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Christopher T. Ritchlin, M.D., M.P.H.

Contact Information

Phone Numbers

Appointment: (585) 486-0901

Office: (585) 273-2125

Fax: (585) 442-3214

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Efforts are focused on the mechanisms of bone resorption and formation, the effect of anti-TNF agents on dendritic cell differentiation and the mechanisms for bone marrow edema in PsA and RA.

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Faculty Appointments

Patient Care Setting

Allergy, Immunology & Rheumatology

Biography

Dr. Ritchlin's basic science research efforts are directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis.

Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit where he is the principle investigator on several clinical trials testing the efficacy of anti-TNF agents and other biologic molecules in the treatment of psoriatic and rheumatoid arthritis and ankylosing spondylitis. In the Clinical Immunology Research Unit, patient oriented research is conducted on multiple levels. Investigator New Drug (IND) trials of novel agents (adalimumab, rituximab) in the treatment of PsA and AS have been completed or are about to start. Additional trials have been performed to study the effect of TNF inhibition on the frequency of osteoclast precursors and enhancing bone marrow edema in PsA. The Unit also conducts multicenter trials with novel biologic agents such as rituximab and abatacept in PsA with special attention directed towards understanding how these agents alter bone remodeling in these disorders. Additional studies underway include microanalysis assays of synovium, skin and intestinal tissues in patients with Immune Mediated Inflammatory Disroders (IMIDs) before and after TNF inhibition. Future plans include the development of ultrasound outcome measures in collaboration with Dr. Ralf Thiele and Dr. Darren Tabechian, to assess synovial, lymph node and periarticular tissue responses to different therapies in inflammatory arthritis.

Research

Dr. Ritchlin's basic science research efforts are directed towards understanding the mechanisms that underlie pathologic bone resorption and new bone formation in psoriatic arthritis and rheumatoid arthritis. Using a translational approach, investigators in his lab are analyzing the cell surface molecules expressed by osteoclast and dendritic cell precursors with the goal to identify susceptibility and response biomarkers in patients with inflammatory arthritis. The lab is also studying the effect of anti-TNF agents on dendritic cell differentiation in RA and PsA patients. In addition, collaborative studies are underway with the lab of Dr. Eddie Schwarz to understand the mechanisms that are responsible for bone marrow edema as recorded on magnetic resonance imaging scans in inflammatory arthritis. The bulk of this work is performed in animal models but insights gained from these studies are applied to the study of human joint diseases such as psoriatic and rheumatoid arthritis.

Dr. Ritchlin is also the Director of the Clinical Immunology Research Unit where he is the principle investigator on several clinical trials testing the efficacy of anti-TNF agents and other biologic molecules in the treatment of psoriatic and rheumatoid arthritis and ankylosing spondylitis. In the Clinical Immunology Research Unit, patient oriented research is conducted on multiple levels. Investigator New Drug (IND) trials of novel agents (adalimumab, rituximab) in the treatment of PsA and AS have been completed or are about to start. Additional trials have been performed to study the effect of TNF inhibition on the frequency of osteoclast precursors and enhancing bone marrow edema in PsA. The Unit also conducts multicenter trials with novel biologic agents such as rituximab and abatacept in PsA with special attention directed towards understanding how these agents alter bone remodeling in these disorders. Additional studies underway include microanalysis assays of synovium, skin and intestinal tissues in patients with Immune Mediated Inflammatory Disroders (IMIDs) before and after TNF inhibition. Future plans include the development of ultrasound outcome measures in collaboration with Dr. Ralf Thiele and Dr. Darren Tabechian, to assess synovial, lymph node and periarticular tissue responses to different therapies in inflammatory arthritis.

Credentials

Education

1976
BA | University of Rochester
Biology

1976
B.A. | University Of Rochester
History

1982
MD | Albany Medical College
Medicine

2008
MPH | University of Rochester
Public Health & Clinical Investigation

Post-doctoral Training & Residency

07/01/1986 - 06/30/1989
Fellowship in Rheumatology at New York University Langone Medical Center

07/01/1983 - 06/30/1986
Residency in Internal Medicine at Mount Sinai Medical Center

