Pathologic Bone Resorption and New Bone Formation in Inflammatory Arthritis
Bone remodeling is a dynamic and complex process finely orchestrated by cell interactions among bone-degrading osteoclasts, bone-synthesizing osteoblastosteoblasts, T cells, B cells, and natural killer cells. An imbalance between osteoclast and osteoblast activity results in skeletal and joint diseases including osteoporosis, arthritis, and non-union bone repair. These diseases impact the quality of life of patients.

Christopher T. Ritchlin, M.D., M.P.H.
Principal Investigator
Publications
View All Publications- Effects of Guselkumab on Structural Damage Progression in Patients with Active Psoriatic Arthritis.; Advances in therapy. 2026 May 05.
- Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From the Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept AFFINITY Study.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Mar 25.
- Telocyte Deletion is Associated with Loss of Lymphatic Drainage and Exacerbation of Inflammatory-Erosive Arthritis in Mice.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Mar 16.
- Bimekizumab safety and efficacy in patients with psoriatic arthritis: 3-year results from two phase 3 studies.; Rheumatology (Oxford, England). 2026 Mar 16.
Affiliations
News
May 8, 2026
Dr. Garcia-Hernandez, PhD to Receive the Women of Distinction Award
May 8, 2026
Dr. John Looney Named a JACI 2026 Outstanding Reviewer
April 13, 2026
Mentee of Dr. Jennifer Barnas Awarded Rochester Academy of Science Student Grant
February 6, 2026
Dr. Katherine Herman Presents Medical Grand Rounds
January 23, 2026
Dr. Theresa Bingemann Presents at the AAAAI Program Directors Assembly Winter Meeting
Contact Us
Ritchlin Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642
(585) 442-3214