Pathologic Bone Resorption and New Bone Formation in Inflammatory Arthritis
Bone remodeling is a dynamic and complex process finely orchestrated by cell interactions among bone-degrading osteoclasts, bone-synthesizing osteoblastosteoblasts, T cells, B cells, and natural killer cells. An imbalance between osteoclast and osteoblast activity results in skeletal and joint diseases including osteoporosis, arthritis, and non-union bone repair. These diseases impact the quality of life of patients.

Christopher T. Ritchlin, M.D., M.P.H.
Principal Investigator
Publications
View All Publications- Psoriatic arthritis and obesity: a review of clinical burden and considerations for comprehensive care.; RMD open; Vol 12(3). 2026 Jul 15.
- Synovial Telocytes are Characterized by Efhd1, Dpp4, and Pi16 Expression, Show High Responsiveness to Osmotic Stress, and Exhibit Fibroblast Plasticity Potential.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Jun 15.
- Effects of Guselkumab on Structural Damage Progression in Patients with Active Psoriatic Arthritis.; Advances in therapy. 2026 May 05.
- Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From the Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept AFFINITY Study.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Mar 25.
Affiliations
News
October 5, 2026
Dr. Stern Awarded Allergy Action Award
June 9, 2026
Fueling Discovery: Meet the 2026 Research and Education Pilot Awardees
May 8, 2026
Dr. Garcia-Hernandez, PhD to Receive the Women of Distinction Award
May 8, 2026
Dr. John Looney Named a JACI 2026 Outstanding Reviewer
April 13, 2026
Mentee of Dr. Jennifer Barnas Awarded Rochester Academy of Science Student Grant
Contact Us
Ritchlin Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642
(585) 442-3214