Pathologic Bone Resorption and New Bone Formation in Inflammatory Arthritis
Bone remodeling is a dynamic and complex process finely orchestrated by cell interactions among bone-degrading osteoclasts, bone-synthesizing osteoblastosteoblasts, T cells, B cells, and natural killer cells. An imbalance between osteoclast and osteoblast activity results in skeletal and joint diseases including osteoporosis, arthritis, and non-union bone repair. These diseases impact the quality of life of patients.

Christopher T. Ritchlin, M.D., M.P.H.
Principal Investigator
Publications
View All Publications- Efficacy and Safety of Guselkumab in Participants with Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week-24 Results of the Phase 3, Randomized, Placebo-Controlled SOLSTICE Study.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Feb 11.
- Automated Joint Space Detection Improves Bone Segmentation Accuracy.; Journal of visualized experiments : JoVE. 2025 Nov 28.
- The Function of Efhd1+ Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis.; bioRxiv : the preprint server for biology. 2025 Nov 05.
- Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial.; Nature medicine. 2025 Oct 06.
Affiliations
News
February 6, 2026
Dr. Katherine Herman Presents Medical Grand Rounds
January 23, 2026
Dr. Theresa Bingemann Presents at the AAAAI Program Directors Assembly Winter Meeting
November 21, 2025
Dr. Rangel-Moreno an International Speaker at the Research Seminars in Biological Sciences and International Biomedicine Workshop
October 22, 2025
Dr. Jennifer Anolik Presents at Upstate Medical Center Symposium
October 20, 2025
National Scleroderma Foundation Rochester Education Forum Held at URMC
Contact Us
Ritchlin Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642
(585) 442-3214