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Harris A. Gelbard, M.D., Ph.D.

Neurology, Pediatrics

Publications

Showing all 121 journal articles & 18 books available

Journal Articles

1/7/2019
Saminathan P, Kevadiya BD, Marker DF, Gendelman HE, Gorantla S, Gelbard HA. "Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2019 Jan 7; Epub 2019 Jan 07.

10/16/2018
Hammond JW, Qiu WQ, Marker DF, Chamberlain JM, Greaves-Tunnell W, Bellizzi MJ, Lu SM, Gelbard HA. "HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q." Glia.. 2018 Oct 16; Epub 2018 Oct 16.

5/5/2018
Kiyota T, Machhi J, Lu Y, Dyavarshetty B, Nemati M, Zhang G, Lee Mosley R, Gelbard HA, Gendelman HE. "URMC-099 facilitates amyloid-? clearance in a murine model of Alzheimer's disease." Journal of neuroinflammation.. 2018 May 5; 15(1):137. Epub 2018 May 05.

2018
"The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis." eNeuro.. 2018 5(6)Epub 2018 Dec 03.

8/3/2017
Tomita K, Kohli R, MacLaurin BL, Hirsova P, Guo Q, Sanchez LHG, Gelbard HA, Blaxall BC, Ibrahim SH. "Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis." JCI insight.. 2017 Aug 3; 2(15)Epub 2017 Aug 03.

6/2017
Gelbard HA. "Neuroimmune Pharmacology, 2nd Edition - A Perspective." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2017 Jun; 12(2):211-212. Epub 2017 Mar 23.

7/11/2016
Dong W, Embury CM, Lu Y, Whitmire SM, Dyavarshetty B, Gelbard HA, Gendelman HE, Kiyota T. "The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-? degradation." Journal of neuroinflammation.. 2016 Jul 11; 13(1):184. Epub 2016 Jul 11.

1/27/2016
Bellizzi MJ, Geathers JS, Allan KC, Gelbard HA. "Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2016 Jan 27; 36(4):1336-46.

1/2016
Zhang G, Guo D, Dash PK, Araínga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, Wysocki TA, Wysocki BJ, Poluektova LY, Liu XM, McMillan JM, Gorantla S, Gelbard HA, Gendelman HE. "The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy." Nanomedicine : nanotechnology, biology, and medicine.. 2016 Jan; 12(1):109-22. Epub 2015 Oct 22.

2016
Hammond JW, Lu SM, Gelbard HA. "Corrigendum: Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation." Frontiers in cellular neuroscience.. 2016 10:113. Epub 2016 May 04.

4/1/2015
Puccini JM, Marker DF, Fitzgerald T, Barbieri J, Kim CS, Miller-Rhodes P, Lu SM, Dewhurst S, Gelbard HA. "Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 Apr 1; 35(13):5271-83.

2015
Hammond JW, Lu SM, Gelbard HA. "Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation." Frontiers in cellular neuroscience.. 2015 9:505. Epub 2016 Jan 08.

11/2014
Dayawansa S, Wang EW, Liu W, Markman JD, Gelbard HA, Huang JH. "Allotransplanted DRG neurons or Schwann cells affect functional recovery in a rodent model of sciatic nerve injury." Neurological research.. 2014 Nov; 36(11):1020-1027. Epub 2014 May 18.

11/2014
Gendelman HE, Gelbard HA. "Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders." Current opinion in HIV and AIDS.. 2014 Nov; 9(6):585-90.

9/1/2014
Guo D, Zhang G, Wysocki TA, Wysocki BJ, Gelbard HA, Liu XM, McMillan JM, Gendelman HE. "Endosomal trafficking of nanoformulated antiretroviral therapy facilitates drug particle carriage and HIV clearance." Journal of virology.. 2014 Sep 1; 88(17):9504-13. Epub 2014 Jun 11.

4/2014
Polesskaya O, Wong C, Lebron L, Chamberlain JM, Gelbard HA, Goodfellow V, Kim M, Daiss JL, Dewhurst S. "MLK3 regulates fMLP-stimulated neutrophil motility." Molecular immunology.. 2014 Apr; 58(2):214-22. Epub 2014 Jan 03.

1/28/2014
Kapetanovic S, Griner R, Zeldow B, Nichols S, Leister E, Gelbard HA, Miller TL, Hazra R, Mendez AJ, Malee K, Kammerer B, Williams PL, . "Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis." AIDS.. 2014 Jan 28; 28(3):355-64.

