S, Brenna JT, Hopke PK, Kane C, Chalupa D, Frampton MW, Block R, Rich DQ. "Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study." Journal of toxicology and environmental health. Part A.. 2016 79(6):287-98. Epub 2016 Mar 30.

Books & Chapters

2011
Chapter Title: "Human exposure studies"
Book Title: Cardiovascular effects of inhaled ultrafine and nano-sized particles
Author List: Langrish, JP; Frampton, MW; Blomberg, A.
Edited By: Cassee, FR; Mills, NL; Newby, DE
Published By: John Wiley & Sons2011 in Hoboken, NJ

1992
Chapter Title: Sulfur dioxide and sulfuric acid aerosols
Book Title: Environmental and occupational medicine
Author List: Utell MJ; Frampton MW
Edited By: Rom WM
Published By: Little, Brown & Co1992 in Boston

1989
Chapter Title: Respiratory infection and oxidants
Book Title: Susceptibility to inhaled pollutants
Author List: Frampton MW, Roberts NJ Jr.
Edited By: Utell MJ, Frank R
Published By: American Society for Testing and Materials1989 in Philadelphia

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