07/01/1982 - 06/30/1983
Internship in Internal Medicine at Albany Medical Center

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Awards

2010 - 2012
Marquis Who's Who

2005
Irene Kohn Teaching Award
Sponsor: Strong Memorial Hospital
Location: Rochester, NY

2004
Irene Kohn Teaching Fellowship Award
Sponsor: Strong Memorial Hospital
Location: Rochester, NY

2003 - 2012
Best Doctors in America

1994
Teacher of the Year Award
Sponsor: Rochester General Hospital
Location: Rochester, NY

1991
Henry Christian Award of Excellence in Clinical Research
Sponsor: American Federation of Clinical Research

1982
Stanley Poole Award for Excellence in Internal Medicine
Sponsor: Albany College
Location: Albany, NY

1981
Alpha Omega Alpha
Sponsor: Albany Medical College
Location: Albany NY

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Patents

Patent Title: Methods of Diagnosing Erosive Arthritis
Patent #: 1604205
Issue Date: Jan 12, 2011
Country: Europe
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: FR1604205
Issue Date: Jan 12, 2011
Country: France
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: DE1604205
Issue Date: Jan 12, 2011
Country: Germany
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: GB1604205
Issue Date: Jan 12, 2011
Country: United Kingdom
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: 7,807,389
Issue Date: Oct 05, 2010
Country: United States
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: 4929341
Issue Date: Feb 17, 2012
Country: Japan
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: 2,339,667
Issue Date: May 18, 2010
Country: Canada
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: 1119362
Issue Date: Feb 08, 2006
Country: Europe
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: IT1119362
Issue Date: Feb 08, 2006
Country: Italy
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: SE119362
Issue Date: Feb 08, 2006
Country: Sweden
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: ES1119362
Issue Date: Feb 08, 2006
Country: Spain
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: RO1119362
Issue Date: Feb 08, 2006
Country: Romania
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: CH1119362
Issue Date: Feb 08, 2006
Country: Switzerland/Liechtenstein
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: BE1119362
Issue Date: Feb 08, 2006
Country: Belgium
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: LV1119362
Issue Date: Feb 08, 2006
Country: Latvia
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: SL1119362
Issue Date: Feb 08, 2006
Country: Slovenia
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: GR1119362
Issue Date: Feb 08, 2006
Country: Greece
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: DK1119362
Issue Date: Feb 08, 2006
Country: Denmark
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: AL1119362
Issue Date: Feb 08, 2006
Country: Albania
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: DE1119362
Issue Date: Feb 08, 2006
Country: Germany
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: FI1119362
Issue Date: Feb 08, 2006
Country: Finland
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: AT1119362
Issue Date: Feb 08, 2006
Country: Austria
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: FR1119362
Issue Date: Feb 08, 2006
Country: France
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: GB1119362
Issue Date: Feb 08, 2006
Country: United Kingdom
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: IE1119362
Issue Date: Feb 08, 2006
Country: Ireland
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: LU1119362
Issue Date: Feb 08, 2006
Country: Luxembourg
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: MC1119362
Issue Date: Feb 08, 2006
Country: Monaco
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: NL119362
Issue Date: Feb 08, 2006
Country: Netherlands
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: PT119362
Issue Date: Feb 08, 2006
Country: Portugal
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: LT1119362
Issue Date: Feb 08, 2006
Country: Lithuania
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: MK1119362
Issue Date: Feb 08, 2006
Country: Macedonia, The Former Yugoslav Rep
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: 509,799
Issue Date: Dec 08, 2003
Country: New Zealand
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: 754515
Issue Date: Nov 21, 2002
Country: Australia
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: Method of Using Tetracycline Compounds to Enhance Interleukin-10 Production
Patent #: 6,015,804
Issue Date: Jan 18, 2000
Country: United States
Invented By: Lorne M Golub, Robert A Greenwald, Sally A Haas, Hsi-Ming Lee, Susan A Moak, Christopher T Ritchlin

Patent Title: DC-STAMP Antibodies
Patent #: 9,988,448
Issue Date: Jun 05, 2018
Country: United States
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 2,760,330
Issue Date: Jul 25, 2017
Country: Canada
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 2424892
Issue Date: Jun 07, 2017
Country: Europe
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: FR2424892
Issue Date: Jun 07, 2017
Country: France
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 602010042851.6
Issue Date: Jun 07, 2017
Country: Germany
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: IT2424892
Issue Date: Jun 07, 2017
Country: Italy
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: ES2424892
Issue Date: Jun 07, 2017
Country: Spain
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: GB2424892
Issue Date: Jun 07, 2017
Country: United Kingdom
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 9,018,358
Issue Date: Apr 28, 2015
Country: United States
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

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Publications

Journal Articles

1/2017
Mease PJ, van der Heijde D, Ritchlin CT, Okada M, Cuchacovich RS, Shuler CL, Lin CY, Braun DK, Lee CH, Gladman DD, . "Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1." Annals of the rheumatic diseases.. 2017 Jan 0; 76(1):79-87. Epub 2016 Aug 23.

11/2016
Chiu YG, Ritchlin CT. "DC-STAMP: A Key Regulator in Osteoclast Differentiation." Journal of cellular physiology.. 2016 Nov 0; 231(11):2402-7. Epub 2016 Jun 14.

9/1/2016
Rahimi H, Bell R, Bouta EM, Wood RW, Xing L, Ritchlin CT, Schwarz EM. "Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential." Arthritis research & therapy.. 2016 Sep 1; 18:194. Epub 2016 Sep 01.

Books & Chapters

2010
Book Title: Pathogenesis of Psoriatic Arthritis
Author List: Ritchlin, CT, McGonagle, DA
Edited By: Hochberg et al
Published By: Elsevier 2010 in Philadelphia

2007
Chapter Title: Pathogenesis of Psoriatic Arthritis
Book Title: Psoriatic and Reactive Arthritis
Author List: Ritchlin CT, Fitzgerald O.
Edited By: Ritchlin, CT and Fitzgerald, O.
Published By: Elsevier 2007 in Philadelphia

2007
Chapter Title: Epidemiology and Pathogenesis of Psoriatic Arthritis
Book Title: Primer of Rheumatic Diseases
Author List: Ritchlin, C.T.
Published By: Arthritis Foundation 2007 in Atlanta

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Videos

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SECOND OPINION | Psoriasis | APT | Webisode