2014
Rhoo KH, Granger M, Sur J, Feng C, Gelbard HA, Dewhurst S, Polesskaya O. "Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model." PloS one.. 2014 9(9):e108487. Epub 2014 Sep 29.

11/1/2013
Tremblay MÈ, Marker DF, Puccini JM, Muly EC, Lu SM, Gelbard HA. "Ultrastructure of microglia-synapse interactions in the HIV-1 Tat-injected murine central nervous system." Communicative & integrative biology. 2013 Nov 1; 6(6):e27670. Epub 2013 Dec 31.

10/24/2013
Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen TX, Xu Y, Todd DE, Sheppard DW, Pollack S, Polesskaya O, Marker DF, Dewhurst S, Gelbard HA. "Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3." Journal of medicinal chemistry.. 2013 Oct 24; 56(20):8032-48. Epub 2013 Oct 03.

10/22/2013
Gelbard HA, Gendelman HE. "Lipids and cognition make good bedfellows for neuroAIDS." Neurology.. 2013 Oct 22; 81(17):1480-1. Epub 2013 Sep 11.

6/12/2013
Marker DF, Tremblay ME, Puccini JM, Barbieri J, Gantz Marker MA, Loweth CJ, Muly EC, Lu SM, Goodfellow VS, Dewhurst S, Gelbard HA. "The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Jun 12; 33(24):9998-10010.

6/2013
Ma Q, Gelbard HA, Maggirwar SB, Dewhurst S, Gendelman HE, Peterson DR, Difrancesco R, Hochreiter JS, Morse GD, Schifitto G. "Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients." Journal of neurovirology.. 2013 Jun; 19(3):254-60. Epub 2013 Jun 05.

11/29/2012
Marker DF, Puccini JM, Mockus TE, Barbieri J, Lu SM, Gelbard HA. "LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein." Journal of neuroinflammation.. 2012 Nov 29; 9:261. Epub 2012 Nov 29.

11/13/2012
Dash PK, Gendelman HE, Roy U, Balkundi S, Alnouti Y, Mosley RL, Gelbard HA, McMillan J, Gorantla S, Poluektova LY. "Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice." AIDS.. 2012 Nov 13; 26(17):2135-44.

9/2012
Lapin ZJ, Höppener C, Gelbard HA, Novotny L. "Near-field quantification of complement receptor 1 (CR1/CD35) protein clustering in human erythrocytes." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 Sep; 7(3):539-43. Epub 2012 Feb 29.

2012
Liu W, Ren Y, Bossert A, Wang X, Dayawansa S, Tong J, He X, Smith DH, Gelbard HA, Huang JH. "Allotransplanted neurons used to repair peripheral nerve injury do not elicit overt immunogenicity." PloS one.. 2012 7(2):e31675. Epub 2012 Feb 09.

3/2/2011
Dash PK, Gorantla S, Gendelman HE, Knibbe J, Casale GP, Makarov E, Epstein AA, Gelbard HA, Boska MD, Poluektova LY. "Loss of neuronal integrity during progressive HIV-1 infection of humanized mice." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011 Mar 2; 31(9):3148-57.

2/2011
Perry SW, Norman JP, Barbieri J, Brown EB, Gelbard HA. "Mitochondrial membrane potential probes and the proton gradient: a practical usage guide." BioTechniques.. 2011 Feb; 50(2):98-115.

1/2011
Kasischke KA, Lambert EM, Panepento B, Sun A, Gelbard HA, Burgess RW, Foster TH, Nedergaard M. "Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2011 Jan; 31(1):68-81. Epub 2010 Sep 22.

2011
Lu SM, Tremblay MÈ, King IL, Qi J, Reynolds HM, Marker DF, Varrone JJ, Majewska AK, Dewhurst S, Gelbard HA. "HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells." PloS one.. 2011 6(9):e23915. Epub 2011 Sep 02.

12/1/2010
Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD, Dewhurst S. "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." Hearing research.. 2010 Dec 1; 270(1-2):21-7. Epub 2010 Oct 27.

10/20/2010
Perry SW, Barbieri J, Tong N, Polesskaya O, Pudasaini S, Stout A, Lu R, Kiebala M, Maggirwar SB, Gelbard HA. "Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 Oct 20; 30(42):14153-64.

10/2010
Gelbard HA, Dewhurst S, Maggirwar SB, Kiebala M, Polesskaya O, Gendelman HE. "Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2010 Oct; 7(4):392-8.

9/19/2010
Marker DF, Tremblay ME, Lu SM, Majewska AK, Gelbard HA. "A thin-skull window technique for chronic two-photon in vivo imaging of murine microglia in models of neuroinflammation." Journal of visualized experiments : JoVE.. 2010 Sep 19; (43)Epub 2010 Sep 19.

6/19/2010
Kapetanovic S, Leister E, Nichols S, Miller T, Tassiopoulos K, Hazra R, Gelbard HA, Malee KM, Kammerer B, Mendez AJ, Williams PL, . "Relationships between markers of vascular dysfunction and neurodevelopmental outcomes in perinatally HIV-infected youth." AIDS.. 2010 Jun 19; 24(10):1481-91.

1/15/2010
Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE. "Neuroprotective activities of CEP-1347 in models of neuroAIDS." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Jan 15; 184(2):746-56. Epub 2009 Dec 04.

9/2009
Joseph J, Clifford D, Douglas SD, Fox H, Gendelman HE, Gonzalez-Scarano F, Grant I, Major E, McArthur J, . "Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2009 Sep; 4(3):283-97. Epub 2009 May 20.

8/18/2009
Eggert D, Dash PK, Serradji N, Dong CZ, Clayette P, Heymans F, Dou H, Gorantla S, Gelbard HA, Poluektova L, Gendelman HE. "Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders." Journal of neuroimmunology.. 2009 Aug 18; 213(1-2):47-59. Epub 2009 Jun 21.

4/2009
Schifitto G, Zhong J, Gill D, Peterson DR, Gaugh MD, Zhu T, Tivarus M, Cruttenden K, Maggirwar SB, Gendelman HE, Dewhurst S, Gelbard HA. "Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment." Journal of neurovirology.. 2009 Apr; 15(2):176-86.

9/2008
DiCenzo R, Peterson DR, Cruttenden K, Mariuz P, Rezk NL, Hochreiter J, Gelbard H, Schifitto G. "Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir." Antimicrobial agents and chemotherapy.. 2008 Sep; 52(9):3035-9. Epub 2008 Jun 23.

2008
Norman JP, Perry SW, Reynolds HM, Kiebala M, De Mesy Bentley KL, Trejo M, Volsky DJ, Maggirwar SB, Dewhurst S, Masliah E, Gelbard HA. "HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization." PloS one.. 2008 3(11):e3731. Epub 2008 Nov 14.

6/2007
Lu SM, Tong N, Gelbard HA. "The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2007 Jun; 2(2):194-201. Epub 2007 Feb 27.

3/1/2007
Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB. "Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Mar 1; 178(5):3226-36.

3/2007
Dewhurst S, Maggirwar SB, Schifitto G, Gendelman HE, Gelbard HA. "Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2007 Mar; 2(1):93-6. Epub 2006 Dec 16.

1/15/2007
Norman JP, Perry SW, Kasischke KA, Volsky DJ, Gelbard HA. "HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Jan 15; 178(2):869-76.

7/1/2006
Sui Z, Fan S, Sniderhan L, Reisinger E, Litzburg A, Schifitto G, Gelbard HA, Dewhurst S, Maggirwar SB. "Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Jul 1; 177(1):702-11.

5/2006
Sui Z, Sniderhan LF, Fan S, Kazmierczak K, Reisinger E, Kovács AD, Potash MJ, Dewhurst S, Gelbard HA, Maggirwar SB. "Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons." The European journal of neuroscience.. 2006 May; 23(10):2623-34.

3/28/2006
Schifitto G, Peterson DR, Zhong J, Ni H, Cruttenden K, Gaugh M, Gendelman HE, Boska M, Gelbard H. "Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report." Neurology.. 2006 Mar 28; 66(6):919-21. Epub 2006 Mar 01.

3/2006
Bellizzi MJ, Lu SM, Gelbard HA. "Protecting the synapse: evidence for a rational strategy to treat HIV-1 associated neurologic disease." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2006 Mar; 1(1):20-31.

11/2005
Bellizzi MJ, Lu SM, Masliah E, Gelbard HA. "Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor." The Journal of clinical investigation.. 2005 Nov; 115(11):3185-92.

10/2005
Perry SW, Norman JP, Gelbard HA. "Adjunctive therapies for HIV-1 associated neurologic disease." Neurotoxicity research.. 2005 Oct; 8(1-2):161-6.

9/14/2005
Dou H, Ellison B, Bradley J, Kasiyanov A, Poluektova LY, Xiong H, Maggirwar S, Dewhurst S, Gelbard HA, Gendelman HE. "Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2005 Sep 14; 25(37):8375-85.

5/15/2005
Nelson JA, Dou H, Ellison B, Uberti M, Xiong H, Anderson E, Mellon M, Gelbard HA, Boska M, Gendelman HE. "Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis." Journal of neuroscience research.. 2005 May 15; 80(4):562-75.

4/1/2005
Perry SW, Norman JP, Litzburg A, Zhang D, Dewhurst S, Gelbard HA. "HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis." The Journal of immunology : official journal of the American Association of Immunologists.. 2005 Apr 1; 174(7):4333-44.

12/2004
Nitkiewicz J, Chao W, Bentsman G, Li J, Kim SY, Choi SY, Grunig G, Gelbard H, Potash MJ, Volsky DJ. "Productive infection of primary murine astrocytes, lymphocytes, and macrophages by human immunodeficiency virus type 1 in culture." Journal of neurovirology.. 2004 Dec; 10(6):400-8.

11/15/2004
Perry SW, Norman JP, Litzburg A, Gelbard HA. "Antioxidants are required during the early critical period, but not later, for neuronal survival." Journal of neuroscience research.. 2004 Nov 15; 78(4):485-92.

11/2004
DiCenzo R, Peterson D, Cruttenden K, Morse G, Riggs G, Gelbard H, Schifitto G. "Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults." Antimicrobial agents and chemotherapy.. 2004 Nov; 48(11):4328-31.

7/15/2004
Ramirez SH, Fan S, Maguire CA, Perry S, Hardiek K, Ramkumar V, Gelbard HA, Dewhurst S, Maggirwar SB. "Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal." Journal of neuroscience research.. 2004 Jul 15; 77(2):258-69.

5/2004
Latchney LR, Fallon MA, Culp DJ, Gelbard HA, Dewhurst S. "Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands." The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.. 2004 May; 52(5):671-81.

2/19/2004
Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. "Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3." Neuron.. 2004 Feb 19; 41(4):563-72.

1/2004
Gelbard HA. "Synapses and Sisyphus: life without paraplegin." The Journal of clinical investigation.. 2004 Jan; 113(2):185-7.

2004
Wang Z, Trillo-Pazos G, Kim SY, Canki M, Morgello S, Sharer LR, Gelbard HA, Su ZZ, Kang DC, Brooks AI, Fisher PB, Volsky DJ. "Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis." Journal of neurovirology.. 2004 10 Suppl 1:25-32.

2004
Dou H, Kingsley JD, Mosley RL, Gelbard HA, Gendelman HE. "Neuroprotective strategies for HIV-1 associated dementia." Neurotoxicity research.. 2004 6(7-8):503-21.

10/8/2003
Dou H, Birusingh K, Faraci J, Gorantla S, Poluektova LY, Maggirwar SB, Dewhurst S, Gelbard HA, Gendelman HE. "Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Oct 8; 23(27):9162-70.

7/20/2003
Wang Z, Pekarskaya O, Bencheikh M, Chao W, Gelbard HA, Ghorpade A, Rothstein JD, Volsky DJ. "Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120." Virology.. 2003 Jul 20; 312(1):60-73.

12/2002
Perry SW, Dewhurst S, Bellizzi MJ, Gelbard HA. "Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?" Journal of neurovirology.. 2002 Dec; 8(6):611-24.

8/2002
Diesing TS, Swindells S, Gelbard H, Gendelman HE. "HIV-1-associated dementia: a basic science and clinical perspective." The AIDS reader. 2002 Aug; 12(8):358-68.

8/2001
Ramirez SH, Sanchez JF, Dimitri CA, Gelbard HA, Dewhurst S, Maggirwar SB. "Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism." Journal of neurochemistry.. 2001 Aug; 78(4):874-89.

5/2001
Tong N, Sanchez JF, Maggirwar SB, Ramirez SH, Guo H, Dewhurst S, Gelbard HA. "Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons." The European journal of neuroscience.. 2001 May; 13(10):1913-22.

4/2001
Zhu Y, Gelbard HA, Roshal M, Pursell S, Jamieson BD, Planelles V. "Comparison of cell cycle arrest, transactivation, and apoptosis induced by the simian immunodeficiency virus SIVagm and human immunodeficiency virus type 1 vpr genes." Journal of virology.. 2001 Apr; 75(8):3791-801.

10/2000
Guo H, Tong N, Turner T, Epstein LG, McDermott MP, Kilgannon P, Gelbard HA. "Release of the neuronal glycoprotein ICAM-5 in serum after hypoxic-ischemic injury." Annals of neurology.. 2000 Oct; 48(4):590-602.

2/1/2000
Tong N, Perry SW, Zhang Q, James HJ, Guo H, Brooks A, Bal H, Kinnear SA, Fine S, Epstein LG, Dairaghi D, Schall TJ, Gendelman HE, Dewhurst S, Sharer LR, Gelbard HA. "Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Feb 1; 164(3):1333-9.

2/2000
Maggirwar SB, Ramirez S, Tong N, Gelbard HA, Dewhurst S. "Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells." Journal of neurochemistry.. 2000 Feb; 74(2):527-39.

10/1999
James HJ, Sharer LR, Zhang Q, Wang HG, Epstein LG, Reed JC, Gelbard HA. "Expression of caspase-3 in brains from paediatric patients with HIV-1 encephalitis." Neuropathology and applied neurobiology.. 1999 Oct; 25(5):380-6.

8/3/1999
Zheng J, Thylin MR, Ghorpade A, Xiong H, Persidsky Y, Cotter R, Niemann D, Che M, Zeng YC, Gelbard HA, Shepard RB, Swartz JM, Gendelman HE. "Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia." Journal of neuroimmunology.. 1999 Aug 3; 98(2):185-200.

8/1999
Maggirwar SB, Tong N, Ramirez S, Gelbard HA, Dewhurst S. "HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity." Journal of neurochemistry.. 1999 Aug; 73(2):578-86.

7/22/1999
Schifitto G, Sacktor N, Marder K, McDermott MP, McArthur JC, Kieburtz K, Small S, Epstein LG. "Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium." Neurology.. 1999 Jul 22; 53(2):391-6.

4/1999
Epstein LG, Gelbard HA. "HIV-1-induced neuronal injury in the developing brain." Journal of leukocyte biology.. 1999 Apr; 65(4):453-7.

3/27/1999
Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff HJ. "Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss." Brain research.. 1999 Mar 27; 823(1-2):1-10.

3/1/1999
Fine SM, Maggirwar SB, Elliott PR, Epstein LG, Gelbard HA, Dewhurst S. "Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia." Journal of neuroimmunology.. 1999 Mar 1; 95(1-2):55-64.

1999
Gelbard HA. "Neuroprotective strategies for HIV-1-associated neurologic disease." Annals of the New York Academy of Sciences.. 1999 890:312-3.

12/20/1998
Hodge S, Novembre FJ, Whetter L, Gelbard HA, Dewhurst S. "Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14." Virology.. 1998 Dec 20; 252(2):354-63.

9/1/1998
Deng SX, Panahian N, James H, Gelbard HA, Federoff HJ, Dewhurst S, Epstein LG. "Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption." Journal of neuroscience methods.. 1998 Sep 1; 83(2):159-64.

7/10/1998
Perry SW, Hamilton JA, Tjoelker LW, Dbaibo G, Dzenko KA, Epstein LG, Hannun Y, Whittaker JS, Dewhurst S, Gelbard HA. "Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis." The Journal of biological chemistry.. 1998 Jul 10; 273(28):17660-4.

7/10/1998
New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA. "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism." The Journal of biological chemistry.. 1998 Jul 10; 273(28):17852-8.

5/15/1998
Teicher MH, Andersen SL, Campbell A, Gelbard HA, Baldessarini RJ. "Progressive accumbens degeneration after neonatal striatal 6-hydroxydopamine in rats." Neuroscience letters.. 1998 May 15; 247(2-3):99-102.

3/1998
"A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders." Neurology.. 1998 Mar; 50(3):645-51.

7/1997
"Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders." Neurology.. 1997 Jul; 49(1):142-6.

6/1997
Perry SW, Epstein LG, Gelbard HA. "In situ trypan blue staining of monolayer cell cultures for permanent fixation and mounting." BioTechniques.. 1997 Jun; 22(6):1020-1, 1024.

6/1997
Perry SW, Epstein LG, Gelbard HA. "Simultaneous in situ detection of apoptosis and necrosis in monolayer cultures by TUNEL and trypan blue staining." BioTechniques.. 1997 Jun; 22(6):1102-6.

6/1997
Krajewski S, James HJ, Ross J, Blumberg BM, Epstein LG, Gendelman HE, Gummuluru S, Dewhurst S, Sharer LR, Reed JC, Gelbard HA. "Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis." Neuropathology and applied neurobiology.. 1997 Jun; 23(3):242-53.

4/1997
New DR, Ma M, Epstein LG, Nath A, Gelbard HA. "Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures." Journal of neurovirology.. 1997 Apr; 3(2):168-73.

2/1997
Gelbard HA, Boustany RM, Schor NF. "Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease." Pediatric neurology.. 1997 Feb; 16(2):93-7.

2/1997
Canki M, Potash MJ, Bentsman G, Chao W, Flynn T, Heinemann M, Gelbard H, Volsky DJ. "Isolation and long-term culture of primary ocular human immunodeficiency virus type 1 isolates in primary astrocytes." Journal of neurovirology.. 1997 Feb; 3(1):10-5.

11/1/1996
Gummuluru S, Novembre FJ, Lewis M, Gelbard HA, Dewhurst S. "Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14." Virology.. 1996 Nov 1; 225(1):21-32.

11/1996
"Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders." Neurology.. 1996 Nov; 47(5):1247-53.

9/1996
Persidsky Y, Limoges J, McComb R, Bock P, Baldwin T, Tyor W, Patil A, Nottet HS, Epstein L, Gelbard H, Flanagan E, Reinhard J, Pirruccello SJ, Gendelman HE. "Human immunodeficiency virus encephalitis in SCID mice." The American journal of pathology.. 1996 Sep; 149(3):1027-53.

6/28/1996
Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dewhurst S, Gelbard HA. "Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia." The Journal of biological chemistry.. 1996 Jun 28; 271(26):15303-6.

6/1996
Sharer LR, Saito Y, Da Cunha A, Ung PC, Gelbard HA, Epstein LG, Blumberg BM. "In situ amplification and detection of HIV-1 DNA in fixed pediatric AIDS brain tissue." Human pathology.. 1996 Jun; 27(6):614-7.

4/1996
Nottet HS, Flanagan EM, Flanagan CR, Gelbard HA, Gendelman HE, Reinhard JF. "The regulation of quinolinic acid in human immunodeficiency virus-infected monocytes." Journal of neurovirology.. 1996 Apr; 2(2):111-7.

1/1996
Dewhurst S, Gelbard HA, Fine SM. "Neuropathogenesis of AIDS." Molecular medicine today. 1996 Jan; 2(1):16-23.

12/1995
Dollard SC, James HJ, Sharer LR, Epstein LG, Gelbard HA, Dewhurst S. "Activation of nuclear factor kappa B in brains from children with HIV-1 encephalitis." Neuropathology and applied neurobiology.. 1995 Dec; 21(6):518-28.

12/1995
Gelbard HA, Epstein LG. "HIV-1 encephalopathy in children." Current opinion in pediatrics.. 1995 Dec; 7(6):655-62.

6/1995
Gelbard HA, James HJ, Sharer LR, Perry SW, Saito Y, Kazee AM, Blumberg BM, Epstein LG. "Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy." Neuropathology and applied neurobiology.. 1995 Jun; 21(3):208-17.

5/1995
Talley AK, Dewhurst S, Perry SW, Dollard SC, Gummuluru S, Fine SM, New D, Epstein LG, Gendelman HE, Gelbard HA. "Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA." Molecular and cellular biology.. 1995 May; 15(5):2359-66.

7/1994
Gelbard HA, Nottet HS, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi YB, Zhang D. "Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin." Journal of virology.. 1994 Jul; 68(7):4628-35.

5/1994
Blumberg BM, Gelbard HA, Epstein LG. "HIV-1 infection of the developing nervous system: central role of astrocytes in pathogenesis." Virus research.. 1994 May; 32(2):253-67.

1/1994
Gelbard HA, Applegate CD. "Persistent increases in dopamine D2 receptor mRNA expression in basal ganglia following kindling." Epilepsy research.. 1994 Jan; 17(1):23-9.

9/1993
Teicher MH, Barber NI, Gelbard HA, Gallitano AL, Campbell A, Marsh E, Baldessarini RJ. "Developmental differences in acute nigrostriatal and mesocorticolimbic system response to haloperidol." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 1993 Sep; 9(2):147-56.

1/1993
Faedda GL, Tondo L, Teicher MH, Baldessarini RJ, Gelbard HA, Floris GF. "Seasonal mood disorders. Patterns of seasonal recurrence in mania and depression." Archives of general psychiatry.. 1993 Jan; 50(1):17-23.

1993
Gelbard HA, Dzenko KA, DiLoreto D, del Cerro C, del Cerro M, Epstein LG. "Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis." Developmental neuroscience.. 1993 15(6):417-22.

1993
Ito Y, Teicher MH, Glod CA, Harper D, Magnus E, Gelbard HA. "Increased prevalence of electrophysiological abnormalities in children with psychological, physical, and sexual abuse." The Journal of neuropsychiatry and clinical neurosciences.. 1993 5(4):401-8.

12/1/1992
Mizrachi Y, Genis P, Volsky DJ, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ. "Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease." The Journal of experimental medicine.. 1992 Dec 1; 176(6):1703-18.

12/1991
Kieburtz KD, Epstein LG, Gelbard HA, Greenamyre JT. "Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syndrome dementia complex. Therapeutic implications." Archives of neurology.. 1991 Dec; 48(12):1281-4.

11/19/1991
Teicher MH, Gallitano AL, Gelbard HA, Evans HK, Marsh ER, Booth RG, Baldessarini RJ. "Dopamine D1 autoreceptor function: possible expression in developing rat prefrontal cortex and striatum." Brain research. Developmental brain research.. 1991 Nov 19; 63(1-2):229-35.

1991
Gelbard, H.A.; Teicher, M.H.; Beers, N.B.; Gallitano, A. and R.J. Baldessarini. "Neonatal depletion of dopamine decreases D1 and forskolin binding sites in rat striatum". Posters in Neuroscience. 1991; 1: 9-11.

10/1/1990
Gelbard HA, Teicher MH, Baldessarini RJ, Gallitano A, Marsh ER, Zorc J, Faedda G. "Dopamine D1 receptor development depends on endogenous dopamine." Brain research. Developmental brain research.. 1990 Oct 1; 56(1):137-40.

9/1/1989
Gelbard HA, Teicher MH, Faedda G, Baldessarini RJ. "Postnatal development of dopamine D1 and D2 receptor sites in rat striatum." Brain research. Developmental brain research.. 1989 Sep 1; 49(1):123-30.

9/7/1981
Gelbard HA, Stern PH, U'Prichard DC. "Characteristics of [3H]1 alpha, 25-(OH)2D3 binding to nuclear fractions from rat pituitary adenoma GH3 cells." Life sciences.. 1981 Sep 7; 29(10):1051-6.

9/12/1980
Gelbard HA, Stern PH, U'Prichard DC. "1 alpha, 25-Dihydroxyvitamin D3 nuclear receptors in pituitary." Science.. 1980 Sep 12; 209(4462):1247-9.

Books & Chapters

2015
Chapter Title: HAND adjunctive therapies: reversing neuronal injury
Book Title: Encyclopedia of AIDS
Author List: Marker DF, Fitzgerald, T and Gelbard HA
Edited By: Hope, TJ, Stevenson, M, and Richman, D
Published By: Springer Science + Business Media2015 in New York

2014
Chapter Title: Human immunodeficiency virus
Book Title: Microglia in Health and Disease
Author List: Marker DF, Lu S-M and Gelbard HA
Edited By: Tremblay MÈ and Sierra A
Published By: Science + Business Media2014 in New York

2012
Chapter Title: Development of Adjunctive Therapies for the Neurological Manifestations of AIDS: HAND and Painful Neuropathy
Book Title: The Neurology of AIDS
Author List: Gelbard, H.A. and Lipton, S.A.
Edited By: Everall, Fox, Gelbard, Grant, Lipton, Swindells and Gendelman
Published By: Oxford Press2012 in New York

2008
Chapter Title: Neuroimmunology and the Pathogenesis of HIV-1 Encephalitis in the HAART Era: Implications for Neuroprotective Treatment.
Book Title: The Spectrum of Neuro-AIDS Disorders: Pathophysiology, Diagnosis, and Treatment.
Author List: Perry, S.W. and Gelbard, H.A.
Edited By: In Goodkin, Shapshak, and Verma (eds.)
Published By: ASM Press2008 in New York

2008
Chapter Title: Infectious agents in neurodegenerative disease
Book Title: Encyclopedia of Neuroscience
Author List: Bellizzi, M.J and Gelbard, H.A.
Edited By: In Larry R. Squire (Editor-in-Chief)
Published By: Academic Press2008 in Oxford

2004
Chapter Title: Development of Adjunctive Therapies for the Neurological Manifestations of AIDS: Dementia and Painful Neuropathy
Book Title: The Neurology of AIDS - 2nd Edition
Author List: Lipton, S.A. and Gelbard, H.A.
Edited By: In Gendelman (ed.)
Published By: Chapman and Hall2004 in New York

2002
Chapter Title: The Neuropathogenesis of HIV-1 Infection
Book Title: AIDS and Other Manifestations of HIV Infections - 4th edition
Author List: Gendelman, H.E., Diesing, S., Gelbard, H.A., and S.Swindells
Published By: In Wormser (ed.)2002

1999
Chapter Title: HIV-1 and Apoptosis in the Nervous System
Book Title: Apoptosis in Neurobiology
Author List: Gelbard, H.A.
Edited By: In Boustany and Hannun (eds.)
Published By: CRC Methods of Neurobiology, CRC Press1999 in Boca Raton

1999
Chapter Title: Neuroprotective strategies for HIV-1 associated neurologic disease
Book Title: Academy of Science
Author List: Gelbard, H.A.
Published By: Ann.1999 in New York

1998
Chapter Title: HIV-induced neurotoxicity in the developing central nervous system
Book Title: The Neurology of AIDS
Author List: Gelbard, H.A.
Edited By: In Gendelman (ed.)
Published By: Chapman and Hall1998 in New York, New York

1998
Chapter Title: Infection of the CNS: Evidence for Apoptosis of Neural Cells
Book Title: Cell Death and Diseases of the Nervous System
Author List: Gelbard, H.A.
Edited By: In Ratan (ed.)
Published By: Humana Press1998 in New Jersey

1997
Chapter Title: Neuropsychiatric disorders of childhood and adolescence
Book Title: Textbook of Neuropsychiatry - Third Edition
Author List: Teicher, M.H., Anderson, S.L., Glod, C.A., Navalta, C.P., and Gelbard, H.A.
Published By: In Yudofsky and Hales (eds.)1997

1996
Chapter Title: Neurophysiological mechanisms of stress response in children
Book Title: Severe Stress and Mental Disturbances in Children
Author List: Teicher, M.H., Ito, Y., Glod, C.A., Schiffer, F., and Gelbard, H.A.
Published By: In Pheffer (ed.)1996

1995
Chapter Title: HIV-1-derived neurotoxic factors: effects on human neuronal cultures
Book Title: Technical Advances in AIDS Research in the Human Nervous System
Author List: Gelbard, H.A., Dzenko, K.A., Wang, L., Talley, A., James, H., and L. Epstein
Edited By: In Major (ed.)
Published By: Plenum Press1995 in New York

1994
Chapter Title: Early Abuse, Limbic System Dysfunction, and Borderline Personality Disorder
Book Title: Biological and Neurobehavioral Studies in Borderline Personality
Author List: Teicher, M.H., Ito, Y., Glod, C.A., Schiffer, F., and Gelbard, H.A.
Edited By: In K.R. Silk (ed.)
Published By: American Psychiatric Press, Inc.1994

1994
Chapter Title: Experimental model systems for studies of HIV-associated CNS disease
Book Title: New Concepts in AIDS Pathogenesis
Author List: Gendelman, H.E., Genis, P., Jett, M., Bernton, E.W., Gelbard, H.A., Cvetkovich, T.A., Lazar, E.S., del Cerro, M., and Epstein, L.G.
Edited By: In Montagnier and Gougeon (eds.)
Published By: Marcel Dekker1994

1990
Chapter Title: Development of dopamine D receptor system depends on endogenous dopamine
Book Title: Psychiatry: A World Perspective Volume
Author List: Gelbard, H.A., Teicher, M.H., Baldessarini, R.J., Gallitano, A., Marsh, E.R., Zorc, J. and Faedda, G.
Published By: Elsevier Science Publishers1990 in Amsterdam

1981
Chapter Title: I alpha, 25-(OH) vitamin D receptors in the pituitary: Characterization and relation to dopaminergic mechanisms
Book Title: Steroid Hormone Regulations of the Brain
Author List: Gelbard, H.A., Stern, P.J. & U'Prichard, D.C.
Published By: Pergamon Press1981 in Oxford, England