Pathologic Bone Resorption and New Bone Formation in Inflammatory Arthritis
Bone remodeling is a dynamic and complex process finely orchestrated by cell interactions among bone-degrading osteoclasts, bone-synthesizing osteoblastosteoblasts, T cells, B cells, and natural killer cells. An imbalance between osteoclast and osteoblast activity results in skeletal and joint diseases including osteoporosis, arthritis, and non-union bone repair. These diseases impact the quality of life of patients.

Christopher T. Ritchlin, M.D., M.P.H.
Principal Investigator
Publications
View All Publications- Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From the Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept AFFINITY Study.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Mar 25.
- Telocyte Deletion is Associated with Loss of Lymphatic Drainage and Exacerbation of Inflammatory-Erosive Arthritis in Mice.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Mar 16.
- Bimekizumab safety and efficacy in patients with psoriatic arthritis: 3-year results from two phase 3 studies.; Rheumatology (Oxford, England). 2026 Mar 16.
- Efficacy and Safety of Guselkumab in Participants with Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week-24 Results of the Phase 3, Randomized, Placebo-Controlled SOLSTICE Study.; Arthritis & rheumatology (Hoboken, N.J.). 2026 Feb 11.
Affiliations
News
February 6, 2026
Dr. Katherine Herman Presents Medical Grand Rounds
January 23, 2026
Dr. Theresa Bingemann Presents at the AAAAI Program Directors Assembly Winter Meeting
November 21, 2025
Dr. Rangel-Moreno an International Speaker at the Research Seminars in Biological Sciences and International Biomedicine Workshop
October 22, 2025
Dr. Jennifer Anolik Presents at Upstate Medical Center Symposium
October 20, 2025
National Scleroderma Foundation Rochester Education Forum Held at URMC
Contact Us
Ritchlin Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642
(585) 442-